C O L D SPRING H A R B O R SYMPOSIA O N QUANTITATIVE B IOLOGY

V O L U M E X L I - P A R T 2

COLD SPRING H A R B O R SYMPOSIA ON QUANTITATIVE B IOLOGY

V O L U M E X L I

Orig ins of Lymphocyte Divers i ty

C O L D SPRING H A R B O R L A B O R A T O R Y

1977

C O L D S P R I N G H A R B O R S Y M P O S I A O N Q U A N T I T A T I V E B I O L O G Y

V O L U M E X L I

© 1977 by The Cold Spr ing Harbor Laboratory

Internat ional S tandard Book N u m b e r 0 -87969-040-2 (clothbound)

L i b ra r y of Congress Cata log C a r d Number 34-8174

P r i n t e d i n t h e U n i t e d S t a t e s o f A m e r i c a

A l l r i g h t s r e s e r u e d

C O L D S P R I N G H A R B O R S Y M P O S I A O N Q U A N T I T A T I V E B I O L O G Y

F o u n d e d i n 1 9 3 3 by

R E G I N A L D G . H A R R I S

D i r e c t o r of the B i o l o g i c a l L a b o r a t o r y 1 9 2 4 to 1 9 3 6

P r e v i o u s Symfwsia V o l u m e s

I (1933) Surface Phenomena II (1934) Aspects of Growth III (1935) Photochemical Reactions IV (1936) Excitation Phenomena V (1937) Internal Secretions VI (1938) Protein Chemistry VII (1939) Biological Oxidations VIII (1940) Permeability and the Nature of Cell Membranes IX (1941) Genes and Chromosomes: Structure and Organization X (1942) The Relation of Hormones to Development XI (1946) Heredity and Variation in Microorganisms XII (1947) Nucleic Acids and Nucleoproteins XIII (1948) Biological Applications of Tracer Elements XIV (1949) Amino Acids and Proteins X V (1950) Origin and Evolution of Man XVI (1951) Genes and Mutations XVII (1952) The Neuron XVIII (1953) Viruses XIX (1954) The Mammalian Fetus: Physiological Aspects of De­

velopment X X (1955) Population Genetics: The Nature and Causes of Genetic

Variability in Population

XXI (1956) Genetic Mechanisms: Structure and Function XXII (1957) Population Studies: Animal Ecology and Demography XXIII (1958) Exchange of Genetic Material: Mechanism and Con-

sequences XXIV (1959) Genetics and Twentieth Century Darwinism X X V (1960) Biological Clocks XXVI (1961) Cellular Regulatory Mechanisms XXVII (1962) Basic Mechanisms in Animal Virus Biology XXVIII (1963) Synthesis and Structure of Macromolecules XXIX (1964) Human Genetics X X X (1965) Sensory Receptors XXXI (1966) The Genetic Code XXXII (1967) Antibodies XXXIII (1968) Replication of D N A in Microorganisms XXXIV (1969) The Mechanism of Protein Synthesis X X X V (1970) Transcription of Genetic Material X X X V I (1971) Structure and Function of Proteins at the Three-

dimensional Level XXXVII (1972) The Mechanism of Muscle Contraction XXXVIII (1973) Chromosome Structure and Function XXXIX (1974) Tumor Viruses X L (1975) The Synapse

The Sympos ium Vo lumes are publ ished by the Co ld Spr ing Harbor Laboratory, Co ld Spr ing Harbor , New York 11724, and may be purchased direct ly from the Laboratory or through booksellers. Pr ice of Vo lume X L I —2-part set $60.00 (inc. postage). M a y be purchased only as a complete set. Pr ice subject to change without notice.

F i r s t Row: A . and B . Benacerraf/N. K . Jerne , G. J . Thorbecke Second Row: R. Rib le t/H. 0 . McDev i t t , W. Bodmer/R. J . Pol jak T h i r d Row: E . Haber , K . Rajewsky/N. A . M i t ch i son , B . A . Askonas F o u r t h Row: D . Dressler, H . Potter/H. Wigze l l , G . M . Shearer

F i r s t Row: A . E . Bussard/P. Doherty/W. E . Paul/D. W. Scott Second Row: J . F. A . P. Mi l l er/O. Mäkelä/C. Mi ls te in/L. Hood T h i r d Row: J . Schräder, G. J . V . Nossal/H. Cantor , P. Matzinger/ . and F. Haurowi tz F o u r t h Row: D. R. Davies, M . Potter/J. J . van Rood, M . Raff

Contents

Part 1

Symposium Participants Foreword

I n t r o d u c t i o n

The Common Sense of Immunology N. K . J e r n e

L Y M P H O C Y T E F U N C T I O N

T - c e l l M a r k e r s a n d D i f f e r e n t i a t i o n

Thymopoietin and Bursopoietin: Induction Signals Regulating Ea r l y Lympho-cyte Differentiation G. G o l d s t e i n , M . S c h e i d , E . A . B o y s e , A . B r a n d a n d D . G. G i l m o u r

Normal and Neoplastic Maturat ion of T-l ineage Lymphocytes /. L . W e i s s m a n , S. B a i r d , R . L . G a r d n e r , V. E . P a p a i o a n n o u a n d W. R a s c h k e

Regulation of Ce l lu lar and Humora l Immune Responses by T-cel l Subclasses H . C a n t o r a n d E . A . B o y s e

Surface Markers and Functional Relationships of Cel ls Involved in Mur ine B-lymphocyte Differentiation L . A . H e r z e n b e r g , L . A . H e r z e n b e r g , S. J . B l a c k , M . R . L o k e n , K . O k u m u r a , W. v a n d e r L o o , B . A . O s b o r n e , D . H e w g i l l , J . W. G o d i n g y G. G u t m a n a n d N. L . W a r n e r

A n U n u s u a l Kappa Immunoglobulin Ant igen Present on the Membrane of T and B Lymphocytes A . B . G o t t l i e b , M . E n g e l h a r d , H . G. K u n k e l a n d S. M . F u

Rat Thy-1 Antigens from Thymus and Bra in : The i r Tissue Distribution, Purifica-tion, and Chemica l Composition A . F . W i l l i a m s , A . N. B a r c l a y , M . L e t a r t e -M u i r h e a d a n d R . J . M o r r i s

Specialized D N A Polymerases i n Lymphoid Cells D . B a l t i m o r e , A . E . S i l v e r s t o n e , P. C. K u n g , T. A . H a r r i s o n a n d R . P. M c C a f f r e y

Studies on the Interactions between Viruses and Lymphocytes B . R . B l o o m , A . S e n i k , G. S t o n e r , G. J u , M . N o w a k o w s k i , S. K a n o a n d L . J i m e n e z

H e l p e r a n d S u p p r e s s o r T C e l l s a n d T h e i r P r o d u c t s

The Hermaphrocyte: A Suppressor-Helper T Ce l l R . K . G e r s h o n , D . D . E a r d l e y , K . F . N a i d o r f a n d W. P t a k

Suppressor T Cel ls i n Tolerance to Non-self and Seif Antigens A . B a s t e n , R . L o b ­l a y , E . C h i a , R . C a l l a r d a n d H . P r i t c h a r d - B r i s c o e

Tolerance: Two Pathways of Negative Immunoregulation in Contact Sensitivity to D N F B H . N. C l a m a n , S. D . M i l l e r a n d J . W. M o o r h e a d

vi i

vi i i C O N T E N T S

Current Concepts of the Antibody Response: Heterogeneity of Lymphoid Cells, Interactions, and Factors M . F e l d m a n n , P. B e v e r l e y , P. E r b , S. H o w i e , S. K o n t i a i n e n , A . M a o z , M . M a t h i e s , I . M c K e n z i e a n d J . W o o d y 113

Suppressive and Enhanc ing T-cel l Factors as J-region Gene Products: Properties and the Subregion Assignment T. T a d a , M . T a n i g u c h i a n d C. S. D a v i d 119

B - c e l l D i f f e r e n t i a t i o n a n d C o m m i t m e n t

In V i t ro Studies on the Generation of Lymphocyte Diversity J . J . T. O w e n , R . K . J o r d a n , J . H . R o b i n s o n , U. S i n g h a n d H . N. A . W i l l c o x 129

Studies of Generation of B-cell Diversity in Mouse, M a n , and Chicken M . D . C o o p e r , J . F . K e a r n e y , P. M . L y d y a r d , C. E . G r o s s i a n d A . R . L a w t o n 139

Ontogeny of Mur ine B Lymphocytes: Development of Ig Synthesis and of Reac-tivities to Mitogens and to Anti - Ig Antibodies F . M e l c h e r s , J . A n d e r s s o n a n d R . A . P h i l l i p s 147

Development and Modulation of B Lymphocytes: Studies on Newly Formed B Cel ls and The i r Putative Precursors in the Hemopoietic Tissues of Mice M . C . R a f f 159

Induction of Immunoglobulin Synthesis in Abelson Mur ine Leukemia Virus -transformed Mouse Lymphoma Cel ls in Culture B . J . W e i m a n n 163

The Interplay of Evo lut ion and Environment i n B-cell Diversifikation N. R . K l i n m a n , N. H . S i g a l , E . S. M e t e a l f , S. K . P i e r c e a n d P. J . G e a r h a r t 165

Synthesis of Mult ip le Immunoglobulin Classes by Single Lymphocytes B . P e r n i s , L . F o r n i a n d A . L . L u z z a t i 175

Immunoglobulin Receptors on Mur ine B Lymphocytes E . S. V i t e t t a , J . C a m b i e r , J . F o r m a n , J . R . K e t t m a n , D . Y u a n a n d J . W. U h r 185

Functional and Structural Characterization of Immunoglobulin on Murine B Lymphocytes R . M . E . P a r k h o u s e , E . R . A b n e y , A . B o u r g o i s a n d H . N. A . W i l l c o x 193

Or ig in and Differentiation of Lymphocytes Involved in the Secretory IgA Re­sponse J . J . C e b r a , P. J . G e a r h a r t , R . K a m a t , S. M . R o b e r t s o n a n d J . T s e n g 201

Mechanism of B-cell Activation and Sel f -Non-sel f Discr imination G. Möller 217 Growth and Maturat ion of Single Clones of Normal Mur ine T and B Lymphocytes

In Vitro J . A n d e r s s o n , A . C o u t i n h o , F . M e l c h e r s a n d T. W a t a n a b e 227 Hapten-specific B Lymphocytes: Enr ichment, Cloning, Receptor Analysis, and

Tolerance Induction G. J . V. N o s s a l , B . L . P i k e , J . W. S t o c k e r , J . E . L a y t o n a n d J . W. G o d i n g 237

Regulation of Clonal B-lymphocyte Proliferation by Anti - immunoglobul in or Anti - Ia Antibodies P. W. K i n c a d e a n d P. R a l p h 245

Ce l lu lar and Molecular Interactions i n Control of B-cell Immunity and Tolerance E . D i e n e r , C. S h i o z a w a , B . S i n g h a n d K . - C . L e e 251

R e c e p t o r s

Lymphocyte Surface Immunoglobulins: Evolutionary Origins and Involvement in Activation J . J . M a r c h a l o n i s , J . M . D e c k e r , D . D e L u c a , J . M . M o s e l e y , P. S m i t h a n d G. W. W a r r 261

Antigen-binding, Idiotypic Receptors from T Lymphocytes: A n Analysis of Their Biochemistry, Genetics, and Use as Immunogens To Produce Specific Im­mune Tolerance H . B i n z a n d H . W i g z e l l 275

O n the Structure of the T-cel l Receptor for Ant igen U. K r a w i n k e l , M . C r a m e r , C. B e r e k , G. Hämmerling, S. J . B l a c k , K . R a j e w s k y a n d K . E i c h m a n n 285

The Immune Response to Staphylococcal Nuclease: A Probe of Cellular and Humora l Antigen-specific Receptors D . H . S a c h s , J . A . B e r z o f s k y , C. G. F a t h m a n , D . S. P i s e t s k y , A . N. S c h e c h t e r a n d R . H . S c h w a r t z 295

Functional Characterization of Rabbit Lymphocytes Car ry ing Fe Receptor P . A . C a z e n a v e , D . J u y a n d C. B o n a 307

Structural and Functional Heterogeneity of Fe Receptors H . M . G r e y , C. L . A n d e r s o n , C. H . H e u s s e r , B . K . B o r t h i s t l e , K . B . V o n E s c h e n a n d J . M . C h i l l e r 315

C O N T E N T S ix

T H E M A J O R H I S T O C O M P A T I B I L I T Y C O M P L E X

S t r u c t u r e o f t h e M o l e c u l a r P r o d u c t s o f t h e M H C

Structure of H L - A A and B Antigens Isolated from Cultured H u m a n Lympho­cytes J . L . S t r o m i n g e r , D . L . M a n n , P. P a r h a m , R . R o b b , T. S p r i n g e r a n d C. T e r h o r s t 323

Structural Studies of ß 2-Microglobulin-associated and Other M H C Antigens P. A . P e t e r s o n , H . A n u n d i , B . C u r m a n , L . K l a r e s k o g , S. K u i s t , L . Östberg, L . R a s k , L . S a n d b e r g a n d K . S e g e 331

Comparative Chemical Analyses and Partia l Amino Ac id Sequences of the Heavy Chains of H L - A Antigens E . A p p e l l a , N. T a n i g a k i , O. H e n r i k s e n , D . P r e s s -m a n , D . F . S m i t h a n d T. F a i r w e l l 341

Structural DifFerences between Parent and Var i ant H - 2 K Glycoproteins from Mouse Strains Carrying//-2 Gene Mutations S. G. N a t h e n s o n , J . L . B r o w n ,

B . M . E w e n s t e i n , T. N i s i z a w a , D . W. S e a r s a n d J . H . F r e e d 343 Structure of Mur ine Histocompatibility Antigens B . A . C u n n i n g h a m , R . H e n ­

n i n g , R . J . M i l n e r , K . R e s k e , J . A . Z i f f e r a n d G. M . E d e l m a n 351 Structural Studies of H-2 and T L Alloantigens J . W. U h r , E . S. V i t e t t a , J . K l e i n ,

Af. D . P o u l i k , D . G. K l a p p e r a n d J . D . C a p r a 363 Chemica l Characterization of Products of the H-2 Complex J . S i l v e r , J . M .

C e c k a , M . M c M i l l a n a n d L . H o o d 369 H u m a n Ia Antigens —Purification and Molecular Structure D . S n a r y , C. B a r n -

s t a b l e , W. F . B o d m e r , P. G o o d f e l l o w a n d M . J . C r u m p t o n 379 Chemi ra l and Immunological Characterization of H L - A - l i n k e d B-lymphocyte

Alloantigens T. A . S p r i n g e r , J . F . K a u f m a n , L . A . S i d d o w a y , M . G i p h a r t , D . L . M a n n , C. T e r h o r s t a n d J . L . S t r o m i n g e r 387

The Guinea P ig M H C : Functional Significance and Structural Characterization B . D . S c h w a r t z , A . M . K a s k a n d E . M . S h e v a c h 397

Part ia l Amino Ac id Sequences of M H C Products J . S i l v e r 405 Ana lys is of Lymphocyte Surface Ant igen Expression by the Use of Var i ant Cel l

Lines R . H y m a n a n d I . T r o w b r i d g e 407

Part 2

G e n e t i c s o f t h e M H C a n d A s s o c i a t e d P r o d u c t s

Polymorphie B-cell Determinants i n M a n J . J . v a n R o o d , A . v a n L e e u w e n , M . J o n k e r , A . T e r m i j t e l e n a n d B . A . B r a d l e y A l l

Cel lu lar Recognition of Major Histocompatibility Complex Antigens F . H . B a c h , M . L . B a c h , O. J . K u p e r m a n , H . W. S o l l i n g e r a n d P. M . S o n d e l 429

Genetics and Serology of H L - A - l i n k e d H u m a n Ia Antigens C. J . B a r n s t a b l e , E . A . J o n e s , W. F . B o d m e r , J . G. B o d m e r , B . A r c e - G o m e z , D . S n a r y a n d M . J . C r u m p t o n 443

Histocompatibility-2 System of Wi ld Mice. IV. Ia and Ir Typ ing of Two Wi ld Mouse Populations J . K l e i n , C. F . M e r r y m a n , P. H . M a u r e r , M . H a u p t f e l d a n d M . B . G a r d n e r 457

Genetic Control of Specific Immune Responses and Immune Suppressions by 7-region Genes B . B e n a c e r r a f a n d M . E . D o r f 465

Serological and Functional Evidence for Further Subdivision of the / Regions of the H - 2 Gene Complex D . C. S h r e f f l e r , C. S. D a v i d , S. E . G u l l e n , J . A . F r e ­i i n g e r a n d J . E . N i e d e r h u b e r 477

Functional and Genetic Analysis of Ia Antigens H . O. M c D e v i t t , T. L . D e l o v i t c h a n d J . L . P r e s s 489

Selective Expression of Separate 7-region Loci in Functional ly DiiFerent Lympho­cyte Subpopulations D . B . M u r p h y , K . O k u m u r a , L . A . H e r z e n b e r g , L . A . H e r z e n b e r g a n d H . O. M c D e v i t t 497

R o l e o f H i s t o c o m p a t i b i l i t y G e n e P r o d u c t s i n T - c e l l C y t o l y s i s

The Concept That Surveil lance of Seif Is Mediated V i a the Same Set of Genes That Determines Recognition of Al logenic Cells R . M . Z i n k e r n a g e l a n d P. C. D o h e r t y 505

Fj Hybr id Antiparental Cell-mediated Lympholysis : A Comparison with Bone Marrow Graft Rejection and with Cell-mediated Lympholysis to Alloantigens G. M . S h e a r e r , G. C u d k o w i c z , A . - M . S c h m i t t - V e r h u l s t , T. G. R e h n , H . W a k s a l a n d P. D . E v a n s 511

Cytotoxic T-cel l Response to Histocompatibility Antigens: The Role of H-2 M . J . B e v a n 519

Recognition of Alterations Induced by Ea r l y Vacc in ia Surface Antigens and Dependence of Virus-specific Lysis on H-2 Ant igen Concentration on Target Cel ls U. K o s z i n o w s k i , H . E r t l , H . W e k e r l e a n d R . T h o m s s e n 529

The Influence of H - 2 Gene Products on Cell -mediated and Humora l Immune Re­sponses H . v o n B o e h m e r , J . S p r e n t a n d W. H a a s 539

The Recognition of H-2 and V i r a l Antigens by Cytotoxic T Cells J . W. Schräder, R . H e n n i n g , R . J . M i l n e r a n d G. M . E d e l m a n 547

O n the Possibility of Mult ip le T-cell Receptors D . B . W i l s o n , E . H e b e r - K a t z , J . S p r e n t a n d J . C. H o w a r d 559

x

C O N T E N T S xi

A n t i g e n P r e s e n t a t i o n a n d T - B C e l l I n t e r a c t i o n s

Genetic Restriction of Macrophage-Lymphocyte Interactions in Secondary A n t i ­body Responses In Vitro C. W. P i e r c e , J . A . K a p p a n d B . B e n a c e r r a f 563

Genetic Restriction in T-lymphocyte Act ivat ion by Antigen-pulsed Peritoneal Exudate Cells W. E . P a u l , E . M . S h e u a c h , D . W. T h o m a s , S. F . P i c k e r a i a n d A . S. R o s e n t h a l 571

Ant igen Activation of T Lymphocytes: Influence of Major Histocompatibility Complex J . F . A . P. M i l l e r a n d M . A . V a d a s 579

Regulatory Mechanisms i n the Immune Response to Cell-surface Antigens P. L a k e a n d N. A . M i t c h i s o n 589

The Significance of T - B Collaboration across Haplotype Barriers S. L . S w a i n , P. E . T r e f t s , H . Y.-S. T s e a n d R . W. D u t t o n 597

The Role of the Histocompatibility Gene Complex in Lymphocyte Differentiation D . H . K a t z 611

Comparison of B-cell Act ivat ion Factors J . K l e i n 625

I M M U N O G L O B U L I N S

A n t i b o d y C o m b i n i n g S i t e

Model-bui lding Studies of Antigen-binding Sites: The Hapten-binding Site of M O P C - 3 1 5 E . A . P a d l a n , D . R . D a v i e s , I . R e c h t , D . G i v o l a n d C. W r i g h t 627

Three-dimensional Structure and Diversity of Immunoglobulins R . J . P o l j a k , L . M . A m z e l , B . L . C h e n , Y. Y. C h i u , R . P. P h i z a c k e r l e y , F . S a u l a n d X . Y s e r n 639

Origins of Antibody Diversity: Insights Gained from Amino Ac id Sequence Studies of Elicited Antibodies E . H a b e r , M . N. M a r g o l i e s a n d L . E . C a n n o n 647

Pr imary Structural Differences i n Mye loma Proteins That B ind the Same Hap­tens M . P o t t e r , S. R u d i k o f f , M . V r a n a , D . N. R a o a n d E . B . M u s h i n s k i 661

Folding, Association, and Interactions of Domains in the Antibody Molecule D . G i v o l , J . S h a r o n , J . H o c h m a n , M . G a v i s h , D . I n b a r , I . P e c h t , L Z . S t e i n b e r g a n d J . S c h i e s s i n g e r 667

A l l o t y p e s a n d I d i o t y p e s

Rabbit Immunoglobulin Allotypes: Complexities of The i r Genetics, Expression, Structural Basis, and Evolut ion R . G. M a g e , G. O. Y o u n g - C o o p e r , J . R e j n e k , A . A . A n s a r i , C. B . A l e x a n d e r , E . A p p e l l a , M . C a r t a - S o r c i n i , S. L a n d u c c i - T o s i a n d R . M . T o s i 677

V-region Genes for Rabbit Ig Heavy Chains K . L . K n i g h t , W. J . H o r n g a n d S. D r a y 687

The Response of Rabbits to Streptococcal Hyper immunizat ion B . A . Fräser, A . P. J o h n s t o n e , S. M . G o r d o n a n d T. J . K i n d t 689

Structure and Immunosuppression of a Cross-reactive Idiotype Associated with Anti-p-azophenylarsonate Antibodies of St ra in -A Mice S.-T. J u , F . L . O w e n a n d A . N i s o n o f f 699

Idiotypes and Anti-idiotypes as Probes i n Analys is of Immunoregulation H . C o -s e n z a , A . A . A u g u s t i n a n d M . H . J u l i u s 709

Immune Responses of B A L B / c Mice to the Idiotype of T15 and of Other Myeloma Proteins of BALB/c Or ig in : Implications for an Immune Network and A n t i ­body Multispecificity N. S a k a t o , C. A . J a n e w a y , J r . a n d H . N. E i s e n 719

Uni formity in a Clonal Repertoire: A Case for a Germ-l ine Basis of Antibody Diversity J . L . C l a f l i n a n d S. R u d i k o f f 725

Inheritance of Antibody Specificity. IV. Control of Related Molecular Species by One V H Gene O. Mäkelä a n d K . K a r j a l a i n e n 735

O n the Genetic Dissection of a Specific Humora l Immune Response to a(l,3) Dextran W. G e c k e i e r , B . B l o m b e r g , C. d e P r e v a l a n d M . C o h n 743

xi i C O N T E N T S

G e n e r a t i o n o f D i v e r s i t y : 1 . B i o l o g i c a l A s p e c t s

The Life Style of B Cells — Ce l lu lar Proliferation and the Invariancy of IgG B . A . A s k o n a s a n d J . R . N o r t h 749

Evolut ion in Microcosm: The Rapid Somatic Diversifikation of Lymphocytes A . J . C u n n i n g h a m 761

The Ontogenesis of Lymphocyte Diversity i n A n u r a n Amphibians L . D u P a s -q u i e r a n d M . R . W a b l 7 7 1

Regulation of Immunoglobulin Expression in Mouse Myeloma Cells D . H . M a r g u l i e s , W. C i e p l i n s k i , B . D h a r m g r o n g a r t a m a , M . L . G e f t e r , S . L . M o r r i s o n , T. K e l l y a n d M . D . S c h a r f f 781

Somatic Cel l Genetics of Antibody-secreting Cells: Studies of Clonal Diversifica­tion and Analysis by Ce l l Fus ion C. M i l s t e i n , K . A d e t u g b o , N. J . C o w a n , G. Köhler, D . S. S e c h e r a n d C. D . W i l d e 793

The I B-peptide Marker and the Ly-3 Surface Al loantigen: Structural Studies of a V K - reg ion Polymorphism and a T-ce l l Marke r Determined by L inked Genes P. D . G o t t l i e b a n d P. J . D u r d a 805

G e n e r a t i o n o f D i v e r s i t y : 2 . S t r u c t u r a l A s p e c t s

The Structure and Genetics of Mouse Immunoglobulins: A n Analysis of N Z B Myeloma Proteins and Sets of B A L B / c Mye loma Proteins Binding Particular Haptens L . H o o d , E . L o h , J . H u b e r t , P. B a r s t a d , B . E a t o n , P. E a r l y , J . F u h r -m a n , N. J o h n s o n , M . K r o n e n b e r g a n d J . S c h i l l i n g 817

Genetic Control of Antibody Var iab le Regions M . W e i g e r t a n d R . R i b l e t 837 Identical Hypervariable Regions in L ight Chains of Differing V K Subgroups

J . D . C a p r a , D . G. K l a p p e r , A . S. T u n g a n d A . N i s o n o f f 847 Or ig in of Immunoglobulin Gene Diversity: The Evidence and a Restriction-

Modification Model P. L e d e r , T. H o n j o , J . S e i d m a n a n d D . S w a n 855 The Significance of Hybridization Kinet ic Experiments for Theories of Antibody

Diversity G . P . S m i t h 863 Somatic Changes i n the Content and Context of Immunoglobulin Genes S. T o n -

e g a w a , N. H o z u m i , G. M a t t h y s s e n s a n d R . S c h u l l e r 877

S u m m a r y

Understanding Selective Molecular Recognition G. M . E d e l m a n 891

Name Index Ii

Subject Index 17i

Recogn i t i on of A l t e ra t i ons I n d u c e d by E a r l y V a c c i n i a Sur face A n t i g e n s and Dependence of V i rus -spec i f i c L y s i s on H-2 A n t i g e n Concen t r a t i on on Target Ce l l s

U . KOSZINOWSKI, H . ERTL , H . W E K E R L E * AND R. THOMSSEN

H y g i e n e - I n s t i t u t d e r Universität, K r e u z b e r g r i n g 5 7 , D - 3 4 Göttingen, West G e r m a n y ; : ] M a x - P l a n c k - I n s t i t u t für I m m u n b i o l o g i e , Stübeweg 51, D - 7 8 F r e i b u r g , West G e r m a n y

Mice generate cytolytic T lymphocytes (CTL) after sensitization with infective virus (Zinkernagel and Doherty 1974; Gardner et al. 1975; Koszinow­ski and Thomssen 1975; E r t l and Koszinowski 1976). C T L lyse virus-infected target cells in vitro. The reaction is specific for the sensitizing virus; there is no cross-reactivity against cells infected with v i ­ruses of another group. In addition to virus specific-ity, H-2 homology of antigenic products of the K or D region is required for specific lysis (Zinkernagel and Doherty 1975). T h e same requirements have been found in the effector phase against chemically modified cells (Shearer 1974; Shearer et al. 1975; Forman 1975; Rehn et al. 1976) and cells bearing the male-specific antigen (H-Y) (Gordon et al. 1975) as well as in the reactivity against minor histo­compatibility antigens (Bevan 1975). The question arose whether this restriction is due to a dual recog­nition process of syngenic H-2 structures and viral antigens or to a Single T -ce l l receptor which recog-nizes a virus-specific altered H-2 antigen. Recent experiments with radiat ion chimeras favor the second possibility since reaction against "modified" alloantigens is possible provided the C T L is tolerant to the al loantigen which is present during the sen­sitization phase (Pfizenmaier et al. 1976).

It must be considered, however, that determina-tion of 5 , Cr-re lease in certain combinations reflects only the requirements of the lethal-hit stage (Gol­stein and Smith 1976). The inference as to recogni­tion requirements can only be drawn indirectly from cytolysis data. Requirements for recognition can be tested by specific absorption on monolayers (Wekerle et al. 1972; Golstein et al. 1972). Data presented here show that absorption is possible only on monolayers bear ing "modif ied" H-2 determinants present dur ing the sensitization phase. Another question is whether C T L can lyse virus-specific infected cells which lack H-2 antigenic determi­nants. To investigate the relationships between H-2 antigenic concentration and degree of virus-specific lysis, infected target cells treated with proteolytic enzymes were tested. In a third ap-proach, we looked for the m in ima l changes that must be induced on cells by the vaccinia virus in -fection to sensitize C T L in vivo and to enable cyto­lysis in vitro. O u r data demonstrate that induction

of early vaccinia virus surface antigens is sufficient for sensitization and specific lysis.

M A T E R I A L S A N D M E T H O D S

M i c e . Mice of the inbred strains C 3 H (H-2 k), DBA/2 (H-2 d), and C57BL/6J (H-2 b) at the age of 6-10 weeks were used throughout. These were purchased from Bomholtgard, Denmark.

V i r u s e s a n d s e n s i t i z a t i o n . Stocks of vaccinia virus strains W R and EIstree were grown in V E R O ( C e r c o p i t h e c u s a e t h i o p s ) kidney cells. V i rus t i -trations were performed on the same cells. Stock Solutions of vaccinia virus strains W R and Elstree (Lister strain) contained 1 x 10 6 T C I D 5 0 (tissue-culture infective dose) per mil l i l iter. Strain DIs, an attenuated vaccinia virus mutant which derived from the Dairen 1 (DIE) strain (Tagaya et al. 1961), was provided by Dr. Ueda, Tokyo. DIs was propa-gated in 12-day-old fertile eggs at 35-36°C for 2 days. Titrations were done on primary chicken fibroblasts (Tagaya et al. 1974). DIs was used in a concentration of 1 x 10 5 T C I D 5 0 per mill i l iter. Purification of strain W R was performed according to the method of Jok l ik (1962). Inactivation of vaccinia virus W R was obtained by incubation at 56°C for 120 minutes, three times interrupted by a short sonication procedure.

L C M virus strain WE -3 , kindly provided by Dr. Lehmann-Grube, Hamburg , was propagated i n L929 cells.

V i rus of vesicular Stomatitis (VSV) strain Indi­ana was propagated in V E R O cells; stock Solutions contained 10 6 T C I D 5 0 per mill i l iter. Mice were sensitized by intraperitoneal injection of the 1-ml virus Suspension. Spleen cells were harvested 6 days later.

A n t i s e r a . Ant i se rum to strain W R (No. 8) was obtained from rabbits immunized with W R strain vaccinia virus. The animals were injected intradermally, and, after a period of 2 weeks, three booster injections were given at intervals of 10 days. Sera were inactivated and stored at — 70°C. The cytolysis titer of the sera measured in a 5 1 C r -release assay, using infected L929 cells as targets

529

530 K O S Z I N O W S K I E T A L .

and guinea pig serum as complement source, was about 1024-2048. A n anticomplementary activity of the sera was demonstrable to a di lution of about 1:8.

Ant i serum to late vaccinia virus surface antigens (anti-LS): serum No. 8 was extensively absorbed with DIs-infected primary chicken fibroblasts. Ant i serum to early vaccinia virus surface antigens (anti-ES): rabbit serum against early vaccinia virus surface antigens was prepared by injection of crude soluble early antigens of DIs-infected rabbit kidney cells into rabbits (Ueda et al. 1972; Ueda and Tagaya 1973). Ant i se rum to structural antigens of the vir ion (anti-VA) was obtained from rabbits injected with purified inactivated vaccinia virus. One optical density unit (ODU) (Joklik 1962), containing about 64 f i g v i ra l protein, was injected intramuscularly, and a booster injection of the same dose was given 14 days later. Neutral iz ing antibody titers were determined by 80% plaque reduction in V E R O cell cultures.

Ant i -H -2 serum was obtained from D. J . G. Ray, Transplantation and Immunology Branch, N IAID , N I H Bethesda, Mary land. We used charge 3b(Snell 1974) , raised in recipient-donor strains (C3H-H-2 0 x

129) ant i -C3H, genotypes (H-2 d / k x H-2") ant i -H-2 k . The serum is directed mainly against specifici-ties coded by H-2 K genes. No cross-reactivity with other private H-2 specificities could be observed by immunofluorescence or complement-dependent antibody-mediated cytolysis.

D e m o n s t r a t i o n o f v i r a l s u r f a c e a n d i n t r a c e l l u l a r a n t i g e n s . Indirect immunofluorescence was per­formed as reported previously (Koszinowski and E r t l 1975). Demonstration of D N A synthesis in vaccinia-virus-infected cells was performed with D A P I (4,6-diamidino-2-phenylindol) (Russell et al. 1975) .

Ea r l y and late surface antigens of cells infected with vaccinia virus were studied by mixed hemag-glutination technique (Ito and Barron 1972) and by cytolytic antibody assay.

T a r g e t c e l l s : L929 cells (haplotype H-2 k ) and mastocytoma P-815-X2 cells were cultivated in Eagle's M E M supplemented with 10% inactivated calf serum and 100 /xg/ml streptomycin and peni-ci l l in (1% SP). For infection of target cells, about 5 x 10 6 to 1 x 10 7 L929 cells growing as monolayer cells in glass bottles were washed with fresh serum-free medium and then incubated with 10-15 ml virus Suspension on a rocker platform at 37°C. After 2 hours, the virus dilution was discarded and fresh serum-free medium was added. The cells were used 3-12 hours later, depending on virus and test conditions.

E n z y m a t i c t r e a t m e n t : The following enzymes were used: (1) papain, water-soluble, 3.5 mAnson units per mi l l ig ram (Merck, Darmstadt, W. Germany,

lot 7144); and (2) neuraminidase from vibrio comma (VCN) , 500 neuraminidase units per mil l i l i ter (Behringwerke, Marburg/Lahn, W. Germany). The enzymes were dissolved and diluted in serum-free M E M .

Cells prepared for enzymatic treatment were washed twice with serum-free medium and diluted to a concentration of 2.5 x 10 K cells/ml. The enzy­matic treatment was performed at 37°C, p H 6.5-7.0, with intermittent shaking for 20 (papain) or 30 minutes (VCN). Treatment with papain was carried out in the presence of 0.01 M cysteine (L(+)-cysteine chloride, Merck, lot 2839). Follow­ing enzymatic treatment, the cells were washed three times with M E M supplemented with 20% fetal calf serum (FCS).

Cel ls were counted and viabi l ity was determined by the trypan blue exclusion test. W i th the enzyme concentrations used, viabil ity did not fall below 70-80%. The cells were stored before use in Eagle's M E M supplemented with 20% F C S . For virus-specific cytotoxic assays, carried out 4 hours after enzymatic treatment, cells were labeled 1 hour before with 100 jxCi 5 1 C r (sodium Chromate; Amersham, Buchler, Braunschweig, W. Germany; No. CJS1P , specific activity 100-200 mCi/mg Cr) per 5 x 10<; cells. For allogenic cell-mediated cytolysis (CMC), cells were labeled before enzy­matic treatment and used as targets immediately after treatment.

S e n s i t i z a t i o n t o a l l o a n t i g e n s . Mitomycin-C-treated stimulator cells, 1 x 10 6, were incubated with 4 x 106 responder cells in 3 m l Dulbecco's modified medium supplemented with 5% F C S and 100 /xg/ml penici l l in and streptomycin in a C 0 2 atmosphere at 37°C. Allogenic spieen cells or tumor cells were used as stimulator cells. F ive or six days later, the cells were harvested, and their effect on the appropriate 5 , Cr - labe led target cells was tested in a 5-10-hour assay. The ratio of attacker to target cells ranged between 20:1 and 50:1.

A d s o r p t i o n o f effector c e l l s o n m o n o l a y e r s . Mouse peritoneal exudate cells were harvested after thioglycolate Stimulation and plated in plastic petri dishes (100-mm diameter, Greiner, Nürtin­gen, W. Germany). Confluent monolayers were in ­fected 24 hours later. The medium containing virus was replaced by fresh medium after an adsorption time of 1 hour. About 6-12 hours later, monolayers were washed carefully and used for lymphocyte absorption. Spleen-cell suspensions, treated for 10 minutes with ammonium chloride Solution (0.14 M , p H 7.5), were added to the monolayers in a quantity of 2 x 10 7 cells in 2 m l medium. The Sepa­ration procedure was performed according to the method of Wekerle et al. (1972). Adsorption time was 3 hours at 37°C. Controls were run at 4°C.

A N T I G E N I C R E Q U I R E M E N T S F O R V I R U S - S P E C I F I C C M C 531

A n t i b o d y - m e d i a t e d c y t o l y s i s . Antibody-mediated lysis of virus-infected cells was performed as de-scribed by Kib le r and ter Meulen (1975).

C o l d - c e l l i n h i b i t i o n assay. The assay was per­formed according to the method of Herberman et al. (1976). Inhibition was calculated as follows:

% Inhibition of specific

lysis

% specific lysis in immune control

% specific lysis in

presence of inhibitory

cells % specific lysis

in immune control

x 100.

Table 1. Inh ib i t i on of Specific Lys i s by Cold Inhibi tory Cel ls

Third-party cells infected with virus

Percent inhibition of lysis" of vaccinia-virus-WR-infected

L929 cells

L929 7.1 3.2 L929 vacc in ia v i rus W R 91.0 ± 1.4 L929 ves icular Stomatitis

v i rus 3.8 ± 2.8 L929 L C M v i rus 14.8 1.6 P-815-X2 vacc in ia v i rus W R 18.7 3.1

a Effector cells derived from a pool of six C3H mice sensitized to vaccinia virus strain WR 6 days previously. Mean of percentage

5 lCr-release ± S.D. of four tubes per group. Specific lysis of target cells without cold cells added, 52.0%. Ratio of attacker to target cells, 100:1; ratio of cold inhibitory cells to target cells, 50:1.

