Endocrine Rachel Boggus [email protected]. 10/19/2015Template copyright 2005 Endocrine...
-
Upload
dwayne-mcdonald -
Category
Documents
-
view
215 -
download
0
Transcript of Endocrine Rachel Boggus [email protected]. 10/19/2015Template copyright 2005 Endocrine...
04/21/23 Template copyright 2005 www.brainybetty.com 2
Endocrine Secretion
• What is it?
• What is a feature common to endocrine tissues?
• Where are endocrine cells found?
04/21/23 Template copyright 2005 www.brainybetty.com 3
Endocrine Secretion• What is it?
• Secretion of chemical messengers (hormones) directly into the blood stream to act on distant tissues
• What is a feature common to endocrine tissues?• Usually highly vascular to facilitate rapid dissemination of
secretory products• Where are endocrine cells found?
• Dispersed as single cells in epithelial tissues (gut and respiratory tract)
• As discrete clusters in another organ (pancreas, ovary, testis)
• Gathered in one specialized organ (pituitary, thyroid, parathyroid, adrenal, pineal glands)
04/21/23 Template copyright 2005 www.brainybetty.com 4
The Pituitary gland
• What is the other name for it?
• What are the two parts of it?
• Where are each of the parts derived?
• What does each part consist of?
04/21/23 Template copyright 2005 www.brainybetty.com 5
The Pituitary gland• What is the other name for it?
• hypophysis• What are the two parts of it?
• Adenohypophysis and neurohypophysis• Where are each of the parts derived?
• Adeno—from oral ectoderm, neuro—from neural ectoderm
• What does each part consist of?• Adeno—pars distalis, pars tuberalis, and pars
intermedia• Neuro—pars nervosa and infundibulum
04/21/23 Template copyright 2005 www.brainybetty.com 6
Adenohypophysis
• What are the cell types in the adenohypophysis?
• How are the major cell types classified?
04/21/23 Template copyright 2005 www.brainybetty.com 7
Adenohypophysis
• What are the cell types in the adenohypophysis?
• Acidophils and Basophils, Chromophobes, Folliculostellate cells
• How are the major cell types classified?
• Based on affinity of dyes for granules
04/21/23 Template copyright 2005 www.brainybetty.com 8
Acidophils
• Stain pink in H&E, PAS
• What are the two types of acidophils and their products?
04/21/23 Template copyright 2005 www.brainybetty.com 9
Acidophils
• Stain pink in H&E, PAS
• What are the two types of acidophils and their products? (remember the Ms)
• Somatotrophs—growth hormone—stimulate growth, RNA and protein synthesis, synthesis of somatomedins stimulate growth of long bones
• Mammotrophs—Prolactin—stimulates milk synthesis from the nips
04/21/23 Template copyright 2005 www.brainybetty.com 10
Basophils
• Stain poorly with H&E, PAS
• What are the cell types and their products
04/21/23 Template copyright 2005 www.brainybetty.com 11
Basophils• Stain poorly with H&E, PAS• What are the cell types and their products
• Thyrotrophs—thyroid stimulating hormone—stims thyroid hormone syn & secretion
• Gonadotrophs—Follicle stimulating hormone—promotes ovarian follicle development and estrogen secretion in females and spermatogenesis in males, Lutenizing Hormone—stims ovarian follicle maturation and progesterone secretion in females, stimulates leydig cells to secrete androgens in males
• Corticotrophs (POMC)—Post trans processing of POMC Adrenocorticotropic hormone (ACTH) Lipotropic Hormone, Melanocyte stimulating hormone, B-endorphin
04/21/23 Template copyright 2005 www.brainybetty.com 12
Chromophobes & Folliculostellate Cells
• Chromophobes—few or no granules, no affinity for stain– What are they?
• Folliculostellate cells—supportive cells– What do they look like?
04/21/23 Template copyright 2005 www.brainybetty.com 13
Chromophobes & Folliculostellate Cells
• Chromophobes—few or now granules, no affinity for stain– What are they?
–Degranulated secretory cells, undifferentiated secretory cells
• Folliculostellate cells—supportive cells– What do they look like?
