Environmental Toxins and Clinical...

69
Prof Marc Cohen MBBS(Hons), PhD (TCM) , PhD (Elec Eng) , B.MedSc(Hons), FAMAS, FICAE, Dip Ac Foundation Professor of Complementary Medicine, RMIT University Environmental Toxins and Clinical Detoxification

Transcript of Environmental Toxins and Clinical...

Page 1: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Prof Marc Cohen MBBS(Hons) PhD(TCM) PhD(Elec Eng) BMedSc(Hons) FAMAS FICAE Dip Ac Foundation Professor of Complementary Medicine RMIT University

Environmental Toxins and

Clinical Detoxification

Chronic disease and lifestyle

gt60 of all deaths are caused by lifestyle related chronic diseases The main modifiable risk factors for these diseases are

- physical inactivity - unhealthy diet - sugar salt fat alcohol tobacco - environmental toxins

Toxins and chronic disease

bull There is a global epidemic of obesity diabetes ADHD depression and cancer

bull Environmental toxins are rarely considered as a risk factor for chronic disease

WHO -World Cancer Report ndash Feb 2014

In Australia and around the world cancer is now the biggest killer Cancer prevention plays a critical role in fighting the tidal wave of cancer - Dr Bernard Stewart Smoking infections obesity alcohol air pollution and radiation are the major sources of lsquopreventablersquo cancer

The true burden of environmentally induced cancers has been grossly underestimated The panel advised President Obama to use the power of your office to remove the carcinogens and other toxins from our food water and air that needlessly increase health care costs cripple our nations productivity and devastate American lives

Presidents Cancer Panel ndashMay 2010

httpdeainfoncinihgovadvisorypcpannualReportspcp08-09rptPCP_Report_08-09_508pdf

Environmental toxins

bull POPs -DDT PCBs Dioxin PBDE PFCs

bull Endocrine disruptors -BPA phthalates alkylphenols PBDE PFOA

bull Nuclear Radiation -mining transport power weapons waste

bull Heavy Metals - Cd Pb Hg Antimony Arsenic

bull EMF -powerlines cordless phone cell phone wireless lights

1 Toxins are everywhere -we are all affected

httpwwwworldwildlifeorgtoxicsbasiccfm

POPs are found in everyone and everywhere on the planet -in our food soil air water and homes

Humans and wildlife around the world carry POPs in their bodies at or near levels that can cause injury

Toxic chemicals are found in all human tissue including cord blood amp breastmilk

Indoor environments are often more contaminated than outdoors

httpwwwwhointcehpublicationsendocrineenindexhtml

EDCs found in pesticides electronics personal care products cosmetics and food are partly to blame for a global increase in obesity birth deformities cancers psychiatric diseases ADHD neurodevelopmental problems in children etc Current findings may be ldquothe tip of the icebergrdquo

WHO UNEP Report on Endocrine Disrupting Chemicals

2 The full extent is unknown

httpwwwworldwildlifeorgtoxicsbasiccfm

Toxins are often invisible deadly amp latent gt 140000 toxic chemicals are used commercially gt3000 in high volume with 1500 new chemicals released each year Many toxic chemicals produced from industrial processes have no use and are not yet named Most chemicals are not tested for toxicity Very few toxic chemicals are routinely tested for in human tissue and toxin measures are rarely used clinically

The future is uncertain Currently used chemicals can impair reproduction behaviour intellectual capacity and the ability to resist disease in current and future generations ldquoworld-wide exposure to endocrine disruption has thrust everyone into a large-scale unplanned unintended experiment with health the outcome of which may not be known for generationsrdquo wwwourstolenfuturecom

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 2: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Chronic disease and lifestyle

gt60 of all deaths are caused by lifestyle related chronic diseases The main modifiable risk factors for these diseases are

- physical inactivity - unhealthy diet - sugar salt fat alcohol tobacco - environmental toxins

Toxins and chronic disease

bull There is a global epidemic of obesity diabetes ADHD depression and cancer

bull Environmental toxins are rarely considered as a risk factor for chronic disease

WHO -World Cancer Report ndash Feb 2014

In Australia and around the world cancer is now the biggest killer Cancer prevention plays a critical role in fighting the tidal wave of cancer - Dr Bernard Stewart Smoking infections obesity alcohol air pollution and radiation are the major sources of lsquopreventablersquo cancer

The true burden of environmentally induced cancers has been grossly underestimated The panel advised President Obama to use the power of your office to remove the carcinogens and other toxins from our food water and air that needlessly increase health care costs cripple our nations productivity and devastate American lives

Presidents Cancer Panel ndashMay 2010

httpdeainfoncinihgovadvisorypcpannualReportspcp08-09rptPCP_Report_08-09_508pdf

Environmental toxins

bull POPs -DDT PCBs Dioxin PBDE PFCs

bull Endocrine disruptors -BPA phthalates alkylphenols PBDE PFOA

bull Nuclear Radiation -mining transport power weapons waste

bull Heavy Metals - Cd Pb Hg Antimony Arsenic

bull EMF -powerlines cordless phone cell phone wireless lights

1 Toxins are everywhere -we are all affected

httpwwwworldwildlifeorgtoxicsbasiccfm

POPs are found in everyone and everywhere on the planet -in our food soil air water and homes

Humans and wildlife around the world carry POPs in their bodies at or near levels that can cause injury

Toxic chemicals are found in all human tissue including cord blood amp breastmilk

Indoor environments are often more contaminated than outdoors

httpwwwwhointcehpublicationsendocrineenindexhtml

EDCs found in pesticides electronics personal care products cosmetics and food are partly to blame for a global increase in obesity birth deformities cancers psychiatric diseases ADHD neurodevelopmental problems in children etc Current findings may be ldquothe tip of the icebergrdquo

