Eric Lam

EDUCATION: Institution Degree Year Department State University of New York B.S. 1977-80 Chemistry at Stony Brook, NY University of California at Ph.D. 1980-84 Biophysics Berkeley (UCB), CA RESEARCH INTERESTS Plant Biotechnology for Biofuels and Biomedicine; Chromatin and Epigenetic Control; Plant Stress Tolerance; Cell Death Control in Plants SCHOLARSHIPS AND HONORS 2012 Senior Visiting Professorship, Chinese Academy of Science

2011 Alexander von Humboldt Research Award in Molecular Biology 2008- present Advisory Board, Rutgers Energy Institute 2004- present Editorial Board, BMC Plant Biology

1996- present Co-Editor, Plant Molecular Biology 1996-2007 Panel Member, NSF Study Section 1995 Special Reviewer for NIH Molecular Biology Study Section 1993 Johnson and Johnson Discovery Fellow 1987 Walter J. Johnson Award from Academic Press 1977 New York State Regents Scholarship PROFESSIONAL EXPERIENCE 2011 Guest Scientist, Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany

2010-present Professor II, Department of Plant Biology and Pathology, Rutgers University, NJ 2009-present Adjunct Professor, School of Environment and Energy, Graduate School of Peking University in Shenzhen, Shenzhen, China

2008-10 Director, Biotechnology Center for Agriculture and the Environment, Rutgers

2000-10 Professor I, Department of Plant Biology and Pathology, Rutgers State University,

Biotech Center, New Jersey 2002-04 Department Head for Botany, The University of Hong Kong 2001-04 Chair of Botany, The University of Hong Kong, Hong Kong SAR of China 1997-98 Instructor for Cold Spring Harbor course on Arabidopsis Molecular Genetics 1995-00 Associate Professor, Department of Plant Science, Rutgers State

University, AgBiotech Center, New Brunswick, NJ 1989-95 Assistant Professor, Department of Plant Science, Rutgers State

University, AgBiotech Center, New Brunswick, NJ 1985-89 Postdoctoral Fellow, Laboratory of Plant Molecular Biology,

Rockefeller University 1984-85 Postdoctoral Fellow, Division of Molecular Plant Biology, UCB

1982-84 Research Assistant, Division of Molecular Plant Biology, UCB 1982 Teaching Assistant, Department of Physiology-Anatomy, UCB 1981 Teaching Assistant, Department of Biophysics, UCB PATENTS AWARDED

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2006 U.S. Patent No. 7,015,023 entitled “Compositions and Methods for Detection of Active Proteases” Inventors: Eric Lam and Olga del Pozo

1997 U.S. Patent No. 5,629,470 entitled "Transgenic Plants and Plant Cells with Enhanced Pathogen Resistance and Related Methods" International Application Number: PCT/US96/00741 (Jan. 1996)

Inventors: Eric Lam and Ron Mittler 1991 U.S. Patent No. 5,023,179 entitled "Promoter Enhancer Element for Gene

Expression in Plant Roots" Inventors: E. Lam, P.N. Benfey, P.M. Gilmartin and N.H. Chua

1991 U.S. Patent No. 4,990,607 entitled "Alteration of Gene Expression in Plants" Inventors: F. Katagiri, E. Lam and N.-H Chua PATENTS PENDING

2009 U.S. Patent (filed April 2010) entitled:

"Chemical Chaperones as Antifungal Agents for Treatment of Plants Against

Fusarium Fungal Pathogens"

Inventors: Eric Lam, Michael Lawton and Hemalatha Saidasan

2012 U.S. Paten (filed April 2012) entitled:

“Edible Transgenic Plants as Oral Delivery Vehicles for RNA-based Therapeutics”

Inventor: Eric Lam

PUBLICATION LIST

1979 1). "Effects of Fluorescamine Modification of Rat Liver Mitochodria on the Action of Uncouplers"

Eric Lam and Shu-I Tu, FEBS Lett. 106, 226-230. 1980

2). "Differential Inhibition of Respiration and Its Dependent H+ Extrusion by Fluorescamine in Rat Liver Mitochondria" Eric Lam, David Shiuan and Shu-I Tu, Arch Biochem. Biophys 201, 330-338.

3). " Effects of Monovalent Cations on the Activities Associated with Coupling Site III of Rat Liver

Mitochondria" Eric Lam and Shu-I Tu, Biochem. Biophys. Res. Commun. 96, 196-202. 1981

4). "Inhibition of the Links Between Electron Transfer and Proton Translocation in Mitochondria" Shu-I Tu, Eric Lam, Fausto Ramirez and James Marecek, Eur. J. Biochem. 113, 3911-396.

5). "Mutual Regulation Between Mitochondrial ATPase and Respiratory Chain Activities" Shu-I Tu,

Hiroshi Okazaki, Fausto Ramirez, Eric Lam and James Marecek, Arch. Biochem. Biophys. 210, 124-131.

6). "Effects of Fluorescamine Modification of Purple Membranes on Exciton Coupling and Light-to-

Dark Adaptation" Eric Lam and Lester Packer, Biochem. Biophys. Res. Commun. 101, 464-471.

