E health 2020 oog. Oog Melanoom "Data rentmeester"
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Transcript of E health 2020 oog. Oog Melanoom "Data rentmeester"
Oog Melanoom“Data rentmeester”
eHealth 2017 27-1-2017
Bert Eussen
Oog Melanoom• ~140 patienten per jaar lft 50-70j
• Diagnose: routine onderzoek, slecht zicht
• Behandeling:
– Verwijderen oog
– Bestraling
• Ondanks behandeling 50% metastase
zeer slecht prognose
• Research: Zoektocht naar prognostische markers.
http://www.erasmusmc.nl/47457/51016/227068/oogmelanoom
Data en monsters
• ErasmusMC EPD (Elpado)
• Arts onderzoekers – ( Pathologie verslag, Opzet nieuwe assay/analyse)
• Materiaal: Bloed ( in de tijd), tumor weefsel , gezond weefsel etc --- DNA /RNA
• Testen: Array, NGS, Chromosoom, FISH, QPCR, SSEQ, IHC
Research support tool ! (mini LIMS Filemaker )
n= 900 personen
n= 10.000 monsters
n= 371/24.000 Arrays
n= 263/6.000 NGS
Inheritance model Study (smallest entity)
Clinical data X Clinical data analysis
Genesis X Front Office X Sample prep X Lab service ( Analysis 1) X Lab Staf X Counseling
Study PI ---------- Project - Sponsor Governor
DATA - Finance - Informed ConsentOOG Tumor E. KilicROMS Prof Vingerling
OOG Dashboard OOG research FM database
Data request
Data request: Assays Raw Assays Analysis Clinical data Reports ?
Data production
Arrays/NGS
Local Network
Author publication folder
Final
Optional: Analysis software, OS
Reference files
Managed Tape model
Track & Trace MyLTO service (web based)- TapeMyLTOservice Basic: data to tape + 2 copies+ index- Tape Storage, data migration, distribution, 5000 arrays or 200 wes/20WGS /LTO6 n=50
TAR- Copy - Checksums
LTO 5-6 6.25 Tb/2,5 Tb rawLTO 8 12 Tb/ 4 Tb raw ( 2017)
Tape Governance ( PI etc)Tape ID Tape type etc.
Index files Tape content
DOI publication_ID Link production/data tapes
Tape location / migration?……
pptArray
NGSClin
Index file
Production archive tapes
TAR - Copy- Checksums
Index file
Distribution: Research, Education, Healthcare ……. patient!! Governance KEYS!!
Publication archive tapes
Data production Publications
Acknowledgements:
PI(s) Emine Kilic Annelies de KleinGovernor(s) Prof VingerlingSponsor ROMSData rentmeester Bert EussenAnalisten & onderzoekers
Dashboard design Rianne Kosterman W Kooning HROBiomics NGSInt. medicine ArraysPathologieICT research Tape/index support
Carelliance Peter WalgemoedFortados Tape LTO storage service