WHO UNEP Report on Endocrine Disrupting Chemicals

2 The full extent is unknown

httpwwwworldwildlifeorgtoxicsbasiccfm

Toxins are often invisible deadly amp latent gt 140000 toxic chemicals are used commercially gt3000 in high volume with 1500 new chemicals released each year Many toxic chemicals produced from industrial processes have no use and are not yet named Most chemicals are not tested for toxicity Very few toxic chemicals are routinely tested for in human tissue and toxin measures are rarely used clinically

The future is uncertain Currently used chemicals can impair reproduction behaviour intellectual capacity and the ability to resist disease in current and future generations ldquoworld-wide exposure to endocrine disruption has thrust everyone into a large-scale unplanned unintended experiment with health the outcome of which may not be known for generationsrdquo wwwourstolenfuturecom

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 3: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Toxins and chronic disease

bull There is a global epidemic of obesity diabetes ADHD depression and cancer

bull Environmental toxins are rarely considered as a risk factor for chronic disease

WHO -World Cancer Report ndash Feb 2014

In Australia and around the world cancer is now the biggest killer Cancer prevention plays a critical role in fighting the tidal wave of cancer - Dr Bernard Stewart Smoking infections obesity alcohol air pollution and radiation are the major sources of lsquopreventablersquo cancer

The true burden of environmentally induced cancers has been grossly underestimated The panel advised President Obama to use the power of your office to remove the carcinogens and other toxins from our food water and air that needlessly increase health care costs cripple our nations productivity and devastate American lives

Presidents Cancer Panel ndashMay 2010

httpdeainfoncinihgovadvisorypcpannualReportspcp08-09rptPCP_Report_08-09_508pdf

Environmental toxins

bull POPs -DDT PCBs Dioxin PBDE PFCs

bull Endocrine disruptors -BPA phthalates alkylphenols PBDE PFOA

bull Nuclear Radiation -mining transport power weapons waste

bull Heavy Metals - Cd Pb Hg Antimony Arsenic

bull EMF -powerlines cordless phone cell phone wireless lights

1 Toxins are everywhere -we are all affected

httpwwwworldwildlifeorgtoxicsbasiccfm

POPs are found in everyone and everywhere on the planet -in our food soil air water and homes

Humans and wildlife around the world carry POPs in their bodies at or near levels that can cause injury

Toxic chemicals are found in all human tissue including cord blood amp breastmilk

Indoor environments are often more contaminated than outdoors

httpwwwwhointcehpublicationsendocrineenindexhtml

EDCs found in pesticides electronics personal care products cosmetics and food are partly to blame for a global increase in obesity birth deformities cancers psychiatric diseases ADHD neurodevelopmental problems in children etc Current findings may be ldquothe tip of the icebergrdquo

WHO UNEP Report on Endocrine Disrupting Chemicals

2 The full extent is unknown

httpwwwworldwildlifeorgtoxicsbasiccfm

Toxins are often invisible deadly amp latent gt 140000 toxic chemicals are used commercially gt3000 in high volume with 1500 new chemicals released each year Many toxic chemicals produced from industrial processes have no use and are not yet named Most chemicals are not tested for toxicity Very few toxic chemicals are routinely tested for in human tissue and toxin measures are rarely used clinically

The future is uncertain Currently used chemicals can impair reproduction behaviour intellectual capacity and the ability to resist disease in current and future generations ldquoworld-wide exposure to endocrine disruption has thrust everyone into a large-scale unplanned unintended experiment with health the outcome of which may not be known for generationsrdquo wwwourstolenfuturecom

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 4: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

WHO -World Cancer Report ndash Feb 2014

In Australia and around the world cancer is now the biggest killer Cancer prevention plays a critical role in fighting the tidal wave of cancer - Dr Bernard Stewart Smoking infections obesity alcohol air pollution and radiation are the major sources of lsquopreventablersquo cancer

The true burden of environmentally induced cancers has been grossly underestimated The panel advised President Obama to use the power of your office to remove the carcinogens and other toxins from our food water and air that needlessly increase health care costs cripple our nations productivity and devastate American lives

Presidents Cancer Panel ndashMay 2010

httpdeainfoncinihgovadvisorypcpannualReportspcp08-09rptPCP_Report_08-09_508pdf

Environmental toxins

bull POPs -DDT PCBs Dioxin PBDE PFCs

bull Endocrine disruptors -BPA phthalates alkylphenols PBDE PFOA

bull Nuclear Radiation -mining transport power weapons waste

bull Heavy Metals - Cd Pb Hg Antimony Arsenic

bull EMF -powerlines cordless phone cell phone wireless lights

1 Toxins are everywhere -we are all affected

httpwwwworldwildlifeorgtoxicsbasiccfm

POPs are found in everyone and everywhere on the planet -in our food soil air water and homes

Humans and wildlife around the world carry POPs in their bodies at or near levels that can cause injury

Toxic chemicals are found in all human tissue including cord blood amp breastmilk

Indoor environments are often more contaminated than outdoors

httpwwwwhointcehpublicationsendocrineenindexhtml

EDCs found in pesticides electronics personal care products cosmetics and food are partly to blame for a global increase in obesity birth deformities cancers psychiatric diseases ADHD neurodevelopmental problems in children etc Current findings may be ldquothe tip of the icebergrdquo

WHO UNEP Report on Endocrine Disrupting Chemicals

2 The full extent is unknown

httpwwwworldwildlifeorgtoxicsbasiccfm

Toxins are often invisible deadly amp latent gt 140000 toxic chemicals are used commercially gt3000 in high volume with 1500 new chemicals released each year Many toxic chemicals produced from industrial processes have no use and are not yet named Most chemicals are not tested for toxicity Very few toxic chemicals are routinely tested for in human tissue and toxin measures are rarely used clinically

The future is uncertain Currently used chemicals can impair reproduction behaviour intellectual capacity and the ability to resist disease in current and future generations ldquoworld-wide exposure to endocrine disruption has thrust everyone into a large-scale unplanned unintended experiment with health the outcome of which may not be known for generationsrdquo wwwourstolenfuturecom

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 5: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

The true burden of environmentally induced cancers has been grossly underestimated The panel advised President Obama to use the power of your office to remove the carcinogens and other toxins from our food water and air that needlessly increase health care costs cripple our nations productivity and devastate American lives