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1982 7). "Ferredoxin-Mediated Reduction of Cytochrome b-563 in a Chloroplast Cytochrome b-563/f

Complex" Eric Lam and Richard Malkin, FEBS Lett. 141, 98-101. 8). "In vitro Reconstitution of the Electron Pathway from Water to Cytochrome f of Spinach

Thylakoids" Eric Lam and Richard Malkin, FEBS Lett. 144, 190-194. 9). "Reconstruction of the Chloroplast Noncyclic Electron Transport Pathway from Water to NADP

with Three Integral Protein Complexes" Eric Lam and Richard Malkin, Proc, Natl. Acad. Sci.

USA 79, 5494-5498. 10). "Comparison of the O640 Photo-intermediate and Acid-induced Species in Membrane Patches from

Halobacterium halobium S9 and R1mW Strains" Eric Lam, Ian Fry, Lester Packer and Yasuo

Mukohata, FEBS Lett. 146, 106-110. 11). "Light Dependent Modification of Bacteriorhodopsin by Tetranitromethane. Interaction of a

Tyrosine and a Tryptophan Residue with Bound Retinal" Tatsuo Katsura, Eric Lam, Lester Packer and Stanley Seltzer, Biochemistry International 5, 445-456.

12). "Photonitration of Phenol by Tetranitromethane Under Visible Light" Stanley Seltzer, Eric Lam

and Lester Packer, J. Am. Chem. Soc. 104, 6470-6471. 13). "Photoreactions of Cytochrome b6 in Systems Using Resolved Chloroplast Electron-Transfer

Complexes" Eric Lam and Richard Malkin, Biochim. Biophys. Acta 682, 378-386. 1983 14). "Construction of Noncycic Electron Flow from Chloroplast Photosystem II and Mitochondrial

Cytochrome b-c1 Complex to Cytochrome c" Eric Lam and Richard Malkin, FEBS Lett. 152, 89-

93. 15). "Nonionic Detergent Effects on Spectroscopic Characteristics and the Photocycle of

Bacteriorhodopsin in Purple Membranes" Eric Lam and Lester Packer, Arch. Biochem.

Biophys. 221, 557-564. 16). "Studies on the Function of the Rieske Iron-Sulfur Center in Photosynthetic Electron Transport

Reactions" Richard Malkin, Richard K. Chain and Eric Lam, Chemica Scripta 21, 75-80. 17). "Characterization of Electron Transfer from Water to Plastocyanin Catalyzed by Resolved

Electron Transfer Complexes from Chloroplasts" Eric Lam and Richard Malkin, Arch. Biochem.

Biophys. 224, 456-463. 18). "Chlorophyll b: An Integral Component of Photosystem I of Higher Plant Chloroplasts" Jan M.

Anderson, Jeanette S. Brown, Eric Lam and Richard Malkin, Photochem. Photobiol. 38, 205-210. 19). "Characterization of a Resolved Oxygen-Evolving Photosytem II Preparation from Spinach

Thylakoids" Eric Lam, Barbara Baltimore, William Ortiz, Susan Chollar, Anastasios Melis and Richard Malkin, Biochim. Biophys. Acta 724, 201-211.

20). "Light-Dependent Nitration of Bacteriorhodopsin" Eric Lam, Stanley Seltzer, Tatsuo Katsura and

Lester Packer, Arch. Biochem. Biophys. 227, 321-328.

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1984 21). "Spectroscopic Characterization of Nitrated Purple Membranes" Eric Lam, Ajay Pande, Robert

Callender, E.F. Hilinski, Peter Rentzepis and Lester Packer, Biochemistry International 8, 217-224.

22). "Fractionation of an Oxygen-Evolving Photosystem II Preparation: Characterization of the Light-

Harvesting Antenna and Reaction Center Components" Eric Lam, Barbara Baltimore, William Ortiz and Richard Malkin, Photobiochem. and Photobiophys. 7, 69-76.

23). "Isolation and Characterization of a Light-Harvesting Chlorophyll a/b Protein Complex

Associated with Photosystem I" Eric Lam, William Ortiz, Stephen Mayfield and Richard Malkin, Plant Physiology 74, 650-655.

24). "Chlorophyll a/b Proteins of Photosystem I" Eric Lam, William Ortiz and Richard Malkin, FEBS

Lett. 168, 10-14. 25). "The Effects of Quinone Analogues on Cytochrome b6 Reduction and Oxidation in a

Reconstitution System" Eric Lam, FEBS Lett. 172, 255-260. 26). "Antenna Function of a Chlorophyll a/b Protein Complex of Photosystem I" William Ortiz, Eric

Lam, Maria Ghirardi and Richard Malkin, Biochim. Biophys. Acta 766, 505-509. 27). "Structure-Function Studies of Chloroplast Photosystem I" Richard Malkin, Eric Lam and William

Ortiz; in Advances in Photosynthesis Research, Vol. I (C. Sybesma, ed.) Martinus Nijhoff/Dr. W. Junk Publishers, The Hague/Boston/Lancaster, 179-185.

28). "Structure and Functional Studies of an Oxygen-Evolving Photosystem II Preparation" Eric Lam,

Barbara Baltimore, William Ortiz, Anastasios Melis, Richard K. Chain and Richard Malkin; in Advances in Photosynthesis Research, Vol. III (C. Sybesma, ed.) Martinus Nijhoff/ Dr. W. Junk

Publishers, The Hague/Boston/Lancaster, 211-214. 29). " Studies of the Reconstitution of Chloroplast Electron Transfer Processes" Eric Lam and Richard

Malkin; in Current Topics in Plant Biochemistry and Physiology, Vol. III (D.D. Randall, D. G. Blevins, R.L. Larson, and B.J. Rapp, eds.) University of Missouri-Columbia, USA, 33-43.

