E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”....
-
Upload
ruby-garrett -
Category
Documents
-
view
214 -
download
0
Transcript of E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”....
![Page 1: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/1.jpg)
Erythropoiesis
Dr. Wasif Haq
![Page 2: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/2.jpg)
Introduction• Red blood cells also called as “Erythrocytes”. • R.B.C. required for transportation of respiratory
gases.• Biconcave disc shaped.• Mean diameter 7.5.-7.8 micrometer.• Initially nucleated, later anucleated.• Flexible cell membrane. • Significance?
![Page 3: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/3.jpg)
Count & Levels• Most numerous amongst all blood cell types.• In males: 5,200,000 (+ 300,000) Million cells/cubic
millimeter.• In females: 4,700,000 (+ 300,000) Million
cells/cubic millimeter.• Why the count in males is greater?
![Page 4: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/4.jpg)
Hemoglobin Levels• Maximum concentrating ability of R.B.C.’s for
Hemoglobin is 34 g/dl.• Every deciliter of blood in men carry 16 grams of
Hemoglobin, while in females; 14 grams.• 1 single gram of Hemoglobin is capable of
combining with 1.39 milliliters of Oxygen.
![Page 5: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/5.jpg)
Functions of R.B.C.’s
• Transportation of Oxygen bound with Hemoglobin: 97% Hemoglobin.
• Carbonic anhydrase enzyme: Transportation of CO2 from tissues back to lungs in form of ‘bicarbonate’ ions.
• Acid-base buffering.
![Page 6: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/6.jpg)
R.B.C.’s Production• Also known as “Erythropoiesis” or
“Erythrogenesis”.
Intra-embryonic/ Intra-uterine life
Postnatal life
![Page 7: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/7.jpg)
Intra-Embryonic Life
• Initially: Yolk sac.• Second trimester: Mainly liver along with Spleen
& lymph nodes.• Third trimester and after birth : Only in bone
marrow.
![Page 8: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/8.jpg)
Post-natal Life
• Bone marrow of all the bones till 5 years of life.• Relation between age & R.B.C.’s production?• Vertebrae, sternum, ribs and ilia produce R.B.C.’s
throughout life.
![Page 9: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/9.jpg)
![Page 10: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/10.jpg)
Erythropoiesis• Pluripotent Hematopoetic stem cells in bone marrow
(also called as Hemocytoblast) are source for R.B.C.’s.• Any type of blood cell type can be formed by
Hemocytoblasts.• Certain number of Pluripotent Hematopoetic stem
cells will become committed to form only R.B.C.’s , hence called “Committed stem cells”.
• Commitment occurs before any structural differences observed.
• Growth & differentiation inducers.
![Page 11: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/11.jpg)
Haematopoetic stem cell Proerythroblasts Basophil erythroblasts Polychromatophil erythroblasts
Orthochromatic erythroblasts
Reticulocytes
Erythrocyte
![Page 12: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/12.jpg)
![Page 13: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/13.jpg)
Nutrients Required• Vitamin B12, Folic Acid & Iron.• Deficiency of Vitamin B 12 & Folic Acid-
Maturation failure.• Larger than normal size R.B.C.’s are produced
called Macrocytes.• Macrocytes can carry O2 but are extremely
fragile.• B12 deficiency takes 3-4 years to develop.• Folic acid destroyed by cooking vegetables, meat
& fruits.
![Page 14: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/14.jpg)
Nutrients Required
• Sprue= Small intestinal disease, difficulty in absorbing Folic acid & Vitamin B 12 due to deficiency of Intrinsic factor.
• Iron: Stored in body in form of “Ferritin”. • Hemoglobin: 65% Iron, Myoglobin 4%, Reticulo-
endothelial cells in bone marrow and liver 15-30%.
![Page 15: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/15.jpg)
Erythropoietin• Concentration of R.B.C.’s is not important but
functional ability to transport respiratory gases.• Protein hormone stimulates R.B.C.’s production.• Released from Kidneys (90%) & Liver (10%).• Epinephrine, Nor-epinephrine & Prostaglandins
stimulate Erythropoietin release.• Production starts within minutes, new cells appear
after 4-5 days.• Action: Stimulates Proerythroblast formation from
hematopoietic stem cell and accelerates progression & maturity of cell through different stages of Erythropoiesis.
![Page 16: E rythropoiesis Dr. Wasif Haq. Introduction Red blood cells also called as “Erythrocytes”. R.B.C. required for transportation of respiratory gases. Biconcave.](https://reader031.fdocuments.net/reader031/viewer/2022032805/56649ef45503460f94c06b8f/html5/thumbnails/16.jpg)
http://coolbluez.t15.org