Presidents Cancer Panel ndashMay 2010

httpdeainfoncinihgovadvisorypcpannualReportspcp08-09rptPCP_Report_08-09_508pdf

Environmental toxins

bull POPs -DDT PCBs Dioxin PBDE PFCs

bull Endocrine disruptors -BPA phthalates alkylphenols PBDE PFOA

bull Nuclear Radiation -mining transport power weapons waste

bull Heavy Metals - Cd Pb Hg Antimony Arsenic

bull EMF -powerlines cordless phone cell phone wireless lights

1 Toxins are everywhere -we are all affected

httpwwwworldwildlifeorgtoxicsbasiccfm

POPs are found in everyone and everywhere on the planet -in our food soil air water and homes

Humans and wildlife around the world carry POPs in their bodies at or near levels that can cause injury

Toxic chemicals are found in all human tissue including cord blood amp breastmilk

Indoor environments are often more contaminated than outdoors

httpwwwwhointcehpublicationsendocrineenindexhtml

EDCs found in pesticides electronics personal care products cosmetics and food are partly to blame for a global increase in obesity birth deformities cancers psychiatric diseases ADHD neurodevelopmental problems in children etc Current findings may be ldquothe tip of the icebergrdquo

WHO UNEP Report on Endocrine Disrupting Chemicals

2 The full extent is unknown

httpwwwworldwildlifeorgtoxicsbasiccfm

Toxins are often invisible deadly amp latent gt 140000 toxic chemicals are used commercially gt3000 in high volume with 1500 new chemicals released each year Many toxic chemicals produced from industrial processes have no use and are not yet named Most chemicals are not tested for toxicity Very few toxic chemicals are routinely tested for in human tissue and toxin measures are rarely used clinically

The future is uncertain Currently used chemicals can impair reproduction behaviour intellectual capacity and the ability to resist disease in current and future generations ldquoworld-wide exposure to endocrine disruption has thrust everyone into a large-scale unplanned unintended experiment with health the outcome of which may not be known for generationsrdquo wwwourstolenfuturecom

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 6: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Environmental toxins

bull POPs -DDT PCBs Dioxin PBDE PFCs

bull Endocrine disruptors -BPA phthalates alkylphenols PBDE PFOA

bull Nuclear Radiation -mining transport power weapons waste

bull Heavy Metals - Cd Pb Hg Antimony Arsenic

bull EMF -powerlines cordless phone cell phone wireless lights

1 Toxins are everywhere -we are all affected

httpwwwworldwildlifeorgtoxicsbasiccfm

POPs are found in everyone and everywhere on the planet -in our food soil air water and homes

Humans and wildlife around the world carry POPs in their bodies at or near levels that can cause injury

Toxic chemicals are found in all human tissue including cord blood amp breastmilk

Indoor environments are often more contaminated than outdoors

httpwwwwhointcehpublicationsendocrineenindexhtml

EDCs found in pesticides electronics personal care products cosmetics and food are partly to blame for a global increase in obesity birth deformities cancers psychiatric diseases ADHD neurodevelopmental problems in children etc Current findings may be ldquothe tip of the icebergrdquo

WHO UNEP Report on Endocrine Disrupting Chemicals

2 The full extent is unknown

httpwwwworldwildlifeorgtoxicsbasiccfm

Toxins are often invisible deadly amp latent gt 140000 toxic chemicals are used commercially gt3000 in high volume with 1500 new chemicals released each year Many toxic chemicals produced from industrial processes have no use and are not yet named Most chemicals are not tested for toxicity Very few toxic chemicals are routinely tested for in human tissue and toxin measures are rarely used clinically

The future is uncertain Currently used chemicals can impair reproduction behaviour intellectual capacity and the ability to resist disease in current and future generations ldquoworld-wide exposure to endocrine disruption has thrust everyone into a large-scale unplanned unintended experiment with health the outcome of which may not be known for generationsrdquo wwwourstolenfuturecom

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 7: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

1 Toxins are everywhere -we are all affected

httpwwwworldwildlifeorgtoxicsbasiccfm

POPs are found in everyone and everywhere on the planet -in our food soil air water and homes

Humans and wildlife around the world carry POPs in their bodies at or near levels that can cause injury

Toxic chemicals are found in all human tissue including cord blood amp breastmilk

Indoor environments are often more contaminated than outdoors

httpwwwwhointcehpublicationsendocrineenindexhtml

EDCs found in pesticides electronics personal care products cosmetics and food are partly to blame for a global increase in obesity birth deformities cancers psychiatric diseases ADHD neurodevelopmental problems in children etc Current findings may be ldquothe tip of the icebergrdquo

WHO UNEP Report on Endocrine Disrupting Chemicals

2 The full extent is unknown

httpwwwworldwildlifeorgtoxicsbasiccfm

Toxins are often invisible deadly amp latent gt 140000 toxic chemicals are used commercially gt3000 in high volume with 1500 new chemicals released each year Many toxic chemicals produced from industrial processes have no use and are not yet named Most chemicals are not tested for toxicity Very few toxic chemicals are routinely tested for in human tissue and toxin measures are rarely used clinically

The future is uncertain Currently used chemicals can impair reproduction behaviour intellectual capacity and the ability to resist disease in current and future generations ldquoworld-wide exposure to endocrine disruption has thrust everyone into a large-scale unplanned unintended experiment with health the outcome of which may not be known for generationsrdquo wwwourstolenfuturecom

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 8: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

httpwwwwhointcehpublicationsendocrineenindexhtml

EDCs found in pesticides electronics personal care products cosmetics and food are partly to blame for a global increase in obesity birth deformities cancers psychiatric diseases ADHD neurodevelopmental problems in children etc Current findings may be ldquothe tip of the icebergrdquo