–Appear stellate and extend branching processes among secretory cells, and are GFAP +
04/21/23 Template copyright 2005 www.brainybetty.com 14
Pituitary – note vascularity of distalis
04/21/23 Template copyright 2005 www.brainybetty.com 15
04/21/23 Template copyright 2005 www.brainybetty.com 16
Pars intermedia
• What does it develop from?
• What does it contain?
• Note that fluid can accumulate giving rise to a cyst
04/21/23 Template copyright 2005 www.brainybetty.com 17
Pars intermedia
• What does it develop from?
• The dorsal portion of Rathke’s pouch
• What does it contain?
• Mostly basophils and a few chromophobes
• Note that fluid can accumulate giving rise to a cyst
04/21/23 Template copyright 2005 www.brainybetty.com 18
Pituitary Vascular Supply
• YOU MUST KNOW THIS!
• It shows you just how much control the hypothalamus has on adenohypophyseal (i.e. pituitary) secretion
04/21/23 Template copyright 2005 www.brainybetty.com 19
04/21/23 Template copyright 2005 www.brainybetty.com 20
Pituitary vascular supply (cont)
• Superior hypophyseal arteriesprimary capillary plexus irrigating median eminance and the stalk
• Small veins (portal) from primary plexus form secondary capillary plexus in adenohypophysis
• Why is the portal system important?
04/21/23 Template copyright 2005 www.brainybetty.com 21
Pituitary vascular supply (cont)
• Why is the portal system important?
• For the delivery of concentrated releasing and inhibiting hormones from median eminance (where 1st cap. Plexus is) to adenohypophysis (where 2nd cap plexus is)
04/21/23 Template copyright 2005 www.brainybetty.com 22
• Inferior hypophyseal arteries provide blood to neurohypophysis and the stalk
• THERE IS NO DIRECT ARTERIAL SUPPLY TO THE ADENOHYPOPHYSIS – this will be on your test!!!
04/21/23 Template copyright 2005 www.brainybetty.com 23
Neurohypophysis
• What does it consist of?
04/21/23 Template copyright 2005 www.brainybetty.com 24
Neurohypophysis
• What does it consist of?
• Unmyelinated axons of supraoptic and paraventricular neurons from hypothalamus
• Neurosecretory material (herring bodies)
• Pituicytes (highly branched glial [i.e. supportive] cells)
• Rich capillary plexus
04/21/23 Template copyright 2005 www.brainybetty.com 25
Products of Neurohypophysis
• ***** NOTHING!!!!******– This will be on your test too!
• How is that possible?
04/21/23 Template copyright 2005 www.brainybetty.com 26
Products of Neurohypophysis
• ***** NOTHING!!!!*******
• How is that possible?
• Vasopressin (ADH) and oxytocin are only STORED in the neurohypophysis but are MADE in the hypothalamus!
• What do these two hormones do?
• ADH—stims reabsorption of water
• Oxytocin stimulates milk let down
04/21/23 Template copyright 2005 www.brainybetty.com 27
Neurohypophysis
04/21/23 Template copyright 2005 www.brainybetty.com 28
The Thyroid gland
• What does it produce?
• What do these hormones do?
04/21/23 Template copyright 2005 www.brainybetty.com 29
The Thyroid gland
• What does it produce?
• Thyroid hormones T3 and T4
• What do these hormones do?
• Regulate mitochondrial respiration, I.e regulate basal metabolic rate
04/21/23 Template copyright 2005 www.brainybetty.com 30
Structure
• Slips from thin fibroelastic capsule divide it into lobules
• Lobules consist of follicles– What do follicles consist of?
04/21/23 Template copyright 2005 www.brainybetty.com 31
Structure
• Slips from thin fibroelastic capsule divide it into lobules
• Lobules consist of follicles– What do follicles consist of?
–Simple cuboidal epithelial cells called principal cells that secrete thyroglobulin into center
–Thyroglobulin is stored as colloid EXTRACELLULARY
–This will be on your test too!!!!!!
04/21/23 Template copyright 2005 www.brainybetty.com 32
THYROID
04/21/23 Template copyright 2005 www.brainybetty.com 33
04/21/23 Template copyright 2005 www.brainybetty.com 34
Principle cells
• What are their features?
