AMERICAN PHYSIOLOGICAL SOCIETY

GASTROINTESTINAL/LIVER SECTION NEWSLETTER SPRING 2007

We hope everyone is planning to attend the EB 2007 meeting that starts at the end of this month in Washington DC. This newsletter contains lots of information about our GI programming at the upcoming meeting. Our section has an excellent series of featured topics and symposia organized by members of our section, which promise to provide outstanding updates on a wide range of topics. Make sure to attend the Davenport lectureship, to be given this year by Mark Donowitz, a leader in understanding how intestinal membrane transporters are regulated. It is also time to buy tickets to our section banquet to be held on Tuesday night at Tony Cheung’s restaurant. The number of tickets are limited so make sure you order yours quickly to avoid disappointment. At the dinner we will be honoring our Davenport lecturer, as well as celebrating the section award winners from this year’s abstract competition. Last but not least, our after-dinner speaker will be John Cuppoletti, who will talk to us about the delights of digestion. See you in Washington !! Your section steering committee

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NEWSLETTER CONTENT 1. GI Section Awardees 2. Call for Symposium and FT proposals for EB2008 3. GI banquet 4. From the Liaison with Industry committee 5. GI and Liver section Sponsored Events At EB2007 6. EB2007 Events for Trainees 7. GI Section Governance

1. CONGRATULATIONS TO GI SECTION AWARDEES The section had an outstanding pool of applicants for awards this year, and due to the generosity of Takeda Pharmaceutical in supporting awards for our young researchers, the GI section steering committee was able to recognize the excellent work of many young scientists. In appreciation for the high quality of all our applicants, all those who applied but did not receive an award are being offered $15 tickets to the GI banquet this year. We hope to see everyone there to congratulate all our awardees, and applicants, in person!

2007 GI Section Awardees

Anthony Illing Univ. Cincinnati Undergraduate student M. J. Donovan Univ. California Davis Graduate student Lymari Lopez-Diaz Univ. Michigan Graduate student W. Vallen Graham Univ. Chicago Graduate student Yanfang Guan Univ. Cincinnati Postdoctoral fellow Veronique Douard New Jersey Med School Postdoctoral fellow Arianne Theiss Emory Univ. Postdoctoral fellow Ravinder Gill Univ. Chicago Early Career ProfessionalDeclan McCole Univ California San Diego Early Career Professional

2. CALL FOR SYMPOSIUM AND FT PROPOSALS, EB 2008 We need symposium proposals for EB 2008, complete with symposium speakers (see http://www.the-aps.org/meetings/eb.htm for information). Briefly, the APS- GI and Liver section will provide to the symposium organizer $4000 for travel reimbursement, and complimentary registration for up to four speakers plus the organizer and the co-organizer. Please send your proposal (along with list of tentative speakers and talks) to our Programming Chair, Ron Ferraris (ferraris@umdnj.edu). We also need proposals for featured topics. The Section can organize up to three each year.

Featured topics are similar to minisymposia in that they are pre-formed oral sessions on a specific topic and not more than two invited speakers (who do not have to submit abstracts). All other presentations are selected from the submitted abstracts for EB2008. The featured speaker and organizer receive complimentary registration (maximum of two). The organizer also receives ~$1000 per featured topic to reimburse the speakers. Please send your proposal to our Programming Chair, Ron Ferraris (ferraris@umdnj.edu). For the best chance to have your idea considered for the coming meeting, get your suggestions to Ron before the EB 2007 meeting, so the section Program Committee can review the best list of proposals when they meet at that time. It may sound crazy, but the EB2008 presentations are decided almost a full year in advance!

3. SECTION BANQUET AND BUSINESS MEETING

Who better to put on a good meal than the GI and Liver section? Those who attended the event last year in San Francisco know this is no idle boast. This year we are meeting at Tony Cheng’s Restaurant on Tuesday evening. Make it a lab outing! Join us for an evening of enjoying your colleagues in the midst of good food and drink (note that ticket price even includes beverages during the reception before dinner). Chris Cheeseman (our noble leader) promises to keep the business

meeting historically brief and the award ceremonies exciting. The capstone experience will be an entertaining and topical after-dinner speech from an internationally known scientist, John Cuppoletti. It will be your most fun evening at EB, all within walking distance of the convention center and at an unbelievable price (thanks to the generosity of Takeda Pharmaceutical). Apply early using the fillable application form on the following page, or by visiting http://www.med.uc.edu/mcp/banquet .

