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Research Update:Mulberry Leaf.seminal trace...Mulberry Leaf Extract.10:1.Morus alba L.,Folium Mori.CAS.NO:94167-05-2,90064-112.Synonyms:Mulberry Extract.Extract of mulberry,Morus nigra, ext....

Phytochemical info of Mulberry Leaf. Product Name: Synonym: Definition:Mulberry Leaf are majorly composed of Chemical information disclosed as following table:

Research Update:Mulberry Leaf. Food-Grade Mulberry Powder Enriched with 1-Deoxynojirimycin Suppresses the Elevation of Postprandial Blood Glucose in Humans.:J Agric Food Chem. 2007 Jul 11;55(14):5869-5874. Epub 2007 Jun 8. Mulberry 1-deoxynojirimycin (DNJ), a potent glucosidase inhibitor, has been hypothesized to be beneficial for the suppression of abnormally high blood glucose levels and thereby prevention of diabetes mellitus. However, DNJ contents in commercial mulberry products were as low as about 0.1% (100 mg/100 g of dry product), implying that the bioavailability of DNJ might not be expected. We carried out studies in two directions: (1) production of food-grade mulberry powder containing a maximally high DNJ content; (2) determination of the optimal dose of the DNJ-enriched powder for the suppression of the postprandial blood glucose through clinical trials. The following method was used: (1) DNJ concentrations in mulberry leaves from different cultivars, harvest seasons, and leaf locations were determined using hydrophilic interaction chromatography with evaporative light scattering detection. (2) Healthy volunteers received 0, 0.4, 0.8, and 1.2 g of DNJ-enriched powder (corresponding to 0, 6, 12, and 18 mg of DNJ, respectively), followed by 50 g of sucrose. Before and 30-180 min after the DNJ/sucrose administration, plasma glucose and insulin were determined. The following results were obtained: (1) Young mulberry leaves taken from the top part of the branches in summer contained the highest amount of DNJ. After optimization of the harvesting and drying processes for young mulberry leaves (Morus alba L. var. Shin ichinose), DNJ-enriched powder (1.5%) was produced. (2) A human study indicated that the single oral administration of 0.8 and 1.2 g of DNJ-enriched powder significantly suppressed the elevation of postprandial blood glucose and

secretion of insulin, revealing the physiological impact of mulberry DNJ (effective dose and efficacy in humans). This study suggests that the newly developed DNJ-enriched powder can be used as a dietary supplement for preventing diabetes mellitus. Keywords: 1-Deoxynojirimycin; HILIC-ELSD; mulberry leaves; Morus spp.; diabetes prevention. Mulberry leaf powder prevents atherosclerosis in apolipoprotein E-deficient mice.:Biochem Biophys Res Commun. 2007 Jul 6;358(3):751-6. Epub 2007 May 7. Mulberry is commonly used to feed silkworms. Here we examined whether a dietary intake of mulberry leaf (ML) could affect atherogenesis in vivo and in vitro. Apolipoprotein E-deficient mice were fed either normal chow (control group) or a diet containing 1% ML powder (ML group) from 6 weeks of age. The mice were sacrificed after 12 weeks. The susceptibility of plasma lipoprotein to oxidation was assessed using diene formation. A significant increase in the lag time of lipoprotein oxidation was detected in the ML group compared with the control group. Furthermore, the ML group showed a 40% reduction in atherosclerotic lesion size in the aortae compared with the control. We also examined the direct anti-oxidative activity of ML in vitro. Aqueous extract of ML had a strong scavenging effect on 1,1-diphenyl-2-picrylhydrazyl and inhibited lipoprotein oxidation. These results confirm that ML contains anti-oxidative substances that might help prevent atherosclerosis. Resource recovery potential from secondary components of segregated municipal solid wastes.:Environ Monit Assess. 2007 May 15;Chanakya HN, Ramachandra TV, Vijayachamundeeswari M.Centre for Sustainable Technologies and Centre for Ecological Sciences, Indian Institute of Science, Bangalore, 560 012, India, cestvr@ces.iisc.ernet.in. Fermentable components of municipal solid wastes (MSW) such as fruit and vegetable wastes (FVW), leaf litter, paddy straw, cane bagasse, cane trash and paper are generated in large quantities at various pockets of the city. These form potential feedstocks for decentralized biogas plants to be operated in the vicinity. We characterized the fermentation potential of six of the above MSW fractions for their suitability to be converted to biogas and anaerobic compost using the solid-state stratified bed (SSB) process in a laboratory study. FVW and leaf litter (paper mulberry leaves) decomposed almost completely while paddy straw, sugarcane trash, sugarcane bagasse and photocopying paper decomposed to a lower extent. In the SSB process between 5060% of the biological methane potential (BMP) could be realized. Observations revealed that the SSB process needs to be adapted differently for each of the feedstocks to obtain a higher gas recovery. Bagasse produced the largest fraction of anaerobic compost (fermentation residue) and has the potential for reuse in many ways. Gluconeogenic substrates and hepatic gluconeogenic enzymes in streptozotocin-diabetic rats: effect of mulberry (Morus indica L.) leaves.:J Med Food. 2007 Mar;10(1):41-8.Andallu B, Varadacharyulu NC.Department of Home Science, Sri Sathya Sai Institute of Higher Learning, Anantapur, Andhra Pradesh, India. andallusss@rediffmail.com Mulberry (Morus indica L.) leaves, the sole food of the silk worm, were evaluated for

