Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon...
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![Page 1: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/1.jpg)
Equivalent Circuit of an Axon Membrane
![Page 2: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/2.jpg)
Hodgkin & Huxley’s voltage clamp of the squid giant axon
Feedback Amplifier current proportional to
difference (E-input)
Input SignalMeasured
Current
Measured voltage
![Page 3: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/3.jpg)
Hodgkin & Huxley’s voltage clamp of the squid giant axon:Current response to hyper-polarization and de-polarization
early inward Na
late outward K
![Page 4: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/4.jpg)
Hodgkin & Huxley’s voltage clamp of the squid giant axon:Current response to hyper-polarization and de-polarization
late outward K
early Na
![Page 5: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/5.jpg)
Hodgkin & Huxley separation of Na and K currents by variation of bath Na concentration
![Page 6: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/6.jpg)
Separation of Na and K Current-Voltage curves
![Page 7: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/7.jpg)
Separation of Na and K Ionic conductance changes
Rapid changes in gNa
Slow changes in gK
![Page 8: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/8.jpg)
Na and K conductance at various voltage clamp steps
![Page 9: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/9.jpg)
Channel openings and closings during Action Potential
![Page 10: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/10.jpg)
Example of time course of changes in n & n^4 ~ gK and m, h & m^3*h ~ gNa
![Page 11: Equivalent Circuit of an Axon Membrane. Hodgkin & Huxley’s voltage clamp of the squid giant axon Feedback Amplifier current proportional to difference.](https://reader036.fdocuments.net/reader036/viewer/2022062714/56649d435503460f94a20079/html5/thumbnails/11.jpg)
Voltage dependence of Hodgkin-Huxley model parameters