ESC Guidelines Where Are We Going? - swisscardio.ch · ESC Guidelines – Where Are We Going? Prof....
Transcript of ESC Guidelines Where Are We Going? - swisscardio.ch · ESC Guidelines – Where Are We Going? Prof....
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ESC Guidelines –Where Are We Going?
Prof. Dan Atar, FESC
Vice-President National Affairs
Courtesy Prof. JL. Zamorano, Chair of the
ESC Guideline Committee,
Mrs. Catherine Despres & Veronica Dean
ESC Guidelines Department
Prof. Jeroen J. Bax, President-elect, ESCZürich 10.6.2015
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1. How are the ESC guidelines generated?
2. How do guidelines work?
3. The ESC scoring system: Class of
recommendations, level of evidence
4. How is this scoring system different from the US?
5. Which topics have been covered in guidelines
over the years?
6. How do the topics relate with the core syllabus?
7. Which topics will be covered in 2015 and 2016?
8. What is the impact of guidelines - how many are
endorsed, how many are downloaded, how many
are translated?
9. How does the GL-App work?
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ESC Guidelines = Evidence + expertize for clinicians
• Evidence-based recommendations developed by Task Forces of leading European experts
• Help physicians weigh benefits & risks of particular diagnostic & therapeutic procedures
• Formats include: full texts, executive summaries, pocket guidelines, slide-sets, books, mobile application…
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ESC Committee for Practice Guidelines (CPG)
The CPG was created in 1994 by the ESC in order to deal with the process of guidelines development.
The CPG has the responsibility of selecting the topics for the documents.
The CPG is responsible for administrative supervision and co-ordination of Task Forces (TF).
Dan Atar, FESCVice President National Affairs
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ESC Committee for Practice Guidelines (CPG) 2014 - 2016
European Association for Cardiovascular Prevention & Rehabilitation (EACPR)
European Association of Cardiovascular Imaging (EACVI)
European Association of Percutaneous Cardiovascular Interventions (EAPCI)
European Heart Rhythm Association (EHRA)
Acute Cardiovascular Care Association (ACCA)
Council on Cardiovascular Nursing and Allied Professions (CCNAP)Council for Cardiology Practice (CCP)
Heart Failure Association (HFA)
First Name Last Name Country Representing
Jose Luis Zamorano SpainCPG Chairperson/ESC Board Mbr
Victor Aboyans France
Stephan Achenbach Germany
Stefan Agewall NorwayWG CV Pharmacotherapy
Lina Badimon Spain
Gonzalo Baron Esquivias Spain CCP
Helmut Baumgartner Germany
Jeroen Bax Netherlands
Héctor Bueno Spain ACCA
Scipione Carerj Italy
Veronica Dean France ESC staff
Cetin Erol Turkey
Donna Fitzimons UK CCNAP
First Name Last Name Country Representing
Oliver Gaemperli Switzerland
Paulus Kirchhof Germany/UK
Philippe Kolh Belgium
Patrizio Lancellotti Belgium EACVI
Gregory Lip UK EHRA
Petros Nihoyannopoulos UK
Massimo F. Piepoli Italy EACPR
Piotr Ponikowski Poland HFA
Marco Roffi Switzerland
Adam Torbicki Poland
Antonio Vaz Carneiro Portugal
Bryan Williams UK
Stephan Windecker Switzerland EAPCI
Dan Atar, FESCVice President National Affairs
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Goals and team Definitions(3 months)
Document elaboration: 2 phases: writing + review
(12–18 months)
Publication(3 months)
Guidelines Production: a 2 year-process
Details available on the ESC Web Site at:
http://www.escardio.org/guidelines-surveys/esc-guidelines/about/Pages/rules-writing.aspx
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1. How are the ESC guidelines generated?
2. How do guidelines work?
3. The ESC scoring system: Class of
recommendations, level of evidence
4. How is this scoring system different from the US?
5. Which topics have been covered in guidelines
over the years?
6. How do the topics relate with the core syllabus?
7. Which topics will be covered in 2015 and 2016?
8. What is the impact of guidelines - how many are
endorsed, how many are downloaded, how many
are translated?
