S L

I D E

‹#

›

Enab

ling

Dig

ital D

iagn

ostic

sW

ith a

Dat

a Sc

ienc

e Pl

atfo

rm

Wad

e L.

Sch

ulz,

MD

, PhD

Dep

artm

ent o

f Lab

orat

ory

Med

icin

e

Ric

hard

Tor

res,

MD

, MS

Dep

artm

ent o

f Lab

orat

ory

Med

icin

e

S L

I D E

‹#

›

Ove

rvie

w

•H

ealth

care

Dat

a an

d D

ata

Sour

ces

•Ya

le/Y

NH

H D

ata

Scie

nce

Plat

form

•Th

e D

ata

Scie

nce

Jour

ney:

Com

puta

tiona

l Hea

lthca

re U

se C

ase

–Q

uesti

on–

Dat

a–

Arc

hite

ctur

e–

Impl

emen

tatio

n•

Oth

er U

se C

ases

in H

ealth

care

S L

I D E

‹#

›

Hea

lthca

re (B

ig?)

Dat

a

S L

I D E

‹#

›

Hea

lthca

re (B

ig?)

Dat

a

S L

I D E

‹#

›

The

Dre

am fo

r Big

Dat

a in

Hea

lthca

re

S L

I D E

‹#

›

The

Dat

a Sc

ienc

e Pl

atfo

rm

K er b er iz e d

S L

I D E

‹#

›

Dat

a Sc

ienc

e Jo

urne

y

S L

I D E

‹#

›

Cre

atin

g D

ata

Scie

nce

Que

stio

ns

•D

efine

the

ques

tion

/ hyp

othe

sis

•A

sses

s the

dat

a so

urce

, cle

an a

s nec

essa

ry•

Itera

tivel

y te

st th

e ex

perim

ent a

nd im

plem

enta

tion

Des

crip

tive

Dia

gnos

ticPr

edic

tive

Pres

crip

tive

S L

I D E

‹#

›

Clin

ical

Lab

orat

ory

Use

Cas

e

•A

dvan

ced

Ana

lytic

s for

Lab

orat

ory

Dia

gnos

tics (

Yale

-New

Hav

en)

–~1

0 m

illio

n la

bora

tory

test

s–

~46

mill

ion

resu

lts p

er y

ear

–Si

gnifi

cant

num

ber r

equi

re p

hysi

cian

inte

rpre

tatio

n–

Lab

base

d ex

ampl

e•

Ana

logo

us to

ana

tom

ic (t

issu

e) p

atho

logy

•A

pplic

able

bey

ond

S L

I D E

‹#

›

Gen

eral

Pro

blem

Defi

nitio

n

•C

an w

e us

e bi

g da

ta a

nd m

achi

ne le

arni

ng to

impr

ove

our d

iagn

ostic

repr

oduc

ibili

ty a

nd th

roug

hput

for l

abor

ator

y te

stin

g? •

Hyp

othe

sis:

The

use

of a

ML

algo

rithm

and

real

-tim

e da

ta p

roce

ssin

g pi

pelin

e w

ill im

prov

e ou

rtu

rnar

ound

tim

e an

d in

terp

retiv

e re

prod

ucib

ility

. Qua

ntita

tive

resu

lts w

ill im

prov

e di

agno

stic

accu

racy

.