Edward Mills
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Transcript of Edward Mills
Microfinance opportunities to improve quality of life and clinical outcomes among HIV+ patients in
Africa
Edward Mills
Microfinance as Pathway to Health
• Increased income and financial stability has been conceptualized as a primary pathway to improve health– Purchase more and better quality food– Sustainable access to medicines– Structural improvements to home– Increases in educational attendance– Reductions in sexual and physical violence
HIV/AIDs and Poverty
• Economic impact of HIV/AIDS to both families and societies can be devastating– Estimated that when HIV affects African households,
its income can drop between 30-50%• Increased spending on health care• Lost productivity to care-seeking and care-giving• Clients tend to liquidate their assets to cope with
financial exigencies• More single parent households
• Clear link between HIV/AIDS and increased food insecurity and malnutrition
• Reduced school enrollment via ability to pay school fees
Poverty Alleviation Strategies1. Microfinance programs
Definition: provides a wide range of financial services including training, savings accounts
2. Microcredit programs Definition: small loans to support entrepreneurship,
empower disadvantaged populations
3. Cash Transfers/Payments Definition: provisions of small cash grants.
• Unconditional: without restriction• Conditional: conditional on some behavioural
requirements
Microfinance
Microcredit Cash Payment
Conditional Unconditional
Before After
• Financial Advice• Open Bank Accounts• Possibility for future
investments
• Loans• Grants
•Conditions to qualify for the grant
• Given incentives for meeting specific targets
Innovations for Poverty Action
• Leading nonprofit organization that designs and evaluates economic programs and brings successful programs to scale in over 35 countries
• Project areas– Agriculture– Charitable Giving– Education– Governance & Community Participation– Health– Enterprise– Water & Sanitation
Microfinance Interventions• 2 articles on the Intervention with Microfinance for AIDS
and Gender Equity (IMAGE)– Site: South Africa– Participants: Women 14-35 years– Intervention: Loans for groups of 5 women with HIV
training• Outcomes of Interest
– HIV communication, VCT, Sexual Risk• Results: Significantly higher levels of HIV
communication, more VCT, less sexual risk– Social capital
• Results: Not statistically significant, however qualitative data indicate increased social capital
Microcredit Interventions
• 1 Study– Site: South Africa– Participants: female and male applicants who had
previously been denied loans– Intervention: give loans with 4-month maturity
• Outcomes of Interest– Stress Scale, Depression
• Results: Significantly higher stress in men and women
• Results: Reduced depression – significant in men, not in women
Cash Payment - conditional• 4 studies evaluating child health outcomes
– Sites: Mexico, Brazil, Honduras, Nicaragua– Participants: Households with Children ≤10– Interventions: Cash payments to parents conditional on
attendance at a pre-existing health program• Successes
– Significant reductions in child behaviour problems– Significant increase in vaccine uptake– Significant increase in antenatal care
• Null– Anthropometric measurements: BMI, height-to-weight etc
• Concerns– In one study, children in the treatment arm lost weight
because parents feared that they would be discontinued from the cash payments if child met developmental targets
Cash Payment - unconditional
• 1 Study– Site: Urban and Rural Ecuador– Participants: youth aged 12-35 years– Intervention: Individuals in treatment group received $15,
comparison group received treatment 2 years later• Outcomes of interest
– Language skills• Results: Rural children had significantly better language
development, non-significant for urban children– Anthropometric scores: height-for-age, hemoglobin
concentration• Results: No significant differences
Can conditional cash transfers increase testing and decrease risk behaviours?• Randomized trial; Damien de Walque, 2012, BMJ open
– Site: Tanzania– Participants: Men and Women aged 18-30 years – Intervention: Participants received cash transfers dependent on
negative HIV/STI test results every 4 months (RESPECT)• Low cash value ($10) per HIV/STI test• High cash value ($20) per HIV/STI test• Control
– Outcomes of interest• HIV/STI infections
– Results• Intervention significantly reduced new infections:
– High vs control: aRR=0.73 (95% CI:0.47-0.99)– Low vs control: aRR=0.69 (95% CI: .45-0.92)
– Conditional cash transfers to incentivize safer sexual practices are potentially a promising new tool in HIV/STI prevention
Can cash transfers conditional on school attendance decrease HIV prevalence?• Cluster randomized trial; Baird et al., 2012, Lancet
– Site: Malawi– Participants: Adolescent schoolgirls aged 13-22 years and their parents– Intervention: Young women received $1-5 monthly and parents received
$4-10• Conditional: school attendance• Unconditional• Control
– Outcomes of interest• HIV and HSV-2 infections
– Results• No difference between conditional and unconditional• Intervention significantly reduced:
– HIV (aOR:0.36, 95% CI:0.14-0.91) and – HSV-2 infections (aOR: 0.24, 95% CI: 0.09-0.65)
– Structural interventions that do not directly target sexual behaviour change can be important components of HIV prevention
Can conditional cash transfers decrease new HIV infections?• Randomized control trial; Kohler, 2011, World Bank Economic Review
– Site: Malawi– Participants: Men and Women aged 14-24 years – Intervention: Participants were given a voucher and if they
maintained they HIV- status a year later would get the cash• Low cash value ($10) per HIV/STI test• High cash value ($20) per HIV/STI test• Control
– Outcomes of interest• HIV/STI infections
– Results• Intervention did not reduce number of new HIV infections:
– Men receiving cash transfers were more likely to engage in risky sex
– Women were less likely to engage in risky sex– Conditional cash transfers to incentivize safer sexual practices are
potentially a promising new tool in HIV/STI prevention
Can conditional cash transfers improve testing uptake and condom purchase?• Randomized trial; Thornton, 2008, American Economic Review
– Site: Malawi– Participants: Adults – Intervention: Participants offered free door-to-door testing
given a voucher redeemable after obtaining HIV/STI test available 2-4 months later, also given voucher for condoms
• Voucher: $1-3• Voucher: $0
– Outcomes of interest• Getting HIV test results
– Among HIV+ buying condoms with voucher– Results
• Treatment arm more likely to go and pick up test results• Receiving HIV diagnosis in the study was associated with
increased condom purchase
Uganda, Wagner et al.
