ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar...

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Transcript of ERCK5/6 Flat epithelial atypia Columnar cell lesions: A spectrum: columnar cell change, columnar...

Page 1: ERCK5/6 Flat epithelial atypia Columnar cell lesions:  A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.
Page 2: ERCK5/6 Flat epithelial atypia Columnar cell lesions:  A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.
Page 3: ERCK5/6 Flat epithelial atypia Columnar cell lesions:  A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.
Page 4: ERCK5/6 Flat epithelial atypia Columnar cell lesions:  A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.

ER CK5/6

Page 5: ERCK5/6 Flat epithelial atypia Columnar cell lesions:  A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.

Flat epithelial atypia

Columnar cell lesions: A spectrum: columnar cell change, columnar cell

hyperplasia, flat epithelial atypiaFEA has mild cytologic atypia (similar to

ADH,DCIS) but without architectural atypia. May be more than one cell layer thick.

Cytology: enlarged nuclei, rounding, crowding, loss of polarity, visible nucleoli, few mitoses.

Page 6: ERCK5/6 Flat epithelial atypia Columnar cell lesions:  A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.

IHC in FEA

Not helpful CCC, CCH, FEA, ADH, low grade DCIS all have the

same immunophenotype ER+, PgR+, HER2 -, E-Cadherin+, LMWK+, HMWK-.

Page 7: ERCK5/6 Flat epithelial atypia Columnar cell lesions:  A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.
Page 8: ERCK5/6 Flat epithelial atypia Columnar cell lesions:  A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has.