C e l l - m e d i a t e d c y t o l y s i s . Var ious numbers of lymphocytes from sensitized mice and control mice were incubated with a constant number (1 x 104) of 5 l Cr - l abe led target cells (Wagner 1973). Specific 5 1 Cr-release was determined (Koszinowski and Thomssen 1975) using the formula:

5 1 Cr-release 5 1 Cr-release by immune — by normal

% Specific _ cells control x Q

lysis maximal 5 I Cr-re lease

Results show that adsorption of virus-sensitized T cells is possible on syngenic monolayers infected with the sensitizing virus (Table 2). If virus-specific effector cells have two receptors, one for syngenic H-2 and one for the vira l antigen, adsorption should be possible on normal syngenic monolayers as well as on allogenic vaccinia-virus-infected cells. How-ever, specific adsorption on normal syngenic mono­layers or allogenic vaccinia-virus-infected mono­layers was not seen, which favors the modified -self hypothesis.

The Standard deviation (S.D.) was calculated from at least a triplicate assay. Some data are given without S.D. because, under the test conditions used, the S.D. values of percent lysis were less than 5%.

R E S U L T S

Cold -ce l l Inhibition and Monolayer Adsorpt ion

Inhibition tests with cold target cells were per­formed to test which antigens have to be expressed for specific lysis. To the test assay consisting of 1 x 10 4 5 1 Cr- labeled target cells and 1 x 10 6 effector cells, different amounts of nonlabeled target cells infected with different viruses were added. In the concentration of 50 inhibitory cells to one target cell, inhibition of 91.0% could be achieved when syngenic cells infected with the sensitizing virus were added (Table 1). Normal syngenic cells or syngenic cells infected with unrelated viruses showed no inhibitory activity. Allogenic cells in ­fected with the sensitizing virus had only slight inhibitory activity.

Since in cold third-party cell experiments block-ing of specific lysis is measured, a hypothetical recognition process without subsequent lysis can-not be tested. Requirements for specific recognition can be tested by adsorption of sensitized effector cells on monolayers; this has been shown after sensitization to alloantigens (Golstein et al. 1972).

Enzymatic Treatment of Target Cells and Anti -v i ra l C M C

Target cells were treated with enzymes to investi-gate the necessity of H-2 antigenic determinants for anti -viral C M C . The effect of papain and V C N on the amount of surface antigens directly after treat­ment and 4 and 24 hours later was controlled by indirect immunofluorescence. H-2, as well as virus-specific fluorescence, was reduced or even abolished directly after treatment. Repetition of immuno-

Table 2. Adsorpt ion of Vaccinia-virus-speci f ic Effector Ce l ls

Percent specific lysis of vaccinia-virus- Percent change

Macrophage monolayers infected C3H relative to used for adsorption macrophages control

Contro l 17.4 ± 1.3 100 C 3 H 16.3 ± 2 . 4 94 C 3 H vaccinia-v irus-

infected 8.1 ± 2.9 47 DBA/2 vaccinia-v irus-

infected 18.9 ± 1.6 109 C 3 H vaccinia-v irus-

infected (4°C control) 18.6 ± 2.3 107

Supernatant (nonadherent) lymphocytes were collected from macrophage monolayers after 3 hr incubation at 37°C on a rocker platform. Attacker-to-target-cell ratio, 50:1; assay time 8 hr.

532 K O S Z I N O W S K I E T A L .

Table 3. Antibody-mediated Lys is of Vacc in ia -v i rus - in ­fected Ce l l s after Treatment w i th Enzymes

Enzyme concentration" Papain V C N

Contro l 13.6 ± 1.8 8.8 ± 1.3 5 24.6 ± 0.2 13.9 ± 2.4

10 33.7 ± 1.4 9.3 ± 2.3 20 24.4 ± 1.8 14.2 ± 2.4 50 23.4 ± 0.3 15.6 ± 3.6

100 29.1 ± 2.5 66.8 ± 2.1

L929 were infected 6 hr before enzymatic treatment; f , , Cr -release test was performed 4 hr after treatment; antiserum to vaccinia virus (No. 8) originated from rabbits, and complement originated from guinea pigs. Assay time was 4 hr. Spontaneous 5 1 Cr-release of enzymatically treated cells, 20-25%. Each value represents the mean of four tubes ± S.D.

a Papain, /ng/ml; V C N , u/ml.

fluorescence (IF) after 4 and 24 hours indicated resynthesis of v i ra l antigens but, due to host-cell protein synthesis inhibition, not of H-2 antigens. Enzymatic treatment of noninfected target cells was followed by resynthesis of H-2 antigenic deter-minants 4 to 24 hours later. V C N treatment had no effect on either H-2 or virus-specific determi-nants; IF was even found intensified.

Results of IF were repeated in complement-dependent antibody-mediated lysis using an anti -vaccinia serum and infected target cells 4 hours after enzymatic treatment. The results verify the IF observations (Table 3). Virus-specific antigens are resynthesized and lysis is even increased after treatment with high doses of enzymes, especially in the case of V C N .

Enzymatic activity on H-2 antigenic determi-nants was tested. Absorption studies were per­formed because concentration differences of surface antigens cannot be distinguished easily by anti ­body-mediated lysis (Lesley et al. 1974). Equa l numbers of nontreated and enzyme-treated (4 hr previously) infected target cells were used for ab­sorption of an H-2 alloantiserum. Absorbing capac-

ity was demonstrated by comparing the cytolytic activity of the alloantiserum before and after ab­sorption. The nearly identical slopes of cytolytic activity of absorbed and nonabsorbed serum after papain treatment of absorbing cells (Fig. 1) demon­strated the reduced capacity of these cells to adsorb H-2 alloantiserum. VCN- t reated cells, however, had nearly the same absorbing capacity as n o n -enzyme-treated cells. Th is means that papain is effective in reducing H-2 antigenic sites. The reduc-tion of H-2 antigenic determinants is constant when vaccinia-virus-infected target cells are treated.

T cells sensitized to vaccinia virus were incubated with enzyme-treated or nontreated infected and noninfected target cells. Enzymat ic treatment i n -fluenced lysis of syngenic infected cells. Removal of sialic acid resulted in enhanced C M C . Digestion of target cells with papain diminished the lysis of target cells (Fig. 2).

To prove the efficiency of enzymatic digestion on H-2 antigenic determinants and to exclude possible toxic activities of enzymes on the effector cells, un-infected L929 cells were subjected to papain treat­ment in both the same and higher concentrations than those of infected target cells. These cells were incubated with allogenic ant i -H-2 k ki l ler T cells for either 5 or 10 hours. The results (Fig. 3) show that papain treatment does in fact reduce the sensitivity of target cells to lysis by T cells directed to H-2 antigens. Since noninfected L929 cells are less frag­ile than infected cells, higher concentrations of papain could be used. Nonspecific effects of enzyme on effector cells could be excluded by the 10-hour assay. Dur ing this incubation period, H-2 antigenic determinants are resynthesized (Schwartz and Nathenson 1971), and effector cells are effective under these conditions. This means that T-ce l l -mediated lysis of virus-infected cells is dependent on expression of H-2 antigenic determinants on these cells. V i r a l surface antigens do not suffice for virus-specific C M C .

164 1128 1256 1512 SERUM DILUTION

11024 12048 14096

Figure 1. Res idual cytotoxicity of an t i -H -2 k al lo­ant i serum after absorption on enzymat ica l ly treated cells. (• •) Cytotoxic act iv i ty of the nonabsorbed serum control; (A Ä ) res idual cytotoxic act iv i ty after absorption of 0.5 m l serum on 5 x 10 7 vaccinia-virus-infected L929 cells; (O O) absorption on 200 U/ml VCN- t r ea t ed infected L929 cells; (• •) absorption on 200 /xg/ml papain-treated infected L929 cells. The plateau act iv i ty of the an t i -H-2 k

serum (44.8 ± 3.2) was taken as 100%. Da ta represent the mean of at least four tubes ± S.D.

A N T I G E N I C R E Q U I R E M E N T S F O R V I R U S - S P E C I F I C C M C 533

Figure 2. A l t e ra t i on of cell-mediated lysis after enzymatic treatment of target cells. The figure represents data from four tubes ± S.D. (O O) VCN- t rea ted target cells (background lys is of enzyme-treated cells, 18-23%; specific lys is of non­treated infected L929 cel l controls, 37.2%); (• •) papain-treated target cells (background lys is of treated cells, 29.3%; specific lys is of nontreated infected L929 cel l controls, 44.0%). Rat io of at­tacker cells to target cells was 100:1; assay t ime, 16 hr . ENZYME CONCENTRATION

Role of Early V i r a l Surface Antigens in Cellular Immune Response to Vaccin ia V i rus

Experiments were performed to test the min imal "alterations" that must be induced on cell surfaces to induce specific sensitization or to render cells sensitive to virus-specific T-cell-mediated lysis. The

60-

50-

,40.

± 30-

20-

0 01 02 05 10 mg/ml Popoin

E N Z Y M E CONCENTRAT ION

20

Figure 3. Influence of target-cell treatment w i th papain on allogenic C M C : (• • ) 5-hr assay (background lysis , 12.5-18.3%; percent specific lys is of nontreated control target L929 cells, 56.4%); (• •) 10-hr assay (back­ground lysis, 17.5-23.9%; percent specific lysis of non­treated control target L929 cells, 63.6%). A t tacker cells were DBA/2 lymphocytes sensitized i n v i tro to C 3 H l ym­phocytes for 5 days. Rat io of attacker cells to target cells was 20:1.

virus strains we put into test varied in the expres-sion of v ira l surface antigens. Characteristics of the three strains used are given i n Table 4. Stra in W R was positive for early and late surface antigens, strain DIs did not propagate in mouse cells but it did induce early surface antigens, and strain Elstree gave mixed hemagglutination of the single-cell type (Ito and Barron 1972) with an ant i -ear ly -surface-antigen serum.

Spleen lymphocytes of C 3 H mice sensitized to any of the three virus strains ki l led al l infected target cells (Table 5). Also, lymphocytes from mice sensi­tized with a low dose of DIs were active, despite the fact that virus propagation did not take place in vivo. This means that D N A replication and produc-tion of late surface antigens is not a prerequisite for cellular anti-vaccinia-virus sensitization. Lymphocytes from mice sensitized to DIs or Elstree showed cross-kil l ing of their relevant infected target cells. A l though early antigen expression is suffi-cient, our data give no clear-cut results about the role of late surface antigens, since strain Elstree is only partial ly defective i n production of early sur­face antigens.

Inhibition of Ant iv i ra l C M C by Specific Antibodies

Cytolytic activities against DIs-infected cells suggest C T L activities against virus-induced early surface antigens. Different antiviral sera were prepared to control these results in inhibition assays. These antibodies were tested for inhib i ­tory activities in the antiviral C M C using L929 cells infected with vaccinia virus strain W R as targets and spieen cells from strain-WR-sensitized C 3 H mice. Table 6 gives the characterization of the antisera and their activity on antiviral C M C . Significant inhibition of C M C was seen with a serum obtained from rabbits after virus infection (No. 8) and ant i -ES serum. A n t i - L S serum and

534 K O S Z I N O W S K I E T A L .

Table 4. Character ist ics of Vacc in i a V i r u s Stra ins

Strain D N A replication

in L929 cells51

Cytopathic effects in L929 cells

Titer of virus in test" (TCID5 0)

Indirect hemagglutination with anti-ES

Indirect IF on surfaces

anti-ES anti-LS

W R yes yes 10 6 positive +++ +++ Elstree yes yes 10 6 single-cell type + ++ DIs no no 10 5 positive ++ —

a Tested with DAPI and by indirect IF with anti-VA. b Strains WR and Elstree were propagated and titrated in V E R O cells; strain DIs was propagated in embryonated eggs (chlorioallantois

membrane) and titrated on primary fibroblasts of 6-day-old chicken embryos.

serum directed against antigens of the virus particle (anti-VA) had no significant inhibitory activities. The inhibition test with 1 O D U of in ­activated vaccinia antigen, after addition of about 1.2 x 10 1 0 inactivated vaccinia elementary bodies, was negative. Therefore, the virus-specific antigen receptor site on the cytolytic T cell does not seem to recognize antigens of the virus particle.

Table 5. A n t i v i r a l C M C of C T L from Mice Sensit ized w i th Different Vacc in i a St ra ins

Percent specific release" from L929 cells infected with

Sensitization DIs WR Elstree

1 x 10 6 T C I D 5 ( ) W R 45.0 41.8 15.7 1 x 10 6 T C I D 5 0 E lstree 18.8 27.3 15.1 1 x 10 5 T C I D 5 0 DIs 27.6 14.2 N .D.

Lymphocytes were derived from C3H mice sensitized 6 days previously.

a Background lysis ranged between 20-25%; assay time was 14 hr; ratio of attacker cells to target cells was 100:1; N.D. = not done.

Table 6. Ac t i v i t i es of Ant i - vacc in ia Se rum

Indirect cell-surface IF a

Serum WR DIs CA 1 ' NT«' Percent specific

lysis"

Ant i - vacc in ia + + 1:1024 1:32 15.0 e

(No. 8) A n t i - E S + + 1:1024 1:<4 17.0* A n t i - L S + - 1:512 N .D . 23.7 A n t i - V A - - 1:<4 1:256 25.8

N o r m a l serum 24.8 None 27.4

1.2 x 10 1 0 vacc in ia particles 32.4

a Indirect IF was tested on L929 cells infected with vaccinia strains WR and DI's 8 hr previously.

'»CA = cytolytic antibody assay. Cytolytic activity was tested on L929 cells infected with vaccinia strain WR in a 4-hr 5 1 Cr-release assay.

c" N.D. = Neutralizing test. Neutralizing activity was tested on V E R O cell monolayers.

Lymphocytes were derived from C3H mice sensitized 6 days previously with vaccinia virus strain WR. Ratio of attacker cells to target cells, 50:1; incubation time, 12 hr; background lysis, 22.8%.

l" Significantly reduced specific 5 1 Cr-release ( P < 0.05).

D I S C U S S I O N

Cold-cell inhibition experiments were performed to look for blocking activities of cells bearing different virus-induced "modifications." Only syn­genic vaccinia-virus-infected cells had blocking activities. No effect was produced by adding allo­genic vaccinia-virus-infected cells or syngenic cells infected with other viruses. The necessity of H-2 homology for effective blocking of C M C of "modified" cells has also been shown by others (Shearer et al. 1975; Rehn et al. 1976). The a im of the absorption studies was to discriminate between cytolysis and recognition. Monolayer absorption can effectively fractionate antigen-sensitive cells (Wekerle et al. 1972; Golstein et al. 1972). If virus-specific C T L have two antigen receptors, one for syngenic H-2 and one for the vira l antigen, specific adsorption should be possible on normal syngenic monolayers or on allogenic vaccinia-virus-infected cells. Lysis would occur only i f both antigens are expressed on the same cell. The finding that specific adsorption takes place only on vaccinia-virus-infected monolayers sharing K and D structures with the effector cells is very much in accord with the altered-self hypothesis (Doherty et al. 1976), which requires only one antigen receptor site on T cells for recognition and cytolysis. There is no independent recognition of both Single antigenic determinants, or at least a very low affinity of the receptors.

It was next of interest to investigate the reac-tivity against target cells bearing vira l antigens but reduced or even abolished H-2 antigenic sites. These target cells could be prepared since vaccinia virus infection inhibits the host-cell protein synthe­sis (Moss 1968). H-2 antigenic sites were not reex-pressed after enzymatic treatment while synthesis of vira l surface antigens took place. The ma in results from these experiments were that v ira l antigenic determinants which are detectable by humoral antibodies (immunofluorescence, antibody-mediated antiviral cytotoxicity) did not suffice for the effector function of antiviral C T L .

C M C of virus-infected target cells was found reduced after papain treatment but not after V C N treatment. As has been shown by Sandford and Codington (1971), removal of sialic acid has no

A N T I G E N I C R E Q U I R E M E N T S F O R V I R U S - S P E C I F I C C M C 535

inhibitory activity on cellular recognition of H-2 antigenic determinants while H-2 can be dissolved from cell membranes by papain treatment (Nathen-son and Davies 1966; Yamane and Nathenson 1970). It could be demonstrated that the inhibi ­tion of C M C acts on the target-cell level. After treatment of normal L929 cells with papain, cyto­lysis by allogenic ki l ler cells sensitized against H -2 k

antigens was found reduced, but under test condi-tions allowing resynthesis of H-2 antigens (Schwartz and Nathenson 1971), there was no inhibition of effector-cell activity. Th is rules out unspecific inhibitory effects of any active enzyme possibly remaining on the effector cells.

These results do not support the finding (Dennert 1975) that the T cell recognizes the modifying hapten on the cell surface. Cytolytic T cells specific for new antigens on cells also need H-2 antigenic sites on the target cell for their effector function. Reduction of H-2 by enzymatic treatment or by capping with alloantiserum (Koszinowski and E r t l 1975; Schmitt-Verhulst et al. 1976) decreases the ability of virus-infected target cells to be lysed by antivira l C T L . This corresponds to observations (Lightbody and Bach 1973; Brondz et al. 1973) that proteolytic treatment reduced allogenic C M C . Thus the virus-specific C T L act in an analogous way to the alloantigen-specific C T L , which are depen-dent on the concentration of K - or D-region products on the target cell (Alter et al. 1973). One can assume that C T L can only be sensitized to and recognize new antigenic determinants which interact with antigens coded by genes of the K or D region of the major histocompatibility complex (MHC).

Investigating the min ima l requirements of cell-surface alterations by a virus infection, it was found that early surface antigens, induced by vaccinia virus, give rise to the generation of anti-vaccinia C T L . Th i s could be demonstrated using a condi-tional lethal mutant strain of vaccinia virus (Tagaya et al. 1961) which does not replicate in mice. The essential role of early vira l antigens for induction of cellular and humoral immune mecha­nisms has been suggested previously (Ueda and Tagaya 1973). Also, in the effector phase, target-cell infection with strain DIs was sufficient for induc­tion of cell-mediated specific lysis.

The inhibit ion experiments with different anti­v ira l sera outline the significance of early antigens. U s ing sera against different v ira l antigens, the neutralizing activity could be separated from C T L inhibitory properties. Contact with complete virus particles is not necessary; they do not inhibit the cytotoxic interaction, nor does the injection of inactivated virus particles give rise to C T L pro-duction (unpubl.). C T L recognition is therefore specific for plasma membrane alterations but not for antigens of the virus surface.

If C T L have biological functions in vivo, sensiti­zation and reactivity against virus-induced early

antigens seem to be advantageous. They are ex­pressed as early as 1 hour after infection (Ueda et al. 1969), whereas maturation of complete in ­fective virus needs several hours. In the reaction against alterations of the cell membrane induced by early antigens, the C T L could prevent synthesis of virus particles and, in later stages of infection, the spreading of virus.

Vaccinia-virus-specific early surface antigens, whose role in virus replication is not clear, per­form the functional H-2 antigenic alteration which gives rise to vaccinia-virus-specific C M C . Charac­terization of the relevant Polypeptides (Esteban and Metz 1973; Pol isky and Kates 1975) that are synthesized very early after infection wi l l help to clarify the biochemical basis of H-2 antigen "alter­ation."

S U M M A R Y

Specific recognition of antigens by cytolytic T lymphocytes sensitized to vaccinia virus was tested by monolayer adsorption. Adsorption was possible only on monolayers also expressing syngenic H-2 as vira l antigens present during the sensitization phase.

Vaccinia-virus-infected target cells were sub-jected to papain and neuraminidase treatment. H-2 antigenic determinants could be removed by papain treatment. Due to virus-specific inhibi ­tion of host-cell protein synthesis, reexpression of H-2 antigenic determinants did not take place, but v ira l surface antigens were resynthesized. Susceptibility of target cells to T-cell-mediated lysis was decreased after papain treatment.

Substrains of vaccinia virus were used in order to define the min ima l changes induced by vaccinia virus necessary for T-cel l sensitization in vivo and target-cell lysis in vitro. When the immune response to a conditional lethal mutant strain of vaccinia virus was investigated, it could be demonstrated that expression of early surface antigens is suffi­cient for induction of the cellular immune reactions. These data were confirmed by inhibit ion studies with virus-specific antisera.

Acknowledgments

We thank Dr. Y. Ueda, Tokyo, for supplying us with DIs virus and ant i -ES serum, and Dr. C. Jungwirth, Würzburg, for purification of vaccinia virus WR.

The technical assistance of Ms. K . B. Henderson and Mrs . S. Siebeis is greatly appreciated. We thank Mrs. I. Dreyer for preparation of the manu-script.

This work was supported by the Deutsche Forschungsgemeinschaft, Grant K o 571/2.

536 K O S Z I N O W S K I E T A L .

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Name Index

Aaskov , J . G. , 251, 253, 257, 259

Aasted, B. , 692, 694, 696 A b b a s , A . K., 2 4 9 , 2 4 9 Abbot, A . ,259 Abbot, J . , 8 , 1 3 6 , 1 3 7 Abelson, H . T., 1 6 3 , 1 6 4 A b e l s o n , L . , 3 8 6 , 3 9 6 , 4 2 7 ,

4 5 4 , 455 Abney, E . R., 39, 40 ,44, 143,

1 4 4 , 1 7 6 , 2 8 2 , 185, 186, 187, 1 9 0 , 1 9 0 , 1 9 1 , 193-200, 193 , 194, 195, 1 9 9 , 266, 270,272 , 365,368

Abo la , E . E . , 3 3 9 , 6 3 6 , 645, 674

A b r a h a m , R . , 3 1 4 , 3 2 1 , 587 Abrahams, S., 321 Ackers , G K. , 353,362 Acton, R. T., 51, 52, 5 3 , 6 1 A d a , G. L . , 1 8 2 , 252,259, 791 Adams, H . , 891, 901 Adelberg, E . A. , 782,787,789,

790, 791 Aden , D. F . , 377 Adetugbo, K. , 645, 665, 793-

803, 795 , 796, 7 9 7 , 8 0 2 , 803

Adle r , R. H . , 2 1 5 Adle r , S . , 4 5 4 Ae l l en , M. -F . , 8 5 2 , 8 6 2 , 888 Agrawa l , B . B . L., 2 2 8 , 2 3 6 Ahlstedt , S.,224 A inswor th , C F., 645 Alber t , E . , 427 A lbe r t i n i , R. J . , 4 2 9 , 4 3 9 Albrecht , P. ,82 A lbrechtsen, D. ,426 Aldo-Benson, M . , 251,259 A l e x a n d e r , C B . , 677-686,

6 8 6 , 6 9 8 , 845 Alexander , R J . , 773, 778 Al ford , C A . , 1 4 4 A l k i n s , R. C . , 2 8 4 A l l a n , D., 379,385 A l l d e r d i c e , P. W., 444, 449 ,

453 A l l e n , F. H . ,426 , 427 A l l e n , J . M . V. , 51, 52, 53 ,59 ,

6 1 , 1 6 3 , 1 6 4 , 4 0 7 , 4 1 4 Al l f r ey , V . G , 269,273 A l l i s o n , A . C . , 1 0 2 A l t e r , B . J . , 2 3 6 , 3 4 9 , 3 5 1 ,

3 6 1 , 4 2 6 , 4 2 9 , 4 3 4 , 4 3 9 , 4 4 0 , 4 4 1 , 535,536, 609

Amano , H . , 536

Amante , L., 4 4 , 47, 50, 164, 183, 791

Ambros ius , H . , 2 7 2 A m k r a u t , A . A. , 598, 609 Arnos , D. B . , 3 4 3 , 3 7 7 , 3 8 6 ,

3 9 6 , 4 2 6 , 4 2 7 . 454 Amze l , L. M . , 377, 635, 636,

6 3 7 , 639-645, 6 4 1 , 6 4 4 , 6 4 5 , 654 , 6 5 8 , 6 5 9 , 6 6 6 , 818, 834 ,834 ,835

Ancona, A . , 50 Anderson, B. , 315,322 Anderson, C. L., 315-321,315,

321 Anderson, C W., 781, 790 Andersson, B . ,272 , 275,284,

710, 72 7, 764, 770 Andersson, J . , 147-158, 147,

148, 149, 150, 153, 257, 163, 164, 1 6 4 , 179, 1 8 2 , 2 1 1 , 2 2 5 , 227-236, 227 , 228 , 230 , 232 , 2 3 5 , 2 3 6 , 248 , 2 4 9 , 2 5 0 , 2 5 5 , 2 5 9 , 754, 758

A n d e r s s o n , L. C , 4 3 0 , 4 3 9 , 4 9 2 , 4 9 5

Anderton, B. H . ,386 Andrews, E . P.,62 Anf insen , C B. , 2 9 5 , 3 0 5 , 3 0 6 ,

670, 674 A n s a r i , A . A. , 677-686, 683,

6 8 4 , 6 8 5 Anteun is , A . ,324 A n u n d i , H . , 3 2 9 , 331-339,

3 3 1 , 3 3 2 , 3 3 8 , 3 3 9 , 363 , 3 6 8 , 3 7 7 , 4 1 1 , 4 1 3

A o k i , T., 3 1 , 4 0 8 , 4 1 3 , 8 1 4 A p p e l l a , E . , 3 2 6 , 3 2 9 , 341-

342, 3 4 1 , 3 4 2 , 3 4 9 , 357 , 3 6 1 , 3 7 1 , 372 , 650 , 6 5 8 , 677-686, 6 8 5 , 6 8 6 , 6 9 1 , 6 9 6 , 6 9 7 , 7 3 1 , 7 3 3 , 830 , 837, 838, 8 3 9 , 8 4 5

Arbe i t , R. D. ,250, 374,377 Arce-Gomez, B. , 443-455,451,

453 A r m e r d i n g , D . , 2 4 , 3 2 , 119,

1 2 6 , 3 6 4 , 3 6 8 , 3 6 9 , 3 7 7 , 4 6 9 , 4 7 4 , 489 , 492 , 4 9 3 , 4 9 5 , 4 9 6 , 5 0 2 , 5 0 3 , 6 2 3 , 625, 626

Armstrong , D. W., 251,259 A rna i z -V i l l ena , A. , 418, 419,

426 Arnd t , R , 59, 61 Arno ld , R. R , 2 2 5 A r n o n , R., 623, 672, 674 Arnze l , L. H . , 675

A r q u i l l a , E . R., 898, 902 Arrenbrecht , S., 95, 101, 202 Ar tz t , K . , 339 , 588 Asch inaz i , G , 204,224 Asherson ,G . L., 105,106,109,

222 Askonas, B . A. , 37, 4 4 . 115,

227, 167, 273 , 193 , 195, 196, 198, 299, 2 4 5 , 2 5 0 , 2 7 6 , 2 8 4 , 726, 733 , 749-759, 749 , 750 , 7 5 1 , 752 , 753 , 754 , 755 , 756 , 757 , 758, 759, 777, 779

A s o f s k y , R., 113, 227 , 237, 245, 1 7 2 , 1 7 3 , 1 8 2 , 1 8 3 , 1 9 9 . 2 7 2 , 432,440

Asterano, A . ,324 A t k i n s , J . F., 790 A t k i n s , R. C , 527, 540, 542,

5 4 4 , 561 Atk inson , P. H. ,386,402, 411,

423, 454 A t w e l l , J . L., 1 9 9 , 2 7 3 , 2 8 4 , Augus t in , A. , 285, 293, 709-

718, 710 , 711 , 713 , 716, 72 7

A u s t i n , C. M . ,282 , 792 Avey, H . , 6 4 5 , 6 7 5 , 8 3 5 Av i v , H . ,836 Avrameas , S., 309, 324, 679,

6 8 5 , 790

B

Baas, P. D., 8 5 6 , 8 6 2 Babinet , C , 338,338 Bach , F. H . , 8 3 , 3 4 9 , 351,362,

418 , 4 2 1 , 4 2 6 , 4 2 7 , 429-441, 429 , 430 , 4 3 2 , 433 , 434 , 436 , 437 , 438 , 439 , 439 , 4 4 0 , 4 4 1 , 5 2 7 , 535 , 5 3 6 , 574, 578, 5 8 7 , 609

B a c h , M . L . , 3 4 9 , 362 , 4 2 7 , 429-441, 429 , 4 3 9 , 4 4 0 , 4 4 1 , 536

Bächi, Th . , 284 Backman , K . , 862 Bag l i on i , C , 874, 883,888 Bai ley , D. W., 2 9 3 , 345, 3 4 8 ,

4 4 1 , 4 6 3 , 4 7 4 , 519 , 521 , 526 , 5 2 7 , 5 9 4 , 5 9 4 , 736 , 740, 8 4 5 , 846

B a i n , B. , 429,440 B a i r d , S., 9-21, 20 B a l d i , I . , 877,886, 888 Bal four , B . M . , 2 0 7 , 2 1 4 Bainer , H . , 427, 463 Bal t imore , D.,8, 63-72,63,65,

70, 72, 164, 774, 778, 818, 834

B a n g a s s e r , S. A . , 704, 706, 722, 724

Bank , A. , 874 B a n k h u r s t , A . D. , 1 0 2 , 1 0 2 ,

1 4 2 , 1 4 4 , 2 7 2 Barc lay , A . N . , 51-61, 54, 55,

56, 57,58, 59 ,62 ,408,410, 4 1 3 , 4 1 4

Barge l les i , T., 282 Barnes, D. W. H . , 236 Barnstable , C , 3 2 9 , 3 6 1 , 379-

386 , 3 8 5 , 4 2 6 , 443-455, 4 5 3 , 454

Barondes, S. H . , 62 Bar ron , A . L., 530, 533, 536 Barry , D. W., 80,82 B a r s t a d , P. , 272 , 654 , 658 ,

662 , 665 , 725 , 7 3 1 , 733, 744 , 7 4 8 , 817-836, 823 , 826, 827 , 8 2 9 , 8 3 4 , 8 3 5 , 838 , 839 , 8 4 1 , 8 4 5 , 847 , 852

Bar ton , M . , 256,257,258,259 Bäsch, R. S., 6, 8, 8, 65, 72 Baserga, R., 234,236 Basham,T . , 400 Basten, A. , 93-103, 93, 94, 95,

96 ,101,202,203, 114,115, 227 , 126, 226, 2 5 1 , 257 , 2 5 9 , 3 0 7 , 3 2 4 , 315 , 317 , 3 2 2 , 579 , 580 , 582 , 587 , 625, 626

Batchelor, J . R., 323,329 Batt isto , J . R . ,22 , 105,222 B a u m a l , R., 763 , 770, 7 8 1 ,

783 , 786, 787 , 790, 792, 803

Bauminger , S., 590,595 Baur , S., 200, 339 Baz in , H . G . , 202, 2 1 3 , 2 1 4 ,

273 Bean, M . A . ,32 Bechtol , K . B . , 114,227, 126,

226 , 3 7 7 , 4 8 9 , 4 9 6 , 5 4 3 , 5 4 4 , 598 , 6 0 7 , 6 0 8 , 6 2 3 , 615, 617, 621, 622

Becka , L . N . , 645 Becker, M . , 2 8 8 , 2 9 2 , 6 4 5 , 1 4 1 Beckw i th , J . , 787, 790 B e l l , C , 678,685 B e l l , G. I., 765, 770 B a l l a n t i , J . A . , 2 2 5 Be lman , S.,222 Belo, M . , 245 Benacerraf, B . , 23, 25, 30 ,32,

88 ,92 , 102, 1 1 6 , 1 1 7 , 119,

H a l l e s indicate where füll reference can be found; boldface type designates where author's article is located in this volume.

Ii

2i N A M E I N D E X

1 2 6 , 275 , 2 8 4 , 285 , 2 9 2 , 2 9 3 , 2 9 5 , 2 9 8 , 3 0 5 , 3 0 6 , 3 4 4 , 3 4 9 , 3 5 8 , 3 6 1 , 369 , 3 7 7 , 4 0 2 , 4 4 3 , 4 5 4 , 4 6 3 , 465-475, 4 6 5 , 4 6 6 , 4 6 7 , 4 7 2 , 4 7 3 , 4 7 4 , 4 7 5 , 486 , 4 8 7 , 4 8 9 , 4 9 6 , 5 0 1 , 5 0 3 , 5 0 4 , 5 0 5 , 5 1 0 , 5 2 2 , 5 2 7 , 539 , 5 4 2 , 5 4 4 , 5 5 3 , 5 5 6 , 559 , 5 6 1 , 563-570, 5 6 3 , 564 , 5 6 9 , 5 7 0 , 5 7 8 , 579 , 580 , 582 , 5 8 4 , 5 8 7 , 597 , 607 , 6 0 8 , 6 0 9 , 6 1 1 , 612 , 6 1 3 , 6 1 4 , 6 2 2 , 6 2 3 , 7 6 3 , 764, 770, 8 9 8 , 9 0 2

Benck, L . , 236 Bengtsson, B . ,454 Ben ike , C. J . , 4 4 0 , 441 Bennette, D., 5 1 , 6 1 , 3 3 9 , 407,

4 1 3 , 5 8 8 , 8 1 4 , 8 1 4 , 896 , 901

Bennett , J . C , 6 1 , 3 6 8 , 855, 8 6 2 , 8 6 3 , 8 7 4

B e n n e t t , M . , 511 , 513 , 514, 517

Ben-Sasson , S. Z. , 572, 5 7 8 , 622

Berek, C , 2 8 4 , 285-294, 286, 2 8 7 , 2 9 3 , 5 4 4 , 6 0 8 , 6 2 4 , 842, 8 4 3 , 8 4 5

Berg , R. B . , 7 3 , 8 2 Berggärd, I., 326 , 329 , 3 3 9 ,

3 5 1 , 3 6 1 , 3 6 8 , 6 4 5 , 674 Berna rd in i , A . , 779, 8 3 6 , 8 5 3 ,

8 6 2 , 883, 886, 887, 8 8 8 B e r n o c o , D . , 4 2 5 , 4 2 6 , 4 4 1 ,

551, 556 Bernoco, M . , 426 Bernste in , D., 697 Bernste in , S. E . , i 3 7 Berzofsky, J . A . , 295-306,297,

298,305, 306 Bet lach, M . C , 888 Beutner , K . R . ,225 Bevan , M . J . , 2 1 , 2 9 , 3 1 , 6 1 ,

408 , 4 1 1 , 4 1 3 , 4 1 4 , 519-527, 519 , 520 , 5 2 1 , 522 , 5 2 3 , 5 2 6 , 527 , 5 2 9 , 5 3 6 , 5 3 9 , 5 4 4 , 554 , 5 5 5 , 5 5 6 , 5 5 9 , 5 6 2 , 5 7 9 , 5 8 7 , 597 , 6 0 8 , 614, 622

B e v e r l e y , P . C . L . , 8 3 , 1 0 2 , 113-118, 114 , 115 , 116, 1 1 7 , 5 8 7

Bianco, C , 284, 307,324 B i a s , W. B . ,463 Bieber, D., 8 7 8 , 8 8 8 Bienenstock, J . , 2 0 1 , 2 1 3 , 2 1 5 Bierhorst -Ei j lander , A . , 4 4 0 Bi jnen , A . , 417 ,418 ,426 Bi lo fsky , H . , 853 Binz , H . , 29, 30 ,31 , 116,117,

2 6 1 , 2 7 1 , 275-284, 2 7 5 , 276 , 277 , 278 , 280 , 2 8 1 , 2 8 2 , 2 8 3 , 2 8 4 , 3 0 0 , 3 0 6 , 5 0 8 , 5 1 0 , 5 4 3 , 5 4 4 , 5 5 9 , 5 6 1 , 585 , 5 8 6 , 5 8 7 , 597 , 6 0 8 , 612 , 618 , 6 1 9 , 6 2 4 , 714,717, 812,814

Biozz i , G , 755, 758 B i rnbaumer , L., 2 1 0 , 2 7 1 Bi r sh t e in , B . , 758, 781, 785,

790, 791, 803

Bishop, J . M . , 8 6 2 , 888 Bishop, J . O., 866, 867, 872,

8 7 4 , 8 8 8 B i s m u t h , A . , 3 6 8 , 556 Bjar ing , B . , 411,413 Björk, I., 333, 3 3 8 , 6 7 4 , 897,

901 Black , R H . , 82 ,82 B l a ck , P. L. , 4 5 1 , 4 6 3 B l a c k S. J . , 33-45, 2 8 4 , 285-

294, 285 , 286 , 2 8 7 , 2 9 3 , 5 0 3 , 5 4 3 , 5 4 4 , 5 9 7 , 6 0 8 , 624

B l a c k m a n , M . , 103 Blaese, R. M . , 249,250 B l a k e , J . T., 3 1 , 3 0 6 , 578 Blakes ley , R W., 8 5 6 , 8 6 2 Blanden , R. V . , 8 2 , 2 4 3 , 505,

506 , 507 , 5 0 9 , 5 1 0 , 519 , 5 2 6 , 5 3 6 , 5 4 4 , 554 , 5 5 6 , 5 6 1 , 5 8 7 , 5 9 1 , 6 0 8 , 6 2 2

Blandova , Z. K . , 3 4 5 , 3 4 8 B l a n k , K . J . , 519, 527, 597,

608 B l ankenho rn , E . R , 51,61 Blease, R. M . , 103 B l i t s t e in -Wi l l inge r , E . , 37,44 B lobe l , G. , 789, 790 Bloch , K . J . , 2 9 3 Blomberg , B . , 172, 286, 293,

645 , 6 5 8 , 700 , 706, 743-748, 7 4 3 , 744 , 745 , 748, 8 0 2 , 8 1 4 , 8 3 5 , 841, 843, 8 4 5 , 8 5 2 , 8 6 2 , 8 8 8