9. How does the GL-App work?
![Page 8: ESC Guidelines Where Are We Going? - swisscardio.ch · ESC Guidelines – Where Are We Going? Prof. Dan Atar, FESC Vice-President National Affairs Courtesy Prof. JL. Zamorano, Chair](https://reader033.fdocuments.net/reader033/viewer/2022053008/5f0bfa077e708231d4332658/html5/thumbnails/8.jpg)
Goals & Team Definitions (3 months)
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Document Elaboration (12–18 months)
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Dan Atar, FESCVice President National Affairs
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Publication Phase (3 months)
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1. How are the ESC guidelines generated?
2. How do guidelines work?
3. The ESC scoring system: Class of
recommendations, level of evidence
4. How is this scoring system different from the US?
5. Which topics have been covered in guidelines
over the years?
6. How do the topics relate with the core syllabus?
7. Which topics will be covered in 2015 and 2016?
8. What is the impact of guidelines - how many are
endorsed, how many are downloaded, how many
are translated?
9. How does the GL-App work?
![Page 13: ESC Guidelines Where Are We Going? - swisscardio.ch · ESC Guidelines – Where Are We Going? Prof. Dan Atar, FESC Vice-President National Affairs Courtesy Prof. JL. Zamorano, Chair](https://reader033.fdocuments.net/reader033/viewer/2022053008/5f0bfa077e708231d4332658/html5/thumbnails/13.jpg)
ESC Class of Recommendation - COR
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Levels of Evidence
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www.escardio.org
European Heart Journal
http://eurheartj.oxfordjournals.org/
2010
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www.escardio.org
Recommendations
Total = 210
Class of Recommendation Level of Evidence
- I: is recommended
- IIa: should be considered
- IIb: may be considered
- III: should not…
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1. How are the ESC guidelines generated?
2. How do guidelines work?
3. The ESC scoring system: Class of
recommendations, level of evidence
4. How is this scoring system different from the US?
5. Which topics have been covered in guidelines
over the years?
6. How do the topics relate with the core syllabus?
7. Which topics will be covered in 2015 and 2016?
8. What is the impact of guidelines - how many are
endorsed, how many are downloaded, how many
are translated?
9. How does the GL-App work?
![Page 18: ESC Guidelines Where Are We Going? - swisscardio.ch · ESC Guidelines – Where Are We Going? Prof. Dan Atar, FESC Vice-President National Affairs Courtesy Prof. JL. Zamorano, Chair](https://reader033.fdocuments.net/reader033/viewer/2022053008/5f0bfa077e708231d4332658/html5/thumbnails/18.jpg)
CLASS (STRENGTH) OF RECOMMENDATION
Speaker
ACC/AHA
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‡ For comparative-effectiveness recommendations (COR I and IIa; LOE A and B
only), studies that support the use of comparator verbs should involve direct
comparisons of the treatments or strategies being evaluated.
CLASS (STRENGTH) OF RECOMMENDATIONACC/AHA
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CLASS (STRENGTH) OF RECOMMENDATIONACC/AHA
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LEVEL (QUALITY) OF EVIDENCE†
Speaker
† The method of assessing quality is evolving, including the application
of standardized, validated evidence grading tools; and for systematic
reviews, the incorporation of an Evidence Review Committee.
ACC/AHA
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† The method of assessing quality is evolving, including the application
of standardized, validated evidence grading tools; and for systematic
reviews, the incorporation of an Evidence Review Committee.
LEVEL (QUALITY) OF EVIDENCE†ACC/AHA
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A recommendation with LOE C or E does not imply that the recommendation is weak.
Many important clinical questions addressed in guidelines do not lend themselves to
clinical trials. Although RCTs are unavailable, there may be a very clear clinical consensus
that a particular test or therapy is useful or effective.
LEVEL (QUALITY) OF EVIDENCE†ACC/AHA
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Who Applies GRADE ?
• American College of Physicians
• American Thoracic Society
• Publishers – BMJ
• Publications – UpToDate
• Cochrane Collaboration
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The GRADE Process for developing recommen
dations
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GRADE Quality Assessment
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Next steps:
• JOIN ACC/AHA?
• Simultaneous ESC / GRADE in some GL’s (same as US)
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ESC – Prevention Guidelines 2012
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1. How are the ESC guidelines generated?
2. How do guidelines work?
3. The ESC scoring system: Class of
recommendations, level of evidence
4. How is this scoring system different from the US?
5. Which topics have been covered in guidelines
over the years?