04/21/23 Template copyright 2005 www.brainybetty.com 35
Principle cells
• What are their features?
• Rest on basal lamina, apices point to center of follicle
• Typical apical junctional complexes (what are the three components?), short microvilli, well-developed supranuclear golgi, numerous RER, abundant lysosomes, mitochondria, and multivesicular bodies
04/21/23 Template copyright 2005 www.brainybetty.com 36
Thyroid Hormone Synthesis
• Where is thyroglobulin synthesized? Modified? Released?
• How is iodide taken up?
• What happens to it once it is in the cell?
• What happens once it leaves the cell?
• What happens upon TSH stimulation?
04/21/23 Template copyright 2005 www.brainybetty.com 37
Thyroid Hormone Synthesis• Where is thyroglobulin synthesized? Modified?
Released?• RER. RER and Golgi (carbs added). apical surface
via vesicles• How is iodide taken up?
• Iodide pump at basal membrane• What happens once it leaves the cell?
• Covalently bound to tyrosyl residues of thyroglobulin at apical memb by thyroid peroxidase
• What happens upon TSH stimulation?• Principal cell takes up colloid via pinocytosis and
releases iodinated tyrosines via lysosomal-derived protease activity
04/21/23 Template copyright 2005 www.brainybetty.com 38
Parafollicular cells
• Where are they?
• What are they?
04/21/23 Template copyright 2005 www.brainybetty.com 39
Parafollicular cells
• Where are they?
• Within follicular epithelium scattered in CT among follicles
• What are they?
• Produce calcitonin—lowers blood calcium levels; calcitonin keeps the Ca in (the bones, that is)
• Lots of RER and large Golgi
04/21/23 Template copyright 2005 www.brainybetty.com 40
Parathyroid Gland
• What do they look like microscopically?
• What are the two cell types?
04/21/23 Template copyright 2005 www.brainybetty.com 41
Parathyroid Gland
• What do they look like microscopically?
• Septa from capsule separate gland into lobules of dense anastomosing cords of cells
• What are the two cell types?
• Chief and oxyphil
04/21/23 Template copyright 2005 www.brainybetty.com 42
Chief Cells
• What do they secrete? What does it do?
• What do they look like in LM and EM?
04/21/23 Template copyright 2005 www.brainybetty.com 43
Chief Cells
• What do they secrete? What does it do?
• Parathyroid Hormone, increases blood calcium concentration
• What do they look like in LM and EM?
• LM—sm, centrally located nuclei in pale cytoplasm
• EM—mod. RER and Golgi, lots of glycogen, sm. Dense granules
04/21/23 Template copyright 2005 www.brainybetty.com 44
Oxyphil
• What do they do?
• What do they look like?
04/21/23 Template copyright 2005 www.brainybetty.com 45
Oxyphil
• What do they do?
• Not sure but they contain PTH
• What do they look like?
• Larger than chief cells but nuclei smaller and more heterochromatin (what does that mean)
• Very eosinophilic cytoplasm (MITOCHODRIA), small RER, golgi and few granules
04/21/23 Template copyright 2005 www.brainybetty.com 46
04/21/23 Template copyright 2005 www.brainybetty.com 47
The Adrenal Gland
• What is the cortex derived from?
• What is the medulla derived from?
04/21/23 Template copyright 2005 www.brainybetty.com 48
The Adrenal Gland
• What is the cortex derived from?
• Intermediate mesoderm
• What is the medulla derived from?
• Neural crest
04/21/23 Template copyright 2005 www.brainybetty.com 49
Cortex
• What are the three zones of the cortex?
• What do the cells do?
• What are the features of the cells?
04/21/23 Template copyright 2005 www.brainybetty.com 50
Cortex
• What are the three zones of the cortex?
• Zona glomerulosa, zona fasciculata, zona reticularis
• What do the cells do?
• Synthesize and secrete (but DON’T store) steroid hormones
• What are the features of the cells?
• Numerous lipid droplets, abundant smooth ER and mitochondria with TUBULAR CRISTAE
04/21/23 Template copyright 2005 www.brainybetty.com 51
Zona Fasciculata & Reticularis
• (75% of cortex)
• What do they secrete?