WHO UNEP Report on Endocrine Disrupting Chemicals

2 The full extent is unknown

httpwwwworldwildlifeorgtoxicsbasiccfm

Toxins are often invisible deadly amp latent gt 140000 toxic chemicals are used commercially gt3000 in high volume with 1500 new chemicals released each year Many toxic chemicals produced from industrial processes have no use and are not yet named Most chemicals are not tested for toxicity Very few toxic chemicals are routinely tested for in human tissue and toxin measures are rarely used clinically

The future is uncertain Currently used chemicals can impair reproduction behaviour intellectual capacity and the ability to resist disease in current and future generations ldquoworld-wide exposure to endocrine disruption has thrust everyone into a large-scale unplanned unintended experiment with health the outcome of which may not be known for generationsrdquo wwwourstolenfuturecom

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 9: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

2 The full extent is unknown

httpwwwworldwildlifeorgtoxicsbasiccfm

Toxins are often invisible deadly amp latent gt 140000 toxic chemicals are used commercially gt3000 in high volume with 1500 new chemicals released each year Many toxic chemicals produced from industrial processes have no use and are not yet named Most chemicals are not tested for toxicity Very few toxic chemicals are routinely tested for in human tissue and toxin measures are rarely used clinically

The future is uncertain Currently used chemicals can impair reproduction behaviour intellectual capacity and the ability to resist disease in current and future generations ldquoworld-wide exposure to endocrine disruption has thrust everyone into a large-scale unplanned unintended experiment with health the outcome of which may not be known for generationsrdquo wwwourstolenfuturecom

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 10: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

The future is uncertain Currently used chemicals can impair reproduction behaviour intellectual capacity and the ability to resist disease in current and future generations ldquoworld-wide exposure to endocrine disruption has thrust everyone into a large-scale unplanned unintended experiment with health the outcome of which may not be known for generationsrdquo wwwourstolenfuturecom

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 11: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

3 Tiny doses can cause big effects

Toxicologists traditionally assumed that the dose makes the poison with a monotonic dose response curve

This is the basis for regulation of public safety limits

Dose response can be non-monotonic

eg In-utero exposure to DES at 100 ppb leads to scrawny adult mice while exposure to 1ppb causes grotesque obesity

httpwwwourstolenfuturecomNewSciencelowdose20072007-0525nmdrchtml

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 12: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

EDC exposure and disease development

httpwwwwhointcehpublicationsendocrineenindexhtml

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 13: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

4 Chemicals cocktails are synergistic Exposure to a mixture of chemicals is far more harmful than exposure to individual chemicals even when the level of each contaminant in the mixture causes no effect by itself Toxins are tested for safety individually if they are tested at all

wwwenvironmentalhealthnewsorgehsnewsciencebad-mix-exposures-safe-only-one-chemical-at-a-time

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 14: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Mixture toxicity -lsquothe dose timing and mixture make the poisonrsquo

httpeceuropaeuenvironmentchemicalseffectspdfreport_mixture_toxicitypdf

ldquosomething from nothingrdquo - dose (concentration) addition ldquostrong evidence that mixture effects may arise when several chemicals are combined at doses or concentrations around or below points of departure [zero effect levels]rdquo

State of the Art Report on Mixture Toxicity Final Report Executive Summary 22 December 2009

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 15: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

5 Windows of development are critical

Prenatal exposure to OP pesticides and phthalates affects intellectual development in later life Whyatt et al (2011) Environmental Health Perspectives wwwcccehorgpdf-papersWhyattEHP2011pdf

bull Thalidomide reduces morning sickness in pregnant women but causes phocomelia in infants

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 16: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

OP exposure during critical periods can alter metabolic function and foster dietary choices favouring high fat intake and development of metabolic syndrome diabetes and obesity [1]

wwwstuffedandstarvedorg Slotkin T Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301

Early exposure leads to latent chronic disease

Effects of EDCs are often irreversible with effects not evident till later in life

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 17: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

6 Kids are more at risk

Compared to adults kids have bull Higher food fluid and air intake per kg bull Higher absorption and metabolic rate bullImmature immune and detox systems bull More exposure to the ground bull More hand to mouth behaviour bull Longer latency period

bull Australian preschool children have widespread chronic exposure to multiple neurotoxic pesticides at levels higher than the US or Germany Adult levels are unknown

Pesticide Action Network

Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 18: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Kids toxic start to life - Prepolluted

A Victorian study of breast milk found that infants are regularly exposed to several pesticides at levels greater than the ADI Quinsey et al Food Chem Toxic 199533(1)49-56

287 toxins have been detected in cord blood Of these 180 are known carcinogens 208 cause birth defects in animals and 217 are toxic to the nervous system and brain wwwewgorgreportsbodyburden2execsummphp environmentaldefencecaprepolluted

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 19: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Neurodevelopmental Toxins The world is facing a ldquosilent pandemicrdquo of ldquochemical brain drainrdquo with increasing rates of neurodevelopmental disabilities including autism attention-deficit hyperactivity disorder dyslexia and other cognitive impairments

Dr Philippe Grandjean Dr Philip Landrigan

bull Lead bull Methylmercury bull PCBs bull Arsenic bull Toluene

bull Manganese bull Fluoride bull Chlorpyrifos bull DDT bull Tetrachloroethylene bull PBDEs

Grandjean P Landigran PJ Neurobehavioural effects of developmental toxicity The Lancet Neurology Volume 13 Issue 3 Pages 330 ndash 338 March 2014

Known neurodevelopmental toxins

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 20: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

wwwanonorgimagesdeadWhalejpg httpchopzblogfileswordpresscom201004biomagnification2jpg

bull Persistent organic pollutants such as DDT amp PCB persist for years in the environment bull They are stored in fatty tissue and biomagnify up to 10 million times through the food chain bull Many sea mammals are so contaminated their carcasses must be treated as toxic waste

7 Biomagnification up the food chain

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 21: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Stockholm Convention Action to reduce global POP exposure Criteria bull Persist in the environment bull Bioaccumulate up the food chain bull Toxic to humans and environment bull Long Range Environment Transport