6. How do the topics relate with the core syllabus?
7. Which topics will be covered in 2015 and 2016?
8. What is the impact of guidelines - how many are
endorsed, how many are downloaded, how many
are translated?
9. How does the GL-App work?
![Page 30: ESC Guidelines Where Are We Going? - swisscardio.ch · ESC Guidelines – Where Are We Going? Prof. Dan Atar, FESC Vice-President National Affairs Courtesy Prof. JL. Zamorano, Chair](https://reader033.fdocuments.net/reader033/viewer/2022053008/5f0bfa077e708231d4332658/html5/thumbnails/30.jpg)
Publication schedule from 2001 to 2017 London
On-going
2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017
Syncope
Peripheral Artery Disease
AMI-STEMI
Valvular Heart Disease
Universal Def of MI
Atrial FibrillationFocused update
Heart Failure
Dyslipidaemias
CVD Prevention
Cardio-Oncology PP
ACS-NSTE
Infective Endocarditis
Pulmonary Hypertension
VA & SCD
Pericardial Disease
Aortic
PE
MR
HCM
Non-Cardiac Surg
Diabetes
SCAD
Cardiac Pacing
Arterial Hypert
Pregnancy
GUCH
Biopsy
ACE-I (ECD)
B-Blockers (ECD)
Antiplatelet Agents ( ECD)
SVA
Chest Pain
Neo ECG (ECD)
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1. How are the ESC guidelines generated?
2. How do guidelines work?
3. The ESC scoring system: Class of
recommendations, level of evidence
4. How is this scoring system different from the US?
5. Which topics have been covered in guidelines
over the years?
6. How do the topics relate with the core syllabus?
7. Which topics will be covered in 2015 and 2016?
8. What is the impact of guidelines - how many are
endorsed, how many are downloaded, how many
are translated?
9. How does the GL-App work?
![Page 32: ESC Guidelines Where Are We Going? - swisscardio.ch · ESC Guidelines – Where Are We Going? Prof. Dan Atar, FESC Vice-President National Affairs Courtesy Prof. JL. Zamorano, Chair](https://reader033.fdocuments.net/reader033/viewer/2022053008/5f0bfa077e708231d4332658/html5/thumbnails/32.jpg)
Speaker
22/28 Core Curriculum topics covered by
ESC Guidelines
Core Curriculum 2013 Topics YES
1. History taking and clinical examination
2. The electrocardiogram (standard & exercise ECG, ambulatory,CPX) x
3. Non-invasive imaging
4. Invasive imaging: cardiac catheterization & angiography
5. Genetics
6. Clinical pharmacology x7. Cardiovascular prevention x8. Acute coronary syndromes x9. Chronic ischaemic heart disease x10. Myocardial diseases x
11. Pericardial diseases x12. Oncology and the heart x13. Congenital heart disease in adult patients x14. Pregnancy & heart disease x15. Valvular heart disease x16. Infective endocarditis x17. Heart failure x18.Pulmonary arterial hypertension x19. Physical activity & sport in primary & secondary prevention
20. Arrhythmias x21. Atrial fibrillation & flutter x22. Syncope x23. Sudden cardiac death & resuscitation x24. Diseases of the aorta & trauma to the aorta & heart x25. Peripheral artery diseases. x26. Thrombo-embolic venous disease x27. Acute cardiovascular care
28. The cardiac consult x
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1. How are the ESC guidelines generated?
2. How do guidelines work?
3. The ESC scoring system: Class of
recommendations, level of evidence
4. How is this scoring system different from the US?
5. Which topics have been covered in guidelines
over the years?
6. How do the topics relate with the core syllabus?
7. Which topics will be covered in 2015 and 2016?
8. What is the impact of guidelines - how many are
endorsed, how many are downloaded, how many
are translated?