antidiabetic effects in streptozotocin (STZ)-diabetic rats. Treatment with dried mulberry leaf powder at 25% of the diet for a period of 8 weeks was found to be remarkably beneficial to STZdiabetic rats as evidenced by controlled hyperglycemia and glycosuria. In addition, mulberry leaves countered (reversed) the alterations in gluconeogenic substrates in STZ-diabetic rats as indicated by significant reduction in serum pyruvic and lactic acid levels, a significant increase in proteins and a significant decrease in free amino acid, urea, and creatinine levels in blood, and a decreased urinary excretion of urea and creatinine. Anomalies in the activities of hepatic gluconeogenic enzymes associated with impaired glucose homeostasis in STZ-diabetic rats were ameliorated by feeding the mulberry leaf-supplemented diet, indicating that control over hyperglycemia and associated complications in the diabetic state by mulberry leaves is by way of regulation of gluconeogenesis. With respect to all the parameters, mulberry leaves were more effective than the oral hypoglycemic drug glibenclamide. Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity.:Neuroreport. 2007 May 28;18(8):813-6. Mulberry leaf has been reported to possess medicinal properties, including hypoglycemic, hypotensive and diuretic effects. Little is known, however, about its medicinal properties for central nervous system disorders, including Alzheimer's disease. Accumulating evidence suggests that amyloid beta-peptide (1-42) plays an important role in the etiology of Alzheimer's disease. Here we show that mulberry leaf extract inhibits the amyloid beta-peptide (1-42) fibril formation by both the thioflavin T fluorescence assay and atomic force microscopy. Furthermore, mulberry leaf extract protected hippocampal neurons against amyloid beta-peptide (1-42)-induced cell death in a concentration-dependent manner. These results suggest that mulberry leaf extract provides a viable treatment for Alzheimer's disease through the inhibition of amyloid beta-peptide (1-42) fibril formation and attenuation of amyloid beta-peptide (1-42)induced neurotoxicity.

Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice.:Asia Pac J Clin Nutr. 2007;16 Suppl 1:290-4.Chen J, Li X.Faculty of Life Science, City College, Zhejiang University, 51 Huzhou Street, Hangzhou, Zhejiang, China 310015. lixr@zucc.edu.cn. The aim of this study was to investigate the hypolipidemic effect of the total flavonoids from mulberry leaves (MTF) in hyperlipidemic mice. The total flavonoids have been isolated from mulberry (Morus alba L.) leaves and purified by macroporous resins. After that, the content of MTF is 581.7 mg g-1 in dried product. The hypolipidemic effect of MTF has been evaluated in triton WR-1339 (400 mg kg-1) induced hyperlipidemic mice. The beneficial effects of MTF on serum lipid levels are more significant at 12h post MTF administration than at 6h. The levels of TG, TC and LDL-C were remarkably reduced to 388, 257 and 189 mg 100 ml-1 in MTF (30 mg kg-1) and triton WR-1339 treated mice, compared with 540, 464 and 299 mg 100 ml-1, respectively, in group treated by triton WR-1339 only. The ratios of HDL-C/TC and HDLC/LDL-C were increased to 0.42 and 0.57 post MTF (30 mg kg-1) administration, whereas these two ratios at the low levels of 0.33 and 0.52, respectively, in the reference group. These findings

support a serum a lipid-favourable activity for mulberry leaf flavonoids. Pathogenicity of Fusarium semitectum against crop pests and its biosafety to non-target organisms.:Commun Agric Appl Biol Sci. 2006;71(2 Pt B):465-73.Mikunthan G, Manjunatha M.Dept. of Agricultural Biology, Faculty of Agriculture, University of Jaffna, Sri Lanka. mikunthan@jfn.ac.lk Microbial control is receiving more attention, since these alternative tactics, compared to chemical control methods, are energy saving, non polluting, ecologically sound and sustainable. A mycopathogen, Fusarium semitectum Berk. and Rav. (ARSEF 7233) was isolated from diseased cadavers of aphid (Aphis gossypii) and cultured in Saboraud Maltose Agar supplemented with Yeast extract medium (SMAY). Being isolated first time from the chilli ecosystem its potential was evaluated. Experiments were conducted to understand its pathogenicity against crop pests as well as to ensure its safety