Blomgren , H . , 536 B loom, A . D., 788, 789, 790 B loom, B . R , 73-83,73,74,75,

78, 82 ,83 , 105,111 B l u e s t e i n , H . G . , 3 0 5 , 3 0 6 ,

397,402 B l u m e , M . R . ,83 B l u s s e v a n O u d A l b l a s , A . ,

3 9 6 , 427 B l y t h , J . L . ,561 B l y t h m a n , H . E . , 2 1 5 B o b r o w , U . , 4 1 4 , 4 4 9 , 4 5 3 ,

454 Boccardo, K , 4 4 0 , 527 Bochert, G . , 157 B o c k m a n , D . E . , 1 4 4 , 1 8 2 ,

2 0 2 , 2 1 1 , 2 1 3 , 2 5 0 Bode, W. ,636 B o d m e r , J . , 3 7 9 , 3 8 5 , 3 8 6 ,

4 2 6 , 443-455, 4 4 3 , 4 4 4 , 445 ,453 ,454 ,

Bodmer, W . F. . 3 2 9 , 3 3 9 , 343, 3 4 8 , 3 4 8 , 3 6 1 , 3 6 7 , 3 6 8 , 3 7 2 , 3 7 7 , 379-386, 3 7 9 , 3 8 5 , 3 8 6 , 4 1 2 , 4 1 4 , 4 2 6 , 443-455, 4 4 3 , 4 4 4 , 4 4 5 , 4 5 1 , 4 5 2 , 4 5 3 , 4 5 3 , 4 5 4 , 455, 678, 685

Bok i sch , V . A . , 697,852 B o l h u i s , R. L . H . , 1 4 4 , 1 8 2 ,

1 9 0 , 1 9 9 B o l l u m , F . J . , 63, 72 Bona , C , 307-314, 307, 308,

309,314 Bondev ik , H . , 422 ,426 Bonnard , G. D . ,426 Bonner , T. L , 872,874 Boone, C. W., 590,595 Bordenave, G. , 756, 758

Bore l , Y . , 106,111, 189,190, 251,259, 316,321

Borth is t le , B . K . , 315-321 Bosma, G . C , 8 1 0 , 8 1 4 Bosma, M . J . , 755, 758, 810,

814 Botste in, D., 7 9 0 , 8 0 3 B o u r g o i s , A . , 172 , 193-200,

663,664 ,665 , 827,834 Boute i l le , M . , 790 Bouth i l l i e r , Y. , 758 Bowern, N . , 2 4 3 , 5 1 0 , 5 3 6 , 5 5 6 Boyce, C. R., 837,845 Boyden, S. V . , 315,321 Boyer, H . W. ,888 Boyer, M . L . , 395 Boyer, S. H . , 393,395 B o y l s t o n , A . W . , 2 6 2 , 2 6 3 ,

264 ,271 ,272 Boyse, E . A . , 5-8, 6, 8, 23-32,

23, 24, 25, 27, 29, 31 , 34, 4 4 , 6 1 , 72, 1 8 , 8 2 , 8 3 , 103, 1 1 6 , 1 1 7 , 137 , 162 , 245 , 2 5 0 , 339 , 3 4 3 , 3 6 2 , 368 , 4 0 7 , 4 1 1 , 4 2 3 , 4 1 4 , 4 2 9 4 3 2 , 4 4 0 , 4 9 2 , 4 9 6 , 5 0 4 , 5 5 6 , 5 5 9 , 5 6 1 , 5 8 4 , 5 8 7 , 5 8 8 , 5 9 0 , 607 , 608 , 609 , 805 , 809 , 8 1 1 , 8 1 2 , 8 1 4 , 8 1 5 , 895, 901

Boyum, A . , 4 4 4 , 4 5 4 , 699, 706 Bozzo, L . ,215 Bradley , B . A. , 417-427, 419,

4 2 1 , 4 2 2 , 4 2 6 , 429 , 430 , 440

B r a d s h a w , R. A . , 636, 675 , 814, 835, 8 7 4 , 888

B r a n d , A . , 5-8, 5, 7 ,8 B r a u n , D. G. , 168, 172, 649,

650 , 656 , 658 , 666 , 690 , 696 , 724, 726 , 733, 756 , 758

B r a u n , V., 1 5 7 , 2 3 6 Brenner , S., 8 1 8 , 8 3 4 B r e t s c h e r , M . S. , 3 5 4 , 3 6 1 ,

410,414 B r e t s c h e r , P . A . , 2 1 7 , 2 2 5 ,

2 5 6 , 2 5 9 , 2 7 0 , 2 7 1 , 4 3 3 , 4 4 0 , 5 0 8 , 5 1 0 , 1 4 3 , 7 4 8

Brew, K. , 636 Brez in , C , 682,685, 687,688,

690,696 B r i a n d , P.-A., 862, 8 8 8 B r i d g e n , J . , 326 , 3 2 9 , 359 ,

3 6 1 , 382 , 3 8 4 , 3 8 5 , 4 4 3 , 453,454

Br idges, S. H . , 700, 706 Br i en t , B . S., 719, 724 Br i l e s , D. E . , 726, 732, 733,

748, 845, 848, 852 Br i t t en , R. J . , 867, 868, 869,

871, 872,874 Brochier , J . , 314 Broder, S., 103 Brondz, B . D., 520, 527, 535,

536 Brouet , J . C. ,44,145,182,191 B rown , B . A . , 261,271 B rown , G . D. ,214, 595 B r o w n , J . L . , 343-349, 343 ,

344 , 345 , 346 , 3 4 7 , 3 4 8 , 356 ,361 ,371 , 373,377

Browne, W. J . , 635,636

B r o w n l e e , G . G . , 697 , 8 3 5 , 8 6 2 , 811, 886,887, 888

Brunner , K . T., 83, 4 4 0 , 556 Buchanan , P. D.,791 Buckner , C. D., 83 Buck ton , K . E . , 82,82 B u e l l , D. N . , 173,183 B u l l , F . G. ,386 Bu l l ock , W. W., 113,117,150,

157 , 1 8 2 , 2 2 5 , 2 2 8 , 2 3 6 , 250

Burakoff , S. T., 548, 550, 554, 556

B u r c k h a r d t , J . J . , 261 , 265, 271

Burkho lder , P. M. ,441 Burnet , F . M . , 237, 2 4 2 , 2 4 3 ,

3 5 1 , 3 6 1 , 5 8 6 , 5 8 7 , 762 , 770, 892,901

Burrows , P., 139 Burs te in , Y , 8 4 7 , 8 5 3 Bussard , A . E . ,314 B y r d , W. J . , 15,21 By r t , P . ,569

C a l k i n s , C. E . , 86,91 Ca l l ahan , G. N . , 364,368 C a l l a r d , R , 93-103 Calne , R. Y., 4 2 6 , 440 C a m b i e r , J . , 162 , 185-191,

189, 190,190 C a m p b e l l , J . H . , 733 , 748 ,

835, 852 Campbe l l , R , 127, 4 9 6 , 609 Campbe l l , S., 202, 211,214 Cane lak i s , E . S., 72 Cannon , L . E . , 645, 647-659,

649 , 652 , 655 , 6 5 6 , 6 5 8 , 659, 682, 685

Cantor , H . , 8, 11, 21 , 23-32, 23, 24, 25, 26, 27, 29, 31 , 34, 44, 72, 78, 82, 86, 87, 91, 94, 103, 113, 114, 116, 117 , 1 1 8 , 1 9 0 , 4 0 1 , 4 1 4 , 429 , 4 3 2 , 4 4 0 , 4 8 7 , 4 9 2 , 4 9 6 , 5 0 4 , 5 5 9 , 5 6 1 , 5 8 4 , 5 8 7 , 6 0 1 , 6 0 8 , 6 0 9 , 8 1 1 , 812,814, 815

Capa ld i , R., 392,395 Capra , J . D., 339, 3 4 9 , 3 6 2 ,

363-368, 3 6 6 , 3 6 7 , 3 6 8 , 377 , 4 5 5 , 6 4 1 , 6 4 5 , 647 , 6 5 4 , 6 5 8 , 6 8 7 , 6 8 8 , 6 9 1 , 693 , 694 , 696 , 700 , 7 0 6 , 7 3 1 , 732 , 733, 7 8 1 , 790, 818 , 8 2 2 , 826 , 827 , 848 , 8 3 4 , 847-853, 8 4 7 , 848 , 8 5 0 , 8 5 1 , 8 5 2 , 8 5 2 , 8 5 3 , 883,888

Carbonara , A . 0 . , 2 1 4 Car l son , B . ,214 Carpenter , C. B . , 4 5 4 Carson, D., 7 4 4 , 7 4 6 , 7 4 8 , 826,

834, 838, 841,845 Carswe l l , E . A. , 61 C a r t a - S o r c i n i , M . , 677-686,

6 8 5 , 686 Carter , P . B . , 2 0 2 , 2 1 3 Car twr i gh t , E . M . , 835, 8 6 2 ,

887, 888 Cava i l l on , J . M. ,314

N A M E I N D E X 3i

C a z e n a v e , P . - A . , 307-314, 6 8 2 , 6 8 5 , 6 8 7 , 6 8 8 , 690 , 696

C e b r a , J . J . , 106, I I I , 176, 1 8 2 , 193 , 1 9 4 , 1 9 9 , 201-215, 2 0 1 , 2 0 3 , 2 0 5 , 207 , 208 , 2 0 9 , 2 1 3 , 2 1 4 , 2 1 5 , 4 9 6 , 644 , 644 , 654 , 658 , 6 5 9 , 781, 790

Cecka , J . M . , 369-377 Celada , F., 679,685 Ceppe l l in i , R., 343, 422, 426,

4 4 1 , 5 5 6 Cerot t in i , J . - C , 83, 120,126,

4 4 0 , 5 5 6 Cesar i , I. M . , 643, 645, 734,

748, 8 1 5 , 8 2 7 , 8 3 5 , 837 , 845, 846, 862, 889

Ces la , R , 4 7 5 Chambon , P . ,888 C h a n , E . L . , 102 , 2 5 0 C h a n , P. L . ,321 Chang , L. M . S., 63, 72 Chanock, R. M . , 2 1 5 Chao, N . , 27 Chaperon, E . A . , 902 Chardonnens, X . , 772, 778 C h a r l e m a g n e , J . , 262 , 270 ,

271 Chase, M . W., 4 7 , 5 0 , 8 2 , 105,

I I I Chas in , L. , 409,414 Ched id , L . ,314 C h e n , B . L . , 3 7 7 , 6 2 7 , 6 3 6 ,

6 3 7 , 639-645, 6 3 9 , 640 , 643 , 6 4 5 , 6 5 9 , 6 6 6 , 6 7 5 , 835

Chen , F . W., 647, 653, 658 Chen , K . C . S., 650, 658, 678,

685, 692, 693, 696 Chen , S. H . ,272 Cheng, W . D., 647, 658 C h e r r y , M . , 2 9 3 , 3 4 8 , 4 8 7 ,

556, 846 Chers i , A . , 658, 696, 697 C h e s e b r o , B . W . , 622 , 709 ,

717, 720,724 C h e s s , L . , 67 , 7 2 , 3 8 6 , 395 ,

396, 4 4 1 C h i a , E . , 93-103,314, 321 Ch iapp ino , G. , 888 Ch i l l e r , J . M . , 1 0 3 , 2 2 6 , 315-

321 C h i n , A . F. , 8 , 136 Ch io razz i , N . , 623 C h i s m , S. E . , 1 0 3 , 588 C h i u , Y . Y . , 639-645 Cho i , Y . S., 411,414 Cholon, J . J . , 4 5 5 Chou , P . Y . , 636, 636 C h r i s t i a n , G . D., 673, 675 Chr i s t i e , G . H . ,172 C h u r c h i l l , W. H . , 191 C i cu r e l , L . ,724 C i e p l i n s k i , W., 781-791 Cinader , B . , 257,259, 3 1 4 C io rba ru , R. ,314 C i sa r , J . , 744, 748 C i t r onbaum, R . ,272 C l a f l i n , J . , 167,172, 661, 662,

6 6 4 , 665 , 710 , 717, 725-734, 725 , 726 , 727 , 728 , 7 3 0 , 7 3 1 , 7 3 2 , 7 3 3 , 733 ,

734, 7 6 3 , 7 7 0 , 809 , 810 , 811,814

Clagett , J . , 52, 61 C l a m a n , H . N . , 105-111, 105,

106,111, 770, 891,902 C lancy , R . ,213 C la rkson , B. , 234,236 C l em , L. W. ,273 Cleve, H . , 5 9 , 6 1 , 1 8 2 C l i c k , R . E . , 229,236 C l i f t , R. A . , 8 3 C l ine , M . J . , 7 4 , 8 2 , 317,321 Codington, J . F., 534,536 Coelho, I. M . , 266,273 Co f f ino ,R , 7 5 5 , 7 5 8 , 781,785,

786 , 788 , 790, 793 , 799 , 802

Cohen, B . E . , 622 Cohen, E . , 411,415, 787, 788,

789,791, 833 ,835 Cohen, G . H . , 8 , 1 3 7 , 6 3 7 , 6 4 5 ,

6 5 9 , 6 6 6 , 686,835 Cohen, J . E . , 902 Cohen, N . , 261,271, 771, 776,

778, 779 Cohen, P., 622 Cohen, S., 840,845 Cohn , M . , 167, 170, 171,172,

1 7 3 , 2 1 7 , 2 2 5 , 2 5 6 , 2 5 9 , 2 7 0 , 2 7 1 , 2 8 5 , 2 9 3 , 2 9 4 , 4 3 3 , 4 4 0 , 5 0 8 , 5 1 0 , 519 , 526 , 6 4 2 , 644 , 645 , 650 , 6 5 8 , 6 6 1 , 6 6 5 , 666 , 687 , 688 , 6 8 8 , 7 3 3 , 7 3 4 , 743 -748 , 743 , 744 , 748, 7 6 1 , 762 , 770, 7 9 7 , 8 0 2 , 807 , 814 , 8 1 5 , 818 , 8 2 1 , 826 , 8 3 1 , 8 3 4 , 8 3 5 , 837, 840 , 8 4 5 , 8 4 6 , 8 4 7 , 8 5 2 , 857 , 8 5 8 , 8 6 2 , 879 , 8 8 1 , 887 , 882, 889

Colberg, J . E . ,213 Co leman, M . S., 63 ,64 ,67 , 72 Co l i gan , J . E . , 286,293 Col le , A . , 339 Co l l i e , M . H . , 771, 779 Co l l i ns , F . M . , 202,213 Co lman ,P . ,636 ,645 , 674,674 Colomb, M . , 667, 674 Co lombani , J . , 122,126, 447,

4 5 4 , 478 , 4 7 9 , 4 8 7 , 497 , 503

Co lombani , M . , 126, 487, 503 Co lon , S. M . ,329 , 339, 414 Condamine, H . ,338 Cone, J . L . , 3 3 9 , 4 8 7 , 500,501,

502,504 C o n e , R. E . , 1 4 8 , 1 5 7 , 199 ,

2 6 1 , 262 , 263 , 2 6 5 , 266 , 2 7 2 , 2 7 3 , 2 8 4

Cooley, M . A . , 4 4 0 Coombs, R R., 313,314, 455 Coons, A . FL, 127, 2 7 3 , 609 Cooper, E . L., 261, 271, 771,

772, 778 Coope r , M . D . , 3 8 , 4 4 , 130 ,

137 , 139 -145 , 140 , 141 , 1 4 2 , 1 4 4 , 145 , 158 , 159, 1 6 0 , 1 6 2 , 182 , 1 9 1 , 194, 1 9 7 , 1 9 9 , 202 , 2 1 1 , 213 ,

2 1 3 , 2 4 3 , 248,250 Cooper, N . R , 4 5 4 Cooper, S. M . , 641, 645

Coppo, F . , 4 2 6 Coppola, E . D. , 202,214 Corne l l , R , 215 Corte, G. , 182 Cosenza , FL , 173 , 182, 1 9 1 ,

2 0 5 , 2 1 4 , 2 8 5 , 2 9 3 , 5 6 3 , 569, 6 6 1 , 665 , 7 0 1 , 706, 707, 709-718, 709 , 710 , 711 , 713 , 716 , 717, 7 1 8 , 719, 722 , 7 2 3 , 7 2 4 , 725 , 733

C o t t o n , R. G . H . , 755 , 758, 788 , 790, 7 9 3 , 797 , 8 0 1 , 802, 803, 853

Cour t -Brown, W. M . , 82 Courtenay, B . M . ,172 Cout inho, A . , 147, 152, 157,

217 , 218 , 219 , 220 , 2 2 1 , 2 2 3 , 2 2 5 , 2 2 6 , 227-236, 227 , 229 , 2 3 5 , 2 3 6 , 248 , 2 4 9 , 2 5 0 , 2 5 6 , 2 5 9 , 314 , 752, 758

Coutsogeorgopoulos, C , 72 Cowan, N . J . , 645, 665, 793-

803, 7 9 3 , 795 , 796 , 797 , 802, 803, 853, 887

Crabbe, P. A . , 201, 202,214 Cra i g , S. W., 194, 199, 201,

207 ,213 ,214 C r a m e r , M . , 1 6 8 , 1 7 2 , 285-

294, 726, 733 Cranda l l , C. A . , 201,214 Cranda l l , R B . ,214 Cresswel l , P., 324, 326, 328,

3 2 9 , 3 3 3 , 3 3 8 , 3 3 9 , 353 , 3 6 1 , 384 , 3 8 5 , 387 , 394 , 395,395

Cr ichton, R , 433,440 Cr ichton, W. B . ,454 C r o n e , M . M . , 275,284 Cron lund , M . , 659 Crook, N . E . , 595 Cross, A . M . , 175,182 Cross, J . , 449,453 Crowle, A . J . , 1 0 3 Crumpton , M . J . , 55, 61, 329,

3 3 9 , 3 6 1 , 379-386, 3 7 9 , 383 , 3 8 4 , 3 8 5 , 3 8 6 , 4 2 6 , 443-455, 4 4 3 , 4 4 4 , 4 5 4 , 455

Cuatrecasas, P., 47, 50, 295, 301,305, 306

Cuchens, U . , 2 7 3 Cudkowicz , G , 511-518, 511,

5 1 2 , 5 1 3 , 514 , 5 1 6 , 5 1 7 , 518

Cu l l en , S. W., 336, 337, 338, 339 , 3 4 3 , 3 4 9 , 3 5 1 , 355 , 3 5 6 , 3 6 2 , 363 , 364 , 368, 3 7 4 , 3 7 7 , 384 , 3 8 5 , 3 8 6 , 3 9 5 , 3 9 5 , 397 , 400 , 402 , 4 0 2 , 4 0 3 , 4 4 3 , 4 5 0 , 4 5 4 , 4 5 5 , 477-487, 4 7 7 , 4 7 8 , 487, 555,556

Cunn ingham, A . J . , 119,126, 1 7 0 , 1 7 2 , 2 5 2 , 2 5 9 , 540 , 544 , 710 , 717, 749 , 758, 761-770, 7 6 3 , 764 , 7 6 5 , 766, 767, 768, 770

C u n n i n g h a m , B . A . , 326,329, 3 3 9 , 3 4 9 , 351-362, 3 5 1 , 3 5 7 , 3 6 1 , 3 6 3 , 3 6 8 , 377 , 4 1 2 , 4 1 4 , 4 5 4 , 5 1 0 , 5 5 6 ,

6 4 5 , 807,814 C u r m a n , B . , 331-339 C u r r y , J . L., 129,136 Cur t i s , S. K. , 771, 778 Cur ton i , E . S., 385, 426, 441,

454

D

D a h l , D . ,396 Damais , C. ,314 D 'Amaro , J . , 427 Dar t , G. ,441 Daugharty , H . , 307,314 D a u s s e t , J . , 3 4 3 , 3 4 9 , 387 ,

3 9 6 , 4 1 8 , 4 2 7 , 4 3 0 , 4 4 0 , 447 ,452 ,454 ,527

Davenport, L . M . , 2 1 5 Dav id , C. S.,45,119-127,122,

126 , 127 , 2 5 0 , 2 9 7 , 3 0 6 , 3 1 4 , 3 3 6 , 3 3 9 , 3 6 8 , 369 , 3 7 4 , 3 7 7 , 3 8 6 , 3 9 5 , 3 9 5 , 396 , 4 2 5 , 4 2 6 , 4 2 7 , 440 , 4 4 3 , 4 4 9 , 4 5 5 , 4 6 9 , 4 7 4 , 4 7 5 , 477-487, 4 7 7 , 4 7 8 , 4 7 9 , 4 8 0 , 4 8 5 , 4 8 6 , 4 8 7 , 489 , 4 9 1 , 4 9 2 , 4 9 6 , 497 , 498 , 499 , 500 , 5 0 1 , 502 , 5 0 3 , 5 0 4 , 5 2 0 , 5 2 7 , 5 9 5 , 609, 626

Dav id , G . S., 690,696 D a v i d s o n , E . H . , 867 , 868 ,

869, 871 ,872 ,874 Davidson, R. L., 782, 790 Dav ie , J . M . , 142, 144, 172,

6 6 1 , 662 , 6 6 4 , 6 6 5 , 717 , 725 , 726, 732 , 733 , 733, 734, 748, 764, 770, 845

Davies, A . J . S., 14 ,21 ,172 Davies, D. A . L., 535,536 Davies, D. R , 627-637, 627,

628 , 636 , 6 3 7 , 645 , 648 , 659 , 6 6 1 , 6 6 6 , 683 , 684 , 6 8 5 , 6 8 6 , 743 , 748, 828 , 834,835, 893, 902

Dav is , F . M . , 7 8 7 , 789,790 Dawson, J . R , 328, 329, 333,

338, 353,361 Day, N . K . , 4 2 6 Day, R. ,213 Dayhoff, M . O., 6 2 8 , 6 3 6 , 640,

645, 818, 823 ,832 ,835 Deak, B . D . , 4 7 4 , 4 9 6 , 5 0 3 , 5 0 4 Debre, P , 23 ,25 ,31 , 471,472,

473,474, 501,503 Decker, J . M . , 261-273, 273,

773, 778, 779 Decleve, A . , 20,21 Deereusefond, C , 758 DeFranco , A . L . ,329, 394,396 DeGroot, M . L., 463 Deisenhofer, J . , 674 De L a Cro ix , F., 126, 474 Delaney, N . L . , 4 5 4 Delaney, R . ,645 Delespesse, G . J . , 4 6 3 D e L i s i , C , 765, 770 Delov i tch, T. L . ,44 , 364,368,

3 7 7 , 4 8 5 , 489-496 ,496 , 497,504, 623, 883,888

DeLuca , D., 261-273,273 de L u c a , F. , 214 Demant , P . ,487

4 i N A M E I N D E X

Denk, H . , 673, 674 Denman, A . M . , 102,202 Denman, E . J . , 202 Dennert, G., 535,536 de Petr is , S., 160, 262, 183,

5 5 6 , 787, 790, 880 de Preva l , C , 272, 665, 743-

748 Desaymard, C , 609 de Sousa, C M . , 475 D ' E u s t a c h i o , P . , 142 , 1 4 4 ,

763, 770, 895, 902 Deutsch, H . F., 627, 636 Dev insky, 0 . ,32 , 44 de Weck, A . L., 105, 222, 398,

4 0 2 , 578 Dewey, A . F., 273 D h a r m g r o n g a r t a m a , B . ,

781-791, 781 Diamants te in , T., 37,44, 147,

257 Diamond, R., 631, 636, 639,

645 Dick, H . , 447,454 Dick le r , H . B. , 249,250, 307,

324, 315 ,322 ,337 Diener, E . , 251-259, 251, 252,

253 , 254 , 255 , 256 , 257 , 258,259, 611

Digge lman, H . , 862 D i m u z i o , H . , 4 5 4 , 5 6 9 , 5 7 0 ,

623 Dine, M . S.,487, 504 Dintz is , H . M . ,645 D i P a u l i , R., 764, 770 Doenhoff, M. ,272 Doherty, P. C , 26, 30, 31,32,

73,82, 101,202, 116,228, 3 5 1 , 3 6 2 , 3 6 9 , 3 7 7 , 439 , 442 , 4 5 1 , 4 5 3 , 4 5 4 , 505-510, 505 , 506, 507 , 508 , 5 0 9 , 5 2 0 , 522 , 5 2 6 , 5 2 6 , 527 , 529 , 5 3 4 , 5 3 6 , 537 , 539 , 540 , 543 , 5 4 4 , 5 4 5 , 547, 548 , 553 , 554 . 555 , 556 , 557 , 559 , 5 6 0 , 5 6 2 , 5 6 8 , 5 7 0 , 5 7 1 , 5 7 7 , 5 7 8 , 579 , 582 , 5 8 4 , 5 8 7 , 597 , 609, 613, 614, 622, 624

Dolejs, L . ,853 Doniach, D. ,203 Donnel ly , N . , 6, 8, 771, 778,

779 Dooley, N . , 250 Dore, C. F., 207,224 Dorf, M . E . , 32 , 295, 297, 304,

3 0 6 , 3 6 2 , 427 , 4 5 4 , 457 , 4 6 3 , 465-475, 4 6 5 , 466 , 467 , 468 , 469 , 472 , 473 , 4 7 4 , 475 , 5 0 1 , 5 0 3 , 5 0 3 , 520 , 544 , 556 , 569 , 570 , 578, 609, 623, 902

Dor ia , F., 223 Dorr ington, K . J . , 6 3 7 Dossetor, J . B . ,427 Doughty, R. A. , 168,172 Douglas, S. D., 202

Douglas, T. C , 51, 53,62, 408, 424

Dray, S., 223, 677, 678, 685, 686 , 687-688, 687 , 688 , 690, 696, 697

Dresser, D. W., 1 0 1 , 1 0 2 , 195,

299 , 2 5 7 , 2 5 9 , 735 , 742, 750, 758, 776, 779

Dreyer, W. J . , 835, 855, 862, 863,874, 881,888

Dube, S., 779, 836, 853, 862, 888

D u b i s k i , S., 324, 696, 803 duBois , M . J . G . J . , 440 Duc-Nguyen, H . , 73,82 Duffus, W. P. I i . , 162, 556 Dugan, E . , 2 5 0 , 3 1 4 , 487, 5 0 4 ,

627 , 636, 659 , 8 0 7 , 8 2 4 , 881,888

Dunkley , M. ,202, 227, 587 Dunlap , R. C. ,82 Dunlop, M . B. C, 5 1 0 , 526 D u n n , D. C , 426, 440 D u n n , P . , 758, 770 D u P a s q u i e r , L . , 262 , 270 ,

2 7 2 , 763 , 770, 771-779, 771 , 772, 773 , 774 , 778 , 778, 779

D u p o n t , B . , 3 9 6 , 4 2 0 , 4 2 6 , 430,432,440, 454

Duprez, V . , 527 Durante , M . L., 182 D u r d a , P. J . , 805-815, 812 ,

813,814,824 Durd ick , J . , 611 D u r h a m , T., 466, 469,475 D u r i n , M . , 203 du Toit, E . D.,426 Dutton, R. W., 24 ,32 , 86, 92,

124, 226, 2 5 2 , 2 5 9 , 2 7 3 . 5 6 9 , 597-609, 598 , 604 , 605 , 608, 609 , 625 , 626 , 750, 758

Dwek, R. A., 634,636

E

Eardley , D. D., 85-91, 86, 87, 92

Ea r l y , P., 817-836 East lake , A. , 296, 300,306 Eaton , B. , 817-836 Ebers, G., 455 Eckerstorfer, R. ,674 Eckhard t , L., 39 Edelhoch, H . , 388,395 E d e l m a n , G . M . , 1 4 4 , 1 5 8 ,

1 7 0 , 1 7 2 , 1 7 3 , 175, 182, 265 , 268, 270, 2 7 1 , 2 7 2 , 2 7 3 , 288 , 2 9 0 , 2 9 3 , 339 , 3 4 9 , 351-362, 3 5 1 , 3 6 2 , 3 6 8 , 3 7 2 , 3 7 7 , 388 , 395 , 3 9 5 , 396 , 4 1 3 , 4 2 4 , 4 5 1 , 4 5 3 , 4 5 4 , 520 , 547-557, 547, 548 , 552, 5 5 3 , 5 5 6 , 5 8 6 , 5 8 7 , 640 , 645 , 667 , 670 , 6 7 4 , 687, 688 , 763 , 770, 779, 789, 790, 805 , 806 , 8 0 8 , 8 1 2 , 8 2 4 , 8 2 5 , 817 , 818 , 8 2 1 , 8 3 5 , 847 , 8 5 2 , 8 8 2 , 8 8 8 , 891-902, 8 9 3 , 895, 896, 898 , 900 , 902

Ede lman , R., 73, 76 ,82 E d i d i n , M . , 429,440 Edmundson , A . B., 333, 339,

628, 6 3 6 , 6 3 6 , 637 , 639 , 642 , 645 , 659, 674 , 6 7 4 , 675

Edwards, G. E . , 147, 257

Edwards , J . M . , 426,440 Eernisse, J . G . ,427 Efstrat iad is , A. , 8 6 9 , 8 7 4 Eggers, H . J . , 53,62 Egorov, I . K . , 3 4 5 , 3 4 8 Ehrenf ie ld , E . , 83 E h r l i c h , P . ,709 , 72 7 E i c h m a n n , K., 29, 30 ,32 , 93,

101 , 2,02, 116, 227, 249 , 2 5 0 , 2 6 1 , 2 7 2 , 2 8 4 , 285-294, 285 , 286, 287 , 288 , 2 9 2 , 2 9 3 , 3 0 0 , 3 0 6 , 315 , 3 2 2 , 5 0 3 , 544 , 585 , 586 , 587 , 597 , 608, 619 , 622 , 624 , 658 , 6 9 3 , 6 9 7 , 7 0 1 , 702 , 704, 706, 714 , 716 , 7 1 7 , 719 , 723 , 724, 725 , 7 2 6 , 7 3 3 , 733 , 7 3 5 , 740, 756, 758 , 777, 778, 8 1 2 , 824 , 8 2 1 , 8 3 5 , 8 4 2 , 843 , 8 4 5 , 847 , 8 4 8 , 8 5 2 , 885 , 888

E i j s v o o g e l , V . P., 418 , 426 . 429,440

E i s en , H . N. , 105, 222, 170, 272, 2 8 5 , 2 9 3 , 317 , 318 , 3 2 2 , 627 , 634 , 636, 637 , 665 , 675 , 712, 727, 719-724, 719 , 720, 721 , 722 , 7 2 3 , 7 2 4 , 7 6 3 , 7 7 0 , 8 1 4 , 835, 874, 888

Elfenbein, G. J . , 1 9 0 , 763, 770 E l g i n , S. C. R., 733, 748, 835,

852 E l l i o t , B. , 25 E l l i o t t , E . V. , 11,22 E l l i o t t , H . L. ,224 E l l i s , A . E . , 262 , 270,272 E l l m a n , L . , 397,402 E l l ne r , J . J . , 3 1 , 306 Elsasser, W. M . , 769, 770 E lson , C. J . , 98 202, 209,224 Elves , M . W., 14,22 E l y , K . R. ,339, 636, 637, 645,

659, 674, 675 E m m r i c h , F., 262, 270, 272 Enders , J . F., 73,83 Ene in , A . A . ,224 Enge lhard , M . , 47-50 Engers, H . D. ,440 Ephruss i , B. , 450,454 Epp , O., 627, 631, 636, 645 Epste in , S., 812 E r b , P. , 113-118, 113 , 114,

1 1 5 , 2 2 7 , 1 1 9 , 2 2 6 , 255 , 2 5 9 , 5 3 9 , 5 4 4 , 5 5 9 , 5 6 2 , 563 , 568 , 569 , 579 , 587 , 5 9 7 , 6 0 8 , 6 1 1 , 6 2 2 , 625 , 626

E r t l , H . , 369, 377, 505, 520, 529-537, 529 , 530 , 535 , 536, 547,556

E s h h a r , Z . , 623, 626 Espinosa, L . , 4 5 5 Esse lman, W. J . , 59, 62 Esteban, M . , 535, 536 Estes, J . D. ,463 Evans , E . P., 236 Evans , J . , 454 Evans , P. D., 511-518 E v r i n , P. E . , 3 3 1 , 3 3 9 , 446,

454 E w e n s t e i n , B . M . , 343-349,

344 , 3 4 6 , 3 4 8 , 354 , 358 ,

3 5 9 , 3 6 2 , 365 , 3 6 6 , 3 6 8 , 369, 371 ,372 ,377

Fagen, G , 322 Fa i rbanks , G., 389,396 F a i r w e l l , T . , 3 2 9 , 341 -342 ,

342 Falkoff, R., 32, 626 F a n , K. , 788, 789, 792 Fanger, M . W., 677, 685 Farace, M. -G . , 8 5 2 , 855, 862,

883, 885, 888 Farnswor th , V . , 658, 678,685,

692 , 693 , 6 9 7 , 7 4 8 , 8 3 4 , 845, 862

Fa r r , A. , 618, 619 Fasman , G D., 636, 636 Fasold, H . ,339 Fa tham, C. G. , 11, 22, 295-

306, 295, 300,306 F a u l k , W. P. ,45,200, 202,224 Faulkes , R. A . ,62 Faust , C. H . , 855 ,862 ,888 Fefer, A . , 83 F e h l h a m m e r , H . , 636, 636,

644, 645 Fe inste in , A.,8Ö3 Fe i z i ,T . , 102,202,244, 282 Fe ldman, J . D . ,62 , 75 ,82 ,83 Fe ldman, U., 5 2 7 , 536 Fe ldmann, M . , 34,44, 96,101,

1 0 2 , 1 0 3 , 113 -118 , 113 , 114, 115, 116, 117, 228 , 119, 226 , 2 8 3 , 251 , 253 , 254 , 255 , 257 , 2 5 8 , 2 5 9 , 2 6 1 , 2 6 4 , 2 7 2 , 539 , 544 , 5 5 9 , 5 6 2 , 5 6 3 , 5 6 8 , 5 6 9 , 579 , 5 8 4 , 5 8 7 , 5 9 7 , 6 0 8 , 6 1 1 , 622 , 6 2 5 , 626, 763 , 770, 888

Fe ldmann, R. J . , 270, 271,273 Fel lous, M . , 338,338, 339 Fel lows, R. E . , 6 4 5 Fernstedt, Y . , 3 3 9 F e r r a r i n i , M . , 176, 177, 182,

282 Ferrone, S. ,368, 452, 4 5 4 , Festenstein, H. ,385, 418,419,

426, 454 Fett , J . W., 627, 636 Fie lds , R., 688 F i e rs , W., 862 F i n k , G , 790, 803 F i n k e l m a n , F . D. , 266, 267,

271 ,272 ,402 F i n n , J . , 898,902 F ins tad , J . , 272 F ischet t i , V . , 82 F i t ch , F. W. ,284, 724 F i t ch , M . W., 6 8 8 , 8 1 5 , 8 3 6 ,

874 Flaher ty , L., 814, 824 F le i schman, J . B . , 655, 658 Florent , G., 683,685 Fog, T. ,454 Fong, C , 722, 723 Font ino, M . , 4 2 6 Ford , C. E . ,236 F o r d , W. L . , 2 7 6 , 2 8 4 , 520 ,

5 2 7 , 540 , 5 4 2 , 5 4 4 , 559 , 562

Fordham, S. A. , 765, 766, 770

N A M E I N D E X 5 i

Forman, J . , 185-191,292, 345, 348 , 4 3 9 , 4 4 0 , 519 , 521 , 5 2 7 , 5 2 9 , 5 3 6 , 547 , 548 , 5 5 4 , 5 5 6 , 613, 614, 622

F o r n i , L . , 4 4 , 50 , 245 , 163, 164, 1 6 4 , 175 -183 , 1 8 3 , 1 9 1 , 1 9 9 , 2 0 0 , 2 4 3 , 2 7 2 , 2 7 3 , 401,402, 7 9 1 , 8 0 3

Forsgren, A. , 7 6 , 8 2 , 1 5 8 , 221, 225

Fot ino, M . , 463 Fougereau, M . , 171, 272, 665,

6 6 6 , 8 2 7 , 8 3 4 Fox, C. F., 57, 61 Frade l i z i ,D . , 430,440 Fraker , P. J . , 706, 722, 723,

724 France, C. M. ,224 Franc is , S. FL, 627, 628, 636,

664, 665, 8 2 7 , 8 3 5 Franek , F . , 8 4 8 , 8 5 2 , 8 5 3 Frangione, B. , 645, 795, 802 F r a n k , L., 7 9 1 , 8 0 3 Frank , M . M . , 1 9 0 , 3 1 4 , 321 F r a n k l i n , E . C . , 2 9 3 , 645, 795,

802 Franks , D . , 4 2 6 , 440 Fräser, B . A . , 6 8 6 , 689-698,

697, 815, 853 Fräser, B. F., 659 Fräser, K . J . , 658, 659, 675 Fraz ier , W. A . , 6 1 , F r e e d , J . H . , 2 2 7, 1 2 6 , 343-

349 , 3 4 8 , 3 6 1 , 3 6 8 , 3 7 7 , 3 8 6 , 4 0 2 , 4 5 4 , 4 8 7 , 6 0 8 , 622

Freedman, H . A . , 527 , 608 Freedman, M . H . , 726, 733 Fre i inger , J . k . , 2 5 0 , 3 1 4 , 369,

3 7 7 , 4 2 6 , 4 7 7 - 4 8 7 , 478 , 483 , 4 8 4 , 4 8 7 , 499 , 500, 5 0 1 , 5 0 3 , 504, 611

Freter, R., 201,224 Frey, J . R., 105, 106,222 F r i d m a n , W. H . , 320,322 Friedberg, S. H. ,22 Friedenson, B. , 6 4 4 , 6 4 5 , 700,

706 Fr i edman , S. ,637 F r i end , C , 163,264, 52 7 Fr i end , P., 417,426 Fro land , S .S . , 200 F u , S. M . , 47-50,50, 143, 244,

1 7 7 , 1 8 2 , 185, 1 8 6 , 1 9 0 , 1 9 3 , 2 9 9 , 2 0 0 , 2 6 1 , 263 , 2 7 0 , 2 7 2 , 3 5 4 , 3 6 2 , 395 , 395, 396, 4 2 6 , 455

Fucci lo , D. A . , 8 2 Fuchs , S. ,306 Fudenberg, H . H . , 102, 202,

224 , 294 , 595 , 710 , 72 7, 792

F u h r m a n , J . , 817-836 Fu j iwara , M . , 257,259 Fuke , M . , 878,888

Gabb, B . W . , 427 Gache l in , G. ,338 Gahmborg , C , 812,824 Galanos, C , 157, 2 3 6 G a l l , W . E . , 6 4 5 , 667 , 670.

