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Etienne Robert 2010 Meas. Sci. Technol.21 025102doi:10.1088/0957-0233/21/2/025102

Mass spectrometer calibration over wide concentration ranges inmulticomponent gas mixtures

Etienne Robert1

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AbstractReferencesCited By

A quadrupole mass spectrometer (QMS) is used to measure the mixture composition of gas samples gathered in anovel burner configuration used to generate unstretched diffusion flames. The large variations of speciesconcentration in the mixtures found in the burning chamber lead to accuracy problems due to the nonlinearitiesinherent to the instrument mode of operation. To obtain precise and real -time measurements, the sensitivity of theinstrument is mapped to account for important changes in the sample composition. The implemented calibrationprocedure accounts for the concentration of the various species of interest in the burner (H 2, He, H2O, CH4, O2, Ar,CO2) in mixtures containing up to five constituents, using up to one hundred reference mixtures. When necessary,calibration adjustments are performed using a small set of measurements to account for the effect of the drift ofinstrument sensitivity resulting from instrument wear or fouling. This procedure allows us to keep the relative error onthe concentration of every species of interest below 5% for most of the mixtures while a classical calibration based ona limited number of reference mixtures often resulted in relative errors in excess of 50%.

PACS

07.75.+h Mass spectrometers

82.33.Vx Reactions in flames, combustion, and explosions

06.20.fb Standards and calibration

Subjects

Instrumentation and measurement

Chemical physics and physical chemistry

Dates

Issue 2 (February 2010)

Received 22 September 2009, in final form 10 November 2009

Published 22 December 2009

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Etienne Robert 2010 Meas. Sci. Technol.21 025102

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Calibration solutions for Thermo Scientific Mass Spectrometers

Ready-to-use standards enable quick instrument calibration.

John C. Rogers, Ph.D.; Michael M. Rosenblatt, Ph.D.; Eugene J. Cichon, B.S.; Rosa Viner, Ph.D.1; Monica Noonan,

M.S.;

June 1, 2011

Routine calibration of mass spectrometers is required for optimal performance. Our new calibration solutions forThermo Scientific Mass Spectrometers are ready-to-use liquid formulations for quick and easy instrument calibration.

Calibration solutions for Thermo Scientific Ion Trap and Orbitrap Mass Spectrometers

Calibration of Thermo Scientific Ion Trap and Orbitrap Mass Spectrometers is required for proper instrumentperformance. These high-quality calibration solutions are for regulated environments and busy laboratories and avoidtime-consuming reagent preparation. Reagents are provided in high-purity Teflon*-coated containers testedrigorously to provide the highest batch-to-batch reproducibility (Figures 1 and 2).

Figure 1. Representative mass spectrum for the Thermo Scientific Pierce LTQ Velos ESI Positive IonCalibration Solution.N-butylamine, caffeine, Met-Arg-Phe-Ala (MRFA) and Ultramark 1621 are used to calibrateThermo Scientific LTQ Velos Ion Trap and Orbitrap Mass Spectrometers in the ESI positive ionization mode. The N-butylamine is included to extend to low mass calibration range.

http://www.piercenet.com/previews/media/88323-v15-Fig1-VelosPos.jpg

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Figure 2. Representative mass spectrum for the negative ion calibration. Sodium dodecyl sulfate, sodiumtaurocholate and Ultramark 1621, comprise the calibration mixture used to calibrate Ion Trap and Orbitrap* Mass

Spectrometers in the negative ionization mode.

Calibration solutions for Thermo Scientific Triple Quadrupole Mass Spectrometers

Thermo Scientific TSQ Mass Spectrometers are calibrated with multimers of tyrosine (Tyr1, Tyr3, Tyr6). All of thecomponents of this mixture are prepared from the highest purity raw materials and are stored in inert Teflon-coatedcontainers (Figure 3).

Figure 3. Representative mass spectrum for the triple-quadrupole MS calibration.Multimers of tyrosine are usedto calibrate the TSQ series of Triple Quadrupole Mass Spectrometers.

To obtain accurate results, keep the cuvette clean and wipe off the sides before placing it into the

machine.

Read more:How to Calibrate a Spectrometer | eHow.comhttp://www.ehow.com/how_6368848_calibrate-

spectrometer.html#ixzz1wOSulksf

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