Dirty Dozen

1 Aldrin 2 Chlordane 3 Dieldrin 4 Endrin 5 Heptachlor 6 Hexachlorobenzene

(HCB)

7 Mirex 8 Toxaphene 9 DDT 10 Dioxins 11 Furans 12 Polychlorinated

biphenyls (PCB)

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 22: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

8 Bioaccumulation over a lifespan

Fat soluble toxins are not usually excreted and accumulate in fatty tissue over an individual lifespan Fatty tissue such as breast prostate and bone marrow is the source of many cancers This body burden of toxins is passed onto the next generation in-utero targeting the fetal brain

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 23: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Pseudo POPs and chronic disease Many EDCs are ingested continually throughout the lifespan making them pseudo-persistent and contributing to chronic disease risk Higher BPA levels are associated with clinically abnormal liver enzymes [1] cardiovascular disease [12] and diabetes [13]

1 Lang et al1Does early-life exposure to organophosphate insecticides lead to prediabetes and obesity Reproductive Toxicology 2011 31(3) p 297-301 2 Lang et al Association of urinary bisphenolA concentration with medical disorders and laboratory abnormalities in adults JAMA 2008300(11) 3Melzer et al Urinary Bisphenol A Concentration and Risk of Future Coronary Artery Disease in Apparently Healthy Men and Women Circulation 2012

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 24: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

9 Effects are epigenetic amp transgenerational

Maternal exposure affects the unborn child and future grandchildren (and possibly great grand children

Mother 1st generation

Fetus 2nd generation

Reproductive cells 3rd generation

Perera and Herbstman (2011) Prenatal environmental exposures epigenetics and disease Reproductive Toxicology 2011 httpcccehhscolumbiaedupdf-papersPereraReproToxic2011pdf

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 25: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Environmental Epigenetics A new paradigm for evolution in a contaminated world

Ancestral exposure to an endocrine disruptor (three generations previously) influences how adult males descendants respond to stress experienced during earlier adolescence Epigenetic effects of environmental contaminants are transforming evolutionary -- not just physiological and ecological ndash trajectories Effects are robust observed at the level of the transcriptome morphology physiology metabolism in critical brain nuclei and behavior

Epigenetic transgenerational inheritance of altered stress responses Crews D Gillette R Scarpino SV Manikkam M Savenkova MI Skinner MK Proc Natl Acad Sci U S A 2012 Jun 5 109(23)9143-8 Epigenetic synthesis a need for a new paradigm for evolution in a contaminated world David D Crews and Andrea C AC Gore F1000 Biol Rep (2012)

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 26: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

10 Injustice and Accidents Happen

Exposure is not equal Toxin exposure varies with bull Public policy bull Demographics -age socioeconomics education occupation

bull Location bull Consumption Usage bull Mitigation measures

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 27: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Accidents happen at every stage

Extraction -BP Oil spill (2010)

Transport -Exxon Valde (1989)

Manufacture -Bhopal (1984)

Use -Chernobl (1986) amp Fukishima (2011)

Disposal -Love Canal (1978)

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 28: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Fossil food fuels the problem

It takes an average of 7 -10 calories of input fossil fuel to produce 1 calorie of food As much as 40 of energy used in the food system goes towards the production of chemical fertilizers and pesticides Heller Martin C and Gregory A Keoleian Life Cycle-Based Sustainability Indicators for Assessment of the US Food System Ann Arbor MI Center for Sustainable Systems University of Michigan 2000 42

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 29: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

bull The largest selling agri-chemical on the planet

bull Use is predicted to double over the next 5 years 1

bull Implicated in fatal kidney disease in rural farmers 2

bull Implicated in celiac disease and gluten intolerance 3

bull Inhibits liver detoxification enzymes 4

bull 125x more toxic when formulated as Roundup 5 bull Recently found in human breast milk 6

bull Levels in Australians is unknown

Glyphosate

1 Global Industry Analysts I (2011) Glyphosate A global stategic business report 2 Jayasumana et a (2104) Glyphosate Hard Water and Nephrotoxic Metals Are They the Culprits Behind the Epidemic of Chronic Kidney Disease of Unknown Etiology in Sri Lanka

Int J Environ Res Public Health 11(2) 2125-2147 3 Samsel amp Seneff (2013) Glyphosate pathways to modern diseases II Celiac sprue and gluten intolerance Interdiscip Toxicol 6(4) 159-184 4 Samsel amp Seneff (2013) Glyphosatersquos Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome Pathways to Modern Diseases Entropy 15

1416-1463 5 Mesnage R Defarge N Spiroux de Vendocircmois J amp Seacuteralini G-E (2014) Major pesticides are more toxic to human cells than their declared active principles BioMed Research

International 1-15 6 httpsustainablepulsecom20140406worlds-number-1-herbicide-discovered-u-s-mothers-breast-milkU21lhK2Sxbw

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 30: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

bull Neurotoxins based on chemical warfare agents

bull Less persistent but more acutely toxic than DDT

bull Fatal in high doses ndashresponsible for 300000 deathspa worldwide

bull Children with high levels have greater risk of ADHD

bull Perinatal exposure is associated with

- ADHD and reduced IQ at age 3-7 1-3

- Obesity metabolic syndrome and diabetes in offspring

Organophosphate Pesticides

1 Bouchard et al (2011) Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children Environ Health Perspect 119(8) 2 Rauh et al (2011) Seven-Year Neurodevelopmental Scores and Prenatal Exposure to Chlorpyrifos a Common Agricultural Pesticide Environ Health Perspect 119(8) 1196-1201 3 Whyatt et al (2011) Maternal Prenatal Urinary Phthalate Metabolite Concentrations and Child Mental Psychomotor and Behavioral Development at Age Three Years Environmental He

Perspectives 1-29

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 31: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Pesticide Residues in Australian Children

bull There is widespread chronic exposure of Australian preschool children to multiple neurotoxic pesticide residues

bull These levels are higher than in the US or Germany

bull The levels of exposure of the Australian adult population is unknown

bull Babina et al Environ Int 2012 148 109-20 exposure to organophosphorus and pyrethroid pesticides in South Australian preschool children A cross sectional study Environ Int 2012 148 109-20