• Glenn Wagner at RAND performed a randomized trial of 192 ART receiving patients in Kampala and Soroti
• Seminar to teach about microfinance opportunities• Low uptake
Uganda, Thirumurthy
• Transportation assistance• Behavioral Outcomes. medication event monitored
system (MEMS) defined treatment interruptions. Mean adherence, ARV drug possession ratio, and missed/late clinical encounters will be secondary outcomes.
• Biologic Outcomes. HIV viral load.• Economic Outcomes. Total hours worked per week.
Secondary outcomes will be participation in the labor force, household consumption, monetary transfers, hours of school attended per week and hours of child labor per week by children in patients’ households
Summary of Outcomes• General health outcomes of interest
– Mental health & stress– Intimate partner violence– Nutritional status for recipients children
• HIV related outcomes– HIV counseling and testing– Unprotected sex, intergenerational sex– STIs: HSV-2, syphilis, chlamydia, gonorrhea– HIV Incidence
• None measure the impact of microfinance interventions on HIV clinical outcomes– Virological Suppression– CD4 count– Adherence
Critiques of Microfinance strategies
• Sustainability of cash transfers– Many studies are short term– Don’t know how they would look in long term
• Microcredit– Challenging for poor populations to pay back loan if business fails
• Does extra disposable income increase risky behaviour?– Malawi – increased sexual risk among men– Brazil – perceptions that they would be discontinued if children
met growth targets• Low control over sexual risk
– Programs contingent on maintaining negative status rely on agency
– Most at risk would be discontinued from program
Empowerment through Positive Living
• Objective– To evaluate the effectiveness of microfinance grant
opportunities for 2000 people living with HIV in Uganda
• Design– Open-label randomized trial with blinded analysis
Study DesignEligible
ParticipantsN=2000
Unstructured GrantN=500
Grant + Planning
N=500
Pure Control
N=500
Control with Expectation
N=500
Intervention: 350,000 UgX, (~130 USD)
Data collection: Baseline, Midline, Final• Baseline questionnaire • Clinical assessment • Household assessment • Blood sample
• >18 years
Study Outcomes
Primary Outcomes– HIV RNA Viral Load– Treatment Adherence– CD4 T-cell changes– Quality of Life
Secondary Outcomes– Food Security– Household income– Savings accumulation– Time allocation– Sexual Behaviour– Child Education
Attendance
Impact• Study will be the first to evaluate the interaction between
socioeconomic wellbeing and health outcomes for HIV patients
• Economic Innovations– Unconditional grants to start a business
• Cash payment• Cash payment + planning• Waitlist controls who have 1 year to plan• Control
• Do grants improve the ability to withstand daily challenges:– HIV specific outcomes– Household economics (e.g. food security)
Conclusions
• Microfinance interventions have shown mixed results on the effects on HIV risk including new infections, testing, and sexual behaviour
• Many studies have included people living with HIV and how microfinance programs can improve peoples lives– None have focused on clinical outcomes
• If we can’t treat our way out of this epidemic, can we buy our way out?
Acknowledgements
Collaborators• Dean Karlan• Gordon Guyatt• Julio Montaner• Monica Taljaard• Curtis Cooper• William Cameron• Lehana Thabane• Sanni Yaya• Evan Wood• Achyuta Advarhyu• Pamela Jakiela• Nathan Ford• Jonathan Wangisi• Teddy Chimulwa• Stephen Okoboi
Collaborating Institutions• Innovations for Poverty Alleviation (IPA)• The AIDS Support Organization (TASO)• University of Ottawa• Yale University• University of British Columbia• BC Centre for Excellence in HIV/AIDS• McMaster University• World Health Organization• University of Maryland• University of Michigan
Funding• Canadian Institute for Health Research