9. How does the GL-App work?
![Page 34: ESC Guidelines Where Are We Going? - swisscardio.ch · ESC Guidelines – Where Are We Going? Prof. Dan Atar, FESC Vice-President National Affairs Courtesy Prof. JL. Zamorano, Chair](https://reader033.fdocuments.net/reader033/viewer/2022053008/5f0bfa077e708231d4332658/html5/thumbnails/34.jpg)
2015: 5 Guidelines, 1 Position paper to be published
Pulmonary Hypertension Chairs: Marc Humbert,
Nazzareno Galie
Ventricular Arrhythmia & Sudden Cardiac Death
Chairs: Silvia Priori,Carina Blomstrom Lundqvist
Acute Coronary Syndroms in Patients presenting without
persistent ST Segment elevation - (ACS – NSTE)Chairs: Marco Roffi, Carlo
PatronoPericardial DiseasesChairs: Philippe Charron,
Yehuda Adler Infective EndocarditisChairs: Gilbert Habib,
Patrizio Lancellotti
Cardio-Oncology Position Paper
Chairs: Pepe Zamorano, Patrizio Lancellotti
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4 Guidelines in writing phaseFor publication in 2016
DyslipidaemiasChairs: Ian Graham, Alberico Catapano
Heart FailureChairs: Piotr Ponikowski,
Adriaan Voors
CVD PreventionChairs: Massimo Piepoli,
Arno W. Hoes
Atrial FibrillationChairs:Paulus Kirchhof,
Stefano Benussi
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1. How are the ESC guidelines generated?
2. How do guidelines work?
3. The ESC scoring system: Class of
recommendations, level of evidence
4. How is this scoring system different from the US?
5. Which topics have been covered in guidelines
over the years?
6. How do the topics relate with the core syllabus?
7. Which topics will be covered in 2015 and 2016?
8. What is the impact of guidelines - how many are
endorsed, how many are downloaded, how many
are translated?
9. How does the GL-App work?
![Page 37: ESC Guidelines Where Are We Going? - swisscardio.ch · ESC Guidelines – Where Are We Going? Prof. Dan Atar, FESC Vice-President National Affairs Courtesy Prof. JL. Zamorano, Chair](https://reader033.fdocuments.net/reader033/viewer/2022053008/5f0bfa077e708231d4332658/html5/thumbnails/37.jpg)
ESC Publications –Massive dissemination
8
11
0
2
4
6
8
10
12
Total ESC Journal Downloads
2013 2014
Talking millions
2014Total ESC Journal Downloads 10 753 135Total ESC Guidelines Downloads 1 472 524Total ESC GL Download Contribution (%) 13,7
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Endorsements per NCS countries (2009 to January 2015)
Dan Atar, FESCVice President National Affairs
2009 2010 2011 2012 2013 2014
3034 35 37
29 30
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21
15
1011
12 12
1415
12
10
8 8
10
6
3 34
3 3
Translations of Pocket Guidelines/titles2010-2014 (Dec 2014)
Published in Barcelona Congress
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Translation of Some Pocket Guidelines AvailableThe translations are done by the NCS
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1. How are the ESC guidelines generated?
2. How do guidelines work?
3. The ESC scoring system: Class of
recommendations, level of evidence
4. How is this scoring system different from the US?
5. Which topics have been covered in guidelines
over the years?
6. How do the topics relate with the core syllabus?
7. Which topics will be covered in 2015 and 2016?
8. What is the impact of guidelines - how many are
endorsed, how many are downloaded, how many
are translated?
9. How does the GL-App work?
![Page 42: ESC Guidelines Where Are We Going? - swisscardio.ch · ESC Guidelines – Where Are We Going? Prof. Dan Atar, FESC Vice-President National Affairs Courtesy Prof. JL. Zamorano, Chair](https://reader033.fdocuments.net/reader033/viewer/2022053008/5f0bfa077e708231d4332658/html5/thumbnails/42.jpg)
ESC POCKET GUIDELINES APPLICATIONOver 90 practical tools linked to the 2011, 2012, 2013 and 2014 ESC Guidelines
http://www.escardio.org/guidelines
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ESC GUIDELINES APPLICATION INTERACTIVE TOOLS
Calculators Algorithms Charts & Scores
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Example of interactive tools in the App: CHA2DS2-VASc Score
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Example of interactive tools in the App: Choice of anticoagulant
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Dan Atar, FESCVice President National Affairs
Conclusions• The ESC Guidelines: highly visible / used world wide
• Quality the primary feature
• Regular updates required for every topic covered
• GLs assist physicians in decision making, however do not
replace individual clinical judgement
• Guidelines are not meant to be the law
• Future developments: GRADE, while keeping the simple and
accepted system of recommendations
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Thank you for your attention