Ecthyma gangrenosum in pediatrics JUAN ROJAS (1) JUAN LOPEZ (2) YULY MUÑOZ (2) GUILLERMO GONZALEZ...
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Transcript of Ecthyma gangrenosum in pediatrics JUAN ROJAS (1) JUAN LOPEZ (2) YULY MUÑOZ (2) GUILLERMO GONZALEZ...
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Ecthyma gangrenosum in pediatrics
JUAN ROJAS (1)
JUAN LOPEZ (2)
YULY MUÑOZ (2)
GUILLERMO GONZALEZ (3)
1. Pediatric Infectious Diseases Fellowship Program. University El Bosque/ University Libre sectional Cali. Colombia, South America.
2. Physician. University Libre sectional Cali, Colombia, South America.3. Pediatric dermatologist. Club Noel Children´s Hospital. University Libre sectional Cali, Colombia, South America.
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IntroductionEtiologyClinical ManifestationsHistologic findingsDifferential diagnosis Treatment
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Introduction Ecthyma gangrenosum (EG) is a rare infection of the
skin
Lesion caused by P. aeruginosa Other types of bacteria: S. aureus or beta hemolytic group
Often associated: Primary and secondary immunodeficiency
Qualitative and quantitative neutrophil defects
Infectio 2013;17(1):43–47Acta Pædiatrica 2015; 104:134–138
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Introduction Mortality: 40%-75% of immunologically
compromised individuals
Characterized by black eschars on an erythematous base
Diagnosis: Symptoms Cultures and skin biopsies
Infectio 2013;17(1):43–47Acta Pædiatrica 2015; 104:134–138
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Etiology
The most common pathogen: P. aeruginosa
A. hydrophila, S. aureus, S. marcescens, E. coli, K. pneumoniae, N. meningitidis, V. vulnificus, B. cepacia
Fungi: Fusarium sp, Candida sp, Mucor and Aspergillus sp
Acta Pædiatrica 2015; 104:134–138Pediatric Dermatology 2013; 30 (6): 1-2
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Clinical Manifestations
Hemorrhagic bullae or necrotic ulcers that have progressed from painless macules or papules
Often the presenting lesion will exhibit an erythematous halo
Depending on the extent of infection and immune status: The patient may also be febrile with other constitutional
symptomsDermatology Online Journal 2012; 18 (3): 3
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Girl: 5 years old Initially presented chickenpox and then infection
with S. aureus EG
Infectio 2013;17(1):43–47
A, B, C, D: Erosions and deep ulcers, with serous and hematic crusts, necrotic background
Treatment: acyclovir, clindamycin and cefepime
Clinical case
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Infectio 2013;17(1):43–47
A, B, C: erythematous papules and macules with irregular borders
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Exudating deep, blackish eschar surrounded by
extendedulceration and erythema
Arch Dis Child 2015;100:54–56
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Necrotic skin lesion with surrounding erythema and
dilated veins
Arch Dis Child Fetal Neonatal 2011; 96 (4): 1
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Erythema, nodules, bulla, and ulcers with necrosison the right femoribus internus
Pediatric Dermatology 2011; 28 (2): 1-3
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Initial presentation Wound at 2 months
Pediatric Dermatology 2013; 30 (6): 1-2
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Histologic findings
Necrotizing vasculitis in which the media and adventitia of the vascular wall are invaded, but the intima is spared
Singapore Med J. 2006; 47: 1080Dermatology Online Journal 2012; 18 (3): 3
Infectio 2013;17(1):43–47
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Differential diagnosis
Bacterial cellulitis
Insect bites In the early, hyperaemic phase
Deep group α β-haemolytic Streptococci impetigo
Burns In the late, eschar-necrotising phase
Arch Dis Child 2015;100:54–56
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Treatment
Empirical antimicrobial therapy: Anti-Pseudomonal penicillins and aminoglycosides
Adjusted on the basis of culture results
Should be started
Pediatric Dermatology 2011; 28 (2): 1-3 Arch Dis Child 2015;100:54–56
Acta Pædiatrica 2015; 104:134–138
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TreatmentDebridement
Assessment of immune functionFull blood count and peripheral blood smearHIV serologyImmunoglobulin levels Neutrophil function tests
Pediatric Dermatology 2011; 28 (2): 1-3 Arch Dis Child 2015;100:54–56
Acta Pædiatrica 2015; 104:134–138
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