30). "Application of a Light-Dependent Electron Donating System to Study Electron Transfer Pathway of Mitochondrial b-c1 Complex" Eric Lam, Photobiochem. and Photobiophys. 8, 333-339.

1985 31). "Topography of the Protein Complexes of the Chloroplast Thylakoid Membrane: Studies of

Photosystem I Using a Chemical Probe and Proteolytic Digestion" William Ortiz, Eric Lam, Susan Chollar, Debbie Munt and Richard Malkin, Plant Physiology 77, 389-397.

32). "The Role of Tyrosine Residues in Functional and Structure Properties of Bacteriorhodopsin" Eric

Lam and Lester Packer; in H+-ATPase: Structure, Function, Biogenesis of the F0F1 Complex of

Coupling Membranes. (S. Papa, K. Altendorf, L. Ernster and L. Packer, eds.) Adriatica Editrice- Bari, 181-189. 33). "Interactions Between Thylakoid Electron Transfer Complexes: In Vitro Kinetic Studies with

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Isolated Photosystem II and Cytochrome b6-f Complexes" Eric Lam and Richard Malkin, Arch.

Biochem. Biophys. 242, 58-63. 34). "Interactions Between Thylakoid Electron Transfer Complexes: Modification Studies with

Glutaraldehyde" Eric Lam and Richard Malkin, Arch. Biochem. Biophys. 242, 64-71. 35). "Characterization of a Photosynthetic Mutant of Lemma Lacking the Cytochrome b6-f Complex"

Eric Lam and Richard Malkin, Biochim. Biophys. Acta. 810, 106-109. 36). "Topography of the Protein Complexes of the Chloroplast Thylakoid Membrane: Studies of

Photosystem II Using Pronase Digestion and Chemical Labeling" Eric Lam and Richard Malkin, Plant Physiology 79, 1118-1124.

37). "Structural Organization of Thylakoid Membrane Electron Transfer Complexs: Photosytem I"

Richard Malkin, William Ortiz, Eric Lam and Julian Bonnerjea, Physiol. Veg. 23, 619-625.38). 38). "Transmembrane Organization of the Photosystem I Complex in Thylakoid Membranes" William

Ortiz, Eric Lam and Richard Malkin; In Molecular Biology of the Photosynthetic Apparatus (Cold Spring Harbor Laboratory Publisher), 99-104.

1986 39). "Nearest-neighbor Relationships of the Constituent Polypeptides in Plastoquinol-Plastocyanin

Oxidoreductase" Eric Lam, Biochim. Biophys. Acta 848, 324-332. 1987 40). "Chloroplast DNA Gyrase and In vitro Regulation of Transcription by Template Topology and

Novobiocin" Eric Lam and Nam-Hai Chua, Plant Molecular Biology 8, 415-424. 1988 41). "Characterization of a Chloroplast Sequence-Specific DNA Binding Factor" Eric Lam, Linda Hanley-Bowdoin and Nam-Hai Chua, J. Biol. Chem. 263, 8288-8293. 1989 42). "In vitro DNA Footprinting" P.J. Green, S.A. Kay, Eric Lam and Nam-Hai Chua, in Plant Mol.

Biol. Man., Suppl. II (Gelvin, S. and R.A. Schilperoort, eds.) Klumer Academic Publishers, Dordrect, 303-310.

43). "Phytochrome Activation of Two Nuclear Genes Requires Cytoplasmic Protein Synthesis" Eric Lam, Pamela J. Green, Mary Wong and Nam-Hai Chua, EMBO J. 8, 2777-2783. 44). "Site-Specific Mutations Alter In Vitro Factor Binding and Change Promoter Expression Pattern in

Transgenic Plants" Eric Lam, Philip N. Benfery, Philip Gilmartin, Rong-Xiang Fang and Nam-Hai Chua, Proc. Natl. Acad. Sci. USA 86, 7890-7894.

45). "Two Tobacco DNA-Binding Proteins Have Homology to CREB" Fumiaki Katagiri, Eric Lam and Nam-Hai Chua, Nature 340, 727-730. 46). "Characterization of Phytochrome Regulated Gene Expression in a Photoautotrophic Cell

Suspension: Possible Role for Calmodulin" Eric Lam, Mark Benedyk and Nam-Hai Chua, Mol.

Cell. Biol. 9, 4819-4823.

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47) "ASF-2: A Factor That Binds to the CaMV 35S Promoter and a Conserved GATA Motif in Cab Promoters" Eric Lam and Nam-Hai Chua, The Plant Cell 1, 1147-1156. 48). "Light to Dark Transition Modulates the Phase of Antenna Chlorophyll Protein Gene Expression" Eric Lam and Nam-Hai Chua, J. Biol. Chem. 264, 20175-20176. 1990 49). "Characterization of AS-1: A Factor Binding Site on the 35S Promoter of Cauliflower Mosaic Virus"

Eric Lam, Philip Benfey and Nam-Hai Chua, in Plant Gene Transfer, C.J. Lamb and R. N. Beachy, eds., UCLA Symposia on Molecular and Cellular Biology, New Series (Alan R. Liss, Inc. New York), pp. 71-79.

