EABPCO-CPHG RESULTS Approximately half of the women hospitalized for AE of COPD were active smokers...
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EABPCO-CPHG RESULTS • Approximately half of the women hospitalized for AE of COPD were active smokers (Fig.1) EABPCO Study: characteristics of COPD women hospitalized for acute exacerbation (AE) according to their tobacco consumption Cyril Maurer (1), Laurence Moncelly (2), François Blanchon (2), Bruno Caillet (3), Eric Kelkel (4), Bernard Duvert (5), Christophe Roy (6), Christian Delafosse (7), Catherine Fouret (8), Patricia Barré (9), Hassane Ziani Bey (10), Olivier Chrétien (11), Jacques Piquet (1) (1) CHI Le Raincy-Montfermeil; (2) CH Meaux; (3) CH Montélimar; (4) CH Chambéry; (5) CH Lons-le-Saunier; (6) CH Sainte-Foy-la-Grande; (7) CH Eaubonne; (8) CH Villeneuve-Saint-Georges; (9) CH Cahors; (10) CH Vire; (11) CH Alençon OBJECTIVES • To describe the population of women at enrolment according to tobacco consumption AIMS • Emerging evidence suggests that COPD women will be at least as numerous as COPD men in the future. However, COPD is still under-diagnosed and little studied in women. • The French College of General Hospital Lung Specialists has enrolled a cohort of 1,824 COPD patients, including 423 women (23.2%) hospitalized for acute exacerbation (AE) of COPD, which it plans to follow up for 3 years. CONCLUSIONS • 46.6% of the COPD women hospitalized for AE in French general hospitals were active smokers, 39.0% were ex-smokers, and 14.4% non- smokers. • The demographic and clinical characteristics of these COPD women before the AE differed according to tobacco consumption. • The characteristics of the AE did not differ according to tobacco consumption. REFERENCES • Piquet J, et al. Exacerbations aiguës de BPCO hospitalisées : facteurs prédictifs de mortalité à 3 ans. Présentation de l’étude EABPCO-CPHG. Rev Mal Resp 2007;24:909-16 ABSTRACT # 989 (3626) METHODS • Data from all female COPD patients admitted for AE between October 2006 and June 2007 in a pneumology department of one of the 68 general hospitals involved in this prospective epidemiological study were collected on a dedicated standardized questionnaire, regardless of hospital admission type, comorbidity, or severity of COPD or AE [Piquet]. • The questionnaire included items concerning: − patients − COPD before the AE − AE leading to hospitalization − treatments and types of hospital discharge. • COPD diagnosis was established by a senior lung specialist. • The Société de Pneumologie de Langue Française (SPLF)’s definition of “acute exacerbation” was used: i.e., enhancement or occurrence of at least one of the symptoms of the disease (cough, expectoration, or dyspnea) regardless of intensity. • Univariate analyses were performed to compare characteristics of female patients before and during the acute exacerbation according to tobacco consumption. The significance threshold was set at 0.05. • All data were collected anonymously. The French Data Protection Authority (Commission Nationale Informatique et Liberté) approved the study protocol. This study was promoted by the Collège des Pneumologues des Hôpitaux Généraux (CPHG) with the help of the Direction Générale de la Santé (DGS) and the Société de Pneumologie de Langue Française (SPLF). It was funded by AstraZeneca, Boehringer-Ingelheim-Pfizer, Comité National contre les Maladies Respiratoires (CNMR), GlaxoSmithKline, Orkyn’, Pneumologie Développement, and VitalAire. Characteristics of the acute exacerbation • 79.2% of the cases of AE were due to infectious causes. • AE was due to tobacco consumption intensification/resumption in 10.7% of active smokers, and left cardiac decompensation was associated with 11.5% of the cases of AE in non-smokers (versus 8.5% in ex-smokers and 2.5% in active smokers). • During the AE, symptom worsening was similar in the 3 groups, as well as signs in relation with AE severity. COPD characteristics before the acute exacerbation (Tab.2) • Before the AE, active smokers had a better respiratory function than the other women, and in particular than ex-smokers. • Their COPD was also less frequently diagnosed before the AE. In addition, when the COPD was diagnosed, active smokers were less frequently followed up by a lung specialist. Characteristics