EB2007 — APS GI/Liver Section Banquet Order

The 2007 GI/Liver Section Banquet and Business Meeting will be held on Tuesday, May 1, 2007 at Tony Cheng’s Restaurant, 619 H Street NW, Washington DC 20024 (Tel: 202-842-8669).

Cocktail Reception begins at 6:30 pm, and Dinner at 7:00 pm.

Deadline for Advance Purchase is April 20, 2006 Please enter your name / your guests’ names and check the appropriate category. No paper tickets will be mailed. Your confirmation will be emailed to the email address you provide. The ticket price includes a cocktail during the reception, wine and dinner. Registration

Name of Guest Member or

Nonmember @ $50 each

Student/ Postdoc/Trainee

@ $25 each

GI/Liver Section Award Applicant

@ $15 each

Total: @ $50 Total: @ $25 Total: @ $15

Total Number of Tickets: Total Cost: $

Confirmation Please e-mail my Confirmation / Payment Receipt to: Payment Information

Check by Mail

Check enclosed in the amount of $_______. To pay by check: Please mail completed form with check payable to APS GI/Liver Section. Mailing address: APS, Linda Allen, 9650 Rockville Pike, Bethesda, MD 20814-3991. All checks must be drawn on a US bank.

I authorize APS to charge my Visa, MasterCard, or American Express card US$_____ for the ___ GI/Liver Section Banquet tickets requested above.

Credit Card Number:

Expiration Date: (Month) (Year)

Name of Cardholder:

Cardholder’s Email:

Billing Address of Cardholder:

Telephone: Fax:

Credit Card by Fax to 301-634-7264 (Secure)

Signature of Cardholder:

Tickets ordered after April 20 will be sold onsite on a space-available basis at an elevated fee

Questions? Call us at 301-634-7172 or visit www.med.uc.edu/mcp/banquet

4. FROM THE LIAISON WITH INDUSTRY COMMITTEE (LWIC)

Stem Cells in Physiology and Drug Discovery Sunday, April 29th from 10:30 AM – 12:30 PM

Convention Center, room 145A The LWIC is sponsoring this symposium, which will describe latest research on stem cells expansion, use of stem cells in target identification and understanding of signaling pathways, as well as its use in Neurodegeneration diseases. Look for the full program on-line at http://www.the-aps.org/meetings/eb07/abs/lwic-montrose.htm

Drug Discovery Efforts for Pain Indications: Ion Channels and GPCRs Tuesday, May 1 from 8:00 AM – 10:00 AM

Convention Center, room 146C

LWIC is also organizing this Translational Symposium, which will describe novel ion channel and GPCR targets for treating chronic pain. The mechanistic rationale for the target as well as the drug testing strategies to identify novel therapeutics will be discussed. Look for the full program on-line at http://www.the-aps.org/meetings/eb07/abs/tr-finley.htm The Novel Disease Model Award will be granted to a graduate student and a postdoctoral fellow who submit the best abstracts at EB2007 that describe a novel disease model. The model can be in vitro or in vivo but should clearly emphasize the potential utility of the system for future research related to a disease. The award is $500 for the graduate student and $800 for the postdoctoral fellow and is sponsored by the LWIC.

7th Annual LWIC Mixer Sunday, April 29, 7 PM

Room 10/11, Renaissance Hotel

You're invited! Come meet and eat with your fellow physiologists who are working in the corporate sector!

5. GI AND LIVER SECTION SPONSORED EVENTS AT EB2007

Davenport Distinguished Lecturer of the Gastrointestinal and Liver Section

Tuesday, 5/1/07, 3:15 pm, Room 146B

Mark Donowitz, MD Johns Hopkins University

“NHE3 and its Signaling Complexes: How a

Transporter is Regulated”

SYMPOSIA

Frontiers in the Cellular and Molecular Physiology of the Hepatic Microcirculation

Monday 4/30/07, 8:00-10:00 AM, Convention Ctr- Room 147B

Speakers: Brigitte Vollmar Makoto Suematsu Mark Clemens Alison Fox-Robichaud

Understanding the role of the Pancreas in Digestion: Placing Current Understanding in a Historical Perspective

Monday 4/30/07, 10:30 AM-12:30 PM, Room 147A

Speakers: Joel W. Adelson Daniel P. Todes John Henderson John A. Williams Joel W. Adelson (speaking twice)

FEATURED TOPICS

Growth Factors, Proliferation and Differentiation in the GI System Sunday, April 29 — 10:30 AM-12:30 PM, Convention Ctr — Room 147B