50). "From Footprint to Function: An Approach to Study Gene Expression and Regulatory Factors in

Transgenic Plants" Eric Lam, in Genetic Engineering, J.K. Setlow, ed. (Plenum Press, New York), Volume 12, pp. 73-86.

51). "GT-1 Binding Site Confers Light-Responsive Expression in Transgenic Tobacco" Eric Lam and Nam-Hai Chua, Science 248, 471-474. 52). "The Plant Nuclear Factor ASF-1 Binds to an Essential Region of the Nopaline Synthase Promoter" Eric Lam Fumiaki Katagiri and Nam-Hai Chua, J. Biol. Chem. 265, 9909-9913. 53). "A Metal-Dependent Protein Binds to a Constitutive Element of a Light-Responsive Promoter"

Eric Lam , Yuriko Kano-Murakami, Philip Gilmartin, Bettina Niner and Nam-Hai Chua, The Plant

Cell 2, 857-866. 1991 54). "Tetramer of a 21 Base-pair Element Confers Seed Expression and Transcriptional Enhancement in Response to Water Stress and Abscisic Acid" Eric Lam and Nam-Hai Chua, J. Biol. Chem. 266, 17131-17135. 1992 55). "A Tobacco DNA Binding Protein That Interacts with a Light-Responsive Box II Element" Olga Perisic and Eric Lam, The Plant Cell 4, 831-838. 1993 56). "G-Protein Involvement in Early Steps of Phytochrome-Regulated Gene Expression" Luis C. Romero and Eric Lam, Proc. Natl. Acad. Sci. USA 90, 1465-1469. 57). "Analysis of Three Tissue-Specific Elements from the Wheat Cab-1 Enhancer" Cecilia Gotor, Luis C. Romero, Keiko Inouye and Eric Lam, Plant Journal 3, 509-518. 58). "Analysis of Tissue-Specific Elements in the CaMV 35S Promoter" Eric Lam, in Results and

Problems in Cell Differentiation, Vol. 20: Plant Promoters and Transcription Factors. E. Dennis and L. Nover, eds., Springer-Verlag (Berlin), pp. 181-196.

59). "Heterotrimeric G-Proteins and Light Responses in Higher Plants" Eric Lam, in Proceedings of

1993 Penn State Symposium in Plant Physiology; J. Schultz, I. Raskin, eds.; Amer. Soc, of Plant Physiol., publisher, pp. 7-13.

1994 60). "Two Binding Sites for the Plant Transcription Factor ASF-1 are Responsive to Auxins" Xiangjun

Liu and Eric Lam , J. Biol. Chem. 269, 668-675.

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61). "TGA3 is a Distinct Member of the TGA1a Family of bZIP Transcription Factors in Arabidopsis

thaliana" Zhong-He Miao, Xiangjun Liu and Eric Lam, Plant Mol. Biology 25, 1-11. 62). "In vitro Expression and Characterization of Recombinant Plant Trans-acting Factors" Lee Meisel

and Eric Lam, in Plant Molecular Biology Manual II; S, Gelvin, R. Schilperoort, D. P. Verma, eds., Kluwer academic publishers (Dordrecht, The Netherlands), section I4, pp. 1-17.

63). "Characterization of a DNA Topoisomerase II cDNA from Arabidopsis thaliana" Shaoping Xie and Eric Lam, Plant Physiology 106, 1701-1702.

64). "Abundance of Nuclear Topoisomerase II is Correlated with Proliferation in Arabidopsis

thaliana " Shaoping Xie and Eric Lam, Nucleic Acids Research 22, 5729-5736. 1995 65). "Coordinated Activation of Programmed Cell Death and Defense Mechanisms in Transgenic

Tobacco Plants Expressing a Bacterial Proton-Pump" Ron Mittler, Vladimir Shulaev and Eric Lam, The Plant Cell 7, 29-42.

66). "Targeted-disruption of the TGA3 Locus in Arabidopsis thaliana" Zhong-He Miao and Eric Lam,

Plant Journal 7, 359-365.

67). "Domain Analysis of the Plant DNA-Binding Protein GT1a: Requirement of Four Putative-Helices for DNA Binding and Identification of a Novel Oligomerization Region" Eric Lam, Mol.

Cell. Biol. 15, 1014-1020. 68). "In Situ Detection of Nuclear DNA Fragmentation During the Differentiation of Tracheids in

Higher Plants" Ron Mittler and Eric Lam, Plant Physiology 108, 489-493.

69). "Plant Gene Expression Regulation" Eric Lam, in Encyclopedia of Molecular Biology And Biotechnology, R. A. Meyers, Editor-in-Chief, VCH publishers (New York), pp. 696-699.

70). "Construction of a Trans-Dominant Inhibitor for Members of a Family of Basic-Leucine Zipper

DNA-Binding Proteins" Zhong-He Miao and Eric Lam, Plant Journal 7, 887-896. 71). "Binding Site Requirements and Differential Representation of TGA Factors in Nuclear ASF-1

Activity" Eric Lam and Yolanda Kam-Po Lam, Nucleic Acids Research 23, 3778-3785. 72). "Isolation of TGA6, a New Member of the TGA Family of bZIP Transcription Factors in

Arabidopsis thaliana" Chengbin Xiang, Zhong-He Miao and Eric Lam, Plant Physiology 109, 721. 73). "Identification, Characterization, and Purification of a Tobacco Endonuclease Activity Induced

Upon Hypersensitive Response Cell Death" Ron Mittler and Eric Lam, The Plant Cell 7, 1951-1962.

