Fries R et al. Circulation 2005; 112:2980-2985.

Effect on Raynaud's symptoms and microcirculation of sildenafil vs placebo

End point Sildenafil

Placebo

p

Mean number of Raynaud's attacks in 4 weeks

35 52 0.0064

Cumulative duration of attacks (min)

581 1046 0.0038

Mean Raynaud's Condition Score

2.2 3.0 0.0386

Mean capillary flow velocity (mm/s)

0.53 0.13 0.0004

Viagra effective in Raynaud's [Rheumawire > News; Nov 9, 2005]