Environmental Toxicity and the Effect on Health
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Transcript of Environmental Toxicity and the Effect on Health
Environmental Toxicityand the Effect on Health
Walter J. Crinnion, ND
Outline1. What is our current toxic burden ?2. How does it affect our health?3. What do the patients and their
doctors need to help with this huge problem?
4. Metametrix is the “go-to lab” for environmental medical testing
What is Our Current Toxic Burden?
Are you toxic?
Better Living Through ChemistryThere are over 80,000 chemicals
registered for use by the US EPA.Over 3,800 of those are “high-use”
chemicals.Less than half of high-use
chemicals have been assessed for toxic effect on humans.
Less than 9% have been assessed for toxic effects on children.
Environmental Working Group (EWG) Neonatal Toxicity Study
www.ewg.org/reports/bodyburden2/
10 babies born in US hospitals
287 chemical compounds identified in their cord blood
Average of 200 chemicals per infant
Toxins in the Cord Blood of US Newborns
EWG Adult Burden Study9 persons
Including several international environmental activists
210 different chemicalsAverage of 91 chemical
toxins per personwww.ewg.org/reports/
bodyburden1/
Bill Moyers’s Burden
Phthalates (plasticizers) in Urine(289 persons from CDC NHANES)Two phthalates in all urine samples testedTwo more were found in over 75% of
the samples as well
Xenobiotics in Meconium(in utero exposures)Nicotine
Lowest but still detectable even in non-smokers
Two metabolites of organophosphate pesticides (DEP and DETP) were found in 19/20 and 20/20 samples
Mercury In 6.4% of the maternal
blood and 46.1% of the meconium
US Children’s Urine Studies1,4-dichlorobenzene in 96% of Arkansas
childrenChlorpyrifos in the urine of 93%, carbaryl
in 45%, malathion in 33% in MinnesotaOP metabolites DMTP and DETP were
found in 70-75%, at least one was present in 99% of samples in Seattle preschoolersOnly one child whose parents
fed them organic food was clear of pesticides in the urine
The Weight…What we are all carrying
1. OCDD 9. Ethylphenol2. HpCDD 10. DDE/T3. HxCDD 11. PCBs4. PeCDD 12. Phthalates5. Styrene 13. Chlordanes6. Dichlorbenzene 14. OP pesticides7. Xylene 15. Pb, Hg, Cd, As,
etc.8. Parabens 16. PAHs
?The Question About Human Toxic BurdenNOT — IF you are toxic
BUT — IF toxins are a causative factor in your health care problem(s), and — IF toxins are an obstacle to cure
Why We Are ExposedPart of mom’s toxic burden passed to usNew compounds added to body
daily through our nasty habits:Eating, Drinking, Breathing
Biggest Sources:Indoor air in our homes
and workplacesFood
Why They Build UpOur bodies are designed to
hold on to fatNeeded for healthy bodiesHistorically hard to come by
Fats cannot leave by urination or defecationReabsorption of fats — recycling
These fat-resorption mechanisms cannot differentiate between good fats (EFA, fat-soluble vitamins) and DDT!!!
Photo by graham
Worse with Weight LossWeight loss increases circulating levels of
persistent fat-stored pollutantsSame increase seen after bariatric
surgery (increases of 24-52%)
Chevrier J, et al. Int J Obes Relat Metab Disord 2000;24:1272-8Hue O, et al. Obes Surg 2006;16:1145-54Imbeault P, et al. Int J Obes 2001;25:1585-91Charlier C, et al. In J Obes 2002;26:1465-8
Photo by slushpup
Do These Toxins Cause Health Problems?
Photo by D Sharon Pruitt
In Total, the Nine EWG Subjects Carried:Ü 76 chemicals linked to cancer in humans or animals
(average of 53)Ü 94 chemicals that are toxic to the brain and
nervous system (average of 62)Ü 86 chemicals that interfere with the hormone
system (average of 58)Ü 79 chemicals associated with birth defects or
abnormal development (average of 55)Ü 77 chemicals toxic to the reproductive system
(average of 55)Ü 77 chemicals toxic to the immune system
(average of 53)
What are The Main Targets?These compounds clearly
affect:Immune system
Allergies/Asthma Chronic infections Autoimmunity
Nervous systemEndocrine/hormonal systemGenerational
How They Cause DamageMitochondrial toxicity
Reduce function of mitochondria Reduced function of cell/organs that contain
mitochondria
Oxidative damageNeurotoxicity
Solvents diminish neural functioning
Pesticides are neurotoxins by design
Photo by get directly down
Associated Adverse OutcomesCancer incidences are increasing
“Boomers” have higher rates of cancer than any previous generation
Childhood brain cancers are risingAsthma rates are rising worldwideAutism and ADD/ADHD rates are increasingChemical SensitivityChronic Fatigue Immune Deficiency
SyndromeGulf War Syndrome
Presenting As:FatigueObesityDiabetesFibromyalgiaCognitive difficulties
Brain FogMood disordersTremorsChronic neurological
illnesses
AsthmaAllergiesChemical sensitivitiesAutoimmune conditionsChronic bacterial,
fungal, and viral infections
Certain cancersInfertilityHormonal imbalancesEtc.