of female patients (Tab.1) • Active smokers were younger than the other women. They had fewer COPD complications and cardiovascular comorbidities. • Bronchiectasis was more frequent in non-smokers than in the other women, with a similar trend for asthma (no statistically significant difference between the 3 groups for asthma). Fig 1. Percentage of active smokers, ex-smokers, and non-smokers in the population of women hospitalized for acute exacerbation of COPD Tab. 1: Characteristics of female patients hospitalized for acute exacerbation of COPD according to their tobacco consumption Active smokers Ex- smokers Non- smokers N=197 N=165 N=61 Age (years) (mean +/- SD) 62.5+/- 12.3 73.7+/- 9.6 78.1+/- 7.5 COPD complications and comorbidities (%) - Arterial hypertension 22.8% 40.0% 49.2% - Ischemic cardiopathy 9.1% 10.9% 23.0% - Cardiac insufficiency 4.6% 13.9% 16.4% - Pulmonary arterial hypertension 4.6% 11.5% 18.0% - Right ventricular insufficiency 2.5% 7.3% 9.8% - Bronchiectasis 6.1% 7.9% 31.1% - Asthma 16.8% 17.0% 24.6% All the differences between the 3 groups were statistically significant except for asthma Tab. 2: COPD characteristics before the acute exacerbation according to tobacco consumption Active smokers Ex- smokers Non- smokers N=197 N=165 N=61 Dyspnea (MRC) - 0/1 30.1% 13.0% 6.6% - 3/4 35.2% 55.0% 57.4% Respiratory function - FEV1 (% pred.): mean +/- SD 50.9+/- 19.7 46.2+/- 16.8 51.9+/- 16.8 - Pa,O2 <60 mmHg 17.2% 36.3% 30.8% COPD previously diagnosed 68.0% 89.1% 91.8% Medical follow-up - General practitioner 26.3% 17.8% 10.7% - Lung specialist 63.9% 80.8% 87.5% - No follow up 9.8% 1.4% 1.8% MRC: Medical Research Council All the differences between the 3 groups were statistically significant Hospital stay and discharge • During hospital stay, active smokers were less frequently ventilated than ex-smokers or non-smokers (18.8% versus 29.7% and 24.6%). • A total of 6 women died during the hospitalization period: 4 were ex-smokers and 2 active smokers.
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Transcript of EABPCO-CPHG RESULTS Approximately half of the women hospitalized for AE of COPD were active smokers...
EABPCO-CPHG
RESULTS
• Approximately half of the women hospitalized for AE of COPD were active smokers (Fig.1)
EABPCO Study: characteristics of COPD women hospitalized for acute exacerbation (AE) according to their tobacco consumption
Cyril Maurer (1), Laurence Moncelly (2), François Blanchon (2), Bruno Caillet (3), Eric Kelkel (4), Bernard Duvert (5), Christophe Roy (6), Christian Delafosse (7), Catherine Fouret (8), Patricia Barré (9), Hassane Ziani Bey (10), Olivier Chrétien (11), Jacques Piquet (1)
(1) CHI Le Raincy-Montfermeil; (2) CH Meaux; (3) CH Montélimar; (4) CH Chambéry; (5) CH Lons-le-Saunier; (6) CH Sainte-Foy-la-Grande; (7) CH Eaubonne; (8) CH Villeneuve-Saint-Georges; (9) CH Cahors; (10) CH Vire; (11) CH Alençon
OBJECTIVES
• To describe the population of women at enrolment according to tobacco consumption
AIMS
• Emerging evidence suggests that COPD women will be at least as numerous as COPD men in the future. However, COPD is still under-diagnosed and little studied in women.
• The French College of General Hospital Lung Specialists has enrolled a cohort of 1,824 COPD patients, including 423 women (23.2%) hospitalized for acute exacerbation (AE) of COPD, which it plans to follow up for 3 years.
CONCLUSIONS
• 46.6% of the COPD women hospitalized for AE in French general hospitals were active smokers, 39.0% were ex-smokers, and 14.4% non-smokers.
• The demographic and clinical characteristics of these COPD women before the AE differed according to tobacco consumption.
• The characteristics of the AE did not differ according to tobacco consumption.
REFERENCES
• Piquet J, et al. Exacerbations aiguës de BPCO hospitalisées : facteurs prédictifs de mortalité à 3 ans. Présentation de l’étude EABPCO-CPHG. Rev Mal Resp 2007;24:909-16
ABSTRACT
# 989 (3626)
METHODS
• Data from all female COPD patients admitted for AE between October 2006 and June 2007 in a pneumology department of one of the 68 general hospitals involved in this prospective epidemiological study were collected on a dedicated standardized questionnaire, regardless of hospital admission type, comorbidity, or severity of COPD or AE [Piquet].
