Etiologies of Acute Thrombocytopenia

ACD09/12/2014

Kevin KuriakosePGY-3UAMS

Pathophysiology

• Decreased production• Increased destruction• Increased consumption• Redistribution• Dilution

Infection

• Viral: HIV, Mumps, Rubella, Parvo, Hep C, EBV, Dengue

• Bacterial: – Sepsis (BM suppression, DIC, TTP/HUS)– Tick borne illnesses– H pylori, Leptospirosis, Brucellosis

• Parasites: Malaria, Babesiosis

Immunological/Rheumatological

• ITP• SLE (Secondary ITP)• Drugs• HIT• APS• RA (Felty’s Syndrome)

Felty’s Syndrome

RA Splenomegaly

Bernard Soulier Syndrome

Evan’s Syndrome

Warm AIHA and ITP

Drugs

• Ampicillin• Zosyn• Vancomycin• Rifampin• Phenytoin• Carbamazepine• Quinine• Sulfonamides

Bone Marrow

• Malignancies – The disease and the treatment• PNH• MDS• Aplastic Anemia

Others

• Hypersplenism• Alcohol• Nutrient deficiencies• Pregnancy• Congenital (Bernard Soulier Syndrome)

Thank you