1996 74). "Sacrifice in the face of foes: pathogen-induce programmed cell death in plants" Ron Mittler and

Eric Lam, Trends in Microbiology 4, 10-15. 75). "The Conserved ELK-Homeodomain of KNOTTED-1 Contains Two Nuclear Localization Signal

Sequences" Lee Meisel and Eric Lam, Plant Molecular Biology 30, 1-14.

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76). "Plant Gene Expression Regulation" Eric Lam, in Encyclopedia of Molecular Biology, R.A. Meyers, Editor-in-Chief, VCH publishers (New York), pp. 465-475.

77). "lem7, A Temperature-Sensitive Arabidopsis Mutant that Inhibits Leaf Development and Affects

the Maintenance of Leaf Morphology" Lee Meisel, Shaoping Xie and Eric Lam, Developmental

Biology 179, 116-134. 78). "Coordinated Activation of as-1 Type Elements and a Tobacco Glutathione S-Transferase Gene

by Auxins, Salicylic Acid, Methyl-Jasmonate and Hydrogen Peroxide" Chengbin Xiang, Zhong-He Miao and Eric Lam, Plant Molecular Biology 32, 415-426.

79). "Inhibition of programmed cell death in tobacco plants during pathogen- induced hypersensitive

response at low oxygen pressure" Ron Mittler, Vladimir Shulaev, Mirjana Seskar and Eric Lam, The Plant Cell 8, 1991-2001.

80). "Isolation and Analysis of the Soybean SGA2 Gene (cDNA), Encoding a New Member of the

Plant G-Protein Family of Signal Transducers" Cecilia Gotor, Eric Lam, Francisco J. Cejudo and Luis C. Romero, Plant Molecular Biology 32, 1227-1234.

1997 81). "Nucleic Acids and Proteins" Eric Lam, in Plant Biochemistry, Dey and Harborne, eds., Harcourt Brace & Company, Ltd., Academic Press., pp. 315-352. 82). "Switching on Gene Expression: Analysis of the Factors That Spatially and Temporally Regulate

Plant Gene Expression" Lee Meisel and Eric Lam, in Genetic Engineering, , Volume 19, J. Setlow, ed., Plenum Press, New York. pp. 183-199.

83). "Characterization of Nuclease Activities and DNA Fragmentation Induced upon Hypersensitive

Response Cell Death and Mechanical Stress" Ron Mittler and Eric Lam, Plant Molecular Biology 34, pp. 209-221.

84). "Characterization of Acquired Resistance in Lesion Mimic Transgenic Potato Expressing Bacterio-

opsin" Mark S. Abad, Salim M. Hakimi, Wojciech K. Kaniewski, Caius M.T. Rommens, Vladimir Shulaev, Eric Lam and Dilip M. Shah, Molecular Plant-Microbe Interactions 10, pp. 635-645.

85). "DNA Binding Properties, Genomic Organization and Expression Pattern of TGA6, a New

Member of the TGA Family of bZIP Transcription Factors in Arabidopsis thaliana" Chengbin Xiang, Zhong-He Miao and Eric Lam, Plant Molecular Biology 34, 403-415.

86). "Pathogen-induced Programmed Cell Death in Tobacco" Ron Mittler, Lee Simon and Eric Lam,

Journal of Cell Science 110, 1333-1344. 87). "Targeted Disruption by Homologous Recombination in Arabidopsis" Sherry A. Kempin, Sarah J. Liljegren, Laura M. Block, Steven D. Rounsley, Martin F. Yanofsky and Eric Lam, Nature 389,

802-803. 88). "Pathogen-Induced Programmed Cell Death in Plants, a Possible Defense Mechanism" Ron

Mittler, Olga del Pozo, Lee Meisel and Eric Lam, Developmental Genetics 21, 279-289. 1998 89). "Activation of HSR203, a Plant Gene Specifically Expressed During Incompatible Plant-Pathogen

Interactions, is Correlated with Programmed Cell Death" Dominique Pontier, Maurice Tronchet,

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Peter Rogowsky, Eric Lam and Dominique Roby, Molecular Plant-Microbe Interactions 11, 544-554.

90). "Caspases and Programmed Cell Death in the Hypersensitive Response of Plants to Pathogens" Olga del Pozo and Eric Lam, Current Biol. 8, 1129-1132. 1999 91). "Signals Controlling the Expression of Cytosolic Ascorbate Peroxidase During Pathogen-Induced

Programmed Cell Death in Tobacco" Ron Mittler, Eric Lam, Vladimir Shulaev and Mira Cohen, Plant Mol. Biol. 39, 1025-1035.

92). "Markers for Hypersensitive Response and Senescence Show Distinct Patterns of Expression"

Dominique Pontier, Susheng Gan, Richard M. Amasino, Dominique Roby and Eric Lam, Plant

Mol. Biol. 39, 1243-1255. 93). "Gene Switches and Stress Management: Modulation of Gene Expression by Transcription

Factors" Eric Lam and Lee Meisel, in Plant Responses to Environmental Stresses: From Phytohormones to Genome Organization, H.R. Lerner, ed., Marcel Dekker, Inc., New York, pp. 51-70.

