Ectrims focused workshop environmental, modifiable risk factors for MS 2016 final programme

3 – 4 March 2016, Florence, Italy

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WELCOME TO FLORENCE

Dear friends and colleagues,

Welcome to Florence for the occasion of the 4th ECTRIMS Focused Workshop on “Environmental, modifiable risk factors for multiple sclerosis”. This year’s workshop follows the previous focused workshops on “MS and Gender”, “New technologies in MS care”, “Immunology of multiple sclerosis—from a human point of view” in 2013, 2014 and 2015.

Why arrange a meeting specifically addressing environmental modifiable risk factors for MS?

As other complex disorders, MS is most probably caused by interaction of genetic factors--largely elucidated--and environmental factors that are now better investigated and recognized, thanks to a great deal of research performed in this field over the past two decades.

In recent years, formidable biochemical, bio-informatic, technological and epidemiological tools have been involved to move on research into the causes of MS. In our view, the MS landscape has been irreversibly transformed by this progress.

Are we now in a time when we can speak of reducing the risk of MS by removing some risk factors, modifying subject lifestyle, working at potential preventive strategies? Are we able to mitigate the severity of the disease course-- not only with appropriate therapies-- by also modifying some of these factors? A few identified factors, in fact, may act not only as risk factors that increase the susceptibility to the disease, but, at the same time, as factors that influence the disease course and prognosis.

During the workshop, we will review current scientific knowledge in the area, coming from epidemiological studies, clinical trials and basic research. Moreover, we will address potential biological mechanisms underlying the association between MS and these factors. Then, we will discuss whether –at the present stage—from the body of available knowledge, there are any implications for improving patient counselling and management.

Lastly, and most importantly, “where are we headed”? The workshop will help identify the most important perceived gaps in knowledge and avenues for future research in this field. Improving our understanding of the environmental factors involved in MS risk and prognosis can in fact lead to new and more-effective approaches to prevention and management of this disease.

We hope that you will enjoy a fruitful and enlightening meeting that will result in the exchange and discussion of the most recent knowledge about the etio-pathogenesis of multiple sclerosis.

Florence has been selected as the venue for this year’s meeting, and we hope that you will enjoy the beauty of the location with its fascinating history and artistic treasures.

Yours sincerely,

Maria Pia Amato Xavier Montalban David Miller Workshop Organiser ECTRIMS President ECTRIMS Vice-President

FOCUSED WORKSHOP PROGRAMME

THURSDAY, 3 MARCH 2016

09.00 – 09.15 Welcome and Introduction San Michele X. Montalban (Barcelona, ES), M.P. Amato (Florence, IT) 09.15 – 10.30 Session 1: Gene-environment interactions San Michele Chair: X. Montalban (Barcelona, ES), M.P. Amato (Florence, IT)

09.15 Insights about the concept of risk M.P. Amato (Florence, IT)

09.30 Gene-environment interactions in inflammatory disease other than MS: the model of celiac disease L. Sollid (Oslo, NO)

10.00 Gene-environment interactions in MS T. Olsson (Stockholm, SE)

10.30 – 11.00 Coffee Break Tower Bar / I Salotti

11.00 – 13.00 Session 2: Infections and vaccines San Michele Chairs: P. Soelberg Sørensen (Copenhagen, DK) 11.00 The hygienic hypothesis in MS J. Correale (Buenos Aires, AR) 11.30 Infectious agents as risk factors I. Steiner (Petach Tikva, IL)

12.00 Epstein Barr Virus: epidemiological evidence J. Lünemann (Zurich, CH)

12.30 Epstein Barr Virus: experimental and pathological evidence, potential mechanisms of action

C. Münz (Zurich, CH)

13.00 – 14.30 Lunch Break Stemma (First Floor) 14.30 – 15.30 Session 2: Infections and vaccines (continued) San Michele Chairs: G. Giovannoni (London, UK), M. Salvetti (Rome, IT)

14.30 Vaccines and the risk of MS/MS relapses: a review of the evidence (or lack of)

S. Vukusic (Lyon, FR)

15.00 Discussion: “Infectious agents and vaccines. What are the implications for prevention and treatment?”

Facilitator: G. Giovannoni (London, UK)


15.30 – 16.00 Coffee Break Tower Bar / I Salotti 16.00 – 18.00 Session 3: Vitamin D San Michele Chairs: A. Ascherio (Boston, US), M. Trojano (Bari, IT)

16.00 Vitamin D: Epidemiological evidence R.M. Lucas (Canberra, AU)

16.30 Vitamin D: Experimental evidence and potential mechanisms of action J. Smolders (Maastricht, NL)

17.00 Results of therapeutic trials A. Ascherio (Boston, US)

17.30 Discussion: Vitamin D. What are the implications for prevention and treatment? What is the most appropriate dose?

Facilitator: E. Waubant (San Francisco, US)

18.00 – 18.15 Wrap Up San Michele 19.15 Focused Workshop Dinner (Meeting point at hotel lobby, Dinner starts at 19.30h)

FRIDAY, 4 MARCH 2016

09.00 – 10.30 Session 4: Other risk factors: epidemiological and San Michele Experimental evidence, potential mechanisms of action Chairs: R. Liblau (Toulouse, FR), T. Riise (Bergen, NO)

