Epilepsy Classification: Hot Controversies in 2012az9194.vo.msecnd.net/pdfs/121201/502.01.pdf ·...
Transcript of Epilepsy Classification: Hot Controversies in 2012az9194.vo.msecnd.net/pdfs/121201/502.01.pdf ·...
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Epilepsy Classification:
Hot Controversies in 2012 December 4th, 2012
Ingrid Scheffer, MBBS, Ph.D and Sheryl Haut, M.D.
Symposium Co-Chairs
North American Commission of the International League Against Epilepsy Symposium 2012
American Epilepsy Society | Annual Meeting
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Disclosure
Dr. Haut Acorda Vivus
Upsher Smith Neuronex
American Epilepsy Society | Annual Meeting 2012
Consultant Consultant Consultant Consultant
Dr. Scheffer Nothing to disclose
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Learning Objectives
1. Participants will become familiar with the
revised classification system for epilepsy, which
will lead to greater diagnostic specificity for
epilepsy treatment and research
2. Participants will become more aware of the role
of genetic and immunologic testing in epilepsy
3. Improvement in coding accuracy for clinical
epilepsy practice.
American Epilepsy Society | Annual Meeting 2012
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Initial controversies
Elimination of the “focal” and “generalized “ epilepsy categories
Revision of the etiologic subgroups from “symptomatic; cryptogenic; and idiopathic” to “genetic; structural-
metabolic; and unknown”
Use of the term “constellations”
Addressing these controversies
Ongoing feedback has been welcome
Development of the new organization continues to be an evolving process
The most recent revisions will be presented during this symposium
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Schedule
• Introduction–Sheryl Haut, M.D.
• Update on the new Organization: Where Have the Modifications Taken Us? Ingrid E. Scheffer, M.B.B.S., Ph.D.
• Diagnostic Specificity: Applying This Concept to Every Patient - J. Helen Cross, M.B.Ch.B., Ph.D.
Controversies • Genetic: How Do I Tell the Patient? Sameer Zuberi, M.B.Ch.B, M.D.
• Structural: Genetic or Acquired? James Barkovich MD
• Immune: Which Patients Should Be Tested? Christian Bien, M.D.
• Coding: Will This Make a Difference to My Practice? Donna C. Bergen, M.D.
• Conclusions - Ingrid E. Scheffer, M.B.B.S., Ph.D.
• Discussion
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Update on the new Organization: Where have the
modifications taken us?
Ingrid E Scheffer, MBBS PhD FRACP Chair, ILAE Commission for
Classification and Terminology
The Florey Institute, University of Melbourne, Australia
American Epilepsy Society | Annual Meeting
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Disclosure
Name of Commercial Funding:
NINDS, CURE, US DOD, NHMRC, ARC
SAB: Dravet.org, PCDH19 Alliance
American Epilepsy Society | Annual Meeting 2012
Type of Financial Relationship
UCB, Janssen-Cilag, Athena Diagnostics,
Biocodex, GlaxoSmithKline
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Impact on Clinical Care and Practice
• Primary clinical tool in daily practice
• Affects every patient we see
• Updated terminology for seizures
• Approaches to epilepsy diagnosis
• New subgroups for etiology of epilepsy
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Learning Objectives
• To learn about the new Organization
• To understand how to use the new Organization
American Epilepsy Society | Annual Meeting 2012
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• To provide a common international terminology and classification
• Largely for clinical (treatment) purposes
• Purpose of classification: to organize items according to their fundamental relationships
Purpose of the International Classification of Seizures and Epilepsies
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• We have listened to your valuable feedback!
