Embryology of the Craniovertebral Junction
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Transcript of Embryology of the Craniovertebral Junction
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Embryology & Development of the
Craniovertebral Junction
Shashank Gandhi, MD
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Craniovertebral Junction
Divided into 2 portions:● Central pivot
o Dens, C2 vertebral body, basiocciput
● 2 ringed structures surrounding central pivoto Foramen magnum ring
clivus, exocciput, occipital condyles, opisthiono Atlantal ring
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Embryology
● Notochord forms early axial skeleton● During 4th week gestation, 42 somites
formedo 4 occipital, 8 cervical, 12 thoracic, 5 lumbar, 5
sacral, 8-10 coccygeal● Each somite differentiates
o outer dermatomeo inner myotomeo medial sclerotome - form vertebrae around notocord
4 occipital sclerotomes● 4th Occipital Sclerotome - Proatlas - important for CVJ
development
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Formation of CVJ
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Sclerotomes in Formation of CVJ
**DO NOT RESEGMENT
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Sclerotome Origins of CVJ
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Posterior Fossa
● Expansion occurs by endochondral reabsorption, sutural growth, & boney accretion until 16-18 years of age
● Growth of basion elongated basiocciput & lowers frontal margins of foramen magnum
● Downward displacement of cerebellum & rotation of occipital and temporal lobes causes resorptive drift down and backward of opisthion
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Development of C2
● Apical dens from proatlas● Dens from 1st cervical sclerotome● VB of C2 from 2nd cervical sclerotome● Odotoid separate from VB at birth by
cartilaginous bands - 2 synchondroses● 3 phases of synchondrosis & ossification
o 1st - 4mo fetus at VB/neural archeso 2nd - 6mo fetus basal dental segment
ossification of lower syndrondrosis at birtho 3rd - 3-5 yrs at apical dental segment
not completely fused to basal dens until 6-9 yrso Fully completed by age 16-18
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Developmental Phases of C2
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Developmental Abnormalities
● In general abnormalities result in:o Central pivot
instability however, basilar impression & retroflexed
odontoid can cause neural compression
o 2 rings (atlas & axis) deformity & crowding however, hypoplasia/aplasia can cause
weakening/loss of ligamentous structures - instability
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Congenital Anomalies & Malformations
● Occipital boneo Manifestations of occipital vertebra
clivus segmentations remnants around foramen magnum atlas variants dens segmentations anomalies
o Basilar invaginationo Condylar hypoplasiao Assimilation of atlas
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Congenital Anomalies & Malformations
● Atlaso Assimilation of atlaso Atlantoaxial fusiono Aplasia of atlas arches
● Axiso Irregular atlantoaxial segmentationo Dens dysplasias
Ossiculum terminale persistens Os odontoideum Hypoplasia-aplasia
o Segmentation failure of C2/3
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Developmental & Acquired Abnormalities
● Foramen Magnumo Secondar basilar invagination (Paget’s dz,
osteomalacia, rheumatoid cranial settling, Rickets)o Foraminal stenosis (achondroplasia)
● Atlantoaxial Instabilityo Errors in metabolism (Morquio’s syndrome)o Down syndromeo Infection (Grisel’s syndrome)o Inflammatory (rheumatoid arthritis)o Traumatic OA & AA dislocation, os odontoideumo Tumors (NF)
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