• What do they do?
• What is secretion regulated by?
04/21/23 Template copyright 2005 www.brainybetty.com 52
Zona Fasciculata & Reticularis
• (75% of cortex)
• What do they secrete?
• Glucocorticoids cortisol and corticosterone
• What do they do?
• Promote natural metabolism, esp. carb metabolism. Also provide resistance to stress and supress inflammatory response
• What is secretion regulated by?
• ACTH – from POMC REMEMBER????
04/21/23 Template copyright 2005 www.brainybetty.com 53
Zona Glomerulosa
• What does it secrete?
• What is the function?
• What is secretion regulated by?
04/21/23 Template copyright 2005 www.brainybetty.com 54
Zona Glomerulosa
• What does it secrete?
• Mineralocorticoids (aldosterone)
• What is the function?
• Maintaining normal mineral balance and body fluid volume
• What is secretion regulated by?
• Renin-angiotensin system and plasma levels of sodium and potassium
04/21/23 Template copyright 2005 www.brainybetty.com 55
Adrenal
04/21/23 Template copyright 2005 www.brainybetty.com 56
Blood Supply to the Adrenal Gland
• What gives rise to the subcapsular plexus?
• What does the subcapsular plexus give rise to?
04/21/23 Template copyright 2005 www.brainybetty.com 57
Blood Supply to the Adrenal Gland
• What gives rise to the subcapsular plexus?• Superior, middle and inferior suprarenal arteries
• What does the subcapsular plexus give rise to?
1. Arterioles supplying capsule
2. Arterioles of the cortexsinusoidal vessels running between columns of fasciculata before forming deep plexus in reticularis that communicates with plexus in medulla
3. Arterioles that directly supply the medulla and forms medullary sinusoidal plexus
04/21/23 Template copyright 2005 www.brainybetty.com 58
Venous Drainage
• Venous channels drain medullary plexus and empty into medullary vein– Has longitudinally oriented smooth muscles
– Thought to act as a gate regulating entry of blood from the reticularis and medullary sinusoidal plexus
04/21/23 Template copyright 2005 www.brainybetty.com 59
Fetal Adrenal Cortex
• What are the zones?
• What do they do?
04/21/23 Template copyright 2005 www.brainybetty.com 60
Fetal Adrenal Cortex
• What are the zones?
• Fetal/provisional zone and definitive zone
• What do they do?
• Fetal zone degenerates rapidly after birth
• Produces inactive androgens that are converted to active in the placenta and enter maternal circulation
• Definitive zone differentiates into adult cortex
04/21/23 Template copyright 2005 www.brainybetty.com 61
Medulla
• What are cell types present?
• What is the vascular supply like?
04/21/23 Template copyright 2005 www.brainybetty.com 62
Medulla
• What are cell types present?
• Chromaffin cells in clumps or cords
• Few ganglion
• What is the vascular supply like?
• Dilated capillary network surrounding medullary secretory cells and drain into medullary vein
04/21/23 Template copyright 2005 www.brainybetty.com 63
Chromaffin Cell
• What does it contain, what do they do?
• What causes release?
04/21/23 Template copyright 2005 www.brainybetty.com 64
Chromaffin Cell
• What does it contain, what do they do?
• Membrane-limited secretory granules
• Contain catecholemines (epinephrine, norepinephrine)
• What causes release?
• Released upon stimulation of preganglionic sympathetic neurons in response to intense emotional reactions
04/21/23 Template copyright 2005 www.brainybetty.com 65
04/21/23 Template copyright 2005 www.brainybetty.com 66
04/21/23 Template copyright 2005 www.brainybetty.com 67
Pineal Gland
• CT septa originate in pia mater and separate gland into irregular lobes
• What are the two cell types?
• What are concretions?
04/21/23 Template copyright 2005 www.brainybetty.com 68
Pineal Gland• CT septa originate in pia mater and separate gland
into irregular lobes• What are the two cell types?
• Pinealocytes—slight basophilic cyto, irregular nuclei, long tortuous processes
• Astroglial—more basophilic lots of intermediate filaments
• What are concretions?• Corpora aremacea (brain sand) made of
calcium phosphate or calcium carbonate and indicate the secretory activity of the gland
04/21/23 Template copyright 2005 www.brainybetty.com 69
04/21/23 Template copyright 2005 www.brainybetty.com 70
Pineal Gland
• What do pinealocytes secrete? How is it regulated?
