XCM BIOLOGIC® Tissue Matrix (xenograft)

XCM BIOLOGIC® and FlexHD®

I require an easily

implantable Biologic

I need a Biologic mesh which provides strength without

cross-linking

My surgical standards require an allograft with superior

strength for optimal

patient healing

Color sticky notes represent customer insights.

Ethicon offers you choice of Biologic meshes for abdominal wall repairFor complete indications, contraindications, warnings, precautions,

and adverse reactions, please reference full package insert.

FlexHD® STRUCTURAL Acellular Hydrated Dermis+ (allograft)

The third-party trademarks used herein are trademarks of their respective owners.

+FlexHD® Structural is a registered trademark of the Musculoskeletal Transplant Foundation, Edison, New Jersey.

Intact collagen fibers retain natural strength and provide pliability to XCM BIOLOGIC Tissue Matrix1

XCM BIOLOGIC® Tissue Matrix: a xenograft backed by the strength of science

Open-pore structure allows for cell ingrowth and revascularization in an animal model1,2

Quality begins at the source

• Excellent performance on the 2 key surgical parameters—tensile strength and stretch resistance1

• Allows tissue ingrowth and incorporation from all sides (20x magnification) at 4 months post-implantation in an animal model3

• Unique OptrixTM processing maintains the natural 3-D fibrous structure and key extracellular matrix components* without cross-linking1,4

• Produced in partnership with DSM Biomedical

STRATTICE™ Firm

N=90

XCM BIOLOGIC Tissue Matrix

62.5

36.7

177.5

140.9

Stretch Resistance (MPa)

Tensile Strength (N/cm)

Optrix™ is a trademark of DSM Biomedical or its affiliates. *The effect of these components on the performance of XCM BIOLOGIC Tissue Matrix has not been clinically evaluated.

FlexHD® STRUCTURAL Acellular Hydrated Dermis+ provides more strength for healing than leading biologic meshes5

FlexHD® STRUCTURAL Acellular Hydrated Dermis+: an allograft with exceptional benchtop performance

FlexHD® STRUCTURAL Acellular Hydrated Dermis+ supports revascularization and cellular infiltration with a minimal inflammatory response7,8*‡

Not all human tissue is the same—processing standards make a difference

• Minimally processed to preserve collagen and retain native human tissue properties8-10

• Produced in partnership with the Musculoskeletal Transplant Foundation

• Available in multiple sizes and thicknesses

• Stronger than AlloDerm Regenerative Tissue Matrix or STRATTICE™ Firm5

• Demonstrated effectiveness for abdominal wall repair environment6-8*†

• In an animal model, mesh (100x magnification) is visibly populated with fibroblasts (see arrow)6

STRATTICE™ Firm

AlloDerm® Regenerative Tissue Matrix

Unprocessed Skin

FlexHD® STRUCTURAL Acellular Hydrated Dermis+

Tensile Strength (MPa)3

P <0.0515.7

11.210.2

9.2

10.1

7.26.5 7.0

Modulus (MPa)3

P <0.05

*In benchtop testing†In an animal model of abdominal wall repair with the graft positioned as an underlay‡ The effect of these components on the performance of FLEXHD® STRUCTURAL Acellular Hydrated Dermis+ has not been clinically evaluated.

+FlexHD® Structural is a registered trademark of the Musculoskeletal Transplant Foundation, Edison, New Jersey.

No prep needed: all products ready to use out of the package XCM BIOLOGIC® Tissue Matrix, sterile (hydrated), Thick