674, 847, 852

Gal lagher, M . T . ,237, 528 G a l l y . J . A . , 170, 272, 175,

1 8 2 , 3 5 1 , 3 6 2 , 3 7 2 , 3 7 7 . 39c, 3 9 5 , 4 5 3 , 4 5 4 , 586 , 587, 687 , 688 , 789 , 790, 79c, 803 , 805 , 808 , 812 , 8 1 t , 818 , 835 , 882 , 8 8 8 , 89S, 898,902

Gambino, R., 865,874 Gamble, J . , 3 2 , 203. 228, 324,

3 2 i , 4 5 5 , 4 7 5 , 5 4 4 , 5 6 2 , 56S, 578, 587, 588, 623

Garbar ino ,C . A . , 3 2 , 1 1 8 , 3 6 1 , 5 2 7 , 5 3 6 , 5 4 5 , 5 5 6 , 5 6 1 , 570, 5 7 8 , 587, 609

Gardner, I. D., 505, 520, 526, 529, 536, 547, 556

Gardner, M . B. , 457-463, 458, 462,463

Gardner, R. L., 9-21 G a t h i n g s , W . E . , 237 , 139,

143, 1 4 4 , 1 4 5 , 1 5 8 , 1 6 2 , 1 9 1 , 2 4 3 , 2 5 0

Gavish, M . , 667-675, 674 Gearhart , P. J . , 165-173, 165,

167, 272 , 273 , 2 0 1 - 2 1 5 , 204, 2 0 5 , 2 0 6 , 2 2 3 . 2 2 4 , 2 1 5 , 6 4 5 , 6 8 5 , 716 , 72 7, 725, 725, 727, 733, 835

G e c k e i e r , W . R., 2 72, 2 9 3 , 645, 658 , 7 0 6 , 7 4 3 - 7 4 8 , 748, 8 0 2 , 8 0 7 , 8 2 4 , 8 3 5 , 845, 852, 862, 888

Geczy, A . F., 397, 398, 401, 4 0 2 , 572, 578

Geczy. C. I,, 772, 778 Gefter, M . L . , 781-791 , 782,

787 Geier, M . D. ,697, 853 G e i e r , S. S. , 3 8 4 , 3 8 5 , 387 ,

394, 395, 395 Geiger, M . D. ,674 Geleick, H.,222 Gelfand, M . C , 1 6 6 , 1 7 2 , 187,

290 Ge l l , P. G. H . , 267, 268, 273,

308,324, 6 5 7 , 6 5 9 , 8 8 8 Gera ld , L., 688 Gerald, P. S., 782, 790 Gerber, H . , 45 , 200 Gerday, C , 357,362 Gergely, J . , 792 Ge rma in ,R . N. ,351,362, 505,

520 , 547 , 5 4 8 , 5 5 6 , 898 , 902

Gershon, R. K . , 27,32, 36, 43, 4 4 , 85-91, 85, 86, 87, 88, 90,92, 106,222, 170,272, 6 1 5 , 6 2 2 , 749 , 758, 7 6 3 , 770

G e s t e l a n d , R. F . , 7 8 1 , 790, 796,803

Gewürz, H . , 50 Ghanta , V . , 272 Gibbons, R. J . , 201,224 Gibson, D. J . , 452, 4 5 4 , 809,

810 ,811 ,825 Gi lber t , W., 860, 861,862 Gi l es , C. M . , 426 G i l l , T. J . , III, 2 7 2 , 2 7 3 Gi l l e ter , R . ,595 G i l m a n , A . M . , 687, 688 G i l m a n , J . G , 373,377

G i l m a n - S a c h s , A . , 688, 690, 697

G i lmour , D. G. , 5-8, 7,8, 273 Giphar t , M . , 387-396 G i r l i n g , R. L., 636, 637, 645,

659, 675 Gis le r , R. H. ,321 G ivo l , D., 294, 627-637, 627,

628, 634, 636, 637 , 667-6 7 5 , 667 , 672 , 673 , 674 , 675

Glaser, M . , 634, 636 Glass , D. ,454 Glaudemans, C. P., 665, 666,

748, 835 Glazer, A . N . , 834,835 Gl imcher , L., 26 Glover, J . S. ,272 Glucksberg , H . ,83 Goding, J . W., 33-45, 38, 39,

40, 4 4 , 190, 290, 237-243, 237 , 238 , 240, 2 4 1 , 2 4 3 , 2 6 1 , 262 , 263, 264, 266 , 267, 270, 271,272

Goetzl , E . J . , 627, 634 ,637 Go id l , E . A. , 623, 763, 770 Go lan , D. T., 106,222 Gold, E. , 710,727 Goldberg, E . , 496 Go ldb lum, R. M . , 207 224 Goldman, J . N. , 369,377 Go ldman, M . G , 369,377 Goldste in, A . L . ,8 , 22, 237 Goldstein, B . , 765, 770 Goldste in, D. J . , 645 Goldste in, G . , 5-8, 5, 6, 8, 8,

65, 72, 176,282, 203,223, 407,424

Goldstein, I. J . , 228,236 Golste in, P., 514,52 7, 520,

527, 529, 531, 534,536 Golub, E . S., 611 Gomard, E . , 519,527 Good, R. A. , 237, 426 Goodfellow, P . ,329, 339, 362,

3 7 9 - 3 8 6 , 3 8 5 , 3 8 6 , 4 1 2 , 4 2 4 , 4 2 5 , 4 2 6 , 443 , 444 , 446 , 4 4 7 , 4 5 1 , 4 5 3 , 4 5 4 , 455

Goodfleish, R. ,685, 697 Goodfriend, L . ,463 Goodman, J . R. ,224 Goodman, M . , 639, 645 Goodman, S. A. , 194, 299 Gorczynski , R. M . , 124, 126,

226, 237 Gordon, J . , 315,322 G o r d o n , R. D . , 2 9 , 3 2 , 519 ,

521 , 5 2 2 , 5 2 7 , 5 2 9 , 5 3 6 , 5 3 9 , 5 4 4 , 554 , 5 5 5 , 5 5 6 , 559,562, 614,622

Gordon, S., 444, 689-698 Gorer, P. A . , 343,349 Gossel in-Rey, C.,362 Gott l ieb, A . B., 47-50 Gott l ieb, P. D., 72, 645, 663,

665 , 8 0 5 - 8 1 5 , 8 0 5 , 806 , 807 , 8 0 8 , 809 , 810 , 8 1 1 , 8 1 2 , 8 1 3 , 8 1 4 , 8 2 4 , 8 2 5 , 842,845

Götze, D., 485,487, 500, 501, 502,503, 520, 587

Gough, J . , 22

Goulmy, E . , 427 Gowans, J . L., 168, 272, 202,

2 1 4 , 2 1 5 , 891,902 Graff, R. J . , 521,527 Granato , D. D., 722, 724 Grant , J . A . , 819, 835 Graves, H . E . , 272 , 778 Graves, M. ,454,569,578,623 Graves, P. N . , 790 Gray , W. R., 825, 835, 888 Greaves , M . , 263, 2 6 8 . 2 7 2 ,

590, 595, 750, 752, 758 Green, C , 773, 778 Green, I., 145, 1 6 4 , 191, 2 0 0 ,

306 , 3 2 2 , 3 9 7 , 4 0 2 , 4 0 3 . 4 7 4 , 5 7 8 , 585, 587, 770

Green, J . , 324 Green, M . , 786, 790, 814, 825 Green, P. C , 778 Greenberg, A . A. , 307,324 Greenblatt , J . J . , 690, 697 Greene, A . E . ,455 Greene, P. J . , 880, 888 Greenspan, S., 18 Greenwood , F . C , 264, 265,

272, 331,339 Greenwood, M . F., 72 Grefrath, S. P., 59, 60, 62 Gregory, C. J . , 237 Gregory, W. ,396 Greineder, D. K., 3 1 , 3 0 6 G r e y , H . M . , 290, 193, 299 ,

3 1 5 - 3 2 1 , 3 1 5 , 3 2 0 , 3 2 2 , 3 2 6 , 3 2 9 , 3 3 1 , 3 3 9 , 368 , 377,424

Gr i f f i th , I. P., 590, 595 Gr i l l o t -Courva l in , C . ,439 Gr isa f i , P., 790, 803 Gr isce l l i , C , 202, 206,224 Gronowicz, E . , 147, 148, 150,

152, 257 , 218 , 220 , 223 , 2 2 5 , 226 , 228 , 230 , 235 , 2 3 6 , 752, 758

Gross, E . , 345,349 Gross, L., 163,264 Gross-Bel lard , M . , 878,888 Grossberg, A . , 4 5 Grossberg, N . , 779 Grosse-Wilde, H . , 427 G r o s s i , C . E . , 139-145, 141,

1 4 4 , 1 4 5 Grubb, R., 689, 697 Grumet , F. C , 297,306, 491,

496, 501,503, 622 Grunnet , N . ,440 Guggesberg, F., 272 Guidot t i , G. , 393,396 Guimezanes, A . , 3 2 1 Günther, E . , 466 , 4 7 0 , 4 7 4 ,

559,562 Gurdon, J . B . , 781, 790 Gurner , B . W., 3 1 4 , 455 Gustafson, G . T . ,158 G u t m a n , G. A. , 11,22, 33-45,

243, 250 Guy -Grand , D., 202, 205, 206,

214

Gyongyossy, M . I. C.,322

H Haas , R., 772, 778 Haas , W., 237, 238,243, 507,

5 2 0 , 5 2 3 , 527 , 5 3 9 - 5 4 5 ,

6i N A M E I N D E X

5 4 1 , 5 4 5 , 547 , 548 , 553 , 557

Habener, J . F . , 3 6 1 , 902 Haber, E . , 645, 647-659, 647,

650 , 653 , 655 , 656 , 6 5 8 , 6 5 9 , 670 , 6 7 4 , 6 7 5 , 6 8 5 , 690 , 6 9 7 , 756 , 7 5 8 , 848 , 852

Habicht , G. S., 103 H a b u , S . , 262 Haddad, J . R . ,527 Hagemeier, A . , 455, 791 Hagg, L . -B . , 273 H a h n , J . , 262,273 Ha imov i ch , J . , 288,293, 627,

628 , 6 3 4 , 6 3 6 , 637 , 6 5 8 , 772, 773, 774, 777, 778

H a k a m o r i , S.-L, 8 1 2 , 8 1 4 Häkansson, S., 331, 337,339 Halbwachs, L., 452,454 Ha l l i day , W. J . , 251,253,257,

259 Ha l l o r an , P . ,250, 314 Hamada , Y . ,284 Hamaguch i , H . , 59, 61 H a m a o k a , T . , 3 1 , 1 1 7 , 5 4 4 ,

5 7 8 , 6 0 9 , 6 2 2 , 623 H a m e r s , R., 6 8 5 , 6 8 6 , 6 9 7 ,

8 1 5 , 842, 843,845, 853 Hamers-Casterman, C , 686,

6 9 7 , 8 1 5 , 842 , 8 4 3 , 8 4 5 , 853

Hami l t on , L .D. , 82 Hami l t on , R , 8 2 , 408 Hammarström, L., 224, 225,

226 Hammerberg , C , 462,463 Hämmerling, G . J . , 282,284,

285-294, 285 , 2 8 7 , 2 9 3 , 377 , 489 , 4 9 2 , 4 9 6 , 500 , 5 0 1 , 502 5 0 3 , 5 4 4 , 5 9 7 , 6 0 8 , 624

Hämmerling, U . , 6,8, 53 ,62, 1 3 4 , 2 3 6 , 1 3 7 , 2 6 1 , 262 , 263 , 265 , 2 7 0 , 2 7 2 , 4 2 4 , 496, 5 0 3 , 597, 608

Hampshi re , B. , 454 Handwerger, B. , 72,426, 515,

517, 5 9 8 , 6 0 8 Han ly , W. C , 687, 688, 690,

697 Hansburg , D., 744, 748, 841,

845 Hansen , G . S. ,440 Hansen , J . A . , 420,426, 454 Hanson, L . A. , 201,224 Hape l , A . J . , 5 2 0 , 556, 608 H a r d m a n , K . D., 645 Har r i s , A . W . ,243 , 264,272,

2 7 3 , 2 8 4 , 7 8 1 , 790, 793 , 794,803, 815

Har r i s , H . ,453 Har r i s , J . E . , 74,82, 131,236 Har r i s , S.,386, 396, 427,454,

862 Har r i s , S. T., 862 Harr i son , T. A. , 63-72, 72 Har r i son , T. M . , 697 Har t , D. A . , 701,702,706, 707 H a r t m a n n , K . - U . , 2 5 3 , 2 5 9 ,

563, 569 Harwe l l , L., 618, 622 Hase lkorn , D., 627, 634, 635,

637

H a s k i l l , J . S., 134, 237, 563, 569

Hass , L., 237 Hathcock, K . S. ,528 Hauptfe ld, M . , 362, 4 4 0 , 457-

463, 462,463, 556 Hauptfe ld, V . , 354, 362, 377,

4 2 5 , 4 2 6 , 427 , 4 4 0 , 458 , 4 6 3 , 5 0 0 , 5 0 3 , 5 4 7 , 5 5 1 , 555, 556

Hausman , S. J . , 755, 758 Haus te in , D., 238, 243 , 261,

262 , 2 6 3 , 264, 2 6 5 , 2 7 2 , 273, 2 1 5 , 2 8 4 , 8 1 2 , 8 1 5

Hayakawa , K . , 227 H a y m a n , M . J . , 55, 62, 379,

386, 455 Häyry,P., 430,439, 495 Hayward , J . A . , 307,324 Heber -Ka t z ,E . , 114,227, 542,

544 , 559-561, 5 6 0 , 5 6 2 , 5 6 9 , 5 6 9 , 5 7 7 , 5 7 8 , 598 , 608, 608, 613, 615, 622

He in r i ch , G., 257, 236, 758 He len ius , A . , 335,339 Helgesen, k . , 4 2 7 Henc in , R , 622 Henderson, B . E . ,463 H e n i n , Y . , 5 2 7 Henkar t , P. A . , 249,250, 396 Henle , W., 73,82 Henley, W. L . ,273 Henney, C S., 78,83,429,440 H e n n i n g , R , 3 4 4 , 3 4 9 , 351-

362, 3 5 1 , 354, 3 5 8 , 3 6 2 , 3 6 5 , 3 6 6 3 6 8 , 3 6 9 , 3 7 1 , 3 7 2 , 3 7 7 , 4 5 3 , 4 5 4 , 547-557, 547, 551 ,552 ,556

Henr iksen , O., 341-342, 341, 342

Henry , C , 202,224, 236, 599, 609, 623, 751, 758, 902

H e r b e r m a n , R , 3 2 2 , 5 1 1 , 5 1 7 , 531,536

Heremans, J . F., 201,202,224 Heri tage, J . , 449 He r rmann , H , 329, 3 8 6 , 396 Hersh , E . M . , 74,82 Herzenberg, L . A . , 2 2 , 23, 24,

32, 33-45, 33, 34, 35, 36, 38, 39, 40,44, 45, 93 ,202 , 227 , 122, 125, 126 , 226 , 227, 147, 258, 2 8 2 , 287 , 290 , 299 , 2 0 3 , 2 2 4 , 2 3 6 , 2 4 9 , 2 5 0 , 2 9 3 , 3 0 3 , 3 0 6 , 3 0 7 , 3 2 4 , 3 1 7 , 3 2 2 , 4 7 5 , 4 8 7 , 497-504, 4 9 7 , 499 , 501 , 5 0 2 , 5 0 3 , 5 0 4 , 528 , 544 , 606 , 608, 6 0 9 , 622 , 706, 709,727, 842 ,845

Herzenberg, L. A., 32 , 33-45, 4 4 , 1 0 2 , 1 2 7 , 1 9 0 , 2 5 0 , 303, 3 0 6 , 4 7 5 , 487 , 497-504, 501,503, 504, 609, 845

Hess, M . , 686 Heusser, C H . , 315-321 Hewg i l l , D., 33-45 Hi jmans, W., 244, 282, 290,

194,299, 200 H i l demann , W. H . , 261, 268,

270,272, 771, 772, 778 H i l l , R L . ,636, 639 ,645 H i l l , S. W., 470

H i r s ch , M . S., 82,82 Hirschberg , H . , 421,426,427,

430,440 H i rschhorn , K. , 429,440 H i r s t , J . A . , 3 2 , 83, 587, 626 H i t a m u r a , T., 536 H o c h m a n , J . , 637, 667-675,

667, 669, 670, 674, 675 Hodes, R J . , 515,528 Hoecker, G. , 343 Ho f fman ,T . ,47 ,50 , 200 Hofrmann, M . K., 8, 32, 83,

237, 587, 599, 609, 626 Hogg, N . M , 117, 263, 272,

626 Holden, H . T., 517, 536 Hol land , J . G . , 264 Ho l l and , P., 72 Hol ley , R , 413,424 Holmes, E . C , 590 Honjo, T., 734, 852, 855-862,

855 , 856 , 857 , 858 , 859 , 862, 877,888

Hood, L., 171, 272, 331 ,339 , 3 4 3 , 3 4 4 , 3 4 9 , 3 5 1 , 352 , 358 , 359 , 3 6 0 , 3 6 2 , 363 , 3 6 5 , 3 6 6 , 3 6 8 , 369-377, 370 , 371 , 372 , 3 7 3 , 3 7 7 , 398 , 4 0 1 , 4 0 2 , 4 0 3 , 4 1 1 , 4 1 4 , 4 5 3 , 4 5 5 , 5 2 3 , 5 2 7 , 627 , 628, 636 , 637 , 650 , 658 , 665 , 682 , 685 , 686 , 688 , 6 8 8 , 6 9 7 , 730 , 7 3 1 , 733, 744, 748, 762 , 770, 8 2 5 , 817-836, 818 , 819 , 820 , 8 2 1 , 822 , 824 , 8 3 2 , 8 3 3 , 8 3 4 , 8 3 5 , 8 3 6 , 838 , 839 , 840 , 8 4 1 , 8 4 5 , 847 , 852, 856,862, 874, 888

Hooper, J . A . , 237 Hooper, R S . , 8 Hopper, J . E . , 285, 293, 324,

725, 733, 792 Hor ibata , K. , 781, 790, 793,

794,803 H o r n , R. G. ,578 Horng , W. J . , 682, 685, 687-

688, 687, 688, 690,697 H o r s , J . , 452,454 Horta-Barbosa, L., 82,82 Hor ton, J . D., 771, 778, 779 Horton, T. L., 778 Horwi tz , D. A . , 299 Hough, B . R , 874 Houssaint , E . , 245 H o w a r d , J . C , 1 5 , 2 2 , 326 ,

3 2 9 , 3 7 2 , 3 7 7 , 4 5 5 , 5 2 7 , 559-561, 560,562

Howard , J . G. , 167,272 Howe, M . L., 15 ,22 ,83 Howe, S. C. ,803 Howie , S., 113-118 H o z u m i , N . , 8 5 2 , 877-889,

877, 882, 884,888 H s i a , J . C . ,637 H s i a , S . , 427 H s u , S. H . , 451,454, 463 Huang , P. C , 269,272 Huang , R. C , 269, 272, 862,

888 Hubbard , L . ,250 Huber , B. , 23, 24, 25, 26, 30,

32, 34,44

Huber , R , 636, 674 Hubert , J . , 817-836, 830 Huchet , R , 763, 770 H u d s o n , L . , 228 , 227 , 3 2 4 ,

3 2 2 , 540 , 5 4 3 , 5 4 5 , 5 6 7 , 570, 609, 624

Huebner , R. J . , 463 Huetteroth, T. H , 282 H u g , K . , 4 5 , 245, 283 , 292 ,

200, 243, 273 Hughes R. C , 60,62 H u m a y u n , M . Z . , 862 Humphrey , J . H . , 168,272 Humphrey , R. L., 645 Humphrey , W. , 1 7 3 , 2 1 4 , 2 9 3 ,

4 8 7 , 6 6 5 , 7 1 7 , 7 2 4 , 7 3 4 , 748, 758, 8 4 5 , 852

Humphreys , R. E . , 329, 339, 386, 387, 394, 3 9 5 , 3 9 6

Hünig, T., 755, 758 H u n t , S. M . ,272 H u n t , S. V . , 264, 268,272 Hunte r , I. R . ,44,245,290,299 Hunte r , P., 625, 626 Hunte r , W. M. ,272 , 331,339 H u r m e , M . , 740 Hurs t , M . M . ,272 Hurw i t z , E . , 636, 637 Huser , H . , 654, 658 Huston , J . B . , 667,674 Hut ton , J . J . , 72, 825 Hy l t on , M . B . , 237, 282 H y m a n , R., 59, 62 , 407-415,

4 0 7 , 408 , 409 , 410 , 4 1 1 , 4 1 2 , 4 2 3 , 424 , 5 2 1 , 522 , 526, 527, 536

H y s h k a , L . , 427

I

Ihde, D. ,454 Il lmensee, K. , 781, 790 Imai , H . T . ,889 I m a n i s h i , T., 289, 2 9 0 , 2 9 3 ,

735 , 736 , 740, 742 , 756 , 758, 764 , 770, 779 , 842 , 845

Inbar, D., 634, 637, 667-675, 674

Inman, J . K . , 536, 6 0 9 , 710, 727 , 7 3 1 , 733, 834 , 8 3 5 , 838, 839,845

Inque, M . , 883 I r i tan i , C. A. , 814 Isac, R , 227, 377 Ish izaka, K. , 34,44, 124,226,

248,250 Israels, M . C. G.,22 Isselbacher, K . J . , 2 1 5 I t akura ,K . ,805 ,824 , 812,825 Ito, M . , 530, 533,536

Jackson , D. C , 520, 556, 608 Jackson , L . , 306 Jackson, R. L., 61, 362 Jackson, S. A. , 659, 686, 697,

748, 853 Jacob, F . ,338 , 339, 588 Jacobs, D . M . , 219,225 Jacobs, J . W., 358, 362, 901,

902 Jacobsen, B . , 4 4 1

N A M E I N D E X 7i

Jacobson, M . W., 442 Jamieson, J . , 411,424 J a n d i n s k i , J . , 23, 24, 25, 3 1 ,

89,92, 189,290, 483,487 J a n e w a y , C . A . J . , J r . , 275,

2 8 4 , 3 1 4 , 590 , 5 9 4 , 5 9 5 , 6 1 1 , 616 , 618 , 6 1 9 , 6 2 2 , 7 1 3 , 72 7, 7 1 9-724 , 7 1 9, 720, 721, 722, 723, 724

Janossy, G . ,272 , 752, 758 Jansz , H . D . ,862 Ja ram i l l o , S . ,427 J a r r e t t , E . , 463 Jarre t t -Toth , E . , 4 4 0 Ja r v i s , J . M . , 8 3 5 , 8 6 2 , 8 7 4 ,

887, 888 Jasek , T., 792, 803 J a t o n , J . - G , 3 0 6 , 4 9 6 , 650 ,

655 , 6 5 8 , 6 6 6 , 683 , 6 8 5 , 690 , 6 9 6 , 6 9 7 , 756 , 758, 778

J a z w i n s k i , S. M . , 900,902 Jeanes, A . , 747 Jefferis, R., 195, 299 Jeffrey, A . , 862 J e h n , U . W., 755, 758 J e n k i n s , V . K . , 137 Jenner , E . , 73 ,83 Jensen, F. B . ,83 Jerne , N . K . , 1-4, 29, 30 ,32 ,

3 3 , 4 4 , 9 3 , 99 , 202 , 149, 1 5 5 , 2 5 7 , 2 2 8 , 2 3 6 , 249 , 2 5 0 , 2 8 5 , 2 9 3 , 5 0 5 , 507 , 520 , 5 2 6 , 5 2 7 , 6 7 7 , 6 8 5 , 6 9 5 , 6 9 7 , 710 , 716 , 727, 722 , 7 2 4 , 7 9 7 , 8 0 3 , 818 , 835, 887,888, 892,902

Je rs i l d , C , 3 9 6 , 4 2 6 , 4 4 0 , 452, 454

J imenez , L., 73-83, 73, 74, 78, 8 2 , 8 3

Johnson, B . J . , 62 Johnson, B . M . , 203, 1 8 9 , 1 9 1 ,

560,562 Johnson, F . L . ,83 Johnson, N . , 817-836 Johnson, P., 202, 226 Johnston, M . F. M . , 723, 724 J o h n s t o n e , A . P . , 655 , 658 ,

689-698, 690, 691, 697 J o k l i k , W . H . , 529, 530,536 Jo l l ey , M . E . , 662, 665, 666,

748, 835 J o n a l , U . , 224 Jonda l , M . , 80 ,83 , 528 J o n e s , E . A . , 379 , 3 8 0 , 3 8 5 ,

3 8 6 , 4 2 4 , 4 2 5 , 4 2 6 , 443-455, 4 4 3 , 4 4 9 , 4 5 1 , 4 5 3 , 454

Jones, P. P . ,44, 178,282,193, 299, 201 ,202 ,223 , 224

Jones, T. L. , 202,224 J o n e s , V . E . , 263 , 2 7 0 , 2 7 2 ,

777, 778 Jonker , M . , 417-427, 422,426 Jonsson, S., 397,402 Jo rdan , R. K . , 129-137,237 Jprgensen, F., 419 ,426 Jos l i n , F . G. , 685, 852 Jotereau, F . V . , 131,237, 245,

J u , G , 73-83 J u , S.-T., 699-707, 703, 706,

707, 853

J u l i n , M . , 6 4 5 , 741 J u l i u s , M . FL, 35,44, 228,236,

2 8 8 , 2 9 3 , 4 8 3 , 4 8 7 , 515 , 5 2 8 , 5 4 0 , 5 4 4 , 598 , 609 , 704 , 706, 7 0 9 - 7 1 8 , 709 , 713,727

J u r d , R. D., 772, 773, 778 J u t i l a , J . W., 178, 282 J u y , D., 307-314, 308,324

K K a a k i n e n , A. , 426, 440 Kaba t , D., 395,396, 882,888 Rabat , E . A. , 171, 273, 294,

627 , 636 , 637 , 6 4 1 , 642 , 6 4 5 , 647 , 648 , 649 , 6 5 1 , 6 5 8 , 6 5 9 , 6 6 1 , 6 6 2 , 6 6 5 , 666 , 687 , 688 , 7 3 1 , 734, 743 , 748, 8 0 7 , 8 2 5 , 818 , 8 2 8 , 8 3 6 , 837 , 838 , 839 , 846, 851,853

K a c i a n , D. ,874 K a d i s h , A . , 8 3 Kafatos, F. C . , 8 7 4 Kagnoff, M . F., 202, 211,224 Kahane , I.,362 K a j i , F L , 595 K a m a t , R., 78, 83 , 201-215,

223 K a m i n , R. M . , 211,224 K a m i s a k u , FL, 611, 613, 615,

617, 624 K a n G , 4 4 0 K a n a m a r u , A. , 528 K a n o , S., 73-83,75, 78 ,82 ,83 Kan to r , F. S., 597, 609 K a p l a n , FL S., 22 K a p p , J . A . , 23 , 2 5 , 3 2 , 95 ,

1 0 2 , 119, 125, 226 , 4 7 1 , 4 7 3 , 4 7 4 , 4 7 5 , 5 0 1 , 5 0 3 , 5 0 4 , 5 6 3 - 5 7 0 , 5 6 3 , 569 , 5 7 0 , 578 , 609 , 618 , 619 , 622, 623

Kapp ler , J . W . , 3 2 , 598, 599, 609, 618, 622, 623, 626

Kapsa l i s , A . A. , 706 K a r a k a w a , W. W . ,697 K a r j a l a i n e n , K . , 7 3 5 - 7 4 1 ,

736, 740 K a r k i n e n - J a a s k e l a i n e n , M . ,

237 Kar l sbad , G , 787, 790 Kar l s son , F. A . , 667, 670,674 Ka rn i e l y , Y. , 491,496 Ka r r e , K . , 528 K a s a k u r a , S., 15,22 K a s k , A . M . , 3 7 7 , 3 9 7 - 4 0 3 ,

402,402 K a t a g i r i , C , 771, 779 K a t a g i r i , M . ,368 Kates , J . , 535,536 Ka to , K. , 339, 348, 349, 362,

377, 403 Ka t z , D. FL, 23, 24, 27, 30,32,

114, 1 1 6 , 2 2 7 , 1 1 9 , 2 2 6 , 2 0 2 , 2 2 4 , 2 7 5 , 2 8 4 , 292 , 2 9 3 , 3 4 4 , 3 4 9 , 3 5 8 , 3 6 2 , 3 6 8 , 3 6 9 , 3 7 7 , 4 4 3 , 4 5 1 , 4 5 4 , 4 6 5 , 4 7 0 , 4 7 4 , 486 , 4 8 7 , 4 9 1 , 4 9 3 , 4 9 5 , 4 9 6 , 503 , 5 0 5 , 5 2 0 , 5 2 2 , 5 2 7 , 539 , 5 4 2 , 5 4 4 , 5 5 3 , 5 5 6 , 5 5 9 , 5 6 2 , 563 , 564 , 568 ,

5 6 9 , 5 7 1 , 5 7 7 , 5 7 8 , 579 , 580 , 5 8 2 , 5 8 4 , 5 8 7 , 597 , 598 , 6 0 7 , 6 0 8 , 609 , 611-624, 6 1 1 , 612 , 6 1 3 , 614 , 6 1 5 , 6 1 7 , 618 , 619 , 620 , 622, 623, 625, 626

Ka t z , L . R , 6 2 3 Ka t z , S. L , 4 2 7 , 4 5 4 , 455 K a u f m a n , J . F., 387-396,387,

394 K a w a t a , T . ,528 K a y , M . M . B . , 60, 62 Kearney , J . F., 38, 44, 139-

145, 140 , 141 , 142, 1 4 4 , 150, 2 5 7 , 176, 178 , 181, 282 , 194 , 197, 229 , 230 , 2 3 6 , 2 4 8 , 2 4 9 , 2 5 0 , 749 , 750, 753,758

Kee ler , K . D. ,299 Kehoe, J . M . , 367, 3 6 8 , 641,

6 4 5 , 6 9 1 , 6 9 3 , 6 9 6 , 822 , 8 3 4 , 8 4 7 , 848 , 8 5 1 , 852 , 852, 853, 883, 888

Ke ight l ey , R. G , 244 K e l l y B . , 113,228 K e l l y , T., 781-791 K e l u s , A . S . , 3 2 4 , 6 5 7 , 6 5 9 ,

803, 888 Kemle r , R . ,338 Kemper , B . ,362 , 902 Kemshead , J . T., 751 Kennet t , R. H . , 447, 451,454,

455 K e r e n , D . F., 209,224 Kess ler , S. W., 1 4 8 , 1 5 7 , 267,

272 K e t t m a n , J . R., 32, 262, 185-

191, 1 8 9 , 2 9 0 , 1 9 1 , 6 0 9 , 625, 626, 755, 758

K e u n i n g , J . J . , 3 9 6 , 419, 420, 4 2 6 , 4 2 7 , 4 4 0 , 4 5 2 , 4 5 4 , 455

K h o r a n a , H . G , 72 K i b l e r , R., 531,536 K idde r , G . M . , 773, 778, 778 K ie fer , FL, 288,293 K i e s s l i ng , R , 517,528 K i l b r i c k , S. ,83 K i l b u r n , D . , 117 K i m , B . S., 6 8 7 , 6 8 8 , 690,697 K i m , J . FL , 262 K i m , Y . , 4 2 6 K i m u r a , A . , 284 K incade , P . W., 1 4 4 , 159,262,

1 7 8 , 1 8 2 , 1 9 9 , 2 1 3 , 245-250, 245, 247, 248,250

K i n d r e d , B . , 539 , 544 , 579 , 587, 611,614, 618,623

K i n d t , T . J . , 2 8 5 , 2 9 3 , 650 , 6 5 7 , 658 , 659 , 677 , 682 , 6 8 5 , 686 , 687 , 688 , 689-698, 689 , 690 , 692 , 693 , 694 , 696 , 697 , 7 3 1 , 733, 7 5 6 , 758, 7 8 1 , 7 9 0 , 8 1 5 , 8 1 8 , 8 2 8 , 8 3 4 , 8 4 2 , 8 4 5 , 847, 848, 851, 852, 853

K i p p , D. E . , 304,306, 470,474 K i r o v , S. M. ,243 K i s h i m o t o , T. , 3 4 , 4 4 , 124,

1 2 6 , 1 2 7 , 248,250 K i s i e l ow , P., 32, 78, 83, 584,

587 K i s s m e y e r - N i e l s e n , F. , 379,

3 8 6 , 4 2 6 , 440 , 443 , 445 , 447,454

K i t a j ima , K . , 753 K i t a m u r a , Y. , 511,528 K lapper , D. G , 3 3 9 , 3 4 9 , 362,

363-368 ,368 , 3 7 7 , 4 5 5 , 659, 847-853,852

K lareskog , L., 329, 331-339, 339, 377

K l a u s , G G . B . , 168,272,195, 299

K l e i n , D . ,463 , 503 K l e i n , E . ,528 , 787, 788,790 K l e i n , G , 80,83,411,423,453 K l e i n , J . , 331, 337,339, 343,

3 4 5 , 3 4 8 , 3 4 9 , 3 5 1 , 354 , 359 , 3 6 0 , 3 6 2 , 3 6 2 , 363-368 , 368 , 369 , 3 7 1 , 373 , 374 , 3 7 5 , 3 7 7 , 418 , 425 , 4 2 6 , 4 2 7 , 429 , 438 , 439 , 4 3 9 , 4 4 0 , 4 5 5 , 457-463, 457 , 458 , 4 6 2 , 4 6 3 , 4 7 4 , 497 , 499 , 5 0 1 , 5 0 3 , 5 0 4 , 5 0 6 , 5 2 0 , 5 2 0 , 5 2 1 , 5 2 4 , 527 , 5 3 6 , 547 , 5 5 1 , 554 , 556 , 5 5 9 , 5 6 2 , 5 8 7 , 597 , 609 , 625-626, 809 , 812 , 814,825, 897,902

K l e i n , K . , 4 2 6 K l e i n , P . ,62 , 550,556 K l e i n , W. H. ,874 K l e p p e , K . , 71, 72 Kleppe, R , 72 K l i n m a n , N . R , 140,141,142,

244, 245 , 1 6 0 , 2 6 2 , 165-173, 165 , 166, 167, 168, 170, 1 7 1 , 2 7 2 , 273 , 189, 292 , 204 , 205 , 206, 209 , 2 1 4 , 2 1 5 , 2 4 5 , 2 5 0 , 489 , 490 , 4 9 1 , 4 9 6 , 5 0 4 , 563 , 570 , 5 9 8 , 6 0 9 , 613 , 614 , 6 2 3 , 644 , 645 , 677 , 685 , 704 , 7 0 6 , 7 1 7 , 7 1 8 , 726 , 733, 763 , 770, 818 , 8 2 1 , 822, 835

K i u s k i n s , L., 719, 723, 724 Knapp , W., 143,244,175,176,

282 , 185 , 186, 290 , 193, 299

K n i g h t , E . J . , 202,224 K n i g h t , K . L., 283, 299, 685,

687-688, 687, 688, 697 Knopf, P., 424 Knot t , J . C A . , 6 3 6 Knowles , B . B . ,377 , 790, 802 Knudson , K . C , 202,224 Kobayash i , FL , 590,595 Kobe l , H . R , 774, 778 Koch , G , 2 8 4 Kodama, T., 595 Köhler, G. , 175,282, 781,789,

7 9 0 , 793-803, 7 9 3 , 794 , 797,798, 799, 801,803

Köhler, FL, 2 4 5 , 1 6 2 , 1 7 3 , 1 9 1 , 2 0 5 , 2 2 4 , 6 6 1 , 665 , 7 0 1 , 706, 7 0 7 , 709 , 710 , 727, 728, 719 , 722 , 7 2 3 , 724, 725, 733

K o h n , F L L , 4 5 5 , 5 1 0 , 5 2 7 Kohne , D. E . , 867, 869,874 Ko ler , R D., 395,396 Ko l l e r , P. C . , 2 1 Komuro , K . , 6,8,8, 65,72,237

8i N A M E I N D E X

Kondo, K . , 9 2 , 763, 770 Königsberg. W. H . , 2 7 3 , 639,

640 , 6 5 8 , 6 6 5 , 7 2 4 , 7 3 3 , 748, 779, 8 3 5 , 853

Kon t i a in en , S., 1 0 2 , 113-118, 113, 1 1 4 , 1 1 7 , 1 1 8 , 5 8 7

Koo, P. H . , 4 9 6 , 6 4 4 , 6 5 8 Kook, A . I., 1 3 3 , 1 3 7 Kopyc insk i , C. F . ,224 Ko r en , H . S., 70, 72, 5 3 6 , 609 Kornfe ld , S., 393,396 K o s h l a n d , M . E . , 6 7 4 , 6 9 7 ,