04/21/23 Template copyright 2005 www.brainybetty.com 71
Pineal Gland
• What do pinealocytes secrete? How is it regulated?
• Melatonin
• Diurnal cycle under control of sympathetic division of ANS. Specifically entrained by light. More light less melatonin release.
04/21/23 Template copyright 2005 www.brainybetty.com 72
Melatonin Secretion
• Why is it important in humans?
04/21/23 Template copyright 2005 www.brainybetty.com 73
Melatonin Secretion
• Why is it important in humans?
• Possible antigonadal effect
• Size of pineal decreases after puberty
• Exogenous melatonin appears to help some people as a sleep inducer.
Image Review
04/21/23 Template copyright 2005 www.brainybetty.com 75
Pituitary from far away
04/21/23 Template copyright 2005 www.brainybetty.com 76
04/21/23 Template copyright 2005 www.brainybetty.com 77
The cellular region to the left is the pars distalis. The fibrous region to the right is the pars nervosa.
You can also see a teeny bit of the intermedia in between the two.
04/21/23 Template copyright 2005 www.brainybetty.com 78
• The intermediate lobe is ill-defined in humans. It consists of a thin zone of cells. Observe the cysts which represent the residual lumen of Rathke’s pouch.
04/21/23 Template copyright 2005 www.brainybetty.com 79
04/21/23 Template copyright 2005 www.brainybetty.com 80
pituitary gland: (1) chromophobe; (2) acidophil; (3) basophil
04/21/23 Template copyright 2005 www.brainybetty.com 81
• How to distinguish acidophils and basophils: – look at the color of the red blood cells in the vessels (V).
– Then, match the color to cells in the pituitary. Those are the acidophils (A).
– Cells that are more "purple", or blue are the basophils (B).
– Cells that have hardly any color are the chromophobes
04/21/23 Template copyright 2005 www.brainybetty.com 82
Anterior pit – sick of this yet?
04/21/23 Template copyright 2005 www.brainybetty.com 83
• Somatotroph from the anterior pituitary. Notice the numerous, spherical secretory granules.
• The granules are full of GH
04/21/23 Template copyright 2005 www.brainybetty.com 84
• Mammotroph from the anterior pituitary. The secretory granules are sparse and elliptical.
• Granules = prolactin
04/21/23 Template copyright 2005 www.brainybetty.com 85
• The posterior lobe is smaller and lighter staining than the anterior lobe. It does not have the appearance of a glandular organ (i.e. FEWER nuclei). Note the masses of unmyelinated nerve fibers and pituicytes (round, dark nuclei).
04/21/23 Template copyright 2005 www.brainybetty.com 86
Pars nervosa: This region consists of a mass of nerve fibers and endings from a fiber tract that extends down from the
hypothalamus. The hormones are stored in the nerve endings which can be quite large (called Herring bodies).
04/21/23 Template copyright 2005 www.brainybetty.com 87
04/21/23 Template copyright 2005 www.brainybetty.com 88
• pituicytes (purple nuclei throughout image) are neuroglia, which are supportive cells for the axons. ALL the nuclei are from pituicytes
PINEAL
04/21/23 Template copyright 2005 www.brainybetty.com 90
• The most distinctive feature of this gland is the presence of "corpora arenacea" or "brain sand" in the aging pineal - it will help you identify the pineal. It is shown in the above photo as a large blue-purple mass in the tissue.
04/21/23 Template copyright 2005 www.brainybetty.com 91
04/21/23 Template copyright 2005 www.brainybetty.com 92
04/21/23 Template copyright 2005 www.brainybetty.com 93
• Pinealocytes, with their pale, round nuclei can be seen along with a few glial cells. The smaller, dense nuclei belong to glial cells. Capillaries are also evident.
PARATHYROID
04/21/23 Template copyright 2005 www.brainybetty.com 95
The parathyroid gland is distinguished by scattered clumps of adipose cells lying among the parenchymal cells. There are two types of parenchymal cells: chief cells and oxyphil cells.