Why Some People Retain More Toxins Than Others Genetic differences in phase
one and phase two enzymes (polymorphism)
Nutrient deficiencies (Mg,Se,B6)
High sugar, low protein diet Stress, emotional stuffing, trauma Heavy metal presence (esp. Hg)
Increased exposure
Photo by get wili hybrid
The Dirty DozenEWG’s 12 most contaminated fruits/vegetables
1. Peaches 7. Cherries2. Apples 8. Pears3. Bell Peppers 9. Grapes (imported)4. Celery 10. Spinach5. Nectarines 11. Lettuce6. Strawberries 12. Potatoes
www.ewg.org
EWG’s 12 Least Contaminated Fruits and Vegetables1. Onion 7. Sweet peas2. Avocado 8. Kiwi fruit3. Sweet corn 9. Bananas4. Pineapple 10. Cabbage5. Mango 11. Broccoli6. Asparagus 12. Papaya
Notes: The levels shown on this figure represent the sum of the 12 PCB compounds that resemble dioxin, widely recognized as the most toxic of all industrial pollutants, and linked to cancer as well as to damage of the nervous, reproductive, and immune systems. PCB concentrations are shown as toxic equivalents (TEQs) of 2,3.7,8-Tetrachlorodibenzo-p-dioxin, the benchmark of dioxin chemical. Source: EWG analysis of data from Axys (2003), Easton et al. (2002), EPA (2000a and 2000b), Fiedler et al. (2000), Jacobs et al. (2002), NMFS (2002), NAS (2003), Schecter et al. (2001), and USDA (2002).
The EPA Recommends:No more than ONE* meal of farmed salmon per MONTH! (This is based on CANCER risk, not
neurobehavioral, endocrine, or immune effects)
• ½ meal per month if the Salmon is from Scotland or the Faroe Islands
Butter – The Global PCB MarkerHighest PCB levels in butter from Europe
and North America. [i] Lowest levels were in Australia and New ZealandLevels of p,p-DDT, p,p-DDE and HCH were
highest in butter from areas where those compounds are in regular use (DDT = India and
south/central America; HCH = India, China, Spain).
[i] Kalantzi OI, Environ Sci Technol 2001;35(6):1013-1018.
EPA List of Mercury in Fishwww.cfsan.fda.gov/%7Efrf/sea-mehg.html
Most Toxic Least Toxic1. Tilefish (Gulf of Mexico) 1.45
ppm2. Shark 0.9883. Swordfish 0.9764. King Mackerel 0.7305. Tuna (bigeye) 0.6396. Orange Roughy 0.5547. Marlin 0.4858. Grouper 0.4659. Mackerel Spanish 0.45410. Tuna (fresh/frozen) 0.41411. Chilean Bass 0.38612. Bluefish 0.33713. Lobster 0.31014. Croaker, white (Pacific) 0.28715. Scorpion fish 0.28616. Weakfish (Sea trout) 0.25617. Halibut 0.25218. Sablefish 0.22219. Bass (saltwater, black) 0.21920. Snapper 0.189
1. Clam ND2. Ocean Perch ND3. Salmon (canned) ND4. Shrimp ND5. Whiting ND6. Tilapia 0.0107. Oyster 0.0138. Salmon (fresh/frozen) 0.0149. Hake 0.01410. Sardine 0.01611. Haddock 0.03112. Crawfish 0.03313. Pollock 0.04114. Anchovies 0.04315. Herring 0.04416. Flounder/Sole 0.04517. Mullet 0.04618. Catfish 0.04919. Scallop 0.05020. Atlantic Mackerel 0.050
What Do Patients and Clinicians Need?
A Current Dilemma(another inconvenient truth)
Natural medicine is built upon finding the nutrient, supplement, or protocol the patient is deficient in which will bring a return to health
All patients are toxic and will NOT get better until the obstacle to cure is identified and removed
Photo by zedzap
What Patients FaceChronic health problems that current
allopathic, naturopathic, and alternative methods are not working for
Realization that this world is toxic
Fear that their problems are caused by a toxic buildup and that no one can help
Photo by DerrickT
What Clinicians FaceChronically ill patients in whom their
sure-fire therapies are not workingAn influx of illnesses caused by toxicity
(ie. Chemical sensitivity and chronic neurologic
problems) that they cannot treat
A knowledge (great or small) that toxins may be the culprit, but not sure how to proceed to confirm the diagnosis
For more information on toxicity testing contact
Metametrix at 800.221.4640 or visit
www.metametrix.com/toxicity