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 32: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Lifestyle measures reduce exposure

bull Remove shoes at homebull Fresh organic foodbull Minimise food packagingbull Hand washingbull Indoor plants

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 33: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

bull 75 Harvard Uni staff and students bull Randomised to lunch of canned or fresh vegetable soup for 5 days bull Canned soup increased BPA levels by 1221

Carwile JL Ye X Zhou X Calafat AM Michels KB (2011) Canned soup consumption and urinary bisphenol A a randomized crossover trial JAMA 2011 Nov 23306(20)2218-20

BPA amp canned food

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 34: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

bull 77 Harvard staff amp students bull 1 week of drinking cold beverages from polycarbonate drinking bottles bull Increased urinary BPA by 69 (p lt 00001)

BPA and drinking bottles

darr

Carwile et al Polycarbonate bottle use and urinary bisphenol A concentrations Environ Health Perspect 2009 117 p 1368ndash1372

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 35: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

bull 12 Harvard MPH students

bull Measured urinary BPA after handling receipts for 2 hours with and without gloves

bull BPA was detected in 83 of participants (mean 18ugL) at baseline and in 100 of participants (mean 58ugL) post-simulation without gloves (P=0005)

bull No change was observed after handling receipts with gloves

BPA and Thermal Receipts

Ehrlich et al 2014 Handling of Thermal Receipts as a Source of Exposure to Bisphenol A JAMA 311(8) 859-60

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 36: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Handwashing amp PBDE exposure

Serum office dust and handwipe samples from 31 participants who spent gt20 hrweek in an office were tested for pentaBDE

Low hand-washers had 33 times the pentaBDE levels in their handwipes than did high hand-washers (p = 002)

Watkins et al (2011) Exposure to PBDEs in the office environment evaluating the relationships between dust handwipes and serum Environ Health Perspect 2011 Sep119(9)1247-52

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 37: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Common plants combat indoor air pollution

Papinchak H et al Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone Horttechnology 19(2) 2009 Orwell R The Potted Plant Microcosm Substantially Reduces Indoor Air VOC pollution Water Air and Soil Pollution (2006) 177 59ndash80

Potted-plant microcosms provide effective self-regulating sustainable bioremediation for VOCs Reduce Formaldehyde xylenetoluene benzene chloroform ammonia acetone Reduces ozone 1 and volatile organic compounds in indoor air to below GC detection limit within 24hr 2

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 38: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

bull ldquoThe true greening of your own life is the basic requirement of a sustainable planetary civilizationrdquo ndash Vandana Shiva

Green your life

Agriculture and food is an area where everyone can begin today

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 39: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Food packaging as a source of BPA and phthalates

bull 20 participants in 5 families

bull 3 days eating fresh organic food

bull 66 darr urinary BPA bull 55 darr urinary phthalates (DEHP)

Rudel RA et al 2011 Food Packaging and Bisphenol A and Bis(2-Ethylhexyl) Phthalate Exposure Findings from a Dietary Intervention Environ Health Perspect - doi101289ehp1003170

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 40: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Food contamination as a major source of BPA and phthalates

bull BPA and Phthalates unexpectedly increased in Dietary Replacement Arm (n=21) with no change in recommendation Arm (n=19)

bull Phthalates went from 2837thinspnmolg to 70275thinspnmolg (Plt00001)

bull Testing for DEHP revealed concentrations of 673thinspngg in milk and 21400thinspngg in ground coriander

bull An estimate of DEHP intake for children in the Dietary Replacement Arm was above the US EPA oral reference dose and the Eu FoodSafety Authoritys tolerable daily intake

Sathyanarayana et al Unexpected results in a randomized dietary trial to reduce phthalate and bisphenol A exposures Journal of Exposure Science and Environmental Epidemiology (2013)

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 41: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Diet and Persistent Pollutants

bull Vegans were found to have significantly less OC levels compared to omnivores [1]

bull Consuming animal products was related to OC levels in umbilical cord samples [2] bullLowest levels of DDT and PCBs were found in milk from lacto-vegetarians [3]

[1] Arquin et al (2010) Impact of adopting a vegan diet or an olestra supplementation on plasma organochlorine concentrations results from two pilot studies Br J Nutrit 103(10)1433-41 [2] Mariscal-Arcasa et al (2010) Organochlorine pesticides in umbilical cord blood serum of women from Southern Spain and adherence to the Mediterranean diet Food and Chemical Toxicology 48(5) [3] Noren K (2008) Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers Acta Paediatrica 72(6) 811-816

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 42: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

American toddlers eating mostly organic food were found to have less than one sixth the pesticide residues in their urine This lowered their exposure from above to below recognised safety levels

Organic food reduces pesticide exposure

Curl et al Organophosphorus pesticide exposure of urban and suburban pre-school children with organic and conventional diets Environ Health Perspect 200311137-382 Lu et al Organic diets significantly lower childrenrsquos dietary exposure to organophosphorus pesticides Environ Health Perspect 2006 114 p 260ndash263

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 43: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

American Academy of Paediatrics Position on Organic Food

bull There is little nutritional difference between organic and conventional food

bull Organic food has less pesticides and antibiotic resistant bacteria

bull Young children are uniquely vulnerable to chemical exposures

bull No studies have yet examined health impacts of reducing chemical exposure

bull Large studies that measure environmental exposures and neurodevelopment are needed

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 44: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

This RMIT study will measure health cognition urinary pesticides (glyphosate amp OPs) heavy metals and genetic polymorphisms in children

Childrenrsquos Health Behaviour and Environmental Exposure Study

Image by Karin Beate Noslashsterud is licensed under the Creative Commons Attribution 25 Denmark license

A follow-up study will aim to determine if organic food can improve childrenrsquos cognition or health symptoms

This will help answer the question ldquoIs eating less poison good for yourdquo

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 45: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Consume SLOW food

Seasonal

Local

Organic

Whole

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 46: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