average 1.5 mm thick ±0.3 mm

Tissue Code Dimensions Tissue Code Dimensions

XM106.0612S 6 x 12 cm XM106.1620S 16 x 20 cm

XM106.0616S 6 x 16 cm XM106.1625S 16 x 25 cm

XM106.0812S 8 x 12 cm XM106.2020S 20 x 20 cm

XM106.0816S 8 x 16 cm XM106.2025S 20 x 25 cm

XM106.0820S 8 x 20 cm XM106.2030S 20 x 30 cm

XM106.1016S 10 x 16 cm XM106.2040S 20 x 40 cm

XM106.1020S 10 x 20 cm XM106.2540S 25 x 40 cm

XM106.1220S 12 x 20 cm XM106.2545S 25 x 45 cm

XCM BIOLOGIC Tissue Matrix, Tailored Coverage™, Thick

Tissue Code Dimensions

XM106.2535TCS 25 x 35 cm

FlexHD® STRUCTURAL Acellular Hydrated Dermis+, Thin

Tissue Code Dimensions Thickness

470407 4 x 7 cm 0.4–0.8 mm

FlexHD® STRUCTURAL Acellular Hydrated Dermis+, Thick0.8–1.7 mm thick

Tissue Code Dimensions Tissue Code Dimensions

471407 4 x 7 cm 471224 12 x 24 cm

471608 6 x 8 cm 471620 16 x 20 cm

471812 8 x 12 cm 471202 20 x 20 cm

471016 10 x 16 cm 471225 20 x 25 cm

471216 12 x 16 cm 471230 20 x 30 cm

FlexHD® STRUCTURAL Acellular Hydrated Dermis+, Ultra Thick1.8–4 mm

Tissue Code Dimensions Tissue Code Dimensions

472812 8 x 12 cm 472620 16 x 20 cm

472016 10 x 16 cm 472224 12 x 24 cm

472216 12 x 16 cm 472225 20 x 25 cm

472230 20 x 30 cm

FlexHD® STRUCTURAL DIAMOND Acellular Hydrated Dermis+, Thick

Tissue Code Dimensions Thickness

4D1331 21-23 x 29.5-31 cm 0.8–1.7 mm

4D1335 23-25 x 34.5-36 cm 0.8–1.7 mm

FlexHD® STRUCTURAL DIAMOND Acellular Hydrated Dermis+, Ultra Thick

Tissue Code Dimensions Thickness

4D2331 21-23 x 29.5-31 cm 1.8–4.0 mm

4D2335 23-25 x 34.5-36 cm 1.8–4.0 mm

References: 1. DSM Biomedical internal data.. Animal and bench test results are not necessarily indicative of clinical performance. 2. Hackett ES, Harilal D, et al. Evaluation of porcine hydrated dermis augmented repair in a fascial defect model. Journal of Biomedical Materials Research. 2011;96B(1):134-138. Rev 12, 02/2012. 3. W. Harry Caulfiled III, M.D. FACS. XCM BIOLOGIC® Tissue Matrix Reconstruction of the anterior abdominal wall following a TRAM flap breast reconstruction. Case Report from DePuy Synthes. (J10753-A). 4. Hoganson DM, O’Doherty EM, Owens GE, et al. The retention of extracellular matrix proteins and angiogenic and mitogenic cytokines in a decellularized porcine dermis. Biomaterials. 2010;31:6730-6737. 5. Choi B.Analysis of Tensile Testing Data of Acellular Dermis. Musculoskeletal Transplant Foundation Report LE-271. October 20, 2010:1-7. 6. Eberli D, RodriguezS, Atala A, Yoo JJ. In vivo evaluation of acellular human dermis for abdominal wall repair. J Biomed Mater Res A. 2010;93(4):1527-1538. 7. Roth JS, DexterDD, Lumpkins K, Bochicchio GV. Hydrated vs freezedried human acellular dermal matrix for hernia repair: a comparison in a rabbit model. Hernia. 2009;13(2):201-207. 8. Ngo M-D. Extracellular matrix components in acellular dermis. Musculoskeletal Transplant Foundation Report LE-268. December 22, 2009:1-6. 9. Choi B. Characterization of acellular dermis via SDS-PAGE. Musculoskeletal Transplant Foundation Report LE-284. February 20, 2010:1-5.10. FlexHD® Instructions for Use PI-31. MTF Biologics.. ©2018 Ethicon US, LLC. All rights reserved. 020244-180102

To order XCM BIOLOGIC® Tissue Matrix, call Synthes CMF Customer Service at 1-800-523-0322.

To order FlexHD® STRUCTURAL, call MTF Customer Service at 1-800-433-6576.

For complete indications, contraindications, warnings, precautions, and adverse reactions, please reference full package insert.

Visit Ethicon.com to learn more

+FlexHD® Structural is a registered trademark of the Musculoskeletal Transplant Foundation, Edison, New Jersey.