10:30 AM SOCS proteins and trophic effect of growth hormone-regulated JAK-STAT

pathways in the intestine. P.K. Lund, Univ. of North Carolina. 11:00 AM Role of epidermal growth factor receptor signaling in the pathogenesis of

Menetrier’s disease. R.J. Coffey, Vanderbilt Univ. Sch. of Med. 11:30 AM Abstract # 6852 Sujoy Bhattacharya 11:45 AM Abstract # 3338 Claudia Amura 12:00 PM Abstract # 6615 Lili Guo 12:15 PM Abstract # 6630 Renu Jain

Roles of Intestinal Epithelia and Bacteria in Inflammatory Disease Monday, April 30 — 3:15-5:15 PM, Convention Ctr — Room 154B

3:15 PM The contribution of inter-epithelial and epithelial-bacterial interactions in

intestinal inflammation. Maria T. Abreu, Mt. Sinai Sch. of Med . 3:35 PM Are probiotics effective treatments for inflammatory bowel disease?

Karen Madsen, Univ. of Alberta 4:00 PM Abstract # 5388 D.M. Wall 4:15 PM Abstract # 6601 J.-M. A. Klapproth 4:30 PM Abstract # 2044 A. Jarry 4:45 PM Abstract # 4245 R.K. Rao 5:00 PM Abstract # 6245 A.M. Marchiando

Disorders of the Enteric Nervous System Tuesday, May 1 — 10:30 AM-12:30 PM, Convention Ctr — Room 154B

10:30 AM Zebrafish enteric nervous system development: the lessons from lessen. Iain Shepherd, Emory Univ. 11:00 AM Development of the enteric nervous system. Alan Burns, Univ. Col. London. 11:30 AM Abstract # 3045 Gundrun Gossrau 11:45 AM Abstract # 3358 Simon Mwangi 12:00 PM Abstract # 5167 Iain Sheppard 12:15 PM Abstract # 894 Colleen Hegg

6. EB2007 EVENTS FOR TRAINEES

SYMPOSIA Publishing 101: Dos & Don’ts of Publishing in APS Journals Sponsored by: APS Publications Committee Sunday, April 29—10:30 AM-12:30 PM, Room 154A Being Heard: The Microinequities That Tilt the Playing Field Sponsored by: ASPET Women in Pharmacology Committee & APS Women in Physiology Committee Monday, April 30—8:00-10:00 AM, Room 201 Guide for Successful Collaboration: From the Handshake to the Collaborative Research Agreement Sponsored by: APS Careers Monday, April 30—2:00-4:00 PM, Room 159A/B Multiple Career Paths for a Physiologist: Understand Your Options and How to Get There Sponsored by: APS Trainee Advisory Committee Tuesday, May 1—8:00-10:00 AM, Room 147B SOCIAL YOUNG EXPERIMENTAL SCIENTISTS (Y.E.S.) MIXER Hyatt Hotel, Constitution Ballroom A/B, Level 3B Monday, April 30, 9:00 PM–11:30 PM The Y.E.S. Mixer is open to all EB registrants. You must wear your badge to gain admittance. Dance, relax, network while enjoying complimentary snacks and soft drinks. Alcohol will not be served to anyone under the age of 21 (be prepared to show identification). NEW!!!!! YOUNG EXPERIMENTAL SCIENTISTS (Y.E.S.) LOUNGE Convention Center, East Registration Area, Level 1 The lounge will be located in the registration area near the Cyber Café. Visit the Lounge to network with your peers, post notices on the designated boards, or just make dinner arrangements. The Lounge is open during registration hours Saturday through Wednesday.

7. SECTION GOVERNANCE

Chair and Section Advisory Committee Rep Christopher I. Cheeseman, Ph.D Department of Physiology, University Alberta, 7-22 medical Sciences Bldg, Edmonton, AB T6G 2H7 Canada Phone: 403-432-2620 Fax: 403-492-8915 Email: chris.cheeseman@ualberta.ca Term ends: 2009 Secretary/Treasurer ex officio AJP:GI &L Editor Marshall H. (Chip) Montrose, Ph.D. Department of Molecular and Cellular Physiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267 Phone: 531-558-5636 Fax: 513-558-5738 Email:mhm@uc.edu Term ends: 2009 Past Chair Matthew B. Grisham, Ph.D Department of Molecular and Cellular Physiology, Louisiana State University Health Science Center, 1501 Kings Highway, Shreveport, LA 71130 Phone: 318-675-6021 Fax: 413-280-9325 Email: mgrish@lsuhsc.edu Term ends: 2008 Joint Program Committee Representative Ron Ferraris, Ph.D. Department of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, 185 Orange Ave, MSB H621, Newark NJ 07103-2714 Phone: 973-972-4519 Fax: 973-972-7950 Email: Ferraris@umdnj.edu Term ends: 2008