09.00 Cigarette smoking P. Sundström (Umea, SE)

09.30 Body Mass Index

M. Pugliatti (Ferrara, IT)

10.00 High dietary salt

R. Linker (Erlangen, DE)

10.30 – 11.00 Coffee break Tower Bar / I Salotti

11.00 – 13.00 Session 4: Other risk factors: epidemiological and San Michele experimental evidence, potential mechanisms of action (continued) Chairs: D. Miller (London, UK), T. Derfuss (Basel, CH)

11.00 Alcohol and caffeine intakes L. Alfredsson (Stockholm, SE); T. Olsson (Stockholm, SE)

11.30 Stress A. Miller (Haifa, IS)


12.00 Modifiable comorbidities; a missed opportunity? H. Tremlett (Vancouver, CA)

12.30 A common pathway for environmental risk factors in MS? The microbiome – gut-brain axis H. Wekerle (Munich, DE)

13.00 – 14.00 Lunch break Stemma (First Floor)

14.00 – 14.30 Session 4: Other risk factors: epidemiological and San Michele experimental evidence, potential mechanisms of action (continued) Chairs: D. Miller (London, UK), T. Derfuss (Basel, CH)

14.00 Discussion: Other risk factors: what are the implications for prevention and treatment?

Facilitator: R. Liblau (Toulouse, FR) 14.30 – 14.45 Wrap-up, state-of-the art and future directions San Michele M.P. Amato (Florence, IT)

ACCOMODATION AND LECTURE ROOM

Hotel Brunelleschi

Piazza Santa Elisabetta, 3

50122 Florence / Italy

Phone +39 05527370

INFORMATION FOR SPEAKERS

The lecture room “San Michele” is equipped with a lectern at which you can hold your presentation. A projector and screen are at your disposal to display your Power Point presentation.

Please bring your presentation on an USB stick or external hard drive and upload it on the presentation laptop in the lecture room before your presentations. A technician will be in the room during the whole time to assist you with any problems that may arise.

FOCUSED WORKSHOP DINNER

The Focused Workshop Dinner on Thursday, 3 March 2016 will take place at the

Restaurant Il Locale.

Please find the details of the evening below

Date: Thursday, 3 March 2016

Meeting Time: 19.15 hrs

Meeting Point: Hotel Lobby

FOCUSED WORKSHOP PARTICIPANTS

First Name Name City Country Email

Alfredsson Lars Stockholm SE [email protected]

Aloisi Luca Rome IT [email protected]

Amato Maria Pia Florence IT [email protected]

Ascherio Alberto Boston US [email protected]

Bjørnevik Kjetil Bergen NO [email protected]

Comabella Manuel Barcelona ES [email protected]

Correale Jorge Buenos Aires AR [email protected]

Cortese Marianna Bergen NO [email protected]

D'Alessandro Roberto Bologna IT [email protected]

Derfuss Tobias Basel CH [email protected]

D'Hooghe Marie Brussels BE [email protected]

Ghezzi Angelo Milan IT [email protected]

Giovannoni Gavin London UK [email protected]

Hellwig Kerstin Bochum DE [email protected]

Hemmer Bernhard Munich DE [email protected]

Koch-Henriksen Nils Copenhagen DK [email protected]

Langer Gould Annette Pasadena US [email protected]

Liblau Roland Toulouse FR [email protected]

Linker Ralf Erlangen DE [email protected]

Lolli Francesco Florence IT [email protected]

Lucas Robyn Canberra AUS [email protected]

Lünemann Jan Dirk Zurich CH [email protected]

Magyari Melinda Copenhagen DK [email protected]

Massacesi Luca Florence IT [email protected]

Miller David London UK [email protected]

Miller Ariel Haifa IS [email protected]

Montalban Xavier Barcelona ES [email protected]

Monteyne Philippe Rixensart BE [email protected]

Morley Pamela London UK [email protected]

Mowry Ellen Baltimore US [email protected]

Münz Christian Zurich CH [email protected]

Nielsen Nette Copenhagen DK [email protected]

Olsson Tomas Stockholm SE [email protected]

Oreja-Guevara Celia Madrid ES [email protected]

Otero Susana Barcelona ES [email protected]

Pugliatti Maura Ferrara IT [email protected]

Reingold Stephen Salibury US [email protected]

Riise Trond Bergen NO [email protected]

Robertson Neil Cardiff UK [email protected]

Salvetti Marco Rome IT [email protected]

Sidhom Youssef Paris FR [email protected]

Siracusa Gianfrano Florence IT [email protected]

Smolders Joost Maastricht NL [email protected]

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FOCUSED WORKSHOP PARTICIPANTS

First Name Name City Country Email

Soelberg Sørensen Per Copenhagen DK [email protected]

Sollid Ludvig Oslo NO [email protected]

Steiner Israel Petach Tikva IL [email protected]

Stenager Egon Aarhus DK [email protected]

Sundström Peter Umeå SE [email protected]

Taylor Bruce Hobart AUS [email protected]

Tremlett Helen Vancouver CA [email protected]

Trojano Maria Bari IT [email protected]

Uccelli Antonio Genova IT [email protected]

Vukusic Sandra Lyon FR [email protected]

Waubant Emmanuelle San Francisco US [email protected]

Wekerle Hartmut Munich DE [email protected]






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Ectrims focused workshop environmental, modifiable risk factors for MS 2016 final programme

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Transcript of Ectrims focused workshop environmental, modifiable risk factors for MS 2016 final programme