EHRA/HRS/APHRS/SOLAECE Expert Consensus on Atrial ...
Transcript of EHRA/HRS/APHRS/SOLAECE Expert Consensus on Atrial ...
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EHRA/HRS/APHRS/SOLAECE
Expert Consensus on
Atrial Cardiomyopathies:
Definition, Characterization and Clinical Implication
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Participating Members
European Heart Rhythm Association (EHRA) Professor Andreas Goette Germany Professor Jose Angel Cabrera Spain Professor Domenico Corradi Italy Professor Dobromir Dobrev Germany Professor Stephane Hatem France Professor Gregory Lip UK Professor Gerhard Hindricks Germany Professor Siew Yen Ho UK
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Heart Rhythm Society (HRS) Professor Stanley Nattel Canada Asso.Professor David Van Wagoner USA Professor Sumeet Chugh USA Professor Mario Gonzalez USA Doctor Robert Helm USA Professor Katherine Murray USA Doctor Greg Marcus USA Asso.Professor Joseph Akar USA Professor José Jalife USA Professor Brian Hoit USA
Participating Members
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Asia Pacific Heart Rhythm Society (APHRS) Professor Jonathan Kalman Australia Professor Prashanthan Sanders Australia Professor Young Hoon Kim Korea Doctor Shih-Ann Chen Taiwan Doctor Chang-Sheng Ma China Doctor Akihiko Nogami Japan
Participating Members
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Sociedad Latino Americana de Estimulación Cardíaca y Electrofisiología (SOLAECE)
Doctor Luis Aguinaga Argentina Professor Guilherme Fenelon Brazil Doctor William Uribe Colombia Doctor Andre d’Avila Brazil
Participating Members
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EHRA/HRS/APHRS/SOLAECE
Expert Consensus on
Atrial Cardiomyopathies:
Definition, Characterization and Clinical Implication
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Atrial Cardiomyopathies: Anatomical Considerations
Goette A, et al. EUROPACE 2016
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Goette A, et al. EUROPACE 2016
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Classification of Atrial Cardiomyopathies
(EHRAS Class I-IV)
Collagen
Fibroblasts
Cardiomyocytes
Non-Collagen interstitial deposits
Primarily Cardiomyocyte-dependent (Class I)
Primarily Fibroblast-dependent (Class II)
Mixed Cardiomyocyte-Fibroblast-dependent (Class III)
Primarily Non-Collagen Deposits (Class IV)
- lone AF - genetic diseases - diabetes mellitus .
- aging - cigarette smoking
- CHF - valvular diseases
- isolated atrial amyloidosis - granulomatosis - inflammatory Infiltrates - glycosphingolipids
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Goette A, et al. EUROPACE 2016
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Classification of Atrial Cardiomyopathies
(EHRAS Class I-IV)
Goette A, et al. EUROPACE 2016
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Goette A, et al. EUROPACE 2016
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Atrial Cardiomyopathies: Mechanical Atrial Function
Goette A, et al. EUROPACE 2016
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Atrial Cardiomyopathies: E/C Coupling
Goette A, et al. EUROPACE 2016
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Drug-induced Atrial Cardiomyopathies
Goette A, et al. EUROPACE 2016
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CHA2DS2VASc Parameters
Atrial Myocardium Atrial Endothelium
Oxidases NF-κB
Oxidases NF-κB
ROS
ROS Troponin Endothelin-1
Angiotensin II
Natriuretic Peptides
Nitric Oxide
vWF VCAM Selectin PAI-1 MCP-1 ICAM
Proteases Phosphatases
Goette A, et al. EUROPACE 2016
Atrial Cardiomyopathies:
„Thrombogenic Endocardial Remodeling“
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EHRA/HRS/APHRS/SOLAECE
Expert Consensus on
Atrial Cardiomyopathies:
Definition, Characterization and Clinical Implication
Goette A, et al. EUROPACE 2016 Heart Rhythm 2016 Journal of Arrhythmia 2016