Essential components of a grant application (Grant Writing Part 1) components... · 2021. 2. 5. ·...
Transcript of Essential components of a grant application (Grant Writing Part 1) components... · 2021. 2. 5. ·...
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Essential components of a grant application
(Grant Writing Part 1)
Sufi Thomas, PhDAssociate Professor,Department of OtolaryngologyUniversity of Kansas Medical Center
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Grant Application Roadmap
• Science• Funding sources• NIH grant review process• Elements of a good grant application
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Tips on getting started
• Identify a gap in knowledge (review literature)• Build a hypothesis• Brainstorm ideas/get feedback
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Observe
Develop a Hypothesis
DrawConclusions
The Scientific Method
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Pursue science that matters!• Preliminary data
– Well powered– Basis for the hypothesis– Demonstrates feasibility
• NIH RePORTERhttps://projectreporter.nih.gov/reporter.cfm• Publish, publish, publish
– Aim for 1 paper a year
– Solidify collaborators
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Journal Impact Factor
Frequency with which an article is cited in 2 y
Search ISI Web of Knowledgehttps://apps.webofknowledge.com/WOS_GeneralSearch_input.do?product=WOS&search_mode=GeneralSearch&SID=5BmU84JZN4iiRXGMfqk&preferencesSaved=
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THE NEXT FRONTIERWriting grants
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Identify funding sources• KUMC SPA portalhttp://www.kumc.edu/kumcri/sponsored-programs-administration.html
• NIH Grants & funding– https://grants.nih.gov/funding/searchguide/index.html#/
• Foundations, Societies, Angel funding
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Types of NIH grants• Research grants (R series) (clinical and basic science)• Career Development Awards (K series)• Research Training and Fellowships (T & F series)• Program Projects/Center Grants (P series)• Resource Grants • Trans-NIH programs (GWAS, Diversity supplements,
etc)• Request for applications (RFAs)/Funding Opportunity
Announcements (FOA)
Know your audience
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NIH grant review process
• Institutes and Centers (ICs) that award grants
• Funding rate around 20%• NIH Center for Scientific
Review– https://art.csr.nih.gov/ART/selection.jsp
• Contact Program Officer (PO)• Study section
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Piecing together an NIH grant• Contact the Research Institute • Set up eRA Commons access https://era.nih.gov/• Title page and routing sheet• Consortium agreements• Define your team• Seek advice
– NIH Program Officer– Peers– Mentors (established investigators)
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Overview of an NIH Grant• Project Summary/Abstract• Project Narrative• Facilities• Biosketches• Budget• Personnel Justification• Research Plan• Human subjects • Vertebrate animals• Letters of Support • Resource sharing plan• Authentication plan
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Make it declarative!
< 200 characters
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Staging of cervical lymph nodes in squamous cell carcinoma: adding PET/CT in clinically lymph node negative patients may improve the diagnostic work-up
• PET/CT for diagnostic staging of cervical lymph nodes in squamous cell carcinoma
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The Critical Core
• Specific Aims• Research Strategy
– Significance– Innovation– Approach
• References
Pay attention to margins (0.5’’)
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Specific Aims
• Rationale and relevance to the NIH mission (why?)• Published and preliminary data (why you?)• Gap in knowledge• Hypothesis• Propose 2-3 hypothesis-driven Aims • Overall impact/significance (so what?)
Limit to a single page
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Significance
• Define the gap in knowledge• Why is the problem important?• Define the critical barriers• How will the proposed work impact the field?
Highlight the impact of the proposed work
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Investigator• Publications• NIH biosketch
– Personal statement: Outline expertise
• Collaborative team – Experts in the proposed area of research– Biostatistician
• Multi-PI leadership plan – Rationale and justification– Governance, conflict resolution– Decision making and resource allocation
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Innovation
• Novel concepts• New technologies• Innovative application of existing ideas
Shift the current paradigm
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Approach• Preliminary data: high rigor, shows feasibility• Outline the rationale• Craft logical Subaims
– Propose multiple angles, include controls– Biohazard handling
• Statistical analysis is critical• Potential Pitfalls• Alternative approachesAims should stand alone-be related but not dependent on each others' outcomes
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Choose the optimal environment
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Environment
• Facilities and resources– Lab space– Equipment– Access to specialized instruments – Core facilities – Mentoring/collaborative support– Include plans for teleconferences or meetings for
MPI applications– Check letters of support for accuracy
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Human subjects
• Exemption 4• Data and Safety monitoring• Inclusion of women, minorities and children
https://grants.nih.gov/policy/humansubjects/research.htm
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Vertebrate Animals
• Description of Procedures• Justifications• Minimization of Pain and Distress• Euthanasia
https://grants.nih.gov/grants/guide/notice-files/not-od-16-006.html
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Resource sharing plan• MTA for cells and animals• Data repositories
Authentication of reagents• Antibodies• Cell lines
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Budget
• Modular vs non-modular• RO1: min 15% effort for PI and 10% for MPI
– Personnel, consortium agreements– Supplies– Travel– Publications– Core facilities– Services– Equipment
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Home-run
• Contact RI a month before submission• Inform RI about LOI submissions• Cayuse: KUMC grant portal• Get a draft of the Research plan 10 business
days prior to the deadline• Submit a few days before the deadline• Track grant on eRA Commons
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Avoid
• Staying depressed for too long• Obsessing about the stupidity of reviewers• Inflexibility about your data/proposal• Desire to give up• Speak to the Program Officer
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Introduction to Grant Reviews
• Fit it all in one page• Address issues raised• Publish preliminary data if possible• Point-by-point responses to the most
pertinent critiques• Stay respectful
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You’ve Got The Power