Councilor Jerrold (Jerry) Turner, Ph.D. University of Chicago, Department of Pathology, 5841 South Maryland Avenue, MC-1089, Chicago, IL 60637 Phone: 773-702-2433 Fax: 773-834-5251 Email: jturner@bsd.uchicago.edu Term ends: 2009

Councilor Deborah C. Rubin, M.D. IM-Gastroenterology, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8124, St. Louis, MO 63110 Phone: 314-362-8951 Fax: 314-362-8959 Email: drubin@im.wustl.edu Term ends: 2007

Councilor John R. Grinder, Ph.D. Department of Physiology, Medical College of Virginia, VCM Box 980551, Richmond, VA 23298 Phone: 804-828-1853 Fax: 804-828-2500 Email: jgrider@hsc.vcu.edu Term ends: 2007

Councilor/ Banquet Coordinator Mark Clemens, Ph.D. Department of Biology University of North Carolina at Charlotte, 9201 University City Blvd., Charlotte NC 28201 Phone: 704 687-8682 Fax: 704 687-3128 Email: mgclemen@email.uncc.edu Term ends: 2008 Liaison with Industry Committee Representative Shaila Basavappa, Ph.D. Medical and Scientific Affairs Takeda Pharmaceutical America Inc., One Takeda Parkway, Deerfield IL 60015 Phone: 877-202-2721; ext. 16134 Fax: 585-482-2237 Email: sbasavappa@tpna.com Term ends: 2009

Awards Coordinator / Committee on Committees Representative Linda C. Samuelson, Ph.D. Department of Physiology, University of Michigan, 7761 Medical Science Building II, Ann Arbor, MI 48109-0622 Phone: 734-764-9448 Fax: 734-936-8813 Email: lcsam@umich.edu Term ends: 2007

Gastrointestinal Response to InjuRy –

Canada 2007october 3-6, 2007

Fairmont Le Chateau Montebello Montebello, Québec, Canada

Hotel ReseRvation DeaDline: september 7, 2007

RegistRation DeaDline: september 21, 2007

ConferenCe organizers

Jonathan D. Kaunitz, MD UCLA School of Medicine

Marshall H. Montrose, PhD University of Cincinnati

• explore factors regulating GI response to injury, agents and

mechanisms of GI injury, and manifestations of gut injury and

the potential to modulate disease outcomes.

• attend state-of-the-art sessions that cover the latest informa-

tion on mucosal barrier, gut inflammation and oxidative stress,

IBd, eosinophilic esophagitis and celiac disease.

• share research and gain valuable feedback from the

distinguished faculty and your peers by participating in an

interactive poster session.

• Benefit from the meeting’s dynamic format and beautiful,

yet secluded location, which promotes maximum interaction

with the expert faculty.

Register now for this conference that spans basic and clinical science and learn the latest about GI mucosal injury, pathogenesis and prevention.

For more information and to register, visit www.gastro.org/GIRI or contact AGA Member Services at 301-941-2651 or member@gastro.org to request a registration form.

Microbes and Mucosal Immunity-2007

Organizing Committee: Peter B. Ernst DVM, PhD, Sheila E. Crowe MD, FRCPC, AGAF and Brian K. Reuter PhD

GI trainees, research fellows and students interested in pursuing careers in GI research should attend this one-day overview as part of an introductory course to learn more about the impact of digestive diseases on society, the basic principles of GI research and current investigative tools. This overview is integrated with the GI Response to Injury conference that will highlight exciting, current and emerging research on a broad spectrum of topics. For more details, visit www.uva-mmi.org.

AGA Institute – JAAGUAR Young Investigators Forum

Chairs: Jonathan D. Kaunitz, MD and

Yvette Taché, PhD

The AGA Institute - Japanese-American Association of Gastrointestinal and Ulcer-Acid Researchers (JAAGUAR) Young Investigators Forum will focus on advancing the careers of young Japa-nese investigators who have worked in, or hope to work in North American laboratories. The seminar will feature two keynote speakers and presenta-tions by fellows and by postdoctoral scholars in a supportive, mentoring environment. Interactions developed during the seminar will generate contacts and new research directions.

pRe-ConFeRenCe syMposIa october 3, 2007