94). “BAXing in the Hypersensitive Response” Eric Lam, Olga del Pozo and Dominique Pontier, Trends in Plant Sci. 4, 419-421.

95). “Die and Let Live - Programmed Cell Death in Plants” Eric Lam, Dominique Pontier and Olga

del Pozo, Curr. Op. in Plant Biol. 2, 502-507. 2000 96). “NPR1 Differentially Interacts with Members of the TGA/OBF Family of Transcription Factors

Which Bind an Element of the PR-1 Gene Required for Induction by Salicylic Acid” Jun Ma Zhou, Youssef Trifa, Herman Silva, Dominique Pontier, Eric Lam, Jyoti Shah and Daniel F. Klessig,

Molecular Plant-Microbe Interations 13, 191-202. 97). “Nitric Oxide and Salicylic Acid Signaling in Plant Defense” Daniel F. Klessig, Jorg Durner,

Robert Noad, Duroy A. Navarre, David Wendehenne, Dhirendra Kumar, Jun Ma Zhou, Jyoti Shah, Shuqun Zhang, Pradeep Kachroo, Youssef Trifa, Dominique Pontier, Eric Lam, and Herman Silva, Proc. Natl. Acad. Sci. USA 97, 8849–8855.

98). “Caspase-like Protease Involvement in the Control of Plant Cell Death” Eric Lam and Olga del

Pozo, Plant Mol. Biol. 44, 417-428 (Cover Photo). 99). “Plant Programmed Cell Death” Eric Lam, Naohiro Kato and Dominique Pontier in

Encyclopedia of Life Sciences, John Wiley & Sons, Ltd.: Chichester http://www.els.net/ [doi:10.1038/npg.els.0001689]

2001 100). “Programmed Cell Death, Mitochondria and the Plant Hypersensitive Response” Eric Lam,

Naohiro Kato and Michael Lawton, Nature 411, 848-853.

101). “Specific Trans-dominant Suppression of Plant TGA Factors Reveals Complex Regulatory Functions in Plant Defense Reponses” Dominique Pontier, Zhong-He Miao and Eric Lam, Plant

Journal, 27, 529-538.

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102). "Detection of Chromosomes Tagged with Green Fluorescent Protein in Live Arabidopsis thaliana Plants" Naohiro Kato and Eric Lam, Genome Biology 2, 0045.1-0045.10.

2002 103). "Mechanism of cell death and disease resistance induction by transgenic expression of bacterio-

opsin" Dominique Pontier, Ron Mittler and Eric Lam, Plant Journal 30, 499-509. 104). " Spectral Profiling for the simultaneous observation of four distinct fluorescent proteins and

detection of protein-protein interaction via fluorescence resonance energy transfer in tobacco leaf nuclei" Naohiro Kato, Dominique Pontier and Eric Lam, Plant Physiology 129, 931-942.

105). "Differential regulation of TGA transcripton factors by post-transcriptional control" Dominique

Pontier, Isabelle Privat, Youssef Trifa, Jun-Ma Zhou, Dan F. Klessig, and Eric Lam, Plant Journal 32, 641-653.

2003 106). "Transcription Factor IIB (TFIIB)-related protein (pBrp), a plant-specific member of the TFIIB-

related protein family" Thierry Lagrange, Mohamed-Ali Hakimi, Dominique Pontier, Florence Courtois, Jean Pierre Alcaraz, Didier Grunwald, Eric Lam and Silva Lerbs-Mache, Mol. Cell.

Biol. 23, 3274-3286. 107). "Chromatin of endoreduplicated pavement cells has greater range of movement than that of

diploid guard cells in Arabidopsis thaliana" Naohiro Kato and Eric Lam, J. of Cell Science 116, 2195-2201 (Cover Photo).

108). "Expression of the baculovirus p35 protein in tobacco inhibits hypersensitive response cell death

and compromises N gene-mediated disease resistance in response to tobacco mosaic virus" Olga del Pozo and Eric Lam, Mol. Plant Microbe Interactions 16, 485-494.

2004

109). “Cell Death in Plant Disease” Dominique Pontier, Olga del Pozo, and Eric Lam, in Cell Death in Plants, L.D. Nooden, ed., Academic Press, pp. 37-50.

110). "Recent advance in the study of caspase-like proteases and Bax inhibitor-1 in plants: their

possible roles as regulator of programmed cell death" Naohide Watanabe and Eric Lam, Molecular Plant Pathology 5, 65-70.

111). "Controlled cell death, plant survival and development" Eric Lam, Nature Reviews in Mol. Cell.

Biology 5, 305-315. 112). "Visualizing Chromosome Structure/Organization" Eric Lam, Naohiro Kato, and Koichi

Watanabe, Annual Review in Plant Biology 55, 537-554. 113). “Transgenic plant-derived siRNAs can suppress propagation of influenza virus in mammalian

cells” Yuanxiang Zhou, Jack Y. Chan, Annie Y. Chan, Regina K.F. Chak, Elaine Y.L. Wong, Mee-Len Chye, Joseph S.M. Peiris, Leo L.M. Poon and Eric Lam, FEBS Letts. 577, 345-350.