• “Reinstated” focal and generalized epilepsies as useful diagnostic entities where they work
• Different approaches to epilepsy diagnosis
• Modified the organization to reflect emerging etiological subgroups
• Aim to reflect current understanding
Refinements to the Organization
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• Seizures
• Epilepsies
• Diagnostic domains
• Syndromes
• Etiologies
Concepts
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• Originate within networks limited to one hemisphere
• May be discretely localized or more widely distributed.…
Focal seizures
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• Previous term: simple partial
• No impairment of awareness or consciousness
• Motor or autonomic components eg. focal clonic
• Subjective sensory or psychic features -> Aura
Focal seizures Blume et al Epilepsia 2001
• Previous term: secondarily generalized
• Evolving to bilateral, convulsive seizure
• With tonic, clonic or tonic and clonic components
• Previous term: complex partial
• Impairment of awareness or consciousness Dyscognitive
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Generalized seizures
• Originate at some point within and rapidly engage bilaterally distributed networks
• Can include cortical and subcortical structures but not necessarily the entire cortex
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Tonic-clonic (in any combination) Absence - Typical - Atypical - Absence with special features Myoclonic absence Eyelid myoclonia Myoclonic - Myoclonic - Myoclonic atonic - Myoclonic tonic Clonic Tonic Atonic
Generalized seizures
Seizure types thought to
occur within and result from
rapid engagement of
bilaterally distributed systems
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• Generalized epilepsies
• Focal epilepsies
Epilepsies
} Use where they work!
• Not every patient can be classified as either focal or generalized
• Overlap not unusual
• Especially many epileptic encephalopathies
• e.g. Dravet syndrome
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Electroclinical syndromes
Diagnostic domains
Clinicoradiological entities
Etiology Other
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• Unchanged!
• A diagnosis can be made as previously e.g.
• Lennox-Gastaut syndrome
• Childhood Absence Epilepsy
• A diagnosis is not the same as a classification
Electroclinical epilepsy syndromes
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• Replace “constellation” as does not translate
• Denote associated findings with treatment
implications such as surgery
• Mesial temporal lobe seizures
and hippocampal sclerosis
• Gelastic seizures and
hypothalamic hamartoma
Clinicoradiological entities
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• Genetic
• Structural
• Metabolic
• Immune
• Infectious
• Unknown
Etiology
• Use terms that mean what they say!
• Replace old fashioned terms: idiopathic, symptomatic, cryptogenic
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Genetic
• Concept:
– Epilepsy is the direct result of a known or inferred genetic defect
– Seizures are the core symptom of the disorder
• Evidence
– appropriately designed family studies or
– replicated molecular genetic studies
• Genetic does not exclude the contribution of environmental factors
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Structural
• Concept: epilepsy is the result of a distinct other structural condition or disease
– eg. tuberous sclerosis
• Evidence: Must have a substantially increased risk of developing epilepsy with the condition
• Can have two etiologies: eg. Structural-genetic
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Metabolic
• Concept: epilepsy is the result of a metabolic condition or disease with widespread manifestations
– eg. aminoacidopathies
– pyridoxine-dependent seizures
• Evidence: Must have a substantially increased risk of developing epilepsy with the metabolic condition
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Immune
• Concept: epilepsy is the result of autoimmune mediated central nervous system inflammation
eg. autoimmune encephalitides
– anti-NMDA encephalitis
– limbic encephalitis
• Evidence: Must have a substantially increased risk of developing epilepsy with the immune condition
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Infectious
• Concept: epilepsy is the result of an infectious cause
eg. Tuberculosis, HIV, neurocysticercosis, malaria
• Evidence: Must have a substantially increased risk of developing epilepsy with infection
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Unknown
• Concept: The underlying cause is unknown
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• Changes in response to feedback - more “user friendly”
• Adoption of new seizure terminology occurring;
concepts well accepted
• Diagnostic domains
• Electroclinical syndromes unchanged
• Clinicoradiological entities
• Etiological subgroups now separated & updated
Modifications to the Organization of the Epilepsies
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• Multiple ways to approach epilepsy diagnosis
• Flexible – you can organize it how you wish
• Must remain a dynamic and evolving classification
• Future – scientifically based classification founded
on biological mechanisms
Modifications to the Organization of the Epilepsies
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ILAE Commission for Classification and Terminology
• Anne Berg
• Edouard Hirsch
• Sameer Zuberi
• Pippo Capovilla
• Mary Connolly
• Laura Guilhoto
• Yue-Hua Zhang
• Sam Berkovic
• Doug Nordli
• Ingrid Scheffer
Classification Taskforce
• Christian Korff
• Andrew Lux
• Lynette Sadleir
• Stephan Schuele
• Yoshimi Sogawa
• Elaine Wirrell
• Jeffrey Buchhalter