Empowering Enzymes for Pharmaceutical Applications · 2020-03-08 · Empowering Enzymes for...

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Empowering Enzymes for Pharmaceutical Applications INOFEA’s enzzen®-Technology makes Enzymes fit for Bioanalysis, Bioconjugation and Biocatalysis empowering enzymes Manufacturing Example: ADC Manufacturing - Process robustness and high product quality - High specificity of the toxin binding to the Ab - Achievement of DAR as expected - No purification steps necessary - Suitable for flow-through reactors Bioconjugation Example: Protein-Modification - Broad spectrum of activity - Highly controlled modifications achievable - High yield - Resistant to chaotropic conditions - High specificity - Enzymes can be easily removed from the reaction Bioanalysis Example: Complete Digestion of large cross-linked Proteins - No self-digestion of the enzymes used - Unpolluted AA spectra - Perfect linearity between protein content in body fluid and concentration of the biomarker INOFEA AG Hochbergerstrasse 60c CH 4057 Basel, Switzerland Tel: +41 76 405 0743 [email protected] www.inofea.com Methylation Phosphorylation Acyl Lipidation Glycosylation Acetylation Hydroxylation Sulfation Phenylation NH 2 NH 2 NH 2 COOH COOH COOH Protein 3 Protein 2 Protein 1 LC-MS

Transcript of Empowering Enzymes for Pharmaceutical Applications · 2020-03-08 · Empowering Enzymes for...

Page 1: Empowering Enzymes for Pharmaceutical Applications · 2020-03-08 · Empowering Enzymes for Pharmaceutical Applications INOFEA’s enzzen®-Technology makes Enzymes fit for Bioanalysis,

Empowering Enzymes for Pharmaceutical ApplicationsINOFEA’s enzzen®-Technology makes Enzymes fit for Bioanalysis, Bioconjugation and Biocatalysis

empower ing enzymes

ManufacturingExample: ADC Manufacturing

- Process robustness and high product quality- High specificity of the toxin binding to the Ab- Achievement of DAR as expected - No purification steps necessary - Suitable for flow-through reactors

Bioconjugation Example: Protein-Modification

- Broad spectrum of activity- Highly controlled modifications achievable - High yield- Resistant to chaotropic conditions- High specificity- Enzymes can be easily removed from the reaction

BioanalysisExample: Complete Digestion of large cross-linked Proteins

- No self-digestion of the enzymes used- Unpolluted AA spectra - Perfect linearity between protein content in body fluid and concentration of the biomarker

INOFEA AG Hochbergerstrasse 60cCH 4057 Basel, Switzerland

Tel: +41 76 405 [email protected]

Methylation

PhosphorylationAcyl Lipidation

Glycosylation

AcetylationHydroxylation

Sulfation

Phenylation

NH2

NH2

NH2

COOH

COOH

COOHProtein 3

Protein 2

Protein 1

LC-MS

Advanced Bioprocess Engineering Enzymes & Enzymes Kinetics

Advanced Bioprocess Engineering Enzymes & Enzymes Kinetics

Enzymes - libvolume4.xyzlibvolume4.xyz/.../foodchemistry2/enzymes/enzymespresentation2.pdf · Enzymes - Activity • Temperature and pH effect enzyme action. Enzymes - Activity •

Enzymes - libvolume4.xyzlibvolume4.xyz/.../foodchemistry2/enzymes/enzymespresentation2.pdf · Enzymes - Activity • Temperature and pH effect enzyme action. Enzymes - Activity •

A Presentation on Enzymes & Co-Enzymes

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ENZYMES - academyepic.com€¦ · Enzymes work in specific pH ranges= Food enzymes = 3.0 to 9.0 / Animal enzymes = 7.2 - 9.0 22. Enzyme deficiencies -links

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AP Biology Enzymes. AP Biology Enzymes Biological catalysts Catalysts – speed up reactions (not all catalysts are enzymes) Enzymes are proteins.

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pharmaceutical enzymes

pharmaceutical enzymes

Contribution of PSCI in Empowering Pharmaceutical Supply Chain

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Radical Enzymes - macmillan.princeton.edu · Enzymes Definition Enzymes are macromolecular biological catalysts. Catalyze more than 5,000 biochemical reaction types. Most enzymes

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Drug Metabolizing Enzymes and Reaction-Phenotyping Carl D. Davis, Ph.D. Pharmaceutical Candidate Optimization Metabolism and Pharmacokinetics Bristol-Myers.

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Chemical Reactions and Enzymes Enzymes - Introduction.

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By: David and Carl. Enzymes Breakdown substances Protein catalyst Specific to substrate Pharmaceutical Industry Develops, produces, and markets.

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Supplementary Materials forscience.sciencemag.org/highwire/filestream/685969/... · Supplemental Tables Pathway with enzymes ay reactions reactions enzymes enzymes enzymes of enzymes

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Immobilized lipases for biocatalysis - Novozymes...Novozymes enzymes are industrial bulk products and are not produced according to pharmaceutical standards. If enzymes are If enzymes

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Chapter 6 Protein Function : Enzymes Part 1. Enzymes – Physiological significance of enzymes – Catalytic power of enzymes – Chemical mechanisms of catalysis.

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Empowering Indian pharmaceutical industry to lead globally.

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Enzymes for Industrial Applications · enzymes, production processes and application areas. ... pharmaceutical, chemical, textile and detergent industry. Network with other experts

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Enzymes, inhibition. ENZYMES, CATALYSTS OF BIOLOGICAL SYSTEMS 1.Enzymes in general 2. Development of enzymes 3. General mechanisms of enzymes 4. Kinetic.

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