EFA Pathway
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©2014 The Institute for Functional Medicine Less inflammatory eicosanoids Less inflammatory eicosanoids Flax, walnut, canola, soy, chia, hemp Sunflower, safflower, peanut, most vegetable oils Borage, black currant seed, evening primrose Animal fat, dairy, shellfish Linoleic acid (LA) 18:2n‐5 Alpha‐linolenic acid (ALA) 18:3n‐3 Delta‐6‐desaturase (Inhibited by age. alcohol) Delta‐6‐elongase Delta‐ 5‐ desaturase (up‐ regulated by insulin) Beta Oxidation Eicosatetraenoic acid 20:4n‐3 Eicosapentaenoic acid (EPA) 20:5n‐3 Docosapentaenoic acid 22:5n‐3 Docosahexaenoic acid (DHA) 22:6n‐3 Docosapentaenoic acid 22:5n‐6 Adrenic acid 22:4n‐6 Arachidonic acid (AA) 20:4n‐6 Gamma‐linolenic acid (GLA) 18:3n‐6 Dihomo‐ gamma‐ linolenic acid 20:3n‐6 Stearidonic acid 18:4n‐3 Delta‐5‐elongase Cold water fish, wild game, enriched eggs Omega 6 Family vegetable oils, grains Omega 3 Family Cold water fish, flax oil Inhibition Retro conversion Retro conversion Less inflammatory eicosanoids Lipoxins (anti‐inflammatory) More inflammatory eicosanoids Cold water fish, wild game, enriched eggs, Algae
description
Essential fatty acid pathway
Transcript of EFA Pathway
©2014 The Institute for Functional Medicine
Less inflammatory eicosanoids
Less inflammatory eicosanoids
Flax, walnut,canola, soy, chia, hemp
Sunflower, safflower, peanut, most vegetable oils
Borage, black currant seed, evening primrose
Animal fat, dairy, shellfish
Linoleic acid(LA)
18:2n‐5
Alpha‐linolenic acid(ALA)18:3n‐3
Delta‐6‐desaturase(Inhibited by age.
alcohol)
Delta‐6‐elongase
Delta‐5‐desaturase(up‐regulated by insulin)
Beta Oxidation
Eicosatetraenoic acid20:4n‐3
Eicosapentaenoic acid (EPA)20:5n‐3
Docosapentaenoic acid22:5n‐3
Docosahexaenoic acid (DHA)22:6n‐3
Docosapentaenoic acid22:5n‐6
Adrenic acid22:4n‐6
Arachidonic acid (AA)
20:4n‐6
Gamma‐linolenic acid(GLA)18:3n‐6
Dihomo‐gamma‐linolenic acid20:3n‐6
Stearidonic acid18:4n‐3
Delta‐5‐elongase
Cold water fish, wild game, enriched eggs
Omega 6 Familyvegetable oils, grains
Omega 3 FamilyCold water fish, flax oil
Inhibition
Retro conversion
Retro conversion
Less inflammatory eicosanoids
Lipoxins (anti‐inflammatory)
More inflammatory eicosanoids
Cold water fish, wild game, enriched eggs, Algae