2005 114). “Vacuolar protease livening up programmed cell death” Eric Lam, Trends in Cell Biology 15,

124-127.

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115). “Inducible double-stranded RNA expression activates reversible transcript turnover and stable translational suppression of a target gene in transgenic tobacco” Clive Lo, Nai Wang and Eric Lam, FEBS Lett. 579, 1498-1502.

116). “Programmed cell death in plants – Book Review” Eric Lam, Annals of Botany 95, 703-705. 117). “Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine

proteases and activate apoptosis-like cell death in yeast” Naohide Watanabe and Eric Lam, J.

Biol. Chem. 280, 14691-14699. 118). “Tandem repetitive transgenes and fluorescent chromatin tags alter the local interphase

chromosome arrangement in Arabidopsis thaliana” Ales Pecinka, Naohiro Kato, Armin Meister, Aline V. Probst, Ingo Schubert and Eric Lam, J. of Cell Science 118, 3751-3758.

119). “The hypersensitive response in plant disease resistance” Naohide Watanabe and Eric Lam, in Multigenic and Induced Systemic Resistance in Plants, T. Sadik and E. Bent (Eds.), Springer Publisher, pp. 83-111. 120). “DNA hypomethylation reduces homologous pairing of inserted tandem repeat arrays in somatic nuclei of Arabidopsis thaliana” Koichi Watanabe, Ales Pecinka, Armin Meister, Ingo Schubert, and Eric Lam, Plant Journal 44, 531-540. 121). “Moonlighting vacuolar protease: multiple jobs for a busy protein” Faye M. Rosin, Naohide Watanabe and Eric Lam, Trends in Plant Science 10, 516-518. 2006 122). “A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is antigenic in mice”

Yuanxiang Zhou, Maggie Yuk-Ting Lee, James Ming-Him Ng, Mee-Len Chye, Wing-Kin Yip, Sze-Yong Zee and Eric Lam, World Journal of Gastroenterology 12, 306-312.

123). “Arabidopsis Bax Inhibitor-1 functions as a negative regulator of biotic and abiotic types of cell death” Naohide Watanabe and Eric Lam, Plant Journal 45, 884-894. 124). “Expression of viral capsid protein antigen against Epstein-Barr virus in plastids of Nicotiana tabacum cv. SR1” Maggie Y.T. Lee, Yuanxiang Zhou, Raymond W.M. Lung, Mee-Len Chye, Wing-Kin Yip, Sez-Yong Zee and Eric Lam, Biotechnology and Bioengineering 94, 1129-1137. 125). "Genetic Transformation of Rangpur Lime (Citrus limonia Osbeck) with the bO (bacterio-opsin)

gene and its initial evaluation for Phytophthora nicotianae resistance" F.A. Azevedo, F.A.A. Mourao Filho, B.M.J. Mendes, W.A.B. Almeida, E.H. Schinor, R. Pio, J.M. Barbosa, S. Guidetti-Gonzalez, H. Carrer and E. Lam, Plant Molecular Biology Reporter 24, 185-196.

126). “Plant Programmed Cell Death” Eric Lam in Encyclopedia of Life Sciences, John Wiley & Sons, Ltd.: Chichester, doi: 10.1002/9780470015902.a0001689.pub2, pp 1-3. 127). "Phytotoxicity and innate immune responses induced by Nep1-like proteins" Dinah Qutob, Birgit

Kemmerling, Frederic Brunner, Isabell Kufner, Stefan Engelhardt, Andrea A. Gust, Borries Luberacki, Hans Ulrich Seitz, Dietmar Stahl, Thomas Rauhut, Erich Glawischnig, Gabriele Schween, Benoit Lacombe, Naohide Watanabe, Eric Lam, Rita Schlichting, Dierk Scheel, Katja Nau, Gabriele Dodt, David Hubert, Mark Gijzen, and Thorsten Nurnberger, Plant Cell 18, 3721-3744.

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2007 128). "Bax Inhibitor-1 modulates endoplasmic reticulum stress-mediated programmed cell death in Arabidopsis" Naohide Watanabe and Eric Lam, J. Biol. Chem. EPub, November. 2008 129). " Size and number of tandem repeat arrays can determine somatic homologous pairing of transgene loci mediated by epigenetic modifications in Arabidopsis thaliana nuclei" Gabriele Jovtchev, Koichi Watanabe, Ales Pecinka, Faye M. Rosin, Michael F. Mette, Eric Lam and Ingo

Schubert, Chromosoma, Epub 10.1007/s00412-007-0146-0.

130). "Genome-wide tagging reveals location-dependent effects on transcription and chromatin organization in Arabidopsis" Faye M. Rosin, Naohide Watanabe, Jean-Luc Cacas, Naohiro Kato, Juana M. Arroyo, Yuda Fang, Bruce May, Matthew Vaughn, Joseph Simorowski, Umamaheswari

Ramu, Richard W. McCombie, David L. Spector, Robert A. Martienssen and Eric Lam, The Plant

Journal 55, 514-525.

131). "Arabidopsis Bax inhibitor-1" Naohide Watanabe and Eric Lam, Plant Signaling & Behavior 3, 564-

566.

132). "Programmed cell death in plants: orchestrating an intrinsic suicide program within walls" Eric Lam,

Critical Rev. Plant Sciences 27, 413-423.