04/21/23 Template copyright 2005 www.brainybetty.com 96
• parathyroid glands synthesize parathyroid hormone. • Each gland is surrounded by a capsule from which
connective tissue septa extend inward and divide it into lobules.
• Two parenchymal cell types can be distinguished by H and E: the abundant chief cells (pale staining cytoplasm) and rarer LARGER oxyphil cells (acidophilic granules).
04/21/23 Template copyright 2005 www.brainybetty.com 97
• THERE ARE NO DUCTS IN THE PARATHYROID GLAND. THIS IS HOW YOU TELL IT APART FROM THE PAROTID AND PANCREAS!!!!
• YOU’VE BEEN WARNED
04/21/23 Template copyright 2005 www.brainybetty.com 98
• The chief cells have a low cytoplasm:nucleus ratio.
• Oxyphil cells are larger than chief cells and have slightly smaller and more intensely staining nuclei. These cells can be easily identified because a unit area contains few nuclei than a comparable unit area of chief cells.
04/21/23 Template copyright 2005 www.brainybetty.com 99
04/21/23 Template copyright 2005 www.brainybetty.com 100
THYROID
04/21/23 Template copyright 2005 www.brainybetty.com 102
• The thyroid gland produces the thyroid hormones T3 and T4 or (thyroxin). The functional unit of the gland which synthesizes these hormones is the follicle. It consists of a layer of cuboidal epithelium (principal cells) enclosing the follicular cavity, which is usually filled with colloid
04/21/23 Template copyright 2005 www.brainybetty.com 103
• A rich capillary network is present in the connective tissue separating the follicles. The principal thyroid cells (follicle cells) appear to form a “ring around the colloid.”
04/21/23 Template copyright 2005 www.brainybetty.com 104
• EM of thyroid principal cell showing sparse microvilli on the apical surface that lies next to the stored colloid in the follicle.
04/21/23 Template copyright 2005 www.brainybetty.com 105
• Parafollicular cells/C cells are found outside the colloid
04/21/23 Template copyright 2005 www.brainybetty.com 106
ADRENAL GLANDS
04/21/23 Template copyright 2005 www.brainybetty.com 108
• 3 regions of the cortex: – The outer region near the capsule has cells
arranged in clusters, like grapes. This is called the Zona Glomerulosa.
– The middle region has cells arranged in straight cords. It is called Zona Fasciculata The innermost region has cells arranged in a branching network. This is called the Zona reticularis.
04/21/23 Template copyright 2005 www.brainybetty.com 109
To remember the order: remember GFR, which you loved to learn about in phys
04/21/23 Template copyright 2005 www.brainybetty.com 110
04/21/23 Template copyright 2005 www.brainybetty.com 111
04/21/23 Template copyright 2005 www.brainybetty.com 112
04/21/23 Template copyright 2005 www.brainybetty.com 113
04/21/23 Template copyright 2005 www.brainybetty.com 114
• A higher magnification of the zona glomerulosa and the Zona fasciculata is shown in this photo. Note the many lipid droplets seen in the zona fasciculata cells.
04/21/23 Template copyright 2005 www.brainybetty.com 115
04/21/23 Template copyright 2005 www.brainybetty.com 116
In the medulla
04/21/23 Template copyright 2005 www.brainybetty.com 117
And something that was on our final…..
In the liver, central veins drain into sublobular
veins…..
04/21/23 Template copyright 2005 www.brainybetty.com 119
Central draining into sublobular
QUIZ TIME
04/21/23 Template copyright 2005 www.brainybetty.com 121
WHAT CELL IS THE BLUE ARROW POINTING TO
04/21/23 Template copyright 2005 www.brainybetty.com 122
pituicyte
04/21/23 Template copyright 2005 www.brainybetty.com 123
• WHAT TISSUE IS THIS
04/21/23 Template copyright 2005 www.brainybetty.com 124
• PARATHYROID – 2 types of cells, NO DUCTS
04/21/23 Template copyright 2005 www.brainybetty.com 125
• A? B? C?
• .