853 K o s k i , I . ,250 K o s z i n o w s k i , U . , 369 , 377 ,

505 , 5 1 0 , 529-537, 529 , 530 , 5 3 1 , 5 3 5 , 5 3 6 , 547 , 556

K o u r i l s k y , F . M . , 3 6 1 , 3 6 8 , 556

K o u r i l s k y , P. ,874 Kov i thavongs, T., 426,427 Kra f t , N . ,259 K r a k o w , J . S., 63, 72 K r a m m e r , P . H . , 264 , 2 7 2 ,

317,322 K r a n s , M . L. ,272 Krause , R. M . , 6 5 8 , 690, 685,

6 9 6 , 6 9 7 , 7 3 2 , 733, 756 , 758, 8 4 8 , 8 5 2

K r a w i n k e l , U . , 282, 283,284, 285-294, 2 8 8 , 289 , 290 , 291, 292,293

Kre je i , J . , 222 K r e t h , H . W., 167, 273, 726,

734 Kr i s t ensen , T., 429,440 Kronenberg , M . , 817-836 K r o n v a l l , G., 267, 272, 397,

402 Krueger , R. G. , 8 8 1 , 8 8 8 K u b o , R. T . , 185, 186, 290 ,

1 9 3 , 2 9 9 , 3 2 9 , 3 3 9 , 3 6 8 , 3 7 7 , 413,424

K u c i c h , U . N . , 59, 62 K u e h l , W. M . , 791, 803 K u e t t n e r , M . G . , 699 , 706,

732, 734, 8 5 0 , 8 5 2 K u h n , L . ,224 K u h n , T. S., 769, 770 K u n g , P. C , 63-72, 63, 64, 65,

66, 67, 69, 70, 72 K u n k e l , H . G. , 47-50, 47, 5 0 ,

1 0 2 , 1 4 4 , 1 8 2 , 1 9 0 , 1 9 9 , 2 0 0 , 2 6 3 , 2 7 2 , 2 8 5 , 2 9 3 , 3 0 7 , 3 2 4 , 3 5 4 , 3 6 2 , 3 9 5 , 3 9 6 , 4 2 2 , 4 2 6 , 4 2 7 , 4 5 5 , 682 , 6 8 5 , 689 , 697 , 736 , 742, 8 4 8 , 8 5 2 : 853

K u p e r m a n , O . J . , 429-441, 436, 437,440

K u r l a n d , J . I., 245, 248,250 K u r n i c k , J . T., 193,299 K v i s t , S., 331-339

Labaw, L . W. ,645 Lachmann , P. J . , 452,454 Lack l and , FL, 658 Ladoul is , C. T., 261,272, 273 L a e m m l i , U . K . , 380,386 Lafferty, K . J . , 433, 437, 438,

4 4 0 , 441

L a F l e u r , L . , 1 3 7 , 139, 244 , 1 5 6 , 1 5 7 , 1 6 4 , 758

Lahat , N . , 262,273 La ing , R. ,272 Lake , P., 589-595, 593,595 L a m m , L . U . , 426 L a m m , M . E . , 245, 160, 262,

1 8 2 , 1 8 3 . 1 9 0 , 1 9 1 , 1 9 9 , 2 0 0 , 2 1 4 , 2 5 0

Lamon , E . W., 264,272 L a m p k i n , B . , 72 Lance, E . M . , 86,92 L a n d u c c i - T o s i , S., 677-686,

678 , 679 , 680 , 6 8 1 , 6 8 5 , 686

Landva l l , P., 221 Lane , I.,264 L a n g m a n , R. E . , 2 5 1 , 2 5 3 ,

259, 526 Laskov , R., 781, 786, 787, 790 L a t t m a n , E . E . , 636, 645 L a v r i n , D. FL, 52 7 Lawson, Y . , 2 2 7 L a w t o n , A . R., 38 , 44 , 132,

237, 139-145, 139 , 140 , 1 4 2 , 2 4 4 , 245 , 1 5 0 , 2 5 7 , 158, 260 , 2 6 2 , 176, 178, 1 8 1 , 1 8 2 , 1 9 1 , 194, 197, 299 , 2 2 3 , 229 , 2 3 0 , 2 3 6 , 2 4 3 , 2 4 8 , 2 5 0 , 749 , 750 , 753, 758

L a y t o n , J . E . , 237-243, 237, 238 , 239 , 2 4 1 , 2 4 3 , 2 5 0 , 2 5 1 , 2 5 9 , 271

Lazar ides, E . , 387,396 Lebowitz, H . E . , 6 4 5 Leder, P., 725, 734, 8 3 6 , 848,

8 5 2 , 855-862, 8 5 5 , 857 , 8 6 2 , 8 8 3 , 8 8 8

Lederberg, J . , 160, 262, 237, 243

Le Douar in , N . M . , 131, 133, 237, 141,245

Leduc, E . FL, 787, 790 Lee, G , 247 Lee, K . - C , 251-259, 251, 252,

253, 254,259 Lee, W., 167,273, 206,224 Lee, W. M . F., 145, 162, 191,

707, 718 Leech, S., 590,595 Lees, R. K . ,322 Lefebre, J . C , 313,324 L e f k o v i t s , I., 155, 257, 235,

236, 727, 778, 779 Legrand, L., 387,396 Lehtonen, E . , 237 Le L ievre , C. S., 133, 237 Lemieux , S., 307,324 L e n n o x , E . , 4 1 4 , 6 8 7 , 6 8 8 ,

8 4 7 , 8 5 2 L e o n , M . A . 6 6 1 , 664 , 665 ,

666 , 7 2 2 , 724 , 725 , 734, 8 3 7 , 8 4 5

Lerner , K . G. , 83 Leserman, L . D., 563, 569 L e s l e y , J . F . , 32 , 532,536,626 Les l ie , G. A . , 732, 734 Lesl ie , R. G. Q., 636, 6 6 5 , 8 3 5 Letar te -Muirhead , M . ,

51-61, 52, 54, 55, 56, 57, 59 ,62 , 4 0 8 , 4 1 3 , 4 1 4

Leuchars , E . , 22 , 272 L e v i , G . , 2 2 3

Lev in , R., 14,22 Lev ine, B . B . , 295, 306, 397,

402, 457,463 Lev ine, FL, 72 Lev ine, S. L., 14,22 Levis , W. R , 74,83 Levy, J . , 1 1 3 , 2 2 7 , 1 1 8 , 5 2 7 Levy, R , 14,22 Lewis , H . , 2 7 3 , 791 Lewis , J . B. , 790 Liao, J . , 748 Lichtenberg, L., 617, 623 L ichter , E . A. , 697 L id in -Janson , G., 224 L ieberman, M . , 22 L ieberman, R., 167, 272, 273,

203 , 205 , 2 0 6 , 2 2 4 , 2 2 5 , 285 , 2 8 6 , 2 9 3 , 3 2 1 , 4 8 6 , 4 8 7 , 6 2 2 , 6 6 1 , 662 , 664 , 665 , 666 , 6 8 6 , 6 8 8 , 709 , 710, 727, 719 , 7 2 1 , 722 , 7 2 4 , 725 , 726, 727 , 730 , 732, 733 , 734, 736 , 742, 744 , 7 4 8 , 1 5 5 , 1 5 6 , 7 5 8 , 8 3 5 , 837 , 842 , 8 4 3 , 8 4 5 , 848,852

Liebhaber, S. A. , 86, 92, 622 Lightbody, J . J . , 535,536 L i l l y , F., 362 , 527, 556, 590,

591, 592,595, 608 L i n , P. K. , 282 L indah l , K . F., 351,362, 520,

521,527, 559 L i n d a h l - K i e s s l i n g , K . , 433 ,

440 L indb lom, J . B . ,329,339,349,

362, 368 L i n d e n m a n n , J . , 2 7 5 , 2 8 4 ,

508,520, 590 ,595 ,608 L i n t h i c u m , D. S., 598, 609 L i p m a n , L. N. ,324 L ipsky , P. E . , 3 1 , 3 0 6 , 5 8 7 Lisco, H . ,455 L isowska-Bernste in , B. , 262,

185, 186, 290 L ister , T. A. , 595 L i t t l e , J . R., 171, 273 , 637 ,

700, 706, 724, 833,835 L i t t l e f i e l d , J . W., 792, 798,

803 L i t w i n , S. D., 175, 282 L i u , S. FL, 491,496 L i vna t , S., 582,587 Loblay, R., 93-103 Lobo, P. L , 193, 299 L o h , E . , 272 , 817 -836 , 822 ,

823 , 824 , 8 2 5 , 8 3 5 , 838 , 839 ,840 ,845

Loken, M . R., 33-45 Lomant , A . J . , 389,396 Lona i , P., 299, 306, 492, 496,

520,527, 536 Loor, F., 67, 72, 237, 263,272,

273, 778 Lord , E . , 666, 734 Los, W. R. T . ,426 Lotzovä, E . , 511,513,527,528 Lowenstein, L., 440 Lozner, E . C , 295, 296,306 Lucas, S. J . , 82 Lüderitz, 0 . ,236 Luther-Davies , S. M . , 778 Lut ter , L . C , 332,339

Luzza t i , A . L., 175-183, 504, 624

Lydyard , P. M . , 139-145,141, 244, 245

L y n c h , R. G. , 675, 835,874 Lyon , M . F., 781, 792

M

MacDermott , R. P., 72 MacDona ld , A . B . , 227, 324 MacDona ld , H . R., 75, 78 ,83 ,

237, 430,440, 514,528 M a c h , B . , 847, 852, 862, 874,

877, 886,888 MacLennan , I. C. M . , 307,324 Mack , C, 2 7 2 , 608 M a c K a y , I. R. ,203 Mage, R. G . 677-686,677,678,

679 , 682 , 6 8 3 , 6 8 5 , 6 8 6 , 6 8 1 , 6 8 8 , 6 9 2 , 6 9 6 , 697 , 698 , 733 , 8 1 8 , 8 3 5 , 842 , 845

M a i a , L. C. S. ,475 Ma i ze l , J . V . , 750, 758 Maize ls , N . M . ,860 ,862 Maize ls , R , 198, 752 Mäkelä, O., 1 7 5 , 2 8 2 , 2 2 5 ,

2 6 1 , 2 7 3 , 288 , 289 , 290 , 2 9 2 , 2 9 3 , 644 , 645 , 659 , 734 , 735-741, 7 3 5 , 736 , 737 , 738 , 739, 740, 742, 755 , 756 , 7 5 8 , 764 , 770, 779, 8 4 2 , 8 4 5 , 8 8 2 , 8 8 8 , 892, 902

Mäkelä, P., 4 0 1 , 4 1 4 Mak inodan , T., 758 Ma law is ta , S. E . , 785, 791 M a l e n k a , D. ,386, 396 Mande l , T. E . , 243, 250, 284,

322 Mandy , W. J . , 678, 686, 697,

803, 842,845 Man ia t i s , T . ,874 Man ju la , B . N . , 661, 665 M a n n , D. L . , 323-329, 3 2 9 ,

339 , 3 4 2 , 349 , 3 6 2 , 368 , 3 7 7 , 3 7 9 , 3 8 6 , 387-396, 387 , 3 9 5 , 3 9 6 , 4 0 3 , 425 , 427, 449, 452,454, 455

M a n n i k , M . , 170,273, 742 M a n n i n g , D . D . , 178,282, 248,

250 M a n n i n g , M . J . , 771, 778, 779 Mans , R. ,273 Manue l , Y., 368, 556 Maoz, A. , 113-118 Marbrook, J . , 559,562, 569 Marchalon is , J . J . , 193, 299,

2 4 3 , 261-273, 2 6 1 , 262 , 2 6 3 , 264 , 265 , 266 , 267 , 268 , 2 7 1 , 2 7 2 , 2 7 3 , 275 , 2 8 4 , 3 2 5 , 3 2 9 , 3 9 2 , 3 9 6 , 585,587, 779, 812,825

M a r c h e s i , V . T. , 59, 60 , 62, 362

Marcus , P. I.,82 Margol ies, M . , 627, 628, 644,

6 4 5 , 647-659, 648 , 649 , 650 , 654 , 655 , 658 , 659 , 685

M a r g u l i e s , D . F L , 781-791, 7 8 1 , 782, 783 , 784 , 785 , 786, 789,792

N A M E I N D E X 9 i

M a r k s , P. A . , 874 M a r o n , E . ,623 M a r r , K . , 3 9 5 M a r r a c k , P . , 599, 605 , 609 ,

618, 6 2 2 , 623 M a r s h , D. G. , 4 5 7 , 4 6 3 , 636 Marshak , A . , 561 M a r s h a l l - C l a r k , S., 763 M a r t e l , J . L., 425,427 M a r t i n , J . W. ,402 Mason, D. W., 1 6 8 , 1 7 2 , 187,

190 Mason , S . , 2 7 2 Masters, B . , 2 7 2 , 608 Masuda , T . , 2 1 Mathews, M . B. , 697 Mathies , M . , 113-118 Math ieson , B . J . , 556 M a t h i e u , F . , 172 M a t t h y s s e n s , G . , 848 , 8 5 2 ,

877-889 Mat t i o l i , C S., 207,224 Maure r , P. H . , 3 1 , 3 0 6 , 457-

463, 4 5 7 , 4 6 2 , 4 6 3 , 4 7 4 , 4 7 5 , 5 0 4 , 5 4 4 , 623

Maure r , R., 862 Mauve , G . , 4 9 6 , 503 M a x a m , A . , 8 6 0 , 8 6 2 , 8 7 4 Mayhew, B . ,222 Mayor , K . S. ,237, 758 Mazauskas , C , 408, 410, 412,

424 McBr ide , R A. f 590,595 McBroom, C. R , 590,595 M c C a f f r e y , R. P. , 63-72, 63 ,

71,72 M c C a l m o n , R , 4 2 4 M c C a r t h y , M . M . ,569 M c C a r t y , M . , 286,293 M c C l u s k e y , R T . ,224 McConnach ie , P. R , 4 2 7 McConne l l , I., 185,292 M c C o r m i c k , J . N . , 4 5 , 2 0 0 ,

2 1 4 , 4 8 7 , 503 M c C u l l a g h , P . J . , 9 5 , 1 0 2 McCu l l o ch , E . , 1 2 9 , 1 3 7 , 4 1 5 M c C u n e , J . M . , 323,329, 339,

3 8 6 , 3 9 6 McDev i t t , FL O., 23, 32, 34,

4 4 , 1 1 7 , 1 2 6 , 1 2 7 , 2 7 5 , 2 8 4 , 295 , 2 9 8 , 2 9 9 , 3 0 5 , 3 0 6 , 3 6 4 , 3 6 8 , 3 6 9 , 374 , 3 7 5 , 3 7 7 , 3 7 9 , 3 8 6 , 4 5 2 , 4 5 5 , 4 6 5 , 4 7 4 , 4 7 5 , 4 8 7 , 489-496, 4 8 9 , 490 , 4 9 1 , 4 9 2 , 4 9 6 , 497-504, 4 9 7 , 500 , 5 0 1 , 5 0 2 , 5 0 3 , 5 0 4 , 543 , 5 4 4 , 5 9 5 , 5 9 7 , 6 0 8 , 613 , 6 2 2 , 6 2 3 , 8 4 5 , 898,902

M c D o n a l d , J . , 6 2 3 M c G a r r y , M . P., 237 McGhee , J . R., 245, 225 Mc lnnes , J . , 790 M c l n t i r e , K . R . ,845 M c K e a n , D . , 627 , 628, 631 ,

6 3 7 , 6 6 1 , 6 6 5 , 824 , 825 , 8 3 1 , 8 3 5 , 8 3 8 , 8 3 9 , 8 4 5 , 8 6 2 , 878, 885 ,888

M c K e a r n , T. J . , 261,273, 280,

284, 719, 723, 724 M c K e n n y , J . A . , 733 M c K e n z i e , I. F. C , 34,44,203,

113-118, 116 , 227 , 5 2 0 , 588

McKenz i e , J . , 407,424 McKeough , M. ,442 M c K u s i c k , V . A . , 417 , 418 ,

427, 454 M c L a u g h l i n , A . C , 636 M c L a u g h l i n , C. L., 645, 667,

6 7 5 , 686 McMas te r , P. R B. ,203 M c M i c h a e l , A . J . , 736, 742,

749 , 756 , 758, 7 6 3 , 770, 777, 779

M c M i l l a n , M . , 369-377, 398 M c W i l l i a m s , M . , 245 , 282,

283 , 290 , 292 , 299 , 200 , 202, 206,224

Meera K h a n , P., 4 2 6 , 455 Mees, J . R., 455 M e g s o n , M . , 237, 245 , 258,

1 6 1 , 2 6 2 , 1 9 1 , 2 4 3 , 2 5 0 Meier , FL, 845 Meinesz, A . , 4 4 0 M e l c h e r , I L , 1 4 3 , 2 4 5 , 176,

282 , 283 , 185, 290 , 292 , 194,299, 200, 365,368

Melchers , F. , 139, 245, 147-158, 147, 148, 149, 150, 152, 153, 155, 156, 257 , 258 , 160, 161, 262 , 163, 164, 264, 282, 187, 292 , 227-236, 228 , 229 , 230 , 2 3 1 , 232 , 2 3 5 , 2 3 6 , 249 , 2 5 0 , 288 , 4 1 0 , 4 2 4 , 754, 758

M e l c h e r s , I., 4 7 0 , 4 7 4 , 486, 487, 501, 503, 504

Melief , C. J . M . , 521, 527 M e l l i , M . , 866, 867,874, 885,

888 Me ln i ck , J . L . ,83 Me lvo ld , R W. ,527 Mempe l , W. ,418 , 419,427 Menck , FL, 463 Meo, T., 427, 440, 469, 474,

487 , 4 9 2 , 4 9 6 , 5 0 3 , 527 , 544

M e r c h a n t , B . , 727, 763,770 Mer l e r , E . , 792 M e r r y m a n , C . F . , 457-463,

457 , 458 , 459 , 4 6 2 , 4 6 3 , 466 , 4 6 8 , 4 7 4 , 4 7 5 , 501 , 503,504

Mestecky, J . , 225 Metealf, D., 9, 22, 129, 237,

2 2 9 , 2 3 6 , 237 , 2 3 9 , 2 4 3 , 245 ,247 ,248 ,250 , 322

Metealf, E . S., 140, 141, 245, 160, 1 6 2 , 165-173, 165 , 168,272, 189,292

Metz , D. FL, 535, 536 M e t z g e r , H . , 6 2 7 , 6 3 4 , 6 3 7 ,

709 , 727, 720 , 724, 727 , 734

M e t z l e r , C . M . , 4 4 , 88, 226, 503

Meyer , B . ,862 Michae l , A . , 4 2 6 Michael ides , M . C , 723, 724 Michae lsen, T. E . , 200 Micha l ek , S., 245, 207,225 M i che l , M . , 307,324, 657,659,

736,742, 756,758 Micke lson , E . , 426 M i g g i a n o , V . C . , 4 1 4 , 4 2 6 ,

4 4 0 , 4 4 1 , 4 4 8 , 4 5 4 , 4 5 5 ,

474, 527, 544 M i l g r om, F., 466, 470,475 M i l i l i , M . , 666 M i l l e r , A . , 3 0 6 , 474 M i l l e r , E . J . , 697 M i l l e r , F., 727, 734 M i l l e r , G , 73, 83, 443, 444,

455 M i l l e r , H . C , 59, 62,224 M i l l e r , J . F. A . P., 30,32, 202,

203 , 113, 116, 228 , 226, 2 3 6 , 2 4 3 , 2 5 0 , 2 7 3 , 3 1 4 , 3 2 1 , 4 5 1 , 4 5 5 , 4 7 4 , 4 7 5 , 539, 5 4 0 , 5 4 4 , 559 , 560 , 5 6 2 , 5 6 8 , 5 6 9 , 5 7 7 , 5 7 8 , 579-588, 579 , 580 , 582 , 583 , 584, 5 8 5 , 5 8 7 , 588 , 6 1 1 , 618, 619 , 6 2 1 , 623 , 891,902

M i l l e r , O. J . , 4 5 3 M i l l e r , R. G., 226, 135, 136,

237, 244, 257, 528 M i l l e r , S. D . , 105-111, 105,

106,107,222 M i l l e r , T. B . ,454 M i l n e r , R J . , 3 4 9 , 351-362,

362 , 368 , 377 , 454 , 547-557, 550, 556

M i l s t e i n , C , 175, 282, 641 , 6 4 4 , 6 4 5 , 6 6 4 , 6 6 5 , 686 , 695 , 697, 758, 7 8 1 , 787 , 788 , 789 , 790, 793-803, 793 , 794, 795 , 796 , 797 , 798, 799 , 8 0 1 , 8 0 2 , 8 0 3 , 818 , 819 , 8 3 3 , 8 3 4 , 8 3 5 , 8 4 0 , 8 4 5 , 8 4 7 , 8 5 3 , 8 5 5 , 8 5 6 , 8 6 2 , 8 6 3 , 8 7 4 , 877 , 885, 886,887, 888

M i l s t e i n , C. P. ,803 Minowada, J . , 447,455 M in t z , B. , 781, 790, 901,902 M i she l l , R L , 86,92, 252,259,

569, 750, 758 M i s r a , D . N . , 2 7 2 , 2 7 3 Mi tche l l , G. F., 95, 101, 202,

113, 228 , 255 , 2 5 7 , 2 5 9 , 496

Mi tch ison , N . A. , 85, 92, 257, 2 5 9 , 589-595, 5 9 0 , 592 595, 891,902

M i u r a , M . , 824 M i y a k a w a , Y. , 341,342 M i yake , T . ,227 Miyazawa , M . , 32 , 824 Modabber, F. , 273, 609 M o h i t , B . , 7 8 8 , 789, 792 Mole, L. E . , 3 4 8 , 3 6 1 , 3 6 8 , 3 7 7 ,

655 , 659 , 667 , 674 , 682 , 6 8 4 , 6 8 6 , 690 , 6 9 1 , 6 9 7 , 743, 748, 847, 852, 853

Mol ineux , L , 72 Möller, E . , 150,257, 221,225,

226, 228,236 Möller, G., 85, 92, 147, 257,

217-226, 2 1 7 , 218 , 219 , 220, 221 , 2 2 4 , 2 2 5 , 226 , 2 2 7 , 2 3 6 , 248 , 2 4 9 , 2 5 0 , 2 5 6 , 2 5 9 , 268 , 2 7 0 , 2 7 3 , 4 6 1 , 4 6 2 , 4 6 3 , 5 1 9 , 5 2 7 , 752, 755, 758

Moloney, J . B . , 163,264 Molony, W. C.,292 Monahan, J . J . , 856, 862 Montgomery, P. C , 637, 763,

770, 777, 779 Montgomery, R , 57,62 Monty , K . J . , 380,386 Moore, G . E . ,283 , 455 Moore, G . W., 639, 645 Moore, M . A . S., 9, 22, 129,

131 , 1 3 4 , 2 3 7 , 245 , 248 , 250

M o o r h e a d , J . W. , 1 0 5 - 1 1 1 , 105, 108, 109,222, 770

Morag , A . , 225 Mor l i n g , N . ,427 Moroz, C , 262,273 Morr i s , J . E . , 658 Mor r i s , R. J . , 51-61,51,52,53,

62, 408,424 Morr ison, D. C , 219,225,226 Morr i son , M . , 901,902 Morr i son , S. L. , 781-791, 781,

786, 787,792, 793,803 Morse, H . C , 823 Mortensen, R. F., 48, 50 Morton, D. L., 590 Moscona, A. , 131,237 Moseley, J . M . , 261-273 Mosier , D. E . , 88,92, 97, 203,

189,292, 560, 561 Moss, K. , 534,536 M o u l i n , A . , 272 Mouton, D., 758 Mowbray, J . F., 262, 263, 264,

272 Moyer, S.,423 Mozes, E . , 125, 227, 251,259,

2 9 6 , 3 0 6 , 3 6 9 , 3 7 7 , 469, 4 7 5 , 4 9 1 , 4 9 6 , 5 8 7 , 617 , 618, 619,623, 624

Mudge t t , M . , 656, 659, 678, 686 , 6 9 5 , 6 9 7 , 8 1 0 , 8 2 5 , 847, 852, 853

Müllen, H . B. , 167,273 Müller, A. , 62 Müller-Eberhard, H . J . , 324,

452,455 Munkre s , K . D., 345, 347,349 Munro , A . J . , 23,32, 228, 119,

1 2 5 , 2 2 7 , 2 7 5 , 2 8 4 , 295 , 3 0 4 , 3 0 6 , 3 6 9 , 3 7 7 , 4 5 1 , 4 5 5 , 4 6 9 , 4 7 0 , 4 7 5 , 4 9 6 , 5 0 4 , 545 , 5 8 5 , 5 8 7 , 609 , 624, 625, 626

M u r a m a t s u , T., 411,424 M u r g i t a , R. A . , 315,322, 726,

734 Murphy , D. B. , 36 ,44 ,44 ,123,

125, 227 , 3 7 1 , 3 7 4 , 3 7 7 , 4 7 2 , 4 7 5 , 478 , 479 , 480, 482 , 4 8 3 , 485 , 4 8 6 , 4 8 7 , 4 9 2 , 4 9 6 , 4 9 7 - 5 0 4 , 498 , 499, 501,502,504

Musche l , R. ,82 M u s h i n s k i , E . B . , 1 7 3 , 2 1 4 ,

2 9 3 , 6 6 1 - 6 6 6 , 6 6 5 , 666 , 706, 707, 72 7, 724, 734, 748, 758, 835, 845, 852

Myers , FL, 845

N

N a b h o l z , M . , 25 , 4 3 9 , 4 4 0 , 4 5 5 , 474 . 5 2 0 , 5 2 1 , 523, 527, 540 ,544 ,545 ,624

Nacht iga l , D., 95, 203

lOi N A M E I N D E X

N a h m i a s , A . H . , 73,83 Naidorf , K . F., 85-91, 87 N a k a m u r a , F . T . , 788, 789 ,

790 N a k a m u r a , I., 2 0 2 , 2 1 5 Nakamuro , K. , 3 2 6 , 3 2 9 , 331,

3 3 9 , 3 4 1 , 3 4 2 , 3 5 1 , 3 6 1 N a k a s h i m a , Y. , 639, 640 Narash im ikas , S. ,424 N a s h , D . R. ,224 Na thans , D., 8 6 0 , 8 6 2 N a t h e n s o n , S. G . , 3 2 4 , 3 2 9 ,

3 3 1 , 3 3 8 , 3 3 9 , 343-349, 3 4 3 , 3 4 6 , 3 4 8 , 3 4 9 , 3 5 1 , 3 5 5 , 3 5 6 , 3 6 1 , 3 6 3 , 3 6 8 , 3 7 7 , 3 8 6 , 3 9 5 , 4 0 2 , 4 0 3 , 4 1 4 , 4 5 4 , 4 8 7 , 5 2 7 , 532 , 535 , 5 3 6 , 5 5 6 , 5 9 5 , 7 9 0 , 802

Na to r i , T., 343, 3 4 6 , 3 4 9 , 3 6 1 , 3 6 3 , 3 6 8

Natv i g , J . B . , 4 7 , 5 0 , 2 0 0 , 685 N a u , M . , 734, 8 5 2 , 8 6 2 , 8 8 8 N e a u p o r t - S a u t e s , C . , 3 2 1 ,

3 5 4 , 3 6 1 , 3 6 5 , 3 6 8 , 5 5 1 , 5 5 5 , 5 5 6

Nehlsen , S., 137 N e i m a n , P. E . , 83 Ne lson, D. L . ,454 , 455 Nev i l l e , D. M . , 783, 791 Newe l l , J . , 658 Newman , C , 536 Newton, J . T . ,803 N i a l l , H . D . ,8 , 3 6 1 , 9 0 2 Nicho ls , W. W. ,455 N i c h o l s o n , G . L . , 270 , 2 7 3 ,

410,424 Niederhuber , J . E . , 2 4 9 , 2 5 0 ,

3 0 1 , 3 1 4 , 3 7 7 , 477-487, 478 , 482 , 4 8 3 , 4 8 7 , 500 , 5 0 3 , 504

Nie lsen , L. S.,442 N i l s on -Hami l t on , M . , 408 N i l sson , B . S., 151,258 N i l sson , K . , 339 , 446,454 Nisbet , N . W., 559, 561 Nish i zawa , Y. , 127 Nis i zawa , T., 343-349 Nisonof f , A . , 2 8 5 , 2 9 3 , 307,

3 1 4 , 6 4 5 , 6 5 8 , 6 8 8 , 6 9 6 , 699-707, 6 9 9 , 700 , 7 0 3 , 7 0 6 , 7 0 7 , 719 , 722 , 7 2 4 , 725 , 733 , 734 , 792 , 8 3 4 , 847-853, 850 , 8 5 1 , 8 5 2 , 853

No rd in , A . A . , 177, 282, 2 3 6 , 2 4 5 , 2 5 0 , 1 1 0 , 7 1 7 , 797 , 8 0 3 , 902

Nord l ing , S . , 237 ,495 N o r m a n , B . , 734, 8 5 2 , 8 6 2 ,

888 Nor th , A . C. T., 636 N o r t h , J . R., 193, 198, 199,

749-759, 749 , 750 , 7 5 1 , 752, 758

Nossal , G J . V . , 115,227, 139, 140, 1 4 1 , 2 4 5 , 1 4 8 , 2 5 7 , 160, 1 6 2 , 2 6 2 , 1 6 6 , 2 7 3 , 1 1 1 , 1 8 2 , 1 8 9 , 1 9 1 , 2 3 6 , 237-243, 237 , 2 3 8 , 2 3 9 , 2 4 1 , 2 4 2 , 2 4 3 , 2 4 9 , 2 5 0 , 2 5 1 , 2 5 7 , 2 5 9 , 2 6 2 , 2 7 2 , 2 7 3 , 4 4 1 , 755 , 758, 783 , 792, 892, 894, 902

No tan i , G. ,293 Not tenburg , C , 38, 272, 835,

845 Novotny, J . , 8 4 8 , 8 5 2 , 853 N o w a k o w s k i , M . , 73-83, 75,

77,82, 83 Nowe l l , P. C , 15 ,22 , 29, 30,

3 1 , 2 8 4 , 4 5 5 , 5 2 7 , 561 N o w i n s k i , R. C , 550,556 Noyes, A . N . ,395 N u n n , M . E . , 517, 536 Nussenzweig , V . , 284 , 324 Nut t , N . B. , 777, 779

O

O'Br i en , C. ,442 O 'Daly , J . A. , 201,225 O 'Donnel l , J . , 874 Oettgen, H . F., 32, 83, 587 O 'Far re l l , P. FL, 387,396 Ogra, P. L., 201,225 Ohms, J . J . , 6 5 8 Ohno, S., 8 4 7 , 8 5 3 , 882,888 O h n u m a , T . ,455 Ojeda, A . , 3 0 6 , 4 0 2 , 6 0 9 Okada , Y. , 797,803 O k u m u r a , K. , 32, 33-45, 34,

3 5 , 36 , 3 7 , 4 4 , 1 2 5 , 2 2 6 , 227 , 290 , 4 7 5 , 487 , 497-504, 498 , 5 0 1 , 5 0 2 , 5 0 3 , 504, 609

O k u y a m a , T., 252,259 Olander , J . , 171,2 73,833,835 O ld , L. J . , 32, 62, 159, 262,

407 , 4 1 1 , 4 2 3 , 424 , 8 2 4 , 825

O ld ing , L. B . , 80 ,83 Oldstone, M . B. A . , 8 3 O l ins , D . E . , 388,396 Ol ive , C. ,22 O 'Ma l l ey , B . W . , 862 O 'Mal l ey , K . A . , 790 Oppenheim, J . J . , 74,83 Orbach-Arbouys, S., 92 Orda l , J . C , 491,496 Or io l , R , 666 O r k i n , S. FL, 787, 788, 792 Or lans , E . , 272, 778 Orme, T., 595 Or r , K . B . , 3 1 5 , 3 2 2 Or r i s , L . ,222 Or t lande l , F . ,339 Or t suka , E . , 72 Osborn, M . , 353,362 Osborne, B . A . , 33-45 Osborne, D. P., J r . , 612, 622,

623 Osmand, A . P . ,50 Osmond, D. G. , 134, 237, 139,

145, 1 6 2 , 2 6 2 , 2 4 1 , 2 4 3 , 249,250

Üstberg, L . , 3 2 9 , 331-339, 3 3 1 , 3 3 8 , 3 3 9 , 3 6 0 , 3 6 2 , 3 6 3 , 3 6 8 , 3 7 7 , 4 1 1 , 4 2 3 , 424

O s t e r l a n d , C . K . , 690 , 697 , 724

Oudet, P . ,888 Oud in , J . , 285,293, 307,324,

6 5 7 , 6 5 9 , 6 8 2 , 6 8 6 , 687 , 688 , 689 , 6 9 0 , 6 9 7 , 736 , 742, 756, 758

Ova ry ,Z . , 293, 770

Owen, F. L., 699-707 Owen, J . J . T . , 38,44,129-137,

130, 131 , 132, 134, 237 , 245 , 1 5 6 , 2 5 8 , 159, 160, 1 6 1 , 2 6 2 , 1 9 1 , 2 4 3 , 2 5 0 , 407, 411,424, 803

Ozer, FL, 225

Packman , S., 734, 852, 8 6 2 , 888

Pad lan , E . A . , 627-637, 627, 628 , 636 , 637 , 6 4 5 , 648 , 659 , 6 6 1 , 6 6 6 , 683 , 684 , 685 , 686 , 734, 748, 818 , 835, 902

Pae tkau, V . FL, 252, 253,259 Palade, G., 411,424 P a l m , W., 636, 674 Pa lmer , J . , 253,259, 563,570 P a n a g i o t o p o u l o s , N . , 3 3 9 ,

645, 674 Pantelouris , E . M . , 132, 237 Papaioannou, V . E . , 9-21 Paranjpe, M . , 595 Paraskevas, F. , 315,322 P a r h a m , P . , 323-329, 324 ,

3 2 5 , 3 2 9 , 3 3 2 , 3 3 9 , 3 4 2 , 3 4 9 , 3 6 1 , 3 6 8 , 3 7 7 , 3 8 6 , 396, 455

Pa r i sh , C. R , 34,44, 237,243, 307,324

Pa rk , W., 273 Parker , D. C , 248,250 Parker , J . C. ,463 Parkhouse, R. M . E . , 44 , 143,

244, 1 7 6 , 2 8 2 , 185, 186, 187, 290 , 292 , 193-200, 193, 194, 1 9 5 , 2 9 9 , 262 , 266 , 2 1 0 , 2 7 1 , 2 7 2 , 365 , 368, 383,386

P a r k m a n , R , 72, 787, 788 , 792

Par lev l ie t , J . , 426 , 427, 455 Passmore, H . C . ,377 Pat r i ck , R.,324 P a u l , W. E . , 2 3 , 3 2 , 3 6 , 4 4 ,

203 , 142, 244 , 245 , 170, 2 72, 290, 1 9 1 , 2 0 0 , 2 7 2 , 2 9 5 , 3 0 6 , 3 1 4 , 3 7 7 , 398 , 4 0 1 , 4 0 2 , 4 0 2 , 4 0 3 , 4 7 4 , 4 7 5 , 487 , 571-587 ,578, 587 , 5 9 0 , 5 9 5 , 622 , 623 , 719 , 720, 722 , 723 , 724, 763, 764, 770

Pau l i ng , L., 631,637 Paw lak , L. L., 286 ,293, 700,

701, 702, 706, 707 Payne, R , 343 Pearson, P. L . ,453 Pearson, T., 799 Peavy, D. L . , 32 , 92, 290, 487 Pecht, I., 627-637, 627, 634,

637, 667-675, 674, 675 Peck, A . B., 439,440, 527 Pel legr ino, M. ,426 , 454 Pemberton, R. ,874 Pena , A . S.,454 Perey, D. Y . E . , 202,223,224,

225 Pe rham, R. M . , 837,845 P e r i m a n , P., 788, 799, 792,

803

Perk ins , E . FL, 755, 758 Pe r lmann , FL, 324 P e r l m a n n , P., 313,324 Pern is , B . , 38, 39,42,44, 143,

245 , 163, 164, 264, 175-183, 175, 176, 177, 178, 180, 1 8 2 , 2 8 2 , 283 , 185, 292 , 1 9 4 , 1 9 9 , 2 0 0 , 2 4 3 , 2 6 6 , 2 7 3 , 783 , 792, 802 , 803, 882,888

Per ramon, A . , 686 P e r s i j n , G . G.,426 Persson, U . , 221,225,226 Pes tka , S., 790 Peter, H . - H . 62 Peterson, J . A. , 785, 792 Peterson, P. A., 326,328,329,

331-339, 331 , 332 , 3 3 3 , 3 3 7 , 3 3 8 , 3 3 9 , 3 4 9 , 3 5 1 , 3 6 2 , 3 6 3 , 3 6 8 , 3 7 2 , 3 7 7 , 423, 424, 639, 645, 674

Petitprez, A . ,324 Pe t rany i , G. ,528 Petz, L . D., 595 P f i z e n m a i e r , K . , 507 , 520 ,

