Epigenetics - National Cancer Institute · 5-azacytidine, valproic acid and ATRA. Histone...

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Epigenetics

Transcript of Epigenetics - National Cancer Institute · 5-azacytidine, valproic acid and ATRA. Histone...

Page 1: Epigenetics - National Cancer Institute · 5-azacytidine, valproic acid and ATRA. Histone inhibitors. Environmental damage

Epigenetics

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Epigenetics

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DNA and destiny

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Cancer Survivors

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Cancer continuum

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Cancer development

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Cancer and age

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Paradigm shift

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Genome landscape

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Cancer genes

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GWAS hits

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Genome wide associations

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Genome sequence

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Kornberg and nucleosome

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DNA methylation

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Epigenetics

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Epigenome components

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Methylation

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Mechanism

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Chromatin modifications

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Exercise

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Environment and development

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E-cigarette vapors

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Cancer etiology

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EGRP studies

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Cohort consortium

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Early life exposure

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Scientific goal

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ECHO advantages

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Epigenetics and behavior

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Toxicoepigenomics

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Tumor alterations

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Genetic mutations

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DNA methylation and carcinogenesis

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Integrin signaling

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Methylation

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Histone acetylation

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Micro RNA signatures

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Micro RNA methylation

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Extracellular vesicles

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Histone modifications

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Histones

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Histone H3 modifications

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Epigenetic regulation

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Single cell epigenomics

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Histone modifications

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Books

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Epigenetic changes

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Epigenetic drugs

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Exfoliated cells

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Histone enzymes

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Methylation and acetylation enzymes

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HDAC inhibitors

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Phase I study

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5-azacytidine, valproic acid and ATRA

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Histone inhibitors

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Environmental damage

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Epigenetic inhibitors

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Approved epigenetic drugs

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Epigenetic drugs

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Combination therapy

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Epigenetic therapy

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Combination epigenetic therapy

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Low doses of DNA-demethylating agents

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Intervention

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Microsatellite instability

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Tumor clusters

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Genetic analysis

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Methylation analysis

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Epigenetic markers

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Mesothelioma

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Epigenetic pattern

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Esophageal cancer

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Pancreatic cancer

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Chromatin states

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Breast cancer

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Organic viruses

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DNA methylation

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HPV and methylation

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Methylated genes

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Immune system and epigenetics

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Biomarkers

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Bladder cancer methylation

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CpG island hypermethylation

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Anticancer phytochemicals

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Key points

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Carcinogenesis

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Hepatocellular epigenetics

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Epigenetic foods

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Research opportunities

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How to address challenges

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NIH Roadmap

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Roadmap

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Epigenome consortium

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IHEC

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Molecular profiling

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Ongoing programs

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NIH