Elizabeth Krupinski, PhD Jeffrey Johnson, PhD Hans Roehrig, PhD Jeffrey Lubin, PhD
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Transcript of Elizabeth Krupinski, PhD Jeffrey Johnson, PhD Hans Roehrig, PhD Jeffrey Lubin, PhD
Human Vision Model to Predict Observer
Performance: Detection of Microcalcifications as a
Function of Monitor Phosphor
Elizabeth Krupinski, PhDJeffrey Johnson, PhDHans Roehrig, PhDJeffrey Lubin, PhD
Michael Engstrom, BS
Acknowledgments This work was supported by
a grant from the NIH R01 CA 87816-01. We would also like to thank Siemens for the loan of 1 of the monitors and MedOptics for 1 of the CCD cameras used in the study
Rationale• Digital mammography potential
– Improve breast cancer detection – CAD does not need digitization
• Display monitors should be optimized– Physical evaluation parameters– Psychophysical evaluation (JNDs)– Clinical evaluation radiologists
Rationale• Observer trials (ROC studies)– Require many images (power)– Require many observers (power)– Are time-consuming
• Predictive models may help– Simulate effects softcopy display
parameters on image quality– Predict effects on performance
JNDmetrix Model• Computational method predicting
human performance in detection, discrimination & image-quality tasks
• Based on JND measurement principles & frequency-channel vision-modeling principles
• 2 input images & model returns accurate, robust estimates of visual discriminability
JNDmetrix Model
sa mpling
proba bility
distance metric
optic s
Q norm
JN Dva lue
input images
frequency specificcontrastpyramid
oriented responses
transducerMasking - gain control
JNDMap
...
Display Monitors• 2 Siemens high-performance– 2048 x 2560 resolution– Dome MD-5 10-bit video
board– 71 Hz refresh rate– Monochrome– Calibrated to DICOM-14
standard• P45 vs P104 phosphor
Physical Evaluation• Luminance: 0.8 cd/m2 – 500
cd/m2)– Same on both
• NPS: P104 > P45• SNR: P45 > P104• Model input
– Each stimulus on CRT imaged with CCD camera
Phosphor Granularity
P45 Phosphor < P104 Phosphor
Monitor NPS
0.00 20.00 40.00 60.00Spatia l F requency (lp /m m )
10.00
100.00
1000.00
10000.00
NPS
P104: R atio 4
P45: R atio 4
N yquist F requency of the C R T under test (3 .5 lp /m m )
Raste r F requency6.9 lp /m m
N PS of tw o S iem ens M onitors for ADU 127, one w ith a P104 phosphor, and one w ith a P45 phosphor.The data were norm a- lized to a C CD exposure of 10,000 AD U . Three CC D to C R T p ixel ratios w ere used: 53:1, 8:1 and 4 :1.
P104:R atio 8
P 45:R atio 8
P104:R atio 53
P45: R a tio 53
Images• Mammograms USF Database • 512 x 512 sub-images extracted• 13 malignant & 12 benign Ca++
• Removed using median filter • Add Ca++ to 25 normals• 75%, 50% & 25% contrasts by
weighted superposition of signal-absent & present versions
• 250 total images • Decimated to 256 x 256
Edited Images
Original 75% Ca++ 50% Ca++
25% Ca++ 0% Ca++
Image Editing Quality
• 512 x 512 & 256 x 256 versions• 200 pairs of images– Original contrast only– Paired with edited version – Paired randomly with others
• 3 radiologists • 2AFC – chose which is edited
Editing Quality Results
Reader 512 x 512 256 x 256 1 47.5% 46% 2 57% 47.5% 3 39% 49.5% Average 47.83%
sd = 7.35 47.67% sd = 1.08
Observer Study• 250 images
– 256 x 256 @ 5 contrasts• 6 radiologists • No image processing • Ambient lights off• No time limits• 2 reading sessions ~ 1 month
apart• Counter-balanced presentation
Observer Study• Images presented individually• Is Ca++ present or absent•Rate confidence 6-point scale•Multi-Reader Multi-Case Receiver
Operating Characteristic*
* Dorfman, Berbaum & Metz 1992
Human Results
00.10.20.30.40.50.60.70.80.9
1
Mea
n Az
25%
50%
75%
100%
Over
all
P104P45
* * *
* P < 0.05
Model Results
02468
101214
JND
25% 50% 75% 100%
P104P45
* P < 0.05
**
* *
Correlation
R2 = 0.973
0.5
0.6
0.7
0.8
0.9
1.0
5 7 9 11 13 15
Model JND
Rad
iolo
gist
s' M
ean
Az
Summary• P104
– > light emission efficiency – > spatial noise due to granularity
• P45– > SNR
• Luminance – noise tradeoff• P45 > P104 detection performance• JNDmetrix model predicted well
Model Additions•Eye-position will be recorded
as observers search images to determine if any attention parameters can be added to JNDmetrix model to improve accuracy of predictions