04/21/23 Template copyright 2005 www.brainybetty.com 126
• a = pale chromophobes
• b = blue basophil
• c = red acidophil
• The cells are separated by a fine reticular fibers (thin blue lines), where the blood capillaries lie.
04/21/23 Template copyright 2005 www.brainybetty.com 127
TISSUE?
04/21/23 Template copyright 2005 www.brainybetty.com 128
PINEAL (note brain sand)
04/21/23 Template copyright 2005 www.brainybetty.com 129
• What cell is this?
04/21/23 Template copyright 2005 www.brainybetty.com 130
• purple basophil
• Can be a thyrotroph, corticotroph, gonadotroph
04/21/23 Template copyright 2005 www.brainybetty.com 131
04/21/23 Template copyright 2005 www.brainybetty.com 132
COLLECTING DUCT
• You know bc you see thin limbs, so nothing else it can be
04/21/23 Template copyright 2005 www.brainybetty.com 133
arrow
04/21/23 Template copyright 2005 www.brainybetty.com 134
PARAFOLLICULAR or C-cell in thyroid
• If its not a follicular cell, it’s a parafollicular/c-cell
• In BETWEEN follicles
04/21/23 Template copyright 2005 www.brainybetty.com 135
• Name that tissue
04/21/23 Template copyright 2005 www.brainybetty.com 136
• Pars nervosa of pituitary• Note Herring bodies, collections of secretion in the
pars nervosa of the pituitary. They represent accumulations of neurosecretion within the axons of neurons whose cell bodies lie in the hypothalamus of the brain.
04/21/23 Template copyright 2005 www.brainybetty.com 137
What is this?
04/21/23 Template copyright 2005 www.brainybetty.com 138
THICK SKIN
• Lots of corneum
04/21/23 Template copyright 2005 www.brainybetty.com 139
Tissue??
04/21/23 Template copyright 2005 www.brainybetty.com 140
PARATHYROID
• The larger cells to the left are oxyphil cells whose function is unknown. They are found only in humans and increase with age. The intense eosinophilia in their cytoplasm reflects an abnormally high number of mitochondria in these cells.
04/21/23 Template copyright 2005 www.brainybetty.com 141
Tissue?
04/21/23 Template copyright 2005 www.brainybetty.com 142
THYROID
• This is the only endocrine gland that typically stores its hormonal secretion extracellularly before releasing it into the bloodstream.
04/21/23 Template copyright 2005 www.brainybetty.com 143
What is this be specific
04/21/23 Template copyright 2005 www.brainybetty.com 144
DUCT OF AN ECCRINE SWEAT GLAND
• Cuboidal
• Darker than the secretory end pieces
04/21/23 Template copyright 2005 www.brainybetty.com 145
Ignore the arrow. What is this
04/21/23 Template copyright 2005 www.brainybetty.com 146
GANGLION
• Fried eggs
04/21/23 Template copyright 2005 www.brainybetty.com 147
• In general, where would be find this cell??
04/21/23 Template copyright 2005 www.brainybetty.com 148
• adrenal cortex
• cytoplasm filled with smooth endoplasmic reticulum, typical of steroid - secreting cells. Parts of two mitochondria are also visible here.
04/21/23 Template copyright 2005 www.brainybetty.com 149
Tissue?
04/21/23 Template copyright 2005 www.brainybetty.com 150
DENSE REG CONNETIVE TISSUE
• Aka tendon
• Flat nuclei
• Wavy appearance
04/21/23 Template copyright 2005 www.brainybetty.com 151
04/21/23 Template copyright 2005 www.brainybetty.com 152
PARS RADIATA
• Found here are TAL and TDL and cortical collecting duct
• In pars convoluta are PCT, DCT, glomeruli, and connecting tubule
04/21/23 Template copyright 2005 www.brainybetty.com 153
Tissue?
04/21/23 Template copyright 2005 www.brainybetty.com 154
PANCREAS
• Look for the islets
04/21/23 Template copyright 2005 www.brainybetty.com 155
Where are we?
04/21/23 Template copyright 2005 www.brainybetty.com 156
In the gallbladder
• Do we see any goblets???????
• Do we see a muscularis mucosa???
04/21/23 Template copyright 2005 www.brainybetty.com 157
QUESTIONS?