5 2 3 , 5 2 7 , 5 2 9 , 5 3 6 , 5 4 1 , 545, 547, 553,556

P f l umm, M . N.,824 Phanuphak , P , 105, 106, 222 Ph i l l i p s , D. C. ,636 Ph i l l i p s , D. R , 901,902 Ph i l l i p s , J . M . , 195, 299, 307,

3 2 4 , 735 , 742, 750 , 758, 776, 779

Ph i l l i p s , R. A., 226, 136, 237, 244 , 245 , 147-158, 147 , 1 5 6 , 2 5 7 , 258, 1 6 2 , 2 3 6 , 518

P h i l l i p s - Q u a g l i a t a , J . , 1 4 5 , 1 8 2 , 1 8 3 , 1 9 1 , 1 9 9 , 2 0 0 , 2 1 4

Phizacker ley , R. P. ,377, 637, 639-645, 645 , 659 , 666 , 675, 835

P iazza, A . , 430,442 P i ckard , A . ,273 P i cke l , H . G , 2 7 2 , 608 P i cke raL S.,402, 571-578 Pierce, C. W., 25, 30 ,32 , 88,

9 1 , 1 0 2 , 1 2 6 , 1 4 2 , 1 4 5 , 1 6 8 , 2 73, 1 7 8 , 2 8 3 , 290 , 198, 299 , 4 7 4 , 4 7 4 , 475 , 483 , 4 8 7 , 504 , 563-570, 5 6 3 , 564 , 565 , 566, 5 6 1 , 5 6 9 , 5 7 0 , 5 1 1 , 5 7 8 , 597 , 607 , 609, 618, 619, 622, 623

Pierce, N . F., 202,225 P i e r c e , S. K . , 145, 165-173,

168, 273 , 491 , 496 , 563 , 570 , 598 , 6 0 8 , 6 0 9 , 6 1 3 , 614,618,623

Pierson, G . R.,562 Piessens, W. F., 185, 292 Piette, L . FL, 637 P ike , B . L. , 139,140,141,245,

148, 257 , 1 6 0 , 2 6 2 , 166, 2 73, 189, 292, 237-243, 894,902

P i l a r s k i , L . M . , 764, 765, 766,

767,768, 770 P incus , J . FL, 697, 733 P i n k , J . R. L., 167, 273, 777,

778, 779

N A M E I N D E X Iii

P inker ton , W. ,778 P i r o f s k y , B . , 1 9 0 , 1 9 9 Pisano, J . J . , 3 4 2 Pisetsky, D. S., 295-306 P la ta , F., 547,556 P la t t , T . ,396 P la t z , P . ,427, 441 Playfa ir , J . H . L . ,322 , 763 P l o e m , J . S . ,427 Poh l , S. L . ,272 Po lak , L., 106,212 P o l i s k y , B . , 5 3 5 , 5 3 6 Poljak, R. J . , 372, 377, 627,

628 , 6 3 2 , 6 3 5 , 6 3 6 , 637 , 639-645, 639 , 6 4 0 , 6 4 2 , 6 4 3 , 644 , 644, 6 4 5 , 647 , 648 , 649 , 658, 6 5 9 , 6 6 1 , 666 , 6 7 3 , 675 , 7 4 3 , 748 , 818, 833 ,834 ,835

Po lsky , F., 862 Pontecorvo, G., 782, 792 Pope, H . , 1 1 8 , 5 4 5 , 6 0 9 , 6 2 4 Porter, L . ,442 Porter, R. R., 307, 324, 659,

667 , 6 7 4 , 686 , 6 9 7 , 748, 853

P o s k u s , E . , 802 Pospis i l , M . , 4 2 6 P o t t e r , M . , 67. 70 , 7 2 , 163 ,

264 , 1 7 3 , 2 0 5 , 2 1 4 , 2 1 5 , 2 8 5 , 2 9 3 , 294 , 6 2 7 , 634 , 636 , 6 3 7 , 645 , 6 5 8 , 659 , 661-666, 6 6 1 , 6 6 2 , 6 6 3 , 664 , 6 6 5 , 666, 6 8 6 , 688 , 7 0 6 , 7 0 7 , 709 , 72 7, 719 , 7 2 4 , 7 2 5 , 727, 730 , 7 3 1 , 733, 734 , 735 , 736 , 742, 744 , 7 4 8 , 755 , 758 , 790 , 7 9 4 , 8 0 3 , 8 1 1 , 8 2 5 , 8 2 1 , 8 2 2 , 8 2 6 , 8 3 0 , 8 3 5 , 8 3 6 , 837 , 8 4 0 , 8 4 5 , 8 5 2 , 8 6 2 , 888, 889

Potts, J . T., 3 6 1 , 9 0 2 Pou l i k , M . D., 329, 339, 357,

3 6 2 , 363-368, 3 6 3 , 392 , 396, 426, 695, 697

Poulsen, K . , 667, 675 Poul ton , P . ,609 P r a h l , J . W., 690, 691, 697,

762, 770 Pra t t , D. M . , 691,697 P r e m k u m a r , E . , 68, 72, 163,

264, 883,888 Prendergast, R. A. , 225 Press, E . M . , 636, 667, 673,

675 Press, J . L . ,44 , 142, 244, 165,

166, 168 , 170, 2 72, 204 , 2 0 6 , 2 2 4 , 2 4 5 , 2 5 0 , 377 , 489-496, 489 , 4 9 0 , 4 9 1 , 4 9 2 , 4 9 6 , 501 , 5 0 2 , 5 0 4 , 6 1 3 , 6 1 5 , 6 1 7 , 6 2 2 , 6 2 3 , 6 4 5 , 6 8 5 , 728, 726 , 733, 7 6 3 , 770 , 818 , 8 2 1 , 822 , 835

P r e s s m a n , D . , 4 5 , 1 8 3 , 3 2 9 , 3 3 9 , 341-342 , 342 , 3 4 9 , 3 6 1 , 3 6 8 , 675, 779

Preud 'homme, J . - L . , 178,283, 755,758, 790, 7 9 1 , 8 0 3

Pr ice , N . C , 636 P r i m i , D. , 224,225 Pr i tchard-Br iscoe , H . , 93-103

Pross, FL, 528 Pross, S. FL, 773, 779 Proudfoot, N . J . ,835 ,862 ,888 P tak , W. P , 85-91, 87, 88,92,

105,222 Ptashne, M . , 860, 861,862 Purce l l , R. FL, 225 Pye, J . , 2 5 9 , 3 1 4 , 3 2 1 , 5 8 7

Q

Quin tans , J . , 235,236, 72 7

R

Rabbi t ts , T. FL, 7 9 3 , 8 0 3 , 833, 8 3 5 , 8 4 7 , 8 5 3 , 8 5 5 , 8 6 2 , 8 6 3 , 8 6 9 , 8 7 4 , 8 8 3 , 885 , 888

Rabel l ino , E . , 236 Rabste in, L . S., 163,264 Race, R , 410,424, 417,427 Rad i , J . , 244, 282, 290, 299 Radola , B . J . , 700, 707 Radovich, J . , 442 Radz imsk i , G., 658 Raff, M . C . , 1 1 , 2 2 , 29 ,32 ,44 ,

5 1 , 6 2 , 8 6 , 9 2 , 130 , 135 , 136, 237 , 139 , 140, 245 , 147, 155, 156, 258 , 159-162, 159 , 160, 161 , 162 , 262 , 175, 283 , 189, 191 , 2 4 1 , 2 4 3 , 2 4 8 , 2 5 0 , 407 , 4 1 0 , 4 1 1 , 4 2 4 , 5 5 6 , 8 8 2 , 888

R a i c h , P . C.,442 Rajewsky, K. , 29, 30 ,32 , 98,

203 , 1 1 6 , 2 2 7 , 2 6 1 , 2 7 2 , 2 8 4 , 285-294, 2 8 5 , 286 , 287 , 288 , 289 , 290 , 292 , 2 9 3 , 3 0 0 , 3 0 6 , 3 1 5 , 3 2 2 , 4 7 0 , 4 7 4 , 4 8 6 , 4 8 7 , 5 0 1 , 5 0 3 , 5 0 4 , 5 4 4 , 5 8 5 , 586 , 5 8 7 , 597 , 608 , 6 1 2 , 618 , 619 , 622 , 6 2 4 , 714 , 72 7, 812,824

R a l p h , P , 245-250,250, 424 R a m a c h a n d r a n , G . N . , 628,

637 Ramakr i shnan , C , 628, 637 Ramasamy, R., 249,250 Ramirez , F., 874 Ramseier , FL, 275, 2 8 4 , 285,

293, 508,520, 811,825 Ramshaw, I. A . , 556 Rao, D. N . , 661-666, 663 Rao, K . V . , 874, 888 Rapson, N . T . ,595 R a s c h k e , W. , 9-22, 20 ,2 72,

645 , 658 , 748 , 8 0 2 , 8 2 4 , 835, 845, 852, 862, 888

Rask, C. S . ,377 Rask, L., 226, 329, 331-339,

3 3 1 , 332 , 3 3 3 , 3 3 7 , 3 3 8 , 3 3 9 , 3 4 3 , 3 4 9 , 3 6 2 , 3 6 3 , 3 6 8 , 3 7 7 , 4 1 3 , 4 1 4

Rassu l in , Y . A . , 536 Raushwerger, J . W., 511,528 Rav i tch , M . M . , 202, 250 Rawls , W. E . , 83 Ray, A . , 225, 644, 658 Read, S. E . ,272 Reempsma, K. , 426 Reese, R. T., 106,222

Rehn ,T . G . , 3 2 , 1 1 8 , 3 6 1 , 511-518 ,527 , 529 , 5 3 4 , 5 3 6 , 545 , 5 5 6 , 5 6 1 , 5 7 0 , 5 7 8 , 587, 598, 609, 624

Reichert, A . E . , 297,306 Reif, A . E . , 51, 52, 53, 59, 61,

163,264, 407,424 Rein isch, C. L . , 290 Reinsmoen, N . ,426 Reisfeld, R A . , 368 , 503, 686,

695, 697 Reisner, FL, 792 Re i therman, R W., 60, 62 Rejnek, J . , 677-686, 686 Reske, K . , 349

3 5 1 - 3 6 2 , 3 6 1 , 3 6 8 , 377, 4 5 4 , 556

I tevi l lard, J . P . ,324 Reynolds, J . A . , 59, 60,62 R h i m , J . S. ,402 R i b l e t , R. J . , 1 0 2 , 147, 151,

1 5 8 , 1 7 2 , 2 1 8 , 2 2 6 , 248 , 250 , 2 8 6 , 2 9 3 , 6 4 5 , 647 , 658 , 659 , 725 , 734, 748 , 802 , 824 , 8 2 1 , 8 3 5 , 837-846, 8 4 1 , 8 4 3 , 8 4 5 , 8 4 6 , 852, 862, 888

Rice, S . A . , 293 R ieh , R. R , 483,486,487, 607,

609, 611,624 Rieh, S. S., 486,487, 607,609 Richards, F . F., 636, 644, 658,

723, 724, 777 , 779, 834 , 8 3 4 , 8 3 5 , 847,853

Richards, F. M . , 380,382,384, 386, 387 ,389 ,396

Richardson, A . , 497, 504 Richardson, D. C , 645 Richardson, J . S., 639, 645 Richardson, M . , 874, 888 Richter, R. F . ,272 Richter, W. ,225 Rieber, E . P., 262, 263,273 Riesen, W. F. , 665, 666 Riethmüller, G. , 262,263,273 Rijder, L . P . ,427 Rijnbeek, A . , 474 , 527, 544 Rimmer , T. T., 778 Ringden, O., 221,226 Rittenberg, M . B. , 202, 598,

609 Risso, A. , 282 Rivat , C , 686 Rivat , L., 678, 686 Robb, R , 323-329, 326, 329,

339, 386, 396 Robberson, D. L., 862 Robbins, J . B . , 201,223 Robbins, J . FL , 74,83 Roberts, I. M . , 102,203 R o b e r t s o n , S. M . , 201-215,

201,208, 209 ,223 ,225 Robineaux, R. ,324 Robinson, J . FL, 129-137, 134

237 Robinson, P. J . , 380,386 Robyns, E . ,362 Rocca-Serra, J . , 272 , 663,664,

666 Roche, R. S. ,675 Rockey, J . FL, 634,637 Rodbeli , M. ,272 Rodkey, L. S., 285, 293, 719,

723,724

Rodkey, S., 6 8 5 , 697 Rodt, FL, 520, 527, 536, 545,

556 Roelants, G . E . , 37,44, 67, 72,

134,237, 262 ,273 ,758 Roger, J . FL, 425,427 Rogers, J . , 3 9 6 Roholt, O. A . , 658, 675 Roitt , I. M . , 203 ,324 , 386 Rol ley, R. T., 267,273 Röllinghoff, M. ,442,520,527,

536, 545, 556 Romano, T., 81 Rongey, R. W. ,463 Ropartz, C., 686 Rosan, R. C . ,83 Rose, N . R , 99, 203 Rosemblatt , M . , 658, 659, 685 Rosen, S. D.,62 R o s e n b e r g , N . , 70 , 72, 163,

264 Rosenberg, S. A. , 393,396 Rosenstein, R. W., 724, 779,

835, 853 R o s e n s t r e i c h , D . L . , 74, 83 ,

572, 578 Rosenthal , A . M . , 74,83 Rosenthal , A . S., 23, 24, 27,

30 ,32 , 300,306, 474,475, 5 2 2 , 5 2 7 , 5 3 9 , 5 4 5 , 563 , 568 , 570 , 5 7 1 - 5 7 8 , 5 7 1 , 574 , 576 , 577 , 5 7 8 , 5 7 8 , 5 7 9 , 5 8 7 , 597 , 6 0 7 , 6 0 9 , 611 ,613,624

Rosenthal , M . S., 73,82 Rossi , G . B. , 513,527 Rossow, P., 787, 790 Roth, J . A . , 590 Roth, J . R. ,790, 803 Rougeon, F., 852, 869,874 Roux, M . E . , 758 Rowe, D. S., 39 ,45 , 143, 245,

175, 176, 283 , 185, 186, 292 , 1 9 3 , 2 0 0 , 2 4 0 , 2 4 3 , 266,273

Rowe, W. P , 72, 264 R o w l a n d s , D . T . , 773 , 779,

821,835 Rowley, D. A. , 245, 262, 292,

707, 728 Roya l , S., 244 Rüben, L. N . , 261,273, 778 Rüben, T. J . , 94,203 R u b i n , A . S., 126, 227 R u b i n , B . , 527, 618, 619, 645 Rubinste in , A . , 82 Rub ins te in , F . , 4 2 6 , 427 Rüde, E . , 466 , 470,474 Rud iko f f , S . , 1 7 3 , 2 1 4 , 2 9 3 ,

627 , 637 , 6 4 5 , 658 , 659 , 6 6 1 - 6 6 6 , 6 6 1 , 662 , 6 6 3 , 665 , 666 , 686 , 724, 725-734 , 725 , 727 , 730 , 731 , 733 , 734, 744 , 748, 758, 827, 830,835, 845, 852

Rudz ik , O., 207 ,223 ,225 R u h l , R , 257 Russe l l , A . S.,202 Russe l l , E . S., 237 Russe l l , P . ,259 Russe l l , W. C , 530,536 R u t i s h a u s e r , U . , 258, 2 73,

288 , 2 9 0 , 2 9 3 , 645 , 779, 902

12i N A M E I N D E X

R y a n , J . L., 249,250 Ryden, A. , 237, 273 Ryder, L . P. ,442 Rynbeek, A . , 440 Ryser, J . E . , 139,245

S

Sachs, D. H . , 221, 249, 250, 2 9 4 , 295-306, 295, 296, 300, 304 , 305 , 3 0 6 , 307 , 3 2 4 , 3 1 5 , 3 2 2 , 3 3 9 , 3 7 7 , 3 8 4 , 3 8 6 , 4 7 4 , 479 , 480 , 4 8 7 , 4 9 6 , 500 , 5 0 1 , 502 , 5 0 3 , 5 0 4 , 5 3 6 , 5 9 1 , 5 9 5 , 734, 758, 825, 836

Sachs, J . , 3 8 5 , 454 Sado, T., 611, 613, 615, 617,

624, 758 Säfwenberg, J . , 331, 433,440 Saito, H . , 595 Sakato , N . , 712, 72 7, 719-724,

719 , 720 , 7 2 1 , 722 , 723 , 724

Sa l aman , M . R , 734 Salsano, P., 193,200 Samelson, L. E . , 32 , 527, 536,

5 4 4 , 5 5 6 , 5 6 1 , 6 2 2 Samurat , C , 307,324 Sandberg, L., 331-339, 331 Sanders, E . , 835 Sanderson, A . R., 47, 50, 323,

329 339 Sandford, B . H . , 534, 536 Sanger, R., 417,427 Sano, Y . , 5 3 6 Santer, V . , 273 Sarma, V . R., 639, 645 Sarvas, H . , 740 Satake, K. , 252,259 Sato, S., 707, 853 Sato, T . ,264 Sato, V . L . , 3 2 , 36,44, 500,504 Sato, W., 398,402 Sauer, R. T . ,862 Sau l , F., 377, 636, 637, 639-

645, 644 , 645 , 658 , 659 , 666, 675, 834, 835

Saxen, L. , 129,237 Schachner, M. ,396, 595 Schachter, FL, 424 Schacter, B . Z., 454 Scha r f f , M . , 4 1 0 , 4 2 5 , 7 5 5 .

758 , 7 6 3 , 770 , 781-791, 7 8 1 , 783 , 785 , 786 , 787 , 790, 792, 793,802, 803

S c h e c h t e r , A . N . , 295-306, 305, 306

Schechter, L , 593, 595, 847, 853, 877, 886,888

Scheid, M . P , 5-8, 5,8, 53,62, 67, 72, 133, 236, 237, 407, 424

Sche l l ek ens , P. T h . A . , 4 2 6 , 440

S c h e n d e l , D . , 8 3 , 3 6 1 , 4 3 3 , 434 , 4 3 9 , 4 3 9 , 440 , 536 , 607,609

Scher, C. D., 72, 163,264 Scher, W. ,264 Schier, P. FL, 292 Sch ierman, L. W., 590, 595 Schiff, C , 272 Sch i f f e r , M . , 3 3 9 , 628, 636,

6 3 7 , 6 4 2 , 645 , 649 , 659 , 673, 674, 675

S c h i l l i n g , J . , 817-836 S c h i m p l , A . , 1 1 5 , 2 2 7 , 228,

124 , 126 , 227 , 6 2 5 , 626 , 750, 758

S c h i r r m a c h e r , V . , 249, 250 , 307 ,324 , 527, 585 ,587

Schles inger , D. FL , 5 ,8 Schles inger , M . , 407,424 S c h i e s s i n g e r , J . , 667-675,

670, 671, 672, 674, 675 Sch lossman, S., 32, 72, 202,

2 9 0 , 3 9 5 , 3 9 6 , 4 4 2 , 4 7 4 , 5 0 4 , 5 4 0 , 5 4 3 , 5 4 5 , 567 , 570

S c h m i t t - V e r h u l s t , A . - M . , 511-518, 535 ,536 ,624

Schnute , W. C . ,293 Schoenberg, L . M . , 144, 245 Schräder, J . W., 37, 45, 251,

2 5 9 , 3 5 1 , 3 5 4 , 3 6 2 , 505 , 5 0 8 , 5 1 0 , 547-557, 547 , 5 4 8 , 5 5 0 , 5 5 1 , 5 5 2 , 553 , 554 ,556

S c h r a m m , FL J . , 636 Schreiber , R. D., 452 ,455 Schrek, R., 14,22 Schreuder, I . ,426 Schroer, J . , 733, 733, 734 Schui t , H . R . E . , 427 , 455 Schulenberg , E . P., 667, 675,

827 ,835 , 8 6 3 , 8 7 4 S c h u l l e r , R., 877-889, 883 ,

888 Schulof, R. S., 8, 237 Schul tz , L. D., 814,825 Schur , P . FL, 454, 673 ,675 Schwaber, J . , 787, 788, 789,

792, 833 ,835 Schwager , P . ,636 , 645 Schwartz , B . D., 333,339, 343,

3 4 9 , 3 5 3 , 3 6 2 , 3 7 4 , 3 7 7 , 3 8 4 , 3 8 6 , 397-403, 397 , 3 9 8 , 3 9 9 , 4 0 1 , 4 0 2 , 4 0 2 , 4 0 3 , 4 4 3 , 4 5 5 , 4 7 8 , 4 8 7 , 5 3 2 , 5 3 5 , 536 , 5 5 6 , 5 7 1 , 572 ,578

Schwartz , M . , 473,475 Schwartz , R. FL , 23, 32, 295-

306, 2 9 5 , 2 9 9 , 3 0 6 , 4 0 2 , 4 7 0 , 4 7 5 , 5 1 5 , 5 2 7 , 598 , 608

Schwartz , R. S . ,527 Scott, R. E . ,62 Scudel ler , G . ,556 S e a l , U . S . ,272 Sears, D . W., 343-349 Secher, D. S., 645, 665, 758,

793-803, 794 , 7 9 5 , 796 , 8 0 2 , 8 0 3 , 848,853

Seeger, R. D. , 74,83 Segal , D . M . , 627, 631, 636,

6 3 7 , 6 4 1 , 6 4 5 , 6 4 7 , 648 , 659 , 6 6 1 , 662 , 6 6 3 , 666 , 683, 686, 748, 835, 902

Segal , G . P . ,273 Segal , S., 489,503 Sega l l , M . , 440 Sege, K . , 329, 331-339, 339,

377 Segrest, J . R , 55,62, 270,271,

273, 354,362

Seide, R. K., 685, 697, 852 S e i d m a n , J . , 855-862, 856 ,

857 Sekhon, G. S. ,455 Sela , M . , 288, 293, 295, 306,

4 6 5 , 4 7 4 , 4 7 5 , 4 9 6 , 580 , 587 , 6 1 7 , 6 2 3 , 6 2 4 , 6 3 7 , 672, 674, 898,902

Seif, S., 244 Se l i gmann, M . , 44, 245, 178,

282, 283, 292 S e i l , S . , 2 8 2 , 267 , 2 6 8 , 2 7 3 ,

308,324, 609 Sendo, F., 595 Senik, A. , 73-83, 78 Seon, B. K., 667, 675 Sercarz, E . E . , 306 , 474, 773,

778 Sever, J . L . ,82 Shamborant, O. G. , 536 Sharon, J . , 667-675, 667, 675 Sharrow, S. 0 . , 595 Shaw, A. , 259 S h e a r e r , G . M . , 26 , 3 0 , 3 2 ,

116, 228, 2 5 1 , 2 5 9 , 295 , 3 0 5 , 306 , 3 5 1 , 3 6 2 , 369 , 377, 496 , 508 , 520 , 511-518, 511 , 512 , 513 , 528 , 5 1 9 , 5 2 7 , 529 , 5 3 4 , 5 3 6 , 539 , 540, 5 4 3 , 5 4 5 , 548 , 552 , 5 5 5 , 5 5 6 , 5 5 9 , 5 6 2 , 568, 570 , 5 7 1 , 5 7 7 , 5 7 8 , 5 7 9 , 5 8 7 , 5 9 7 , 6 0 9 , 613 , 614, 617, 623, 624

S h e e h y , M . , 4 2 1 , 4 2 6 , 427 , 430,440, 442

Shek, P. N. ,324 She lansk i , M . L . ,396 Shelton, E . , 261,273 Shelton, K . R , 269,273 S h e n , F . -W. , 23, 2 5 , 3 2 , 4 4 ,

203, 504 , 588 , 598 , 609 , 812,825

Shen, L . ,324 Sheppard, H . W., J r . , 267,273 Sher, A. , 167, 273, 294, 661,

666, 725, 734, 826,835 Sherwin , W. K., 821,835 S h e v a c h , E . M . , 264, 299,306,

3 1 7 , 3 2 2 , 3 7 7 , 397-403, 397, 4 0 1 , 4 0 2 , 4 0 2 , 4 0 3 , 4 7 4 , 4 7 5 , 5 2 2 , 5 2 7 , 539 , 545 , 563 , 5 6 8 , 5 7 0 , 571-578, 5 7 1 , 573 , 574 , 576, 577, 5 7 8 , 5 7 8 , 5 8 7 , 597 , 607,609, 611, 613,624

S h i h , C. Y. ,442 S h i k u , FL, 23,32, 83, 587 S h i m a d a , A . , 3 2 3 , 3 2 9 , 346,

349

Sh inn ick , C. J . , 368 Sh i o zawa , C , 251-259 ,259,

611 Sh i r a i , T . , 595 ShofTher, F . , 487, 504 Shortman, K., 236, 250, 253,

259, 563,570 Shortmann, K . ,442 Shoyab, M . , 888 Shreffler, D. C , 83, 226, 250,

2 9 7 , 3 0 6 , 324 , 3 3 1 , 336 , 339 , 343 , 3 5 1 , 354 , 359 , 3 6 2 , 368 , 369 , 3 7 1 , 374 ,

3 7 7 , 3 9 5 , 3 9 5 , 3 9 6 , 418 , 4 2 5 , 4 2 6 , 427 , 4 4 0 , 4 4 3 , 4 4 9 , 4 5 5 , 4 6 9 , 4 7 0 , 4 7 4 , 4 7 5 , 477-487, 4 7 7 , 4 8 6 , 4 8 7 , 4 8 9 , 4 9 1 , 4 9 2 , 4 9 6 , 4 9 7 , 4 9 9 , 5 0 1 , 5 0 3 , 5 0 4 , 5 2 0 , 5 2 7 , 5 3 9 , 5 4 4 , 579 , 587, 595, 611 ,614 ,623

Siddoway, L . A. , 387-396, 387 S idman , C. L. , 140, 245, 156,

258 , 159 , 160, 262 , 189, 292, 241,243, 248,250

Siegel, L. M . , 380 ,386 Siegler, R , 163, 264 S i g a l , N . F L , 165-173, 165 ,

166, 1 6 7 , 1 7 2 , 1 7 3 , 204 , 2 1 4 , 2 1 5 , 6 4 5 , 6 8 5 , 716 , 727, 728, 733, 821 ,835

S i l ver , J . , 331 ,339, 343, 344, 3 4 8 , 3 4 9 , 3 5 1 , 3 5 2 , 358 , 359 , 3 6 0 , 3 6 2 , 3 6 3 , 365 , 3 6 6 , 3 6 8 , 369-377, 3 7 0 , 371 , 372 , 3 7 3 , 3 7 7 , 398 , 4 0 1 , 4 0 2 , 4 0 3 , 4 1 1 , 4 2 4 , 4 5 3 , 4 5 5 , 5 2 3 , 5 2 7 , 682 , 686

Si lvers , W. K . , 284 S i lvers te in , A . M . , 894,902 Si lverstone, A . L. , 8 ,8 , 63-72,

65, 67, 68, 72 Si lver ton, E . W., 637,645,659 Silvestre, D . ,362 , 556 S i m i n o v i t c h , L . , 2 3 7 , 4 0 9 ,

424, 425 Simmonds, S. J . ,284,527,562 S imms, E . S., 636, 675, 724,

824, 835, 874, 888 Simons, K. , 335,339 Simonsen, M . , 284, 520, 527,

562 Simpson, E . , 3 1 , 4 4 , 94, 203,

114, 228 , 2 3 6 , 2 9 3 , 487 , 528 , 5 2 7 , 5 3 6 , 5 4 4 , 5 5 6 , 562 , 5 9 5 , 609 , 6 2 2 , 706, 727

S inc la i r , N . R , 315,322 Singer, P. A . , 72, 264 Singer, S., 410,424, 634, 636 S ingh , B . , 251-259 S ingh , U . , 129-137, 134,237 Sinsheimer , R. L . , 862 S i r i s i n h a , S. , 2 8 5 , 2 9 3 , 719,

720, 722, 724 S i sk ind , G. W., 170, 272, 755,

758, 763, 764, 770 Sjöberg, O. , 257 , 2 2 5 , 2 3 6 ,

252,259 Sjöquist, J . , 148,258 Skehe l , J . J . , 395,396 Skidmore, B . J . , 218,226, 620 Sk inner , M . A . , 559, 562 Sk la r , M . D., 72, 163,264 Slater, R. J . , 689, 697 Sly , W. S., 4 4 4 , 4 5 5 Sma l l , M. ,22 Smi th , C. B., 201,225 Smi th , D. F., 341-342,342 Smi th , E . , 219,225, 226, 529,

536 Sm i th , G . P., 688, 688, 805,

8 2 5 , 8 2 0 , 836 , 863-875, 870,872,874

Smi th , H . O., 860, 862

N A M E I N D E X 13i

S m i t h , M . J . , 867, 868, 869, 871,874

S m i t h , N . , 261,273 S m i t h , P., 261-273 S m i t h , P. G . , 82 S m i t h , W. L , 262, 263, 267,

273 S m i t h i e s , O., 3 5 7 , 3 6 2 , 363,

3 6 8 , 3 9 2 , 3 9 6 , 6 8 8 , 6 8 8 , 817,836

Smoler, D. F . , 72 S m y t h , D . G. , 6 1 7 , 6 8 5 Snary , D . ,329 , 333,339, 362,

379-386, 379 , 3 8 0 , 384 , 3 8 5 , 3 8 5 , 386 , 426 , 443-455, 443, 447,454, 455

Snegeröva, A . E . , 536 S n e l l , G . D . , 3 4 3 , 3 4 8 , 3 4 9 ,

4 0 7 , 4 2 4 , 474 , 4 7 8 , 4 8 7 , 4 9 7 , 5 0 4 , 5 2 4 , 5 2 7 , 530 , 536

Sogn, J . A „ 693, 694, 697 Soh l , A . , 224 So lhe im, B . G. , 365,368, 422,

426 ,427 Sol l iday, S. M . , 245, 273, 283,

299, 570 So l l i day -R ich , S., 611, 624 S o l l i n g e r . H . W. , 429-441,

438,442 So l omon , A . , 2 1 5 , 6 4 5 , 667,

675, 686 Solomon, E . , 424 , 453, 454 Sondel, P. M . , 427, 429-441,

4 2 9 , 4 3 0 , 432 , 4 3 3 , 434 , 4 3 5 , 4 3 6 , 4 3 9 , 4 3 9 , 4 4 0 , 4 4 1

S o p o r i , M . L. , 429,440,442 Sordat, B . , 83 Sorg, C , 268,273 S o r k i n , E . , 315,322 Sorvar i , T., 624 Soter iades -V lachos , C , 317,

322 Southern, E . M . , 870, 874 Spande, T., 637 Spea r , P . G . , 149 ,258 , 166,

2 73 , 7 7 3 , 779, 894 , 895 , 902

Spe i r s ,R . S . ,237 Spiegelberg, H . L., 194,200 Spiro , R , 410,424 Sp iva , D . ,262 Sprent , J . , 114,228, 2 2 7 , 1 3 7 ,

2 7 3 , 3 1 4 , 3 2 1 , 507 , 520 , 5 2 3 , 5 2 7 , 539-545, 539 , 540 , 5 4 2 , 543 , 5 4 4 , 5 4 4 , 5 4 5 , 559-561, 560 , 582 , 588, 609, 618, 621,624

S p r i n g e r , T . , 323-329, 323 , 3 2 6 , 3 2 7 , 3 2 8 , 3 2 9 , 3 3 9 , 3 7 4 , 3 7 6 , 3 8 6 , 387-396, 3 8 7 , 3 8 8 , 389 , 3 9 1 , 392 , 394 ,396 , 401,403

Staats, J . , 519,527, 809, 810, 825

Stadler , J . K . , 782, 792 Stafford, D . W., 878,888 Sta ines , N . A . , 127, 4 9 6 , 609 Sta l l i ngs , V . , 408, 409, 411,

412 ,424 , 522,527 S tankus , R. P., 732, 734 Stanley , P., 410,424

Stanton, T. FL, 363,368 Stark , O., 559,562 S tark , R , 52, 62 S t a r z i n s k i - P o w i t z , A . , 520 ,

527, 536, 545, 556 Staskawicz , M . O., 92 Staub-Nie lsen, L . ,427 , 440 Stavnezer, E . , 862 , 888 Stavnezer, J . , 855, 862, 877,

888 S t e c k , T . L . , 57, 59 , 60 , 62 ,

331 ,333 ,339 Steel, C. M , 4 5 4 Stefani, S., 14,22 Ste igemann, W., 636, 645 Ste in , G., 269,273 Ste in , J . , 2 7 3 Steinberg, A . G.,645, 678,686 Steinberg, C , 779, 836, 853,

862, 882, 888 Steinberg, L-Z. , 667-675,674,

675 Steinberg, M . , 258 Steinberger, FL, 674 Steiner, L. A. , 763, 770, 778 Stember, R. H . ,463 Stern , C , 185, 292 Stern , P. L., 53, 62 Sterz l , J . , 245,250, 894,902 Stevens, S. M . , 778 Stevenson, G. T., 772, 778 Stif fel , C , 758 S t i l l e r , C. R.,322 S t i m p f l i n g , J . FL , 297, 3 0 6 ,

3 4 3 , 3 6 2 , 4 3 9 , 4 6 3 , 466 , 4 6 9 , 4 7 4 , 4 7 5 , 487 , 497 , 5 0 3 , 504 , 5 1 1 , 5 2 7 , 536 , 590,595

St i t t , D . ,455 Stocker, B. , 407,424 Stocker, J . W., 237-243, 237,

2 3 8 , 241 , 2 4 3 , 2 4 3 , 2 5 0 , 261 ,264 ,273

S t o c k e r t , E . , 1 6 2 , 2 5 0 , 4 1 4 , 814

Stolen, J . S., 261,273 Sto lenheim, G., 258 Stone, H . A . , 8 Stoner, G. , 73-83,82, 83 Storb, R , 8 3 Storb, U . , 855,862, 883, 888 Storr ie , B. , 6, 7 ,8 Stout, R. D., 34, 38, 39, 45,

3 0 7 , 3 2 4 , 3 1 7 , 3 2 2 , 499 , 500, 502, 504

Straus, N . A . , 872,874 Strausbauch, P. FL, 636 Strayer, D. S., 140, 245, 160,

262 , 189, 292 , 7 0 1 , 707, 710, 728

Streis inger, G. ,803 Strober, S., 15 ,22 , 168, 273,

489 S t r o b e r , W. , 203 , 427 , 454 ,

455 S t r o m i n g e r , J . L . , 323-329,

326 , 327 , 3 2 8 , 3 2 9 , 333 , 3 3 9 , 3 4 2 , 3 4 9 , 3 6 1 , 3 6 8 , 3 7 7 , 384, 3 8 5 , 3 8 6 , 387-396, 387 , 388 , 389 , 3 9 1 , 392 , 393 , 3 9 4 , 3 9 6 , 4 0 3 , 455

S t r o s b e r g , A . D . , 645 , 649 , 650 , 655 , 656 , 658 , 659 ,

678 , 6 8 2 , 686 , 6 9 3 , 6 9 5 , 697 , 6 9 8 , 810 , 8 2 5 , 8 4 7 , 853

Stuart , F . P . ,284, 724 Studier , F . W., 387 ,396 S tu tman , O., 92, 134 ,237 Suc iu-Foca , N . , 418 ,426 , 427 Sug i ta , A . , 8 0 3 S u l l i v a n , J . L . , 82 Sultzer , B . M . , 151, 258, 225 Summers , D . F . , 83 , 423 Sutcl i f te, S., 73,83 Suther land , D. J . A . , 130,237 Svast i , J . , 797, 8 0 1 , 8 0 2 , 8 0 3 ,

885,888 Svejgaard, A . , 3 8 5 , 4 2 6 , 4 2 7 ,

4 4 0 , 4 4 1 , 4 5 3 , 454 Svedjelund, A . , 82, 2 2 5 S v e d m y r , E . , 430 , 4 4 2 , 527 ,

536 Swa in , S., 263, 273, 597-609,

598, 599, 605, 606, 609 Swan , D. , 734, 833, 836, 852,

855-862,862, 888 Swank, R. T., 345, 347 ,349 Sweet, G . FL, 699, 707 Sweet, V . C , 74,82 Szenberg, A . , 119, 1 2 6 , 1 8 2 ,

2 5 2 , 2 5 9 , 266 , 2 6 8 , 2 7 3 , 540,544, 710,72 7, 792

Tacey, S. E . , 727 Tacier-Eugster , FL, 182 T a c k , B . F., 685, 690 ,697 Tada, T., 23, 30,32, 33, 36 ,45 ,

106 , 2 2 2 , 119-127, 119 , 121 , 122 , 124 , 227 , 2 7 5 , 2 8 4 , 3 6 9 , 3 7 7 , 4 6 9 , 4 7 2 , 4 7 3 , 4 7 5 , 4 7 8 , 4 7 9 , 4 8 0 , 4 8 2 , 4 8 5 , 4 8 7 , 4 8 9 , 4 9 6 , 499 , 5 0 2 , 5 0 4 , 6 1 1 , 6 1 8 , 619, 624, 625, 626

T a d a k u m a , T. , 3 2 , 92 , 290 , 487

Tagaya, L , 529, 530, 535 ,536 Takag i , N . ,283 Takahash i , M . , 1 7 5 , 1 8 3 T a k a h a s h i , T., 32, 408 ,423 Takasug i , M . , 425 ,427 T a k e m o r i , T . , 3 2 , 222 , 119 ,

121,227, 2 7 5 , 2 8 4 , 4 7 5 T a l m a g e , D . W . , 4 3 8 , 4 4 2 ,

688, 723,724, 821 ,835 T a n f o r d , C , 3 3 3 , 3 3 8 , 6 7 4 ,

897 902 Tan i gak i , N . , 329, 339, 341-

342,342, 349, 3 6 1 , 3 6 8 Tan i guch i , M . , 3 2 , 33, 36 ,45 ,

2 2 2 , 119-127, 2 2 9 , 120 , 121 , 123 , 1 2 4 , 2 2 7 , 3 6 9 , 3 7 7 , 4 7 5 , 4 8 7 , 4 8 9 , 4 9 6 , 502 , 5 0 4 , 6 1 1 , 6 1 8 , 6 1 9 , 624, 625, 626

