Editorial Advances in Biliary Tract Disorders: Novel ... Editorial Advances in Biliary Tract...

Editorial Advances in Biliary Tract Disorders: Novel ... Editorial Advances in Biliary Tract Disorders:
Editorial Advances in Biliary Tract Disorders: Novel ... Editorial Advances in Biliary Tract Disorders:
Editorial Advances in Biliary Tract Disorders: Novel ... Editorial Advances in Biliary Tract Disorders:
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  • Editorial Advances in Biliary Tract Disorders: Novel Biomarkers, Pharmacotherapies, Endoscopic Techniques, and Surgical Management

    Mohamad H. Imam,1 Sooraj Tejaswi,2

    Mohammed Nabil Quraishi,3 and James H. Tabibian2

    1Division of Gastroenterology and Hepatology, University of Tennessee Health and Science Center, Memphis, TN, USA 2Division of Gastroenterology and Hepatology, University of California, Davis, Sacramento, CA, USA 3Department of Gastroenterology, University Hospital Birmingham, Birmingham, UK

    Correspondence should be addressed to James H. Tabibian; jtabibian@ucdavis.edu

    Received 9 November 2016; Accepted 9 November 2016

    Copyright © 2016 Mohamad H. Imam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

    Biliary tract disorders encompass a wide range of benign and malignant disease processes. In this special issue, we aimed to highlight advances in novel biomarkers, pharmacotherapies, endoscopic techniques, and surgical management of a variety of biliary tract disorders. Such advances continue to lead to improved diagnostic accuracy, better therapies, and subse- quently superior patient outcomes. Manuscripts selected for publication in this issue come from around the world and address clinically relevant topics and advances in biliary tract disorders, as briefly summarized below.

    Endoscopic retrograde cholangiopancreatography (ERCP) is an established procedure with numerous applications in biliary tract disorders. However, it may be associated with several periprocedural complications, including acute pan- creatitis and cholangitis. The presence of periampullary diverticula (PAD) may influence the technical success and safety of ERCP and hence affect patient outcomes. Z. Sun et al. evaluate the difference in clinical outcomes between 161 patients with PAD as compared to matched controls.

    Technical modifications and ancillary techniques to ERCP are areas of ongoing research. A strategy that involves placement of a biliary stent to avoid sphincterotomy in patients undergoing ERCP for common bile duct stones is described by T. Ueda et al.; preserving papillary integrity via such a technique may be especially desirable in younger patients.The use of endoscopic ultrasound (EUS) guided bil- iary drainage as an alternative treatment for biliary obstruc- tion in cases of failed ERCP is growingly implemented; J. Guo

    et al. describe the outcomes of their experience utilizing this approach for the management of biliary obstruction. T. A. P. Franzini et al. provide an overview of various cholangioscopy techniques and comment on recent advances in visualization of the biliary system and its application to biliary disease management.

    Evolution of specific surgical techniques such as those employed in Roux-en-Y hepaticojejunostomy is reviewed from a technical standpoint by D. Moris et al. They sum- marize their 25-year experience with RYHJ for management of bile duct injury and different perioperative measures they implement to optimize patient outcomes.

    Various malignancies have been associated with primary biliary diseases. Optimization of surveillance strategies and care for these patients is crucial. A review manuscript by V. Hrad et al. summarizes the cancer risks found in different pri- mary biliary diseases, including primary sclerosing cholangi- tis, primary biliary cholangitis, and overlap syndrome. This is complemented by a review paper in which L. Z. C. T. Pu et al. discuss evidence for best practice in management of malignant biliary strictures. For unresectable intrahepatic cholangiocarcinoma, treatment options are limited and often disappointing.

    R. Seidensticker et al. aim to assess the outcomes of patients with unresectable intrahepatic cholangiocarcinoma treated by a tailored therapeutic approach, combining sys- temic and advanced image-guided local or locoregional therapies.

    Hindawi Publishing Corporation Gastroenterology Research and Practice Volume 2016, Article ID 1583486, 2 pages http://dx.doi.org/10.1155/2016/1583486

  • 2 Gastroenterology Research and Practice

    Lastly, gallstone disease remains a major public health burden worldwide. A. Hayasaki et al. aim to identify signifi- cant independent variables influencing postoperative hospi- tal stay andmedical costs in patients with definite, suspected, or unmatched acute cholecystitis diagnosis according to the 2013 Tokyo Guidelines.

    We hope the manuscripts in this special issue will high- light useful advances in the field and help lay groundwork for further studies addressing the etiopathogenesis, diagnosis, and management of biliary tract disorders.

    Mohamad H. Imam Sooraj Tejaswi

    Mohammed Nabil Quraishi James H. Tabibian

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