The Dirty Dozen vs Clean 15

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 47: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

lsquoFood Rulesrsquo

Donrsquot Eat Anything - that wonrsquot rot

- that has a TV add

- you couldnrsquot make yourself

- with ingredients you cannot pronounce

- that is labelled lsquodietrsquo lsquofat freersquo or lsquolow fatrsquo

- your grandmother wouldnrsquot recognise as food

copy Prof Marc Cohen

Michael Pollan

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 48: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

The evidence for detox is scanty

ldquothe science of detoxicology is still in its infancyrdquo

There is little evidence for juices diets nutritional supplements saunas scrubs purging fasting colonics exercise oral rectal and intravenous chelating agents detox programs and retreats

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 49: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

lsquoDetoxrsquo is seen as Quackery by mainstream medicine

ldquoThe principles of AD make no sense from a scientific perspective and there is no clinical evidence to support themrdquo

ndash Edzard Ernst Alternative Detox British Medical Bulletin 2012 101 33-8

ldquoThe pathophysiology of lsquodetoxrsquo is non-existentrdquo

ldquoAs a therapeutic approach detox is implausible unproven and dangerousrdquo

ldquoDetox promotions may contribute to ill health by suggesting we can all over-indulgerdquo

wwwquackwatchcom

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 50: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Scientology Purification Rundown

1 Cecchini et al Chemical exposures at the World Trade Center use of the Hubbard Sauna Detoxification Regimen to improve the health status of New York City rescue workers exposed to toxicants Townsend Letter 200627358ndash65

2 Tretjak et al PCB reduction and clinical improvement by detoxification an unexploited approach Hum Exp Toxicol 19909235ndash44

3 Root et al Excretion of a lipophilic toxicant through the sebaceous glands A case report J Toxicol Cutaneous Ocul Toxicol 1987613ndash8

4 Wisner et al Neurotoxicity and toxic body burdens relationship and treatment potentials Proceedings of the International Conference on Peripheral Nerve Toxicity 1993

5 Schnare DW Denk G Shields MG Brunton S Evaluation of a detoxification regimen for fat stored xenobiotics Med Hypotheses 19829265ndash82

6 Schnare DB Ben M Shields MG Body burden reduction of PCBs PBBs and chlorinated pesticides in human subjects

7 Ambio 198413378ndash80

8 Tretjak ZR Tretjak A et al Xenobiotic reduction and clinical improvements in capacitor workers a feasible method J Environ Sci Health 19907A25

9 Tretjak ZB Tretjak A Gunnerson C Occupational environmental and public health in Semic a case study of polychlorinated biphenyl (PCB) pollution Proceedings of the Annual Meeting of the American Society of Civil Engineers 1989

10 Schnare DR Reduction of the human body burdens of hexachlorobenzene and polychlorinated biphenyls World Health Organization International Agency for Research on Cancer Scientific Publications Series 198677597ndash603

11 Kilburn KH Warsaw RH Shields MG Neurobehavioral dysfunction in firemen exposed to polychlorinated biphenyls (PCBs) possible improvement after detoxification Arch Environ Health 198944345ndash50

12 Shields MB Cassidy-Brinn G Improvement in perception of transcutaneous nerve stimulation following detoxification in firefighters exposed to PCBs PCDDs and PCDFs Clinical Ecology 1989647ndash50

13 Dahlgren et al (2007) Persistent organic pollutants in 911 world trade center rescue workers Reduction following detoxification Chemosphere 69 1320-1325

The Purification Rundown is the controversial Scientology Detox Program based on exercise high dose niacin and saunas (up to 5 hours a day for 5 weeks) A number of case reports cohort studies and nRCTS suggest that this program reduces the body burden of PCBs PBBs dioxins various drugs and pesticides and reduce symptoms and improves neurological function

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 51: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Ancient Healing Meets Modern Science

- Genomics - Nutrigenomics- Pharcogenomics- Toxicogenomics- Ayugenomics

httpchrissemsarianfileswordpresscom201206the-sequencing-explosion1jpg

Prakriti ndash (doshas - constitution)

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 52: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

httpubiomecom

Agni ndash (digestive fire)

- Microbiome- Newly discovered organ- Enterotyping- Crowd funded citizen science

business startup

Ancient Healing Meets Modern Science

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 53: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

httpwwwnaturecomjesjournalv21n1fig_tabjes201050f1htmlhttpwwwlivesciencecom39453-urine-chemical-compositionhtml

- Metabolomics- Proteomics- Transcriptomics- Exposome -the combined

sources of toxins reaching theinternal environment fromconception onwards

Ama ndash (toxins)

Ancient Healing Meets Modern Science

gt30000 chemicals in bloodgt3000 chemicals in urine

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 54: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Removal of lipophilic toxinsAyurvedic detox program (panchakama)Non-randomised 2 week clinical trial (n=15)

-oleation (ingestion of lipophilic foods)-herbal oil massage amp enemas-herbal steam baths amp supplements -purgation amp dietary restriction

- 46 reduction in PCBs - 58 in beta-HCH- Health effects were not studied

Herron RE Fagan JB (2002) Lipophil-Mediated Reduction Of Toxicants In Humans An evaluation of an Ayurvedic detoxification procedure Alternative Therapies 8(5) 40-51

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 55: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Fecal excretion of PCBs dioxin and HCB increased with olestra in 3 subjects [1] Clinical trial of 2 patients with chloracne found olestra increased TCDD excretion 8-10 fold and potentially reduced half-life of from 7 to 1-2 years [2]

[1] Moser et al Chemosphere 1999 39 (9)1513 -15 21 [2] Geusau et al Lancet 1999 354 (9186)1266-1267

Increasing POP excretion

Olestra may decrease absorption of fat-soluble vitamins A D E and K and cause loose stools cramps diarrhea flatulence or nausea

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 56: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Jandacek et al 2014 Reduction of the Body Burden of PCBs and DDE by Dietary Intervention in a Randomized Trial J Nutrit Biochem