• The questionnaire included items concerning:
− patients
− COPD before the AE
− AE leading to hospitalization
− treatments and types of hospital discharge.
• COPD diagnosis was established by a senior lung specialist.
• The Société de Pneumologie de Langue Française (SPLF)’s definition of “acute exacerbation” was used: i.e., enhancement or occurrence of at least one of the symptoms of the disease (cough, expectoration, or dyspnea) regardless of intensity.
• Univariate analyses were performed to compare characteristics of female patients before and during the acute exacerbation according to tobacco consumption. The significance threshold was set at 0.05.
• All data were collected anonymously. The French Data Protection Authority (Commission Nationale Informatique et Liberté) approved the study protocol.
This study was promoted by the Collège des Pneumologues des Hôpitaux Généraux (CPHG) with the help of the Direction Générale de la Santé (DGS) and the Société de Pneumologie de Langue Française (SPLF). It was funded by AstraZeneca, Boehringer-Ingelheim-Pfizer, Comité National contre les Maladies Respiratoires (CNMR), GlaxoSmithKline, Orkyn’, Pneumologie Développement, and VitalAire.
Characteristics of the acute exacerbation
• 79.2% of the cases of AE were due to infectious causes.
• AE was due to tobacco consumption intensification/resumption in 10.7% of active smokers, and left cardiac decompensation was associated with 11.5% of the cases of AE in non-smokers (versus 8.5% in ex-smokers and 2.5% in active smokers).
• During the AE, symptom worsening was similar in the 3 groups, as well as signs in relation with AE severity.
COPD characteristics before the acute exacerbation (Tab.2)• Before the AE, active smokers had a better respiratory function than the other women, and in particular than ex-smokers.• Their COPD was also less frequently diagnosed before the AE. In addition, when the COPD was diagnosed, active smokers were less frequently followed up by a lung specialist.
Characteristics of female patients (Tab.1)• Active smokers were younger than the other women. They had fewer COPD complications and cardiovascular comorbidities. • Bronchiectasis was more frequent in non-smokers than in the other women, with a similar trend for asthma (no statistically significant difference between the 3 groups for asthma).
Fig 1. Percentage of active smokers, ex-smokers, and non-smokers in the population of women hospitalized for acute exacerbation of COPD
Tab. 1: Characteristics of female patients hospitalized for acute exacerbation of COPD according to their tobacco consumption
Active smokers
Ex-smokers
Non-smokers
N=197 N=165 N=61
Age (years) (mean +/- SD) 62.5+/-12.3 73.7+/-9.6 78.1+/-7.5
COPD complications and comorbidities (%)
- Arterial hypertension 22.8% 40.0% 49.2%
- Ischemic cardiopathy 9.1% 10.9% 23.0%
- Cardiac insufficiency 4.6% 13.9% 16.4%
- Pulmonary arterial hypertension 4.6% 11.5% 18.0%
- Right ventricular insufficiency 2.5% 7.3% 9.8%
- Bronchiectasis 6.1% 7.9% 31.1%
- Asthma 16.8% 17.0% 24.6%
All the differences between the 3 groups were statistically significant except for asthma
Tab. 2: COPD characteristics before the acute exacerbation according to tobacco consumption
Activesmokers
Ex-smokers
Non- smokers
N=197 N=165 N=61
Dyspnea (MRC)
- 0/1 30.1% 13.0% 6.6%
- 3/4 35.2% 55.0% 57.4%
Respiratory function
- FEV1 (% pred.): mean +/- SD 50.9+/-19.7 46.2+/-16.8 51.9+/-16.8
- Pa,O2 <60 mmHg 17.2% 36.3% 30.8%
COPD previously diagnosed 68.0% 89.1% 91.8%
Medical follow-up
- General practitioner 26.3% 17.8% 10.7%
- Lung specialist 63.9% 80.8% 87.5%
- No follow up 9.8% 1.4% 1.8%
MRC: Medical Research Council All the differences between the 3 groups were statistically significant
Hospital stay and discharge
• During hospital stay, active smokers were less frequently ventilated than ex-smokers or non-smokers (18.8% versus 29.7% and 24.6%).
• A total of 6 women died during the hospitalization period: 4 were ex-smokers and 2 active smokers.
