EPIDEMIOLOGY AND CONTROL OF FUNGAL INFECTIONS
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Transcript of EPIDEMIOLOGY AND CONTROL OF FUNGAL INFECTIONS
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EPIDEMIOLOGY AND CONTROL OF FUNGAL INFECTIONS
Dr IgbinedionMBBS, MPH, FRSPH
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SUPERFICIAL FUNGAL INFECTIONS
Affects the skin, nails and hair Dermatophytes, yeast and mould are
the main fungi that cause superficial skin infections
There are three genera of dermatophytes that cause superfical fungal infections and they are:
Microsporum (affects hair and skin)Trichophyton(affects skin, hair and nails)Epidermophyton (affects nails and skin)
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The dermatophytes can be classified into three groups based on their habitats
HumansAnimals Soil
It should be noted that the skin is a normal habitat for some of these fungi
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Distribution
There is worldwide distribution Commonly seen in daily practice Geographic distribution of these
dermatophytes varies with different presentations in different parts of the world
Migration, drug therapy, lifestyle and socioeconomic factors all influence the changes that have been observed in the epidemiology of these infections
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Distribution (contd)
Affects all ages and sexes but more commonly found in children
Higher incidence in tropical countries and may be attributed to the warm climate (fungi thrive well in moist environments) and poor infrastructure (lack of water)
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Determinants
Man is the main reservoir of infection but as mentioned earlier, animals and soil play a part
Transmission can be direct or indirectDirect transmission e.g. during sexual
intercourse, the moist surface of the lesion allows for easy transfer of the organism
Indirect transmission is by close body contact, sharing of clothing, towels, razors, hair clippers
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Determinants (contd)
Incubation period 4-14 days Host immunity is an important factor.
Drug therapy, e.g. steroids or other immunosuppressive drugs can increase susceptibility to developing infections. Poor personal hygiene also increases susceptibility
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Clinical Features
Affects the body, scalp, nails, moist skin of the feet or groin
Tinea corporis (ringworm) produces lesions on the skin that spread out from the centre with depigmentation
Tinea capitis affects the scalp and causes areas of baldness. More common in prepubertal children
Tinea (Pityriasis) versicolor caused by the yeast malassezia furfur can be mistaken for leprosy because of the blotchy hypopigmentation
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Clinical Features (contd)
Tinea pedis affects the feet and can cause scaling. Common in men who wear shoes and socks all day long
Tinea cruris usually only found in the groins and occurs more in males. May extend to thigh and buttocks
Tinea unguium affects the nails, with toenails more affected than fingernails. Usually found along with tinea pedis
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Diagnosis
Clinical diagnosis is usually sufficient for diagnosis
Laboratory diagnosis can be done by staining or culturing scrapings of skin and scales, and plucked out diseased hairs (in cases of T. capitis)
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Treatment
Topical antifungals- clotimazole, Whitfield’s ointment
Systemic antifungals- griseofulvin, terbinafine, fluconazole, itraconazole, ketoconazole
Anti bacterials in cases of secondary bacterial infection
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Prevention and Control
Primary preventionHealth education on the cause of
diseaseAdequate housing facilities to
prevent overcrowdingAdequate water supplyAdequate protective clothing and
avoidance of moist feetAvoid sharing clothes and other
items
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Prevention and Control (contd)
Secondary preventionEarly detectionPrompt treatment
Advantages Reduces rate of transmission and
infectivity Reduces morbidity and illness
duration Limits disability that may result from
secondary bacterial infection
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Prevention and Control (contd)
Tertiary preventionRehabilitation
Surveillance is important and should be carried out especially in children to examine head, feet and groin.
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CANDIDIASIS
Dr IgbinedionMBBS, MPH, FRSPH
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Caused by yeast of the genus Candida There are about 20 Candida species that
can infect man but the most common is Candida albicans
Candida yeasts are normally found in the skin and mucous membranes but problems arise when there is overgrowth of the organisms in predisposed conditions such as pregnancy, infancy, diabetes, moist environments, immunosuppression, etc.
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Candida infection can be found in skin folds, moist areas such as webspaces, genitals and areas covered by diaper
Incubation period is 1 week Can be transmitted directly or
indirectly through sexual intercourse
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Types
Oropharyngeal candisiasis aka Thrush- This causes white plaques on the oral mucosa which may bleed when removed
Vulvovaginal candidiasis- causes itching and soreness with resultant erythema and edema of the vulva and vagina
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Diagnosis
Clinical Laboratory- Gram staining of
samples which shows yeasts with pseudohyphae, pathognomic of tissue invasion
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Treatment
Topical or systemic antifungals depending on the extent of disease
NystatinClotrimazoleCarnestin creamFluconazole ItraconazoleKetoconazole
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References
Ameen, M. (2010). Epidemiology of superficial fungal infections. Clin dermatol; 28(2): 197-201
King-man, H.O. and Cheng, T. (2010). Common superficial fungal infections- a short review. The Hong Kong Medical Diary; vol 15: 23-27.
Webber, R. (2010). Communicable Disease Epidemiology and Control: A Global Perspective. 3rd edition.