T a n i u c h i , FL , 305 T a n n e n b e r g , W . J . K . , 755 ,

758 T a n s , E . M . , 2 2 5 Tappimer , G. ,674 Ta r i kas , FL , 661, 666 T a u s s i g , M . J . , 2 3 , 3 2 , 229 ,

225 , 226 , 227 , 2 5 7 , 2 5 9 , 2 7 5 , 2 8 4 , 2 9 5 , 3 0 4 , 3 0 6 ,

3 6 9 , 3 7 7 , 4 5 1 , 4 5 5 , 469 , 4 7 0 , 4 7 5 , 489 , 4 9 2 , 4 9 6 , 5 0 2 , 5 0 4 , 5 8 5 , 5 8 7 , 598 , 6 0 8 , 6 0 9 , 6 1 8 , 6 1 9 , 6 2 4 , 625, 626

Taylor , B . A. , 293, 842, 843, 845

T a y l o r , R. B . , 98 , 1 0 1 , 2 0 2 , 203 , 258 , 1 5 9 , 2 6 2 , 209 , 224, 555,556

Teherani , J . , 678, 686 Teorey,T. , 874,874 Terasak i , P. L , 343, 449 T e r h o r s t , C , 323 -329 , 325 ,

3 2 9 , 3 3 6 , 3 3 9 , 3 4 1 , 3 4 2 , 3 4 4 , 3 4 9 , 359 , 3 6 0 , 3 6 2 , 3 6 7 , 3 6 8 , 3 7 1 , 3 7 2 , 3 7 7 , 3 8 6 , 3 8 7 - 3 9 6 , 387 , 388 , 392 , 393 , 3 9 5 , 3 9 6 , 4 4 3 , 453,455

ter Meu l en , V. , 531, 536 Termijte len, A. , 417-427,422,

426, 427, 440, 455 Ternynck, T., 679, 685 Terry, W. D., 245, 292, 200,

645, 686, 688, 835, 845 Thie le , H , - G , 52,62 Thierfelder, S. ,427 Thomas, C. A. , J r . , 878,888 Thomas, D. W., 571-578, 576,

577, 578 Thomas, E . D., 81 ,83, 426 Thomas, K . A . , 6 4 5 Thomsen, M . , 385, 420, 426,

427 , 4 3 0 , 4 4 0 , 4 4 2 , 4 5 3 , 454

Thomssen, R , 529-537, 529, 531,536

Thorbecke, G . J . , 2 7 3 T h o r s b y , E . , 3 6 5 , 3 6 8 , 418 ,

4 2 2 , 4 2 6 , 427 , 4 3 0 , 4 4 0 , 442

T h r a l l , C , 2 7 3 T h u n b e r g , A . L . , 659 , 6 9 2 ,

697, 851,852, 853 T i l l , J . E . , 237, 425 T i l l ack , T. W.,62 Tochina i , S., 771, 779 T o d d , C . W . , 6 8 5 , 6 9 0 , 6 9 6 ,

697, 803 Toivanen, A. , 624 Toivanen, P., 611, 614, 624 Tokuhisa , T., 227 Tomasi , T. B. , 201, 207, 224,

225 Tomasz, A . , 709, 728 Tomi ta , M . , 59, 60,62 Tonegawa, S., 725, 734, 778,

779, 8 2 1 , 8 3 3 , 8 3 6 , 838 , 8 3 9 , 8 4 6 , 8 4 7 , 8 5 2 , 8 5 3 , 8 5 5 , 8 6 2 , 863 , 864 , 865 , 866 , 867 , 868 , 8 7 0 , 8 7 5 , 8 7 7 - 8 8 9 , 877 , 878 , 882 , 883 , 884 , 885 , 8 8 6 , 8 8 7 , 888

Tonnel le, C. ,339 Tor r i g i an i , G., 102, 202, 203,

203,225 Tosi , R. M . , 677-686,679,685,

686 Tournefier, A . , 262, 270,272 Tourv i l l e , D. R , 201,225 Toy, S. T., 73, 83 Tracey, D. ,528

14i N A M E I N D E X

T r a i n i n , N . , 133 ,237 T rav i s , M . , 2 2 T r e f t s , P . E . , 5 9 7 - 6 0 9 , 599 ,

605, 606, 609, 751, 758 Trenkne r , E . , 248, 2 5 0 , 843,

8 4 6 T r e n t i n , J . J . , 129, 1 3 6 , 1 3 7 ,

5 1 8 T r i n c h i e r i , G . , 369 ,377 , 429,

4 4 1 , 5 1 0 , 5 5 6 , 5 8 7 Tr ip le t t , R. F . , 9 0 2 Tr ipp , M . , 4 5 4 T r i s h m a n n , T. M . , 654, 659 Trotter , J . , 631, 637 Trowbr idge , I. S., 11, 2 1 , 59,

6 1 , 407-415,407, 408, 409, 4 0 9 , 4 1 0 , 4 1 2 , 4 2 4 , 5 2 3 , 527

Trucco, M . , 3 8 5 , 4 5 4 Tse , H . Y . - S . , 597 -609 , 598 ,

604, 605, 609 Tseng, J . , 201-215,223 Tsu , T . T . , 44 Tumi l ow i c z , J . , 4 4 7 , 4 5 5 T u n g , A . S . , 2 9 3 , 6 4 5 , 6 5 8 ,

6 9 9 , 7 0 0 , 7 0 3 , 7 0 6 , 7 0 7 , 7 3 3 , 8 3 4 , 8 4 7 - 8 5 3 , 8 4 8 , 850, 851 ,852 , 8 5 3

Türk, J . L. , 106,222 Turne r , M . J . , 3 2 4 , 3 2 9 , 3 3 9 Turner , R. S., 771, 779 Twarog , F . J . , 103 Twigg , M . B . , 474 T y a n , M . L . , 147 , 1 5 8 , 249 ,

2 5 0

U

Ueda , Y . A . , 530, 5 3 5 , 5 3 6 U h r , J . W . , 6 2 , 245, 1 6 2 , 176,

1 8 2 , 1 8 3 , 1 8 5 - 1 9 1 , 1 8 5 , 1 9 0 , 1 9 1 , 198 , 1 9 9 , 2 0 0 , 2 4 0 , 2 4 1 , 2 4 3 , 2 6 1 , 2 6 6 , 2 7 0 , 2 7 1 , 2 7 3 , 2 8 4 , 3 0 7 , 3 2 4 , 3 3 9 , 3 4 9 , 3 6 2 , 3 6 3 -3 6 8 , 3 6 5 , 3 6 8 , 3 7 7 , 4 2 4 , 455

U n a n u e , E . R , 1 2 0 , 1 2 6 , 140, 1 4 5 , 156 , 258 , 159 , 160 , 1 6 2 , 1 8 9 , 1 9 1 , 2 4 1 , 2 4 3 , 2 4 8 , 2 4 9 , 2 4 9 , 2 5 0 , 5 6 3 , 5 6 9 , 5 7 0 , 618, 619, 623

Underdown , B . J . , 637 Unke less , J . C , 317, 318,322

V a d a , M . A . , 3 2 , 9 7 , 1 0 3 , 1 1 8 , 4 5 5 , 4 7 5 , 4 9 2 , 5 4 4 , 5 6 1 , 5 6 9 , 5 7 8 , 5 7 9 - 5 8 8 , 5 7 9 , 5 8 0 , 5 8 1 , 5 8 2 , 5 8 3 , 5 8 4 , 585 ,587 , 588, 623

V a e r m a n , J . P., 201 ,224 V a i n i o , O., 624 V a l e n t i n e , E . A . , 4 2 6 , 4 3 0 ,

4 4 0 , 4 4 1 V a n A c k e r , A . M . , 852 V a n a m a n , T. C . , 6 3 6 van Boxe l , J . , 143, 245, 175,

2 8 3 , 1 8 5 , 2 9 2 , 1 9 3 , 2 0 0 , 272, 313,324

van den Twee l , J . G . , 419 ,427 van der Hoven , A . , 2 7 3 Vande rkoo i , G . , 392 ,395

v a n der Loo, W., 33-45, 679, 6 8 2 , 6 8 5 , 6 8 6 , 6 9 7 , 8 1 5 , 8 5 3

V a n de Vorde , A . , 862 v a n H e y n i n g e n , V . , 4 2 4 , 454 v a n H o e g a e r d e n , M . , 6 5 0 ,

655, 659 v a n Hooff, J . P . ,427, 454 v a n L e e u w e n , A . , 3 9 6 , 417-

4 2 7 , 4 1 8 , 422 , 4 2 5 , 426 , 4 2 6 , 4 2 7 , 4 4 3 , 4 4 4 , 4 5 4 , 455

V a n n , D., 32 , 626 v a n Rood, J . J . , 343, 387, 392,

3 9 6 , 4 1 7 - 4 2 7 , 4 1 7 , 4 1 8 , 4 2 2 , 4 2 3 , 4 2 5 , 4 2 6 , 4 2 7 , 4 2 9 , 4 3 0 , 4 4 0 , 4 5 0 , 4 5 4 , 455

v a n Someren , H . , 443 ,455 v a n Vreeswi jk , W . , 427 V a r g a , J . M . , 636, 6 4 4 , 658,

724, 7 7 9 , 8 3 4 , 8 3 5 , 853 V a s , M . R . , 440 V a s , S. I., 726, 734 V a s s a l l i , P . , 1 3 9 , 2 4 5 , 185,

186 , 2 9 0 , 2 2 4 , 724 , 8 5 2 , 862, 888

V a z , N . M . , 466,475 V e n k a t a c h a l a m , C. M . , 631,

637 Vesterberg , O., 387,396 V i a l e , G . , 282 V i c a r i , G . , 286,294 V i l l a r e j o , M . , 409,425 V i r e l l a , G , 266,273 V i t e t t a , E . S . , 59 ,62 ,143,245,

160 , 2 6 2 , 1 7 6 , 2 8 2 , 283 , 1 8 5 - 1 9 1 , 185 , 186 , 187 , 1 8 8 , 2 9 0 , 1 9 1 , 193 , 194, 1 9 8 , 2 9 9 , 2 0 0 , 2 4 0 , 2 4 1 ,

2 4 3 , 2 6 1 , 266 , 270 , 2 7 1 , 2 7 3 , 2 7 5 , 2 8 4 , 3 3 1 , 338 , 3 3 9 , 3 4 4 , 3 4 9 , 3 5 8 , 359 , 3 6 0 , 3 6 2 , 3 6 3 - 3 6 8 , 3 6 3 , 3 6 4 , 3 6 5 , 3 6 6 , 3 6 8 , 369 , 3 7 1 , 3 7 2 , 3 7 7 , 4 1 1 , 4 2 4 , 4 2 7 , 453 ,455 , 586,588

V i v e s , J . , 544 Vogt , W . , 2 5 7 Vo l k e r s , W. S. ,426 Vo lpe , E . P., 771, 778 v o n B o e h m e r , H , 15,22, 114,

2 2 8 , 126 , 227 , 137 , 145, 157 , 162 , 236 , 5 0 7 , 510 , 5 2 3 , 5 2 7 , 5 3 9 - 5 4 5 , 539 , 5 4 0 , 5 4 1 , 542 , 5 4 3 , 544 , 5 4 5 , 5 4 7 , 548 , 5 5 3 , 5 5 7 , 5 8 2 , 5 8 8 , 598 , 607 , 609 , 6 1 3 , 6 1 5 , 617 , 6 1 8 , 6 2 1 , 624

V o n Eschen , K . B. , 315-321 von Fe l l enberg , R , 272 von P i rque t , C , 73,83 Vos , G . H . , 590,595 Vossen , J . M . , 194,200 V r a n a , M . , 661-666, 663,665,

666, 744, 748 Vr iesendorp , H . M. , 470

W

W a b l , M . R , 763, 770, 771-779, 773, 778

Wadd ing ton , C. H . , 769, 770

W a g n e r , H . , 113, 228 , 432 , 4 4 1 , 5 1 0 , 5 2 7 , 5 3 1 , 5 3 6 , 545, 556

Wagner, R. M . , 609 Waksa l , H . , 511-518 W a k s a l , S . D . , 45, 504 W a k s m a n , B . H . , 202 , 2 1 1 ,

225 Wa ldmann , H , 114,228, 543,

545 , 598 , 6 0 8 , 6 0 9 , 613 , 615, 617, 618, 624

Wa ldmann , T. A . , 93, 203 Waldron , J . A . , 5 7 1 , 5 7 8 Wa lke r , J . G , 758, 770 Wa lke r , K . Z., 440 Wa lke r , W. A. , 202,225 Wa lke r , W. S., 318,322 Wa l l i s , E. ,22 W a l t e n b a u g h , C , 472 , 474 ,

475 Wal ters , C. S., 193, 198,200,

763,770 Walzer , P. D., 244, 282 Wang , A . C , 783, 792 Wang , A . L., 158, 1 7 3 , 706,

734, 779, 8 5 2 , 902 Wang , J . L . , 3 6 1 , 3 6 8 , 902 Wang, K. , 380, 382, 384,386,

387, 389,396 Wank , R , 427, 440 Ward , S. M . , 697 Warner , N . L., 33-45, 44, 47,

50, 1 4 2 , 1 4 4 , 1 9 0 , 2 3 6 , 2 4 3 , 2 5 0 , 2 6 1 , 262 , 2 6 8 , 2 7 2 , 2 7 3 , 3 1 4 , 3 2 1 , 5 8 7 , 791

Warner , T. F. C. S., 881,888 W a r r , G . W. , 44 , 290 , 2 4 3 ,

2 6 1 - 2 7 3 , 2 6 1 , 2 6 2 , 2 6 3 , 264 , 265 , 266, 270 , 271 , 2 7 2 , 2 7 3 , 1 1 1 , 7 7 9

Warren , L., 388,396 Wart iovaara , J . , 237 Wasserman, R. W., 834, 848,

852, 853 Watanabe, T., 227, 227-236 Waterf ie ld, E . , 226 Waterne id , J . D., 225,226 Waterf ie ld, M . D., 329, 395,

396, 690, 697, 852 Watk ins , W., 410,425 Watson, J„ 147,151,258, 218,

226, 270, 271,273 Waxda l , M . J . , 265,273, 398,

401,645 Webb, S. R , 141,245 Weber, K. , 353,362, 387,396 W e c k e r , E . , 115 , 227 , 228 ,

124, 126, 227, 625 , 626 , 750, 758

Wegmann, T. G., 622 Weiden, P. L . ,250 We i g e r t , M . , 172, 2 8 5 , 2 9 3 ,

2 9 4 , 642 , 6 4 3 , 6 4 4 , 6 4 5 , 658 , 659 , 6 1 1 , 6 8 6 , 7 0 6 , 725 , 726 , 733 , 734, 735 , 742 , 743 , 744 , 746 , 748, 756 , 757 , 758, 8 0 2 , 805 , 807 , 8 1 0 , 8 2 4 , 8 2 5 , 8 2 1 , 824 , 826, 8 2 1 , 8 3 4 , 8 3 5 , 8 3 6 , 8 3 7 - 8 4 6 , 837 , 838 , 839 , 840 , 8 4 1 , 8 4 5 , 846 , 8 4 7 , 8 5 2 , 8 5 5 , 8 6 2 , 879 , 881 ,885 ,888 ,889

W e i g l e , W . 0 . , 6 2 , 93 , 101, 203 ,226

We imann , B . J . , 888 We inbaum, F. I., 261,273 Weiner , A . M . , 388,396 Weiner , F., 787, 788, 790 Weiss, M . C , 785, 792 Weiss, N . ,272 , 771, 772, 778,

779 We issman, I. L., 9-21, 9, 11,

12, 14, 15, 16, 20 ,22 , 23, 2 9 , 3 1 , 6 1 , 4 1 4 , 5 2 7

Wei tzman, S., 410, 425, 781, 785, 792

W e k e r l e , H . , 5 2 7 , 529-537, 529, 530, 534,536

Wel ls , J . V . , 285,294 Wel ls , R. D., 8 5 6 , 8 6 2 Welstead, J . L., 758 We l tman , J . K. , 325,329, 392,

396 Werb l in , T. P . ,622 Wernet, D., 590,591,592,595 Wernet, P . ,202,396, 422,427 Westerveid, A . , 4 5 5 Westervelt, F . B . , 299 Westho lm, F. A. , 636 Wetmur , J . G , 872,875 Wheeler, T. B . , 790 Wheelock, E . F., 73,76,82,83 Whi te , A . I., 636 Whi te , B . J . , 264 Whi te , D. W. ,595 Whi te , E . ,243 Whi te law, A . M. ,32 ,203 , 228,

4 5 4 , 4 7 5 , 5 4 4 , 5 6 1 , 5 6 9 , 5 7 8 , 587, 5 8 8 , 623

Whit f i e ld , C , 874, 888 Whitsett , C , 4 2 6 Wh i t t en , H . D . , 2 7 2 Whi t t ingham, S. ,203 Wide, L . , 339

Widmer , M .B . , 345, 349, 429, 442

W i emann , B . , 68, 163-164 W i g z e l l , H . N . , 29,30, 32, 8 2 ,

1 1 6 , 1 1 7 , 193 , 1 9 8 , 2 0 0 , 2 2 5 , 2 6 1 , 2 7 2 , 275 -284 , 275 , 276 , 277 , 278 , 280 , 2 8 1 , 282 , 2 8 3 , 2 8 4 , 300 , 3 0 6 , 3 3 9 , 3 6 1 , 3 6 8 , 4 1 4 , 5 0 8 , 5 2 0 , 5 1 7 , 5 1 8 , 5 2 7 , 543 , 544 , 5 5 9 , 5 6 2 , 585 , 5 8 6 , 5 8 7 , 5 9 7 , 6 0 8 , 6 1 2 , 618 , 619 , 624 , 714 , 7 1 7 , 8 1 2 , 8 1 4 , 883,889

Wi lborn , F .L . , 699, 707 Wi lchek , M . , 636 Wi lde , C D . , 793-803 W i lde rmann , G. , 674 W i l k i n s o n , J . M . , 655 , 659 ,

686 , 690 , 6 9 1 , 6 9 7 , 698 , 748, 847,853

Wi lkes , C .F . ,224 W i l l c o x , H . N . A . , 1 2 9 - 1 3 7 ,

193 -200 , 195 , 299 , 7 4 9 , 756, 758, 763, 770

Wi l l ems , F.T.C. , 73 ,83 W i l l i a m s , A .F . , 51-61, 51, 52,

53, 55, 62, 187, 202, 225, 264,272, 423, 424

W i l l i ams , C A . , 47, 50 W i l l i ams , H . , 227

N A M E I N D E X 15i

W i l l i a m s , R.C. , J r . , 272 , 741, 848,853

W i l l i a m s o n , A . R . , 1 6 7 , 1 7 3 , 1 9 9 , 2 5 0 , 726 , 727 . 7 3 3 , 7 3 4 , 735 , 7 4 1 , 749 , 755 , 756 , 757 , 7 5 8 , 7 5 9 , 7 6 3 , 770, 773, 777, 7 7 9 , 8 8 8

Wi l l i amson , D . H . , 536 Wi l l i s t on , C S . , 631,637 Wi l son , A . B . , 314 Wi l son , A . D . , 444,455 Wi l son , D .B. , 15, 2 1 , 29, 30,

3 1 , 1 1 4 , 1 1 7 , 2 7 6 , 2 8 4 , 452, 4 5 5 , 5 2 0 , 5 2 7 , 5 4 2 , 5 4 4 , 559-561, 559 , 5 6 0 , 5 6 2 , 5 6 9 , 5 6 9 , 5 7 7 , 5 7 8 , 598 , 6 0 8 , 6 0 8 , 613, 615, 622

Wi l son , G.A. , 878,889 Wi l son , J . H . , 835 Wi l son , J .W. , 2 5 0 Wi l son , S.K. , 792 Winchester , R . J . , 47, 5 0 , 144,

1 8 2 , 1 9 0 , 1 9 3 , 2 9 9 , 2 0 0 , 2 7 2 , 3 8 7 , 3 9 5 , 3 9 6 , 4 2 7 , 452 ,455 , 852

Win f i e ld , J . B . , 693, 697, 698 Winz l e r , R. J . , 59, 60,62 Wiss ler , F. C. ,324 Wi t te , O . N . , 15 ,16 ,18 , 20,22 W i t t i g , B . ,82 Wofsy, L . ,623 Wolcott , M . J . , 3 6 8 Wolf, B . , 144,245 Wolf, M . N . , 237

Wolfner, M . , 790, 803 Wong, L . T. L. , 634, 637 Wood, D. D. ,570 Wood, M . K. , 645 W o o d , S . L . C . ,862 Wood, W. B. , 835 Woodland, R . ,273 Woodruff, J . F. , 73 ,83 Woodruff, J . J . , 73 ,83 Woods, F . R . ,455 Woody, J . , 113-118, 114, 116,

227 Woolnough, J . , 4 4 0 Wort is , H . H , 132, 237 Wr ight , B . E . G . , 2 9 9 , 2 5 0 , 733 Wright , C , 627-637 W u , A. , 407,425 W u , C - Y . , 86, 92 W u , T. T., 171,273, 627, 636,

637 , 6 4 1 , 6 4 2 , 6 4 5 , 647 , 648 , 649 , 6 5 1 , 658 , 659 , 6 6 1 , 662 , 665 , 666 , 687 , 688 , 7 3 1 , 734, 743 , 748, 8 0 7 , 8 2 5 , 818 , 8 2 8 , 8 3 6 , 837 , 838 , 8 3 9 , 8 4 6 , 8 5 1 , 853

Wunder l i ch , J . R , 72

Y Y a c h n i n , S., 590,595 Y a g i , Y . , 283, 342 Y a h a r a , I., 270, 271,273 Y a m a m u r a , Y . , 2 2 7

Yamane , K . , 535,536 Y a n g , R. C. A. , 856 ,862 Yard l ey , J . H . ,224 Y a r m u s h , M . L . , 6 9 7 Yeger, H , 733 Y e n , S . -H . , 394,396 Y i n , E . , 758 Y o c u m , D . , 261,273 Y o c u m , R. R. ,329 Yoffey, J . M . ,224 Y o n k o v i c h , S. J . , 6 4 5 , 734 ,

748, 8 1 5 , 8 4 6 , 8 6 2 , 8 8 9 Yosh ida , T. H. , 879, 881 ,889 Yosh ida , T. O., 275,284, 315,

322 Young , D. ,385, 4 5 3 , 454 Young , F . E . , 878 ,889 Young , G . O., 688, 696, 845 Young , H . , 4 4 0 , 5 2 7 , 5 4 4 Young , N . M . , 664, 665, 722,

724, 725, 734, 8 4 5 Y o u n g - C o o p e r , G . O. , 6 7 7 -

686 ,686 ,697 Yount , W. J . , 792 Y s e r n , X . , 639-645 Y u , A . , 4 1 1 , 4 2 5 Y u a n , D., 185-191, 185 Y u n i s , E . J . , 237, 426 Yussa , T., 536 Y u t o k u , M . , 38 ,45

Z

Zab in , I . ,409,425

Zabr i sk i e , J . , 4 5 5 Zajdel , S., 264 Z a k u t , R , 627, 628 Za l e sk i , M . , 466,470,475,562 Z a n - B a r , I., 103 Z a r l i n g , J . M . , 439,442 Zauderer , M . , 749, 750, 752,

753, 755, 758 Zeeuws, R , 693, 698 Zehav i -W i l l n e r , T., 790 Zemba la , M . , 106, 109,222 Zey l emaker , W. P . , 440 Z ier , K . S., 4 3 0 , 4 3 9 , 4 4 0 , 4 4 1 Ziffer, J . A . , 351-362 Z ige lbaum, S. D. , 201,225 Z i m m e r m a n , A . , 590, 595 Z i m m e r m a n , S. C , 341,342 Z i n k e r n a g e l , R. M . , 26 ,30 ,31 ,

3 1 , 8 2 , 1 0 1 , 1 0 2 , 1 1 6 , 1 1 8 , 3 5 1 , 3 6 2 , 3 6 9 , 3 7 7 , 439 , 4 4 1 , 4 5 1 , 4 5 3 , 454 ,505-510, 5 0 5 , 506 , 507 , 508, 5 0 9 , 5 2 0, 5 2 2 , 5 2 3 , 526 , 5 2 6 , 5 2 7 , 5 2 9 , 5 3 6 , 537 , 5 3 9 , 5 4 1 , 5 4 3 , 5 4 4 , 5 4 5 , 547 , 5 4 8 , 5 5 3 , 554 , 555, 5 5 6 , 5 5 7 , 5 6 2 , 5 6 8 , 5 7 0 , 5 7 1 , 5 7 7 , 5 7 8 , 5 8 7 , 597 , 6 0 9 , 6 1 3 , 6 1 4 , 6 2 0 , 6 2 2 , 624

Zoalberg, O. B . , 4 5 5 Zoschke, D. C , 574, 578 Zweerus, R . , 427

Subject Index A

A b e l s o n m u r i n e l e u k e m i a v i r u s -t r a n s f o r m e d mouse l y m -p h o m a c e l l s , i n d u c t i o n of Immunog lobu l in synthes is i n , 163 -164

Ac t i va t i on B c e l l , m e c h a n i s m of, 2 1 7 - 2 2 5 ,

2 5 1 - 2 5 9 l y m p h o c y t e , r o l e of sur face Im­

munoglobul in i n , 2 6 8 - 2 7 1 T cel l , macrophage-lymphocyte i n ­

teractions i n , 571 -587 Adherent cells, role of i n B-cel l t r ig -

gering and i n tolerance i n ­duction, 2 5 3 - 2 5 9

A l loant igens , B ce l l genetic studies of, 4 2 2 - 4 2 6 immunologic and chemical charac­

terizat ion of, 3 8 7 - 3 9 5 Al logenic effect factor (AEF ) , analysis

o f I a d e t e r m i n a n t s o n , 4 9 2 - 4 9 5

A l l o g e n i c effect, nega t i ve , suppres-s ion of T - B co l l abo ra t i on between allogenic cells by, 6 0 0 - 6 0 8

Al logra f t rejection, role of L D and C D antigens i n , 4 3 7 - 4 3 8

A l l o t y p e s , r a b b i t I m m u n o g l o b u l i n , 6 7 7 - 6 9 5

A l lo type suppression, 3 5 - 3 7 A l t e r e d - s e l f hypo thes i s , to e x p l a i n

genetic restr ic t ion of cy to tox ic T - c e l l responses, 5 0 5 -

509, 5 1 9 - 5 4 1 , 5 4 7 - 5 5 6 m a c r o p h a g e - l y m p h o c y t e in t e r ­

a c t i o n s , 5 6 8 - 5 7 8 , 5 8 2 -584

T - B c o l l abo ra t i v e i n t e rac t i ons , 5 4 2 - 5 4 4 , 6 1 1 - 6 2 2

Amph ib ians , anuran , ontogenesis of the i m m u n e r esponse i n , 7 7 1 - 7 7 8

Ant ibody. S e e a l s o Immunog lobul in a n t i - a l l o t y p e , e n h a n c e m e n t of

a n t i b o d y - d e p e n d e n t c e l l -m e d i a t e d c y t o t o x i c i t y by, 3 0 8 - 3 1 1

ant i - Ia inh ib i t i on of i n v i tro pr imary

a n t i b o d y r e s p o n s e b y , 4 8 4 - 4 8 5

r e g u l a t i o n o f c l o n a l B -lymphocyte prol i feration by, 2 4 5 - 2 4 9

x e n o g e n i c , s p e c i f i c i t y a n d properties of, 4 4 6 - 4 4 8

anti- idiotype a n t i - s t a p h y l o c o c c a l nuc lease

idiotypes, 3 0 0 - 3 0 4 e n h a n c e m e n t o f a n t i b o d y -

d e p e n d e n t c e l l m e d i a t e d cytotoxicity by, 3 1 1 - 3 1 4

raised against T cell receptors, 2 7 5 - 2 8 3

react iv i ty of w i th helper T cells, 285 -288 , 7 1 4 - 7 1 7

s u p p r e s s i o n of i d i o t y p e pro-duction by, 7 0 1 - 7 2 1

ant i - immunoglobul in a c t i v a t i o n of r a b b i t l y m p h o ­

cytes by, 2 6 8 - 2 6 9 func t i ona l i nac t i v a t i on of i m -

ma tu r e B lymphocytes by , 1 3 9 - 1 4 1 , 159 -161

i n h i b i t i o n of B - c e l l m i t o g e n react iv i ty by, 153 -156

r e g u l a t i o n o f c l o n a l B -l y m p h o c y t e p r o l i f e r a t i o n by, 245 -249

an t i - p - a zopheny l a r sona t e , i d i o ­type compos i t ion of, 6 9 9 -706, 848 -851

an t i phosphory l cho l ine , id io type composition of, 7 2 6 - 7 3 0

clonal constancy of, 755 -758 Variation i n , 765 -766

c o n f o r m a t i o n a l changes subse-quent to a n t i g e n b i n d i n g , 6 7 1 - 6 7 4

diversity, generation of i n a n u r a n a m p h i b i a n s , 7 7 3 -

778 f o l l o w i n g a n t i g e n i c S t i m u l a ­

t ion, 7 6 1 - 7 7 0 v i a m u l t i p l e germ- l ine genes,

6 4 7 - 6 5 8 , 7 2 5 - 7 4 8 , 7 7 3 -778 , 8 1 7 - 8 5 2 , 8 6 3 - 8 7 1 , 886 -887

n u c l e i c a c i d h y b r i d i z a t i o n studies of, 8 3 2 - 8 3 3 , 8 5 5 -887

p o s s i b l e m o l e c u l a r m e c h a ­nisms of, 8 3 3 - 8 3 4

restr ict ion-modif icat ion model of, 860 -861

v i a somat i c m u t a t i o n s , 6 4 7 -658 , 7 6 1 - 7 7 0 , 7 9 3 - 7 9 7 , 8 1 7 - 8 6 1 , 8 8 2 - 8 8 6

d o m a i n s , i n t e r a c t i o n s be tween , 6 6 7 - 6 7 4

el icited, amino acid sequences of, 6 4 7 - 6 5 8

f o r m a t i o n , i n B - c e l l c u l t u r e s s t i m u l a t e d by L P S , 7 5 2 -755

gene famil ies, 817 -834 germ-line, 840 -842 heteroclit ic, 7 3 5 - 7 4 0 response

i n a n u r a n a m p h i b i a n s , 7 7 2 -773

to a( l ,3)dextran, genetic ana l ­ysis of, 743 -748

g e n e t i c r e s t r i c t i o n o f m a c r o p h a g e - l y m p h o c y t e

interactions i n , 5 6 3 - 5 6 9 genetic restr ict ion of T - B col­

labora t i ve in te rac t i ons i n , 1 2 3 - 1 2 6 , 5 4 2 - 5 4 4 , 5 9 7 -622

IgA, by Peyer's patch lympho­cytes, 2 0 1 - 2 1 3

polyclonal, 2 1 7 - 2 2 5 p r i m a r y I g M , r o l e o f m a c ­

rophage Ia determinants i n , 4 8 4 - 4 8 6

r e g u l a t o r y e f f ec ts o f T - c e l l subclasses on, 2 7 - 3 0 , 8 9 -91 . S e e a l s o T - B i n t e r a c ­tions

ro l e of s o lub l e factors i n the regulat ion of, 95, 113 -126

role of T - T interactions in the r e g u l a t i o n of, 8 5 - 9 1 , 113 -116

to streptococcal hyper immuni -zation, 6 8 9 - 6 9 6

suppression of, 3 0 - 3 1 , 9 3 - 1 0 2 , 1 1 9 - 1 2 3 , 4 7 1 - 4 7 3

secretion, IgG, requirement for cel­l u l a r p ro l i f e ra t i on preced-ing , 7 5 0 - 7 5 5

s y n t h e s i s , r e g u l a t i o n o f i n myeloma cells, 7 8 1 - 7 9 0

A n t i b o d y - c o m b i n i n g s i t e , t h r e e -d i m e n s i o n a l s t r u c t u r e of, 6 2 7 - 6 4 4

Ant ibody-dependent , ce l l -med ia ted cy to tox ic i ty , enhancement of by antial lotype and ant i -idiotype sera, 3 0 7 - 3 1 4

A n t i g e n . S e e a l s o s p e c i f i c a n t i g e n s s u c h a s H - 2 ; I a ; T h y - 1 ; etc.

cell surface, regulat ion of immune responses to, 5 8 9 - 5 9 4

presentation, role of i n B-cel l t r ig -gering, 2 5 5 - 2 5 9

role of i n diversi f ication of B-ce l l s p e c i f i c i t y r e p e r t o i r e , 167 -172

t h y m u s - i n d e p e n d e n t , as p o l y ­c l o n a l B - c e l l a c t i v a t o r s , 2 1 7 - 2 2 5

v i ra l , association w i th H-2 deter­m i n a n t s on v i rus - in f e c t ed cells, 5 5 0 - 5 5 6

Ant igen-b ind ing cells, generation of i n the b u r s a of F a b r i c i u s , 1 4 1 - 1 4 2

A n t i g e n - b i n d i n g s i te , th ree -d imen-s i o n a l s t r u c t u r e of, 6 2 7 -644

Ant igen ic competit ion, between H-2 and Thy-1, 5 9 2 - 5 9 3

Ant igen ic modulat ion, of surface Im­m u n o g l o b u l i n on B c e l l s by a n t i - i m m u n o g l o b u l i n , 1 5 9 - 1 6 0

17 i

18i S U B J E C T I N D E X

B

B e e i l act ivat ion factors, 625 a c t i v a t i o n , m e c h a n i s m of, 2 1 7 -

2 2 5 , 2 5 1 - 2 5 9 adherent cel l in terac t ion w i t h , role

of i n B-ce l l t r i g ge r ing and to l e rance i n d u c t i o n , 251 — 259

al loantigens c h e m i c a l a n d i m m u n o l o g i c

c h a r a c t e r i z a t i o n of, 3 8 7 -395

genetic studies of, 4 2 2 - 4 2 6 c lonal prol i ferat ion of, r egu la t i on

b y a n t i - I g o r a n t i - I a a n ­tibodies, 2 4 5 - 2 4 9

clones, antibody produced by constancy of, 7 5 5 - 7 5 8 Variation i n , 7 6 5 - 7 6 6

dif ferentiation changes i n c l ass o f I m m u n o ­

g l o b u l i n receptors d u r i n g , 1 8 5 - 1 9 0 , 1 9 7 - 1 9 8

i n gut-associated l y m p h o i d t is -sue, 2 1 1 - 2 1 3

i n d u c e d b y h o r m o n e s a n d pharmacologic agents, 5 - 8 , 1 3 3 - 1 3 4

i n v i t ro models for the s tudy of, 1 2 9 - 1 3 6

i n ontogeny , 1 3 9 - 1 6 2 , 1 6 5 -172

s u r f a c e m a r k e r s o f c e l l s i n , 3 3 - 4 4

hapten-spee i f ie , e n r i c h m e n t a n d c loning of i n v i t ro , 2 3 7 - 2 3 9

immature cytoplasmic I g M i n , 1 3 5 - 1 3 6 ,

1 3 9 , 1 6 1 - 1 6 2 f u n c t i o n a l i n a c t i v a t i o n by

m o d u l a t i o n w i t h a n t i - I g , 1 3 9 - 1 4 1

i n d u c t i o n o f t o l e r a n c e i n , 1 5 9 - 1 6 1 , 1 6 8 - 1 7 0 , 1 8 8 -190

memory dif ferentiation of, 3 6 - 3 9 Immunog lobu l in receptors on,

1 9 5 - 1 9 9 surface markers of, 34

Peye r ' s pa t ch , sec re to ry I g A re ­sponse by, 2 0 1 - 2 1 3

pr imary and secondary, propert ies of, 168

receptor I m m u n o g l o b u l i n c l a s s e s of,

1 7 6 - 1 9 9 , 2 4 0 - 2 4 1 m o d u l a t i o n of f o l l o w i n g i n ­

teract ion w i th specific ant i ­gen, 2 3 9 - 2 4 0

r o l e of i n B - c e l l a c t i v a t i o n , 2 1 8 - 2 2 5

speci f ic i ty reperto ire , d i ve rs i f i ca -t ion of du r ing development, 1 6 5 - 1 7 2

subpopu la t i ons , e x p r e s s i o n of Ia antigens on, 4 8 9 - 4 9 1

surface Immunog lobul in dur ing ontogeny, 149—150 phylogeny of, 2 6 6 - 2 6 8

tr igger ing. S e e B ce l l , a c t i va t i on mechanism of

B o n e m a r r o w ce l l s , t e r m i n a l t r ans -ferase i n , 6 4 - 6 7

Bone m a r r o w graft rejection, F, an-t iparenta l , 5 1 1 - 5 1 7

Bursa-equ iva lent , m a m m a l i a n , 159 B u r s a o f F a b r i c i u s , g e n e r a t i o n of

a n t i g e n - b i n d i n g c e l l s i n , 1 4 1 - 1 4 2

Bursopo ie t in , 5 - 8

C

C-determinant (CD) antigens C M L tolerance induct ion resu l t ing

f rom neonatal injection of, 4 3 6 - 437

role of i n al lograft rejection i n vivo, 4 3 7 - 438

r o l e o f i n t h e g e n e r a t i o n o f cytotoxic T lymphocytes i n v i t ro , 4 3 2 - 4 3 3

C e l l interact ions. See specific type of i n t e r a c t i o n s u c h a s M a c r o p h a g e - l ymphocyte ; T - B ; T - T ; etc.