2009

133). "Charting functional and physical properties of chromatin in living cells" Eric Lam, Chongyuan Luo

and Naohide Watanabe, Curr. Op. Genet. & Development 19, 135-141.

134). "Defining the functional network of epigenetic regulators in Arabidopsis thaliana" Chongyuan

Luo, Brittany G. Durgin, Naohide Watanabe and Eric Lam, Mol. Plant 2, 661-674. doi:10.1093/mp/ssp017.

135). "Chromatin Charting: Global mapping of epigenetic effects" Chongyuan Luo and Eric Lam, in Methods in

Molecular Biology: Plant Systems Biology, Humana Press, vol. 553, pp 127-139. 136). "Improving sugarcane for biofuel: engineering for an even better feedstock" Eric Lam, James Shine Jr.,

Jorge da Silva, Michael Lawton, Stacy Bonos, Martin Calvino, Helaine Carrer, Marcio C. Silva Filho, Neil Glynn, Zane Helsel, Jiong Ma, Edward Richard Jr., Glaucia Mendes Souza and Ray Ming, Global Change Biology Bioenergy 1, 251-255.

137). "Bax Inhibitor-1, a conserved cell death suppressor, is a key molecular switch downstream from a variety of biotic and abiotic stress signals in plants" Naohide Watanabe and Eric Lam, Int. J. Mol. Sci. 10, 3149-3167.

138). "Programmed cell death in plants: apoptotic but not quite" Naohide Watanabe and Eric Lam, in Essentials

of Apoptosis: A Guide for Basic and Clinical Research, 2nd edition, Humana Press, Yin, X.-M. and Dong, Z. eds., pp 301-324.

2010

139). "ANCORP: a high-resolution approach that generates distinct chromatin state models from multiple

genome-wide datasets" Chongyuan Luo and Eric Lam, The Plant Journal 63, 339-351 (Cover Photo & Featured Article).

140). "Chromatin Beacons: Global Sampling of Chromatin Physical Properties Using Chromatin Charting

Lines." Anica Amini, Chongyuan Luo and Eric Lam, Methods in Molecular Biology (Humana press),

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701:301-314. 2011 141). “Arabidopsis Metacaspase 2d is a positive mediator of cell death induced during biotic and abiotic stresses”

Naohide Watanabe and Eric Lam , The Plant Journal 66, 969-982.

142). “Calcium-dependent activation and autolysis of Arabidopsis metacaspase 2d” Naohide Watanabe and Eric Lam, J. Biol. Chem. 286, 10027-10040.

143). “Green death: revealing programmed cell death in plants” Peter V. Bozhkov and Eric Lam, Cell Death and

Differentiation 18, 1239-1240. 144). “Bax Inhibitor-1: a highly conserved endoplasmic reticulum-resident cell death suppressor” Toshiki

Ishikawa, Naohide Watanabe, Minoru Nagano, Maki Kawai-Yamada and Eric Lam, Cell Death and Differentiation 18, 1271-1278..

145). “Morphological classification of plant cell deaths” WG van Doorn, EP Beers, JL Dangl, VE Franklin-Tong, P

Gallois, I Hara-Nishimura, AM Jones, M Kawai-Yamada, E Lam, J Mundy, LAJ Mur, M Petersen, A Smertenko,

M Taliansky, F Van Breusegem, T Wolpert, E Woltering, B Zhivotovsky and PV Bozhkov, Cell Death and Differentiation 18, 1241-1246.

146). “Metacaspases” Liana Tsiatsiani, Frank Van Breusegem, Patrick Gallois, Anton Zavialov, Eric Lam and Peter V. Bozhkov, Cell Death and Differentiation 18, 1279-1288.

147). "Improving efficiency of cellulosic fermentation via genetic engineering to create "Smart Plants" for

biofuel production" Zeyu Xin, Naohide Watanabe and Eric Lam, in The Routes to Cellulosic Ethanol, Springer Press, ed. Marcos Buckeridge, pp.181-197.

148). “Sheathing the swords of death: Post-translational modulation of plant metacaspases” Yi Zhang and Eric

Lam, Plant Signal Behav. 6, 2051-2056. 2012 149). “Duckweed Rising at Chengdu: Summary of the 1

st International Conference on Duckweed Application

and Research” Hai Zhao, Klaus Appenroth, Louis Landesman, Armando A. Salmean and Eric Lam, Plant

Molecular Biology 78, 627-632. 150). “Quantitatively profiling genome-wide patterns of histone modifications in Arabidopsis thaliana using

Chip-Seq” Chongyuan Luo and Eric Lam, Methods in Molecular Biology (Humana press), Epigenetic Phenomena in Plants: Understanding and analysis, eds. C. Spillane and P. McKeown, in press.

151). “Regulating the Reapers – Activating metacaspases for programmed cell death” Eric Lam and Yi Zhang,

Trends in Plant Science 17, 487-494. 152). “Integrative analysis of chromatin states in Arabidopsis identified potential regulatory mechanisms for

Natural Antisense Transcript production” Chongyuan Luo, David J. Sidote, Yi Zhang, Randall A. Kerstetter, Todd P. Michael

and Eric Lam, The Plant Journal, in press.

153). "Wasserlinsen als Nutzpflanzen" Klaus-J. Appenroth and Eric Lam, Biol. Unserer Zeit 3, 181-187.