Increasing PCB excretion

PCB exposure in Anniston AL leading to high body burden of PCBs and increased HPT and NIDDM Double-blind RCT (n=23) 1 year trial of 15gday of olestra (12 crisps) versus vegetable oil (6 crisps) Elimination rate of PCBs did not change with vegetable oil and increased with olestra (from-000864 to -00829 (p =004) PCB concentrations decreased by 4 and DDE by 5 in VO group and PCB decreased by 8 and DDE by 16 in olestra group

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 57: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Better safe than sorryrdquo The Precautionary Principle - The idea that action should be taken to prevent harm to the environment and human health even if scientific evidence is inconclusive Late Lessons from Early Warnings - CFCs PCBs BSE DES sulphur dioxide antibiotics as growth promoters asbestos

Precaution is the Principle

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 58: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

bull Parents will often change their own behaviour for the benefit of their children

bull Ecoparenting provides the best start to life and holistically impacts on parenting style consumption patterns and toxin exposure

bull Creates communities of practice around childrearing food production harvesting preparation and consumption

Ecoparenting -growing greener children

wwwecoparentingnet

httphealthychildorgawakeupstory

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 59: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Many Questions Remain

bullWhat are levels of different toxins bullDo they vary across populations bullWhat are the main exposureexcretory pathways bullDoes exposureexcretion correlate with Health status Cognitive function Nutritional microbiome status Genetic polymorphisms epigenetic changes bullHow can exposure be reduced and excretion enhanced bullDoes detoxification improve health outcomes

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 60: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Human biomonitoring studies

httpwwwcdcgovexposurereport

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 61: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

SmartPhonePhysicalorg

Multiple biometric and diagnostic devices

bull Body analysis scanbull Electrocardiogrambull Opthalmoscopebull Blood pressurebull Oximeterbull Visual Acuitybull Otoscopebull Spirometerbull Stethescopebull Ultrasound

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 62: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Scanaducom Personal vital signs monitor Heart rate Blood flow Oximetry ECG Temperature

Biozoomnet Antioxidant levels Cyochrome c-Oxidase Stress levels VO2 Max skin moisture

Zephyranywherecom Biopatch Heart rate Activity Level R-R interval ECG Position Posture

My lapkacom Personal environment monitor ndash Temperature Humidity Radiation Organic nitrates EMF Breath alcohol

Tellspeccom Personal spectrometer that can analyse food ampbeverages for Allergens Chemicals Toxins Nutrients Calories Ingredients

New Wellness Technology

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 63: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Online Cognitive Function testing

Cogstatecom

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 64: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Wearable technology

Apple i-watch release in late 2014

Nike Fuel Band

Samsung Galaxy Gear

Angel Sensorcom Open platform architecture for wristband biosensors bull acoustic - pulse blood flow bull optical - oximetry blood flow waveformbull acceleration - activity calories steps

Bracelets can detect peoples chemical exposures

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 65: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Airqualityeggcom Personal air quality monitor

bull Air Pollutants bull NO2 bull Dust bull Ozone bull Carbon Monoxide bull Sulfur dioxide bull PM24 bull PM10 bull Black Carbon bull Benzene bull 13-butadiene bull Ethylene oxide bull Acrylonitrite bull Acetaldehyde bull Fromaldehyde bull Tetrachlororethylene

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 66: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Personalised wellness focused medicine

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

Convergence of

- Quantified Self Movement- Sensor technology ndashlab on a chip- Mobile devices - smartphonephysical- Big data amp cloud computing- Crowdfunding amp citizen science

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 67: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Wellness Audits

httpswwwniehsnihgovnewsnewsletter2011septemberscience-chipindexcfm

If you donrsquot measure you canrsquot manage

If you donrsquot state you canrsquot communicate

- subjective wellbeing - sustainability - health - economics - social Applicable to

- Individuals - Communities - Workplaces - Gamification - P2P networking

Combine measures of

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 68: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Is eating less poison good for you

we donrsquot know yet What level of neurotoxicants are we willing to have in our bodies and our children for the sake of cheap convenient industrially-produced food

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits
Page 69: Environmental Toxins and Clinical Detoxificationcongress.metagenics.com.au/postcongress/media/... · • More hand to mouth behaviour • Longer latency period • Australian preschool

Imagine a world bull Free of toxic petrochemicals

bull Where our lifestyles enhance our wellbeing rather than contribute to chronic disease

bullWhere food forests and edible landscapes allow everyone to enjoy seasonal local organic whole food

bull Everyone interacts with wealth of the worldrsquos knowledge and interacts with a global wellness curriculum

Image

  • Slide Number 1
  • Chronic disease and lifestyle
  • Slide Number 4
  • Slide Number 5
  • 1 Toxins are everywhere -we are all affected
  • Slide Number 8
  • 2 The full extent is unknown
  • The future is uncertain
  • EDC exposure and disease development
  • Slide Number 13
  • Slide Number 14
  • Slide Number 15
  • Slide Number 16
  • Slide Number 17
  • Kids toxic start to life - Prepolluted
  • Neurodevelopmental Toxins
  • Slide Number 20
  • Slide Number 21
  • Slide Number 22
  • Pseudo POPs and chronic disease
  • Slide Number 25
  • 10 Injustice and Accidents Happen
  • Fossil food fuels the problem
  • Slide Number 29
  • Slide Number 30
  • Slide Number 31
  • Slide Number 33
  • Slide Number 34
  • Slide Number 35
  • Slide Number 36
  • Slide Number 37
  • Food packaging as a source of BPA and phthalates
  • Diet and Persistent Pollutants
  • Slide Number 42
  • Slide Number 43
  • Slide Number 44
  • Consume SLOW food
  • Slide Number 46
  • lsquoFood Rulesrsquo
  • The evidence for detox is scanty
  • Slide Number 50
  • Slide Number 55
  • Slide Number 56
  • Slide Number 57
  • Many Questions Remain
  • Human biomonitoring studies
  • Online Cognitive Function testing
  • Airqualityeggcom
  • Wellness Audits