Ce l l -med ia ted lympholys is , F, ant ipa-r en ta l , 5 1 1 - 5 1 7

Ce l ls . S e e specific type of c e l l s u c h as B ce l l ; Cytotoxic T cel l ; Helper T ce l l ; etc.

C e l l u l a r in terac t ion (CI) struetures poss ib l e r o l e of i n l y m p h o c y t e -

m a c r o p h a g e i n t e r a c t i o n s , 5 6 8 - 5 7 8 , 5 8 2 - 5 8 4

possible role of i n T - B collabora-t ive interact ions, 6 1 1 - 6 2 2

C l o n a l s e l e c t i on theory , 2 - 3 , 8 9 2 -900

C l o n i n g of hapten-speei f ie B lymphocytes

i n v i t ro , 2 3 7 - 2 3 9 of n o r m a l l y m p h o c y t e s i n v i t r o ,

2 2 7 - 2 3 6 C o n c a n a v a l i n A , i n d u c t i o n o f

c y t o t ox i c T ce l l s by, 5 1 9 -520

C o n t a c t s ens i t i z e r s , mechan i sms of tolerance to, 105 -111

Cyc l i c A M P , role of i n T- and B-ce l l d i f f e rent ia t ion , 5 - 8 , 1 3 3 -134

Cytotox ic T-ce l l response H - 2 r e s t r i c t i o n of, 5 0 5 - 5 0 9 ,

5 1 9 - 5 4 1 , 5 4 7 - 5 5 6 to m i n o r histocompat ib i l i ty ant i ­

gens, 5 1 9 - 5 2 6 suppression of by cells generated

i n m i x e d l y m p h o c y t e c u l -tures , 4 3 3 - 4 3 6

to syngenic tumor cells, 5 4 7 - 5 5 0 to v irus-coated cells, 5 5 2 - 5 5 6 to v i r u s - i n f e c t e d c e l l s , 5 0 5 -

509, 5 2 9 - 5 3 5 Cytotox ic T cel ls

detection of by a v i rus plaque as­say, 7 8 - 8 0

generat ion of role of L D and C D antigens i n ,

4 3 2 - 4 3 3 r o l e o f T - c e l l s u b c l a s s e s i n ,

2 4 - 3 0 i n d u c t i o n of by c o n c a n a v a l i n A ,

5 1 9 - 5 2 0 Ly phenotype of, 2 4 - 3 0

v i r u s - i m m u n e , s p e c i f i c i t y of, 5 0 5 - 5 0 9 , 5 2 9 - 5 3 5

D

Delayed-type hypersens i t i v i t y genetic res t r ic t ion of transfer of,

5 8 0 - 5 8 7 mediat ion of by Ly -1 T cells, 584

a ( l , 3 ) D e x t r a n , g e n e t i c a n a l y s i s of antibody response to, 7 4 3 -748

D i f f e r e n t i a t i o n . S e e B c e l l , d i f f e r ­ent iat ion; Lymphocyte , dif­f e r en t i a t i on ; T c e l l , differ­ent ia t ion

D ime thy l sulfoxide (DMSO ) , use of to i n d u c e I m m u n o g l o b u l i n s y n t h e s i s i n l y m p h o m a cells, 1 6 3 - 1 6 4

D N A polymerases i n l ympho id cells, 6 3 - 7 1

D u a l r e cogn i t i on hypo thes i s , to ex-p l a in genetic restr ic t ion of,

cy to tox ic T - c e l l responses , 5 0 5 -509, 5 1 9 - 5 2 6 , 5 4 7 - 5 6 1

macrophage - l ymphocy te i n t e r a c t i o n s , 5 6 8 - 5 7 8 , 5 8 2 - 5 8 4

T - B c o l l a b o r a t i v e i n t e r a c t i o n s , 6 1 3 - 6 2 2

E

Enhanc ing T-ce l l factor, 123 - 1 2 5 F

Factors B-cel l act ivat ion, 625 carr ier-spee i f ie he lpe r , role of i n

B-ce l l t r i gger ing , 2 5 6 - 2 5 9 enhancing T-ce l l , 1 2 3 - 1 2 5 gene t i ca l l y r e l a t e d ( G R F ) , 1 1 3 -

116 soluble, role of

i n the r e g u l a t i o n of an t i body responses, 95, 1 1 3 - 1 2 6

i n suppression of contact sen­s i t i zat ion, 1 0 9 - 1 1 1

suppressive T-ce l l , 1 1 9 - 1 2 3 Fe receptor. S e e Receptor, Fe F V antibody fragments

denaturat ion and renaturat ion of, 6 6 9 - 6 7 1

preparat ion of, 6 6 7 - 6 6 8

G

Generat ion of ant ibody divers i ty . See Ant ibody d ivers i ty , genera­t ion of

G e n e t i c a l l y r e l a t e d f a c t o r ( G R F ) , 1 1 3 - 1 1 6

Genetic restr ic t ion o f c y t o t o x i c T - c e l l r e s p o n s e s ,

5 0 5 - 5 0 9 , 5 1 9 - 5 4 1 , 5 4 7 -556

of m a c r o p h a g e - l y m p h o c y t e i n ­t e r a c t i ons , 114, 5 6 3 - 5 7 8 , 5 8 2 - 5 8 4

of T - B col laborat ive interact ions, 1 2 3 - 1 2 6 , 5 4 2 - 5 4 4 , 5 9 7 -622

of transfer of delayed-type hyper­sensi t iv i ty , 5 8 0 - 5 8 7

Germ-l ine theory of antibody diver­s i t y , 6 4 7 - 6 5 8 , 7 2 5 - 7 4 8 ,

S U B J E C T I N D E X 19i

Germ-l ine theory ( c o n t i n u e d ) 7 7 3 - 7 7 8 , 8 1 7 - 8 5 2 , 8 6 3 -871, 8 8 6 - 8 8 7

Goldf ish, surface Immunoglobul ins on lymphocytes of, 2 6 1 - 2 6 4

G P L A B and S antigens, molecular structure of, 3 9 8 - 3 9 9

Graf t rejection bone m a r r o w F , a n t i p a r e n t a l ,

5 1 1 - 5 1 7 r o l e o f L D a n d C D a n t i g e n s i n ,

4 3 7 - 4 3 8

H

H-2 antigens. See a l s o Histocompati­b i l i t y antigens, major

association of w i t h v i r a l determin­ants on virus-infected cells, 5 5 0 - 5 5 6

molecular structure of, 3 4 3 - 3 7 4 poss ib le gene t i c m e c h a n i s m s i n

the evo lut ion of, 3 7 1 - 3 7 4 regulat ion of antibody response to,

5 9 0 - 5 9 2 r es t r i c t i on of cy to tox ic T - c e l l re­

sponse by, 5 0 5 - 5 0 9 , 5 1 9 -541, 5 4 7 - 5 5 6

s t r u c t u r a l d i f f e r ences b e tween mutant forms of, 3 4 3 - 3 4 8

H - 2 complex g e n e t i c r e s t r i c t i o n o f m a c r o ­

p h a g e - l y m p h o c y t e i n ­t e r a c t i o n s c o n t r o l l e d by , 5 6 3 - 5 7 8 , 5 8 2 - 5 8 4

g ene t i c r e s t r i c t i o n of T - B co l ­laborat ive interactions con­trol led by, 123 -126 , 5 4 2 -5 4 4 , 5 9 7 - 6 2 2

genet ic r e s t r i c t i o n of t rans f e r of delayed-type hypersensit iv-ity control led by, 5 8 0 - 5 8 7

I - A subregion of, enhanc ing T-ce l l factor determined by, 1 2 3 -125

I - E s u b r e g i o n of, d e f i n i t i o n of, 4 7 8 - 4 8 2

I - J subregion of control of macrophage function

i n p r imary i n vi tro antibody response by, 4 8 4 - 4 8 5

def init ion of, 4 9 7 - 4 9 9 mapping of Ia determinants on

allotype suppressor T cells to, 4 9 7 - 4 9 9

mapp ing of Ia determinants on Con-A-responsive T cells to, 4 8 2 - 4 8 3

s u p p r e s s i v e T - c e l l fac tor de­termined by, 121 -123

H-2 gene products, as seif markers for T-ce l l surve i l lance, 509

H - 2 K and H-2D antigens, comparison of mo l e cu l a r s t ruc tures of, 3 4 3 - 3 4 5 , 3 5 4 - 3 6 0 , 3 7 0 -374

Heavy -cha in genes mur ine , 8 4 2 - 8 4 3 rabbit , 6 9 0 - 6 9 1

He lper mechanisms, i n the immune response to cell-surface an­tigens, 5 8 9 - 5 9 4

He lper T cells. S e e a l s o T - B interac­t ions, he lper

cel l interactions i n the induct ion of, 1 1 3 - 1 1 6

co l l abo ra t i v e responses w i t h a l ­logenic B cells, 5 4 2 - 5 4 4

express ion of I - reg ion d e t e r m i n ­ants on, 5 0 0 - 5 0 1

L y phenotype of, 2 3 - 2 9 , 34 r e a c t i o n of a n t i - i d i o t y p e s e r u m

w i th , 2 8 5 - 2 8 8 , 7 1 4 - 7 1 7 role of i n antibody responses to a l ­

loantigens, 5 9 0 - 5 9 4 specificity of for class and al lotype

commitment of B cel ls, 34 surface markers on, 2 3 - 2 9 , 34

Hematopoiet ic stem cells, embryonic or ig in of, 9 - 1 1

Hemopoiet ic -h is tocompat ib i l i ty (Hh) genes, 5 1 1 - 5 1 7

Hermaphrocyte, 8 5 - 9 1 Histocompat ib i l i ty ant igens. S e e a l s o

G P L A B and S ant igens; H-2 antigens; H L - A antigens

major amino acid sequences of, 405 r e s t r i c t i o n of cy to tox i c T - c e l l

r e s p o n s e s b y , 5 0 5 - 5 0 9 , 5 1 9 - 5 4 1 , 5 4 7 - 5 5 6

minor, cytotoxic T-ce l l response to, 5 1 9 - 5 2 6

H L - A a n t i g e n s , s t r u c t u r e of, 3 2 3 -336, 3 4 1 - 3 4 2

H L - A complex, genetics of, 4 1 7 - 4 1 9 H L - A D antigens, detection of, 4 2 9 -

432 H L - A D l o cus , g ene t i c a n a l y s i s of,

4 1 9 - 4 2 6 Homozygous typ ing cel l (HTC ) test,

4 2 9 - 4 3 0 H y b r i d cells. See Somat ic ce l l hybr ids H y p e r v a r i a b l e r e g i ons of a n t i b o d y

molecules, 6 4 7 - 6 4 9 , 6 5 4 -655, 8 1 8 - 8 4 0 , 8 4 7 - 8 5 2

I

Ia antigens amino acid sequences of, 406 association w i th specific immune

response genes, 400, 469 on B-ce l l subpopulations, 4 8 9 - 4 9 1 on c o n c a n a v a l i n - A r e spons i v e T

cells, 4 8 2 - 4 8 3 on helper T cells, 5 0 0 - 5 0 1 h u m a n , serologic character izat ion

of, 4 4 5 - 4 4 8 . S e e a l s o H L - A D antigens

on macrophages, role of i n p r imary antibody responses i n v i t ro , 4 8 4 - 4 8 5

molecular structure of, 3 3 6 - 3 3 7 , 3 7 4 - 4 0 1 , 406

poss ib le f unc t i ons of, 4 5 1 - 4 5 3 , 4 9 1 , 5 0 1 - 5 0 3

possible role of i n med ia t ing I g M to IgG swi tch, 491

presence of determinants on sup­p r e s s i v e a n d e n h a n c i n g T-ce l l factors, 1 1 9 - 1 2 6

somatic cel l genetics of, 4 4 8 - 4 5 1 o n s u p p r e s s o r T c e l l s , 9 6 - 9 7 ,

1 1 4 - 1 1 5 , 4 9 7 - 5 0 1 on T - c e l l s u b p o p u l a t i o n s , 4 8 2 -

483,492, 4 9 7 - 5 0 1 i n w i l d mouse populat ions, 4 5 7 -

463

Ia.22 spec i f i c i t y , i d en t i f i c a t i on a n d use of to define I - E subreg­ion of#-2, 4 7 8 - 4 8 2

I - A subregion of H - 2 complex. S e e H - 2 complex, I - A subregion

I B peptide marker , 805 -814 Idiotype

ant i -/?-azophenylarsonate , 6 9 9 -706

ant iphosphorylchol ine, 7 0 9 - 7 3 3 a n t i s t a p h y l o c o c c a l n u c l e a s e ,

3 0 0 - 3 0 4 autologous, antibody response to,

7 1 2 - 7 1 3 , 7 1 9 - 7 2 4 -spec i f ic T ce l ls , 7 0 4 - 7 0 6 , 7 1 3 -

714, 7 2 1 - 7 2 2 s u p p r e s s i o n of p r o d u c t i o n of by

a n t i - i d i o t y p e a n t i b o d y , 7 0 1 - 7 2 1

T15, 7 0 9 - 7 2 4 T ce l l , genetic analysis of, 2 7 8 -

280, 2 8 6 - 2 8 7 use of as genetic markers , 6 9 3 -

694 Idiotypic receptors, T cell

antibodies to, 275 -283 b i o c h e m i c a l propert ies of, 2 7 6 -

278 use of to induce specific tolerance,

2 8 0 - 2 8 2 I - E subreg ion of H - 2 complex. See H - 2

complex, I - E subregion I g A , s e c r e t o r y , p r o d u c t i o n o f by

Peyer 's patch lymphocytes, 2 0 1 - 2 1 3

IgD al lotypes i n mice, 3 9 - 4 3 on memory B cells, 195 -197 surface

an t i gen -b ind ing speci f ic ity of, 241

o n B ce l l s d u r i n g d i f f e rent ia ­t i on , 142 -143 , 185 -190

o n l y m p h o i d c e l l s s i m u l t a -n e o u s l y b e a r i n g I g M , 1 7 6 - 1 7 7 , 2 4 0 - 2 4 1

IgG b i n d i n g o f subc lasses of to l y m ­

phoid cells, 3 1 7 - 3 1 9 p r o d u c t i o n of i n B - c e l l c u l t u r e s

s t i m u l a t e d w i t h L P S , 7 5 2 - 7 5 5

requ i rement for ce l lu lar prolifer­a t ion preceding production of, 7 5 0 - 7 5 5

synthesis of by lymphocytes s imu l -t a n e o u s l y s y n t h e s i z i n g I g M , 177-182

I g M al lotypes i n mice, 3 9 - 4 3 cytoplasmic, i n immature B cells,

1 3 5 - 1 3 6 , 139, 161 -162 surface

o n B ce l l s d u r i n g d i f f e rent ia ­t i o n , 1 4 9 - 1 5 0 , 1 5 9 - 1 6 2 , 1 8 5 - 1 9 0

on memory B cells, 195 -197 modula t ion of on immature B

cells, 159-162 synthes is of by Abelson mur ine

l e u k e m i a v i r u s - t r a n s -f o r m e d l y m p h o m a c e l l s , 1 6 3 - 1 6 4

20i S U B J E C T I N D E X

I g M ( c o n t i n u e d )

synthesis of by lymphocytes s i m u l -t a n e o u s l y s y n t h e s i z i n g o ther c lasses of I m m u n o ­g l obu l in , 1 7 6 - 1 8 2

I g M to I gG swi tch , possible role of Ia ant igens i n Controlling, 491

I - J d e t e r m i n a n t s , c e l l u l a r d i s t r i b u -t i on of, 4 9 9 - 5 0 0

I - J subregion of H - 2 complex. S e e H - 2 complex, I - J subreg ion

Immune response gene product, pos­sible expression of i n mac-rophages, 578, 5 8 4 - 5 8 5

Immune response genes assoc i a t i on w i t h spec i f ic Ia a n t i ­

gens, 400, 469 c omp l emen ta t i on be tween , 4 6 5 -

471 c o n t r o l o f a n t i b o d y r esponses to

s y n t h e t i c Po l ypep t i des by , 4 6 5 - 4 7 1

c o n t r o l o f i m m u n e r e s p o n s e to staphylococcal nuclease by, 2 9 5 - 3 0 5

r o l e o f i n a n t i b o d y r e s p o n s e to et (1, 3)dextran,"747

i n wi ld-mouse populat ions, 4 5 7 -463

Immune suppressor genes, 471 - 4 7 3 Immunog lobu l in . S e e a l s o An t ibody ;

IgA; IgD; IgG; I g M allotypes, rabbi t , 6 7 7 - 6 9 5 amino ac id sequences of, 6 4 7 - 6 6 5 ,

8 1 7 - 8 3 4 , 8 4 7 - 8 5 2 classes

changes i n on the surface of B cells d u r i n g d i f ferent iat ion, 1 8 5 - 1 9 0 , 1 9 7 - 1 9 8

mul t ip l e , synthes is of by s ingle lymphocytes, 1 7 5 - 1 8 2

class heterogeneity, generat ion of, 1 4 2 - 1 4 3

d o m a i n s , i n t e r a c t i o n s b e t w e e n , 6 6 7 - 6 7 4

e x p r e s s i o n , r e g u l a t i o n o f i n mye loma cel ls, 7 8 1 - 7 9 0

fold, 639 F v fragments, 6 6 7 - 6 7 1 heavy-chain

f ramework, 6 5 5 - 6 5 6 , 8 1 8 - 8 3 4 h y p e r v a r i a b l e r e g i ons , 6 5 4 -

6 5 5 , 8 1 8 - 8 3 4 heavy-cha in genes

mur ine , 8 4 2 - 8 4 3 rabbi t , 6 9 0 - 6 9 1

l i gh t - cha in f r a m e w o r k , 6 4 9 - 6 5 2 , 8 1 8 -

834, 8 4 8 - 8 5 2 h y p e r v a r i a b l e r e g i o n s , 6 4 7 -

6 4 9 , 8 1 8 - 8 4 0 , 8 4 7 - 8 5 2 l i gh t - cha in genes, rabbi t , 692 - 694 surface

on lymphocytes of a n u r a n am­phib ians , 772

phylogeny of, 2 6 1 - 2 7 1 ro l e of i n l y m p h o c y t e a c t i v a ­

t ion, 2 6 8 - 2 7 1 o n T cells, 2 6 1 - 2 7 0

synthesis d u r i n g B - c e l l on togeny , 1 4 8 -

150 induct ion of i n Abe l s on mur ine

l e u k e m i a v i r u s - t r a n s -f o r rned l y m p h o m a c e l l s , 163 -164

t h r e e - d i m e n s i o n a l s t r u c t u r e of, 6 2 7 - 6 4 4

from T- lymphoma cells, 2 6 4 - 2 6 6 V and C genes, j o in ing of dur ing

o n t o g e n y , 8 7 7 - 8 8 2 . S e e a l s o V - C Integration

V H g enes , 6 8 7 - 6 9 1 , 7 3 5 - 7 4 0 , 8 1 9 - 8 4 5

V K s u b g r o u p s , a s s o c i a t e d w i t h identical hypervar iable re­gions, 8 4 7 - 8 5 2

V x g e n e s , m u r i n e , 8 3 7 - 8 4 1 , 857 — 858

V L genes, 8 0 5 - 8 1 4 , 8 1 9 - 8 4 5 V t r eg i on , I B pept ide m a r k e r i n ,

8 0 5 - 8 1 4 V-reg ion subgroups, 8 1 8 - 8 3 4

Immunoregulat ion, possible role of Fe receptors i n , 3 1 5 - 3 1 7

Immunosuppression, latent v i r a l i n ­fection of lymphocytes and, 81

I-region gene produets, role of i n reg-u la t ing antibody responses, 119 -126

I-region of H - 2 complex, evidence for subdiv is ion of, 4 7 7 - 4 8 6

I-region loci, expression of i n lympho­cyte subpopulat ions , 4 9 7 -503

K

K a p p a Immunoglobul in antigen, on T and B lymphocytes, 4 7 - 5 0

L

L-determinant (LD) antigens detection of, 4 2 9 - 4 3 2 role of i n allograft rejection i n vivo,

4 3 7 - 4 3 8 r o l e o f i n t h e g e n e r a t i o n o f

cytotoxic T lymphocytes i n vitro, 4 3 2 - 4 3 3

L igh t -cha in genes, rabbit , 6 9 2 - 6 9 4 Lipopolysaccharide (LPS)

development of B-cel l react iv i ty to dur ing ontogeny, 150 -156

i n d u c t i o n o f I m m u n o g l o b u l i n s y n t h e s i s b y , 1 7 8 - 1 8 2 , 187 -188 , 7 5 2 - 7 5 5

use of to st imulate growth of B-cel l clones i n vitro, 2 3 3 - 2 3 6

Ly-1 cells func t i ona l proper t i es of, 2 3 - 3 1 ,

114 -117 mediat ion of delayed-type hyper-

sensi t iv i ty by, 584 Ly-1 , 2, 3 cells, 2 5 - 3 1 , 8 9 - 9 1 , 1 1 4 -

117 Ly-2, 3 cells

i m m u n o s u p p r e s s i v e a c t i v i t y of, 2 4 - 3 1 , 9 6 - 9 7 , 114-117

k i l l e r Function of, 24 - 31,114 - 1 1 7 Ly -3 ant i gens , mo lecu la r na ture of,

8 1 2 - 8 1 4 L y - 3 locus, genetic l inkage of to locus

d e t e r m i n i n g I B p e p t i d e marker , 8 0 9 - 8 1 4

L y m p h o c y t e - m a c r o p h a g e i n t e r a c ­tions, genetic restr ict ion of,

5 6 3 - 5 7 8 , 5 8 2 - 5 8 4 Lymphocytes

B. S e e B cel l clones, growth of i n v i tro, 2 2 7 - 2 3 6 dif ferentiation

role of major histocompatibi l i ty complex i n , 6 1 1 - 6 2 2

sites of, 130 -131 Fc - r e c ep t o r -b ea r ing , f u n c t i o n a l

c h a r a c t e r i z a t i o n of, 3 0 7 -314. S e e a l s o Receptor, Fe

m i t o g e n - r e a c t i v e a n d M L C -reac t i v e , g e n e r a t i o n of i n organ cultures of embryonic thymus, 1 3 4 - 1 3 5

Peyer ' s pa t ch , secretory I gA re­sponse by, 2 0 3 - 2 1 5

s ing l e , synthes i s of m u l t i p l e Im­m u n o g l o b u l i n c l asses by , 175 -182

subpopulations I - r e g i o n d e t e r m i n a n t s o n ,

4 9 7 - 5 0 3 ontogeny of i n anuran amphi ­

bians, 7 7 1 - 7 7 8 phylogeny of, 261

surface Immunog lobu l ins , phy lo­geny of, 2 6 1 - 2 7 1

T. See Cytotoxic T cells; He lper T cells; Suppressor T cells; T cells

thymic m a t u r a t i o n a l l i n e a g e s a n d

subpopulations of, 1 1 - 1 5 te rmina l transferase i n , 64

M

M a c r o p h a g e - l y m p h o c y t e i n t e r a c ­tions, genetic restr ict ion of

i n antibody responses i n v i tro, 114, 5 6 3 - 5 6 9

i n delayed-type hypersens i t i v i t y , 5 8 2 - 5 8 4

i n T-lymphocyte proli ferative re­sponses, 5 7 1 - 5 7 8

Macrophages. See a l s o Adherent cells heat-k i l led , use of to block T - T i n ­

teractions, 8 7 - 9 1 possible expression of immune re­

sponse gene product i n , 578, 5 8 4 - 5 8 5

role of i n F, ant iparenta l graft re­j e c t i o n a n d c e l l - m e d i a t e d lympholysis , 5 1 3 - 5 1 4

ro l e of i n h e l p e r - c e l l i n d u c t i o n , 113 -116

role of Ia determinants on, i n p r i ­mary antibody responses i n vitro, 4 8 4 - 4 8 5

M a j o r h i s t o c o m p a t i b i l i t y c o m p l e x ( M H C ) . S e e H - 2 c o m p l e x ; H L - A complex

2-Mercaptoethanol, use of to support growth of lymphocyte clones in v i t ro , 2 2 8 - 2 2 9

jS 2-Microglobulin amino acid sequence of, 357 association of w i th blastocyst a n d

s p e r m sur face m o l e c u l e s , 3 3 7 - 3 3 8

s e r u m leve l s of f o l l o w i n g s t r ep -tococcal immunizat ion , 695

as a subuni t of H-2 and T L a n t i ­gens, 363 -367

S U B J E C T I N D E X 2 1 i

ß2-Microglobulin ( c o n t i n u e d )

as a s u b u n i t o f H L - A a n t i g e n , 3 2 4 - 3 3 6

M i t o g e n . S e e a l s o C o n c a n a v a l i n A ; Lipopolysaccharide

reactivit ies of B cells, development of d u r i n g ontogeny , 1 5 0 -156

use of to s t imulate growth of l ym­p h o c y t e c l o n e s i n v i t r o , 2 2 8 - 2 3 6

Modified-self, role of T-cel l subclasses i n i m m u n e r e s p o n s e t o , 2 6 - 3 0

M O P C - 3 1 5 , h a p t e n - b i n d i n g s i te of, 6 2 7 - 6 3 6

Mye loma cells regulat ion of Immunoglobul in ex­

pression in , 7 8 1 - 8 0 2 somatic ce l l hybr ids of, 7 8 1 - 8 0 2 spontaneous muta t i ons i n , 7 9 3 -

797 Mye loma proteins

b ind ing of different IgG subclasses of to l ympho id cells, 3 1 7 -319

hapten-binding, 8 2 6 - 8 3 0 idiotypic s im i l a r i t y to induced an­

t ibod ies of the same spec­i f ic i ty, 6 6 1 - 6 6 2

mutant forms of, 7 9 4 - 7 9 7 N Z B and BALB/c , differences be­

tween, 8 2 1 - 8 2 5 pr imary structure of, 6 6 1 - 6 6 5

N

Nuc lear proteins, synthesis of dur ing l y m p h o c y t e a c t i v a t i o n , 2 6 8 - 2 6 9

Nuclease, staphylococcal, immune re­sponse to, 2 9 5 - 3 0 5

Nuc le ic acid hybr id izat ion, use of to d e t e r m i n e n u m b e r o f g e r m - l i n e V genes , 8 3 2 -833, 8 5 5 - 8 8 7

O

One, nonspecific s ignal hypothesis of B-ce l l act ivat ion, 2 1 8 - 2 2 5

Ontogeny, B-ce l l dif ferentiation dur­ing, 139 -162 , 165 -172

O r i g i n of antibody diversity. See A n t i ­body d i ve rs i t y , generat ion of

P

Per i tonea l exudate cells, T-cel l act i­v a t i o n by, genet ic r e s t r i c ­t ion of, 5 7 1 - 5 7 8

P e y e r ' s p a t c h e s , s e c r e t o r y I g A re­sponse by l ymphocy t es of, 2 0 1 - 2 1 3

P h y l o g e n y , of l y m p h o c y t e sur f ace Immunoglobul ins, 261 - 2 7 1

P o l y c l o n a l B - c e l l a c t i v a t o r s , 2 1 7 -225. S e e a l s o L ipopo lysac ­charide

Pre -B cells, 139, 1 6 1 - 1 6 2 P r i m e d L D typ ing (PLT) test, 4 3 0 -

432 Pro te in A of S t a p h y l o c o c c u s a u r e u s

polyc lonal act ivat ion of B cells by,

2 2 1 - 2 2 3 use of i n hemolyt ic plaque assays,

230 Prothymocytes

properties of, 7 - 8 t e rmina l transferase i n , 65

R

Receptor B-cel l

I m m u n o g l o b u l i n c l a s s es of, 176 -199 , 2 4 0 - 2 4 1

m o d u l a t i o n o f f o l l o w i n g i n ­teract ion w i th specific ant i ­gen, 2 3 9 - 2 4 0

r o l e o f i n B - c e l l a c t i v a t i o n , 2 1 8 - 2 2 5

Fe . S e e a l s o L y m p h o c y t e s , F c -reeeptor-bearing

f u n c t i o n a l h e t e r o g e n e i t y of, 3 1 5 - 3 2 1

physicochemical properties of, 3 1 9 - 3 2 1

possible role of i n immunoregu-lat ion, 3 1 5 - 3 1 7

for p o l y c l o n a l B - c e l l a c t i v a t o r s , 221

T c e l l idiotypes, 2 7 5 - 2 9 2 , 7 1 4 - 7 1 7 mult ip le , 5 5 9 - 5 6 1 nature of, 1 1 6 - 1 1 7 , 2 6 1 - 2 7 0 ,

2 7 5 - 2 9 2 , 5 8 5 - 5 8 6 , 7 1 4 -717,897

S

Se l f -nonse l f d iscr iminat ion , role of T a n d B c e l l s i n , 2 6 - 3 0 , 2 2 4 - 2 2 5

Soluble factors. See Factors Somatic cell hybrids

m y e l o m a c e l l x m y e l o m a c e l l , 7 8 1 - 8 0 2

myeloma cell x spieen cel l , 7 9 7 -802

Somat i c g ene ra t i on of an t ibody d i ­versity, 6 4 7 - 6 5 8 , 7 6 1 - 7 7 0 , 7 9 3 - 7 9 7 , 8 1 7 - 8 6 1 , 8 8 2 -886

Staphylococcal nuclease, immune re­sponse to, 2 9 5 - 3 0 5

S t rep tococca l h y p e r i m m u n i z a t i o n , antibody response to, 6 8 9 -696

Suppression allotype, 3 5 - 3 7 of antibody responses

control of by immune suppres­sor genes, 4 7 1 - 4 7 3

effector ce l l s r espons ib l e for, 2 4 - 3 1 , 9 4 - 1 0 2 . S e e a l s o Suppressor T cells

mechanism of, 3 0 - 3 1 , 9 5 - 1 0 2 , 1 1 9 - 1 2 3

role of soluble mediator i n , 95, 1 1 9 - 1 2 3

of contact s e n s i t i z a t i o n , mecha­nisms of, 108 -111

o f c y t o t o x i c T - c e l l r e s p o n s e s , 4 3 3 - 4 3 6

of i d i o t ype p r o d u c t i o n , by a n t i -i d i o t y p i c a n t i b o d y , 7 0 1 -721

of i n v i tro immune responses, pos­sible role of Fe receptors i n ,

3 1 5 - 3 1 7 of T - B col laborat ive responses be­

t w e e n a l l o g e n i c c e l l s , 6 0 0 - 6 0 8 , 6 1 4 - 6 1 7

Suppressive T-ce l l factor, 119 -123 Suppressor T-cel ls

ce l l interact ions i n the induct ion of, 1 1 4 - 1 1 5

for the cy to tox ic T - c e l l response, generat ion of i n mixed lym­phocyte cul tures , 4 3 3 - 4 3 6

Ia determinants on, 9 6 - 9 7 , 1 1 4 -115, 4 9 7 - 4 9 9

L y phenotype of, 2 4 - 3 1 , 9 6 - 9 7 role of i n tolerance to contact sen-

sit izers, 1 0 5 - 1 1 1 role of i n tolerance to nonself and

seif ant igens, 9 3 - 1 0 2 sur face m a r k e r s o n , 2 4 - 2 5 , 36,

9 6 - 9 7 , 1 1 4 - 1 1 5 , 4 9 7 - 4 9 9 suppression of T - B collaborative

responses between allogenic cells by, 6 0 0 - 6 0 8

T

T - B interact ions genet i c r e s t r i c t i o n of, 1 2 3 - 1 2 6 ,

5 4 2 - 5 4 4 , 5 9 7 - 6 2 2 helper

between al logenic T and B cells, 5 4 2 - 5 4 4 , 5 9 7 - 6 0 8

role of soluble factor i n , 1 2 3 -126

ro l e s o f T - c e l l subc l asses i n , 2 1 - 3 0

i n the product ion of IgA antibody responses, 2 0 3 - 2 0 4

suppressive mechan ism of, 3 0 - 3 1 , 3 5 - 3 7 ,

9 8 - 1 0 2 , 1 1 9 - 1 2 6 role of soluble factor i n , 1 1 9 -

126 ro l es o f T - c e l l subc l a s s es i n ,

2 4 - 3 1 , 9 6 - 9 7 T-ce l l - rep lac ing factor (TRF) , 115 T c e l l s . S e e a l s o C y t o t o x i c T c e l l s ;

He lper T cel ls; Suppressor T cells

act ivated, enumerat ion by means o f a v i r u s p l a q u e a s s a y , 7 3 - 8 2

a c t i v a t i o n of by a n t i g e n - p u l s e d per i toneal cells, genetic re­s t r i c t ion of, 5 7 1 - 5 7 8

C o n - A - r e s p o n s i v e , genet ic map­p ing of Ia determinants on, 4 8 2 - 4 8 3

di f ferent iat ion of, 5 - 8 , 129 -136 idiotype-speeif ie, 7 0 4 - 7 0 6 , 7 1 3 -

714, 7 2 1 - 7 2 2 L y subclasses of, 2 3 - 3 1 m a c r o p h a g e i n t e r a c t i o n s w i t h ,

g e n e t i c r e s t r i c t i o n of, 5 6 3 - 5 7 8 , 5 8 2 - 5 8 4

m e d i a t i o n o f F , a n t i p a r e n t a l c e l l -med ia t ed l ympho l y s i s by, 5 1 4 - 5 1 7

mul t ip l e receptors on, 5 5 9 - 5 6 1 prol i ferat ive response, genetic re­

s t r i c t i o n o f m a c r o p h a g e -lymphocyte interact ions in , 5 7 1 - 5 7 8

receptor idiotypes, 2 7 5 - 2 9 2 , 7 1 4 - 7 1 7

22i S U B J E C T I N D E X

T-cells ( c o n t i n u e d )

nature of, 1 1 6 - 1 1 7 , 2 6 1 - 2 7 0 , 2 7 5 - 2 9 2 , 5 8 5 - 5 8 6 , 7 1 4 -717, 897

subpopu la t i ons , express ion of Ia antigens on, 492

s u r f a c e i m m u n o g l o b u l i n o n , 2 6 1 - 2 7 0

Tj cells, role of i n the regulat ion of antibody responses, 8 9 - 9 1

Te rm ina l transferase, 6 3 - 7 1 T H B ant igen, 3 8 - 3 9 Thy-1 ant igen

r a t , t i s s u e d i s t r i b u t i o n a n d physicochemical properties of, 5 1 - 6 0

r e g u l a t i o n of t h e a n t i b o d y r e ­sponse to, 5 9 2 - 5 9 4

Thy -1 " var ian t ce l l l ines, 4 0 7 - 4 1 1 Thymopoiet in , 5 - 8 T L an t i g en , mo l e cu la r s t ruc ture of,

360, 3 6 3 - 3 6 7 T L " va r i an t cel l l ines, 4 1 1 - 4 1 3 T l ymphoma cells

Immunoglobul ins from, 2 6 4 - 2 6 6 presence of sur face receptors for

m u r i n e l e u k e m i a v i r u s e s on, 1 5 - 2 1

Tolerance

B cel l , use of polyclonal B-cel l ac­t ivators to detect, 2 2 3 - 2 2 5

to contact sensitizers, mechanisms of, 105 -111

i n c y t o t o x i c T c e l l s i n d u c e d by n e o n a t a l i n j e c t i o n of C D antigens, 4 3 6 - 4 3 7

i n d u c t i o n of v i a c l o n a l a b o r t i o n mechanism, 2 4 1 - 2 4 2

induct ion of i n immature B cells, 1 5 9 - 1 6 1 , 1 6 8 - 1 7 0 , 1 8 8 -190

role of adherent cells i n , 2 5 3 - 2 5 9 role of suppressor T cells i n , 9 3 -

1 0 2 , 1 0 5 - 1 1 1 seif, modulat ion of surface I g M on

i m m a t u r e B c e l l s a n d , 159 -161

transplantat ion, induced by auto-i m m u n i z a t i o n w i t h i d i o -t y p i c r ecep to r mo l e cu l e s , 2 8 0 - 2 8 2

Tr igger ing , B cel l . See Ac t i va t ion , B cel l

T — T interactions i n the i n d u c t i o n of he lpe r ce l l s ,

1 1 3 - 116 i n the induct ion of suppressor cells,

1 1 4 - 115 role of i n the regulat ion of antibody

r e s p o n s e s , 8 5 - 9 1 , 113 — 116, 125 -126

T u m o r ce l l s , syngen ic , H-2 r es t r i c -tions of cytotoxic T-cel l re­sponse to, 5 4 7 - 5 5 0

U Ub iqu i t i n , 5 - 8

V

V - C I n t e g r a t i o n , m e c h a n i s m of, 8 0 1 - 8 0 2 , 8 6 0 - 8 6 1 , 8 8 1 -882

V i r a l surface antigens, early, role of i n cytotoxic T-cel l response to vacc in ia v irus, 5 3 3 - 5 3 5

Virus-coated cells, H-2 restr ict ion of cytotoxic T-cel l response to, 5 5 2 - 5 5 6

V i r u s - i n f e c t e d c e l l s , s p e c i f i c i t y o f cytotoxic T cells med ia t ing lysis of, 505 -509 , 5 2 9 - 5 3 5

V i r u s infection of lymphocytes, latent or persistent, 77 - 82

V i r u s plaque assay for enumerat ing activated T cells, 7 3 - 8 2

V„ genes, 6 8 7 - 6 9 1 , 7 3 5 - 7 4 0 , 8 1 9 -845

V K - 1 locus, 809 -814 V,. genes, 8 0 5 - 8 1 4 , 8 1 9 - 8 4 5