DysmenMefenamic Acid & Dicyclomine Hydrochloride Tablets.

Dispels Pain & Spasm FastDispels Pain & Spasm Fast

Menstrual CycleMenstrual Cycle

The Menstrual Cycle Days 1–4 The uterine lining is shed during menstruation.

Days 5–13 An egg matures in one of the ovaries, and the uterine lining starts to thicken.

Egg

Egg

Maturing Egg

Days 14–15 The ovary releases the mature egg during ovulation.

Days 16–22 The egg travels through the fallopian tube to the uterus, and the uterine lining continues to thicken.

Days 23–28 The unfertilized egg enters the uterus.

THE LUNAR CYCLE

• INTERVAL 28 DAYS

• FLOW 5 DAYS

• OVULATION DAY 14

PHASES OF THE MENSTRUAL CYCLE

• MENSTRUATION

• PROLIFERATION

• OVULATION

• SECRETORY

PHASES OF THE MENSTRUAL CYCLE

• MENSTRUATION

• PROLIFERATION

• OVULATION

• SECRETORY

• DAY 1 to 5

• DAY 6 to 13

• DAY 14

• DAY 15 to 28

• VARIES• NEW FOLLICLE IS FORMING• THE UTERINE LINING IS SHEDDING• HORMONES ARE AT THEIR LOWEST• MUCUS IS LOW IN VOLUME &

ELASTICITY,CLOUDY,THICK• TEMPERATURE IS NORMAL• SYMPTOMS: ANXIETY,

HEADACHES, CRAMPS, NAUSEA, DEPRESSION, DIARRHEA, DECREASED LIBIDO

• VARIES• FOLLICLE MATURING• UTERINE LINING BUILDING UP• HORMONES START TO RISE• MENSTRUAL SYMPTOMS SUBSIDING• FEELING PRETTY AND GOOD• LIBIDO INCREASING

• FAIRLY CONSTANT time in your cycle• MATURE EGG LEAVES THE FOLLICLE• HORMONE PEAK • MUCUS IS HIGH VOLUME & ELASTICITY, THIN, CLEAR• TEMP IS LOW• SYMPTOMS: INCREASE SECRETIONS,

NAUSEA, SHARP OR DULL PAIN, SPOTTING,

• CONSTANT• EGG DEGENERATES• CORPUS LUTEUM REGRESSING• HORMONES STABLE- MODERATE• MUCUS IS LOW IN VOLUME & ELASTICY, THICK, CLOUDY• TEMP- SPIKES JUST AFTER OVULATION, THEN STABLIZES• SYMPTOMS: WEIGHT GAIN, BLOATING,

SWELLING, BREAST TENDERNESS, ANXIETY, DEPRESSION,ANXIETY, HEAD ACHE, SPOTTING , CONSTIPATION,ACNE

What’s the impact?

Women’s fluctuating hormones make us very variable in nature; men’s hormones are very steady state and don’t fluctuate much at all.

Basically it means that if you don’t like us today, wait-more than likely a female will improve in a few days…

With men, if you don’t like them on day one, more than likely they won’t change a whole lot.

Prostaglandin

Prostaglandins

Activation of the inflammatory response, production of pain, and fever

When tissues are damaged, white blood cells flood to the site to try to minimize tissue destruction

Prostaglandins are produced as a result. Blood clots form when a blood vessel is damaged

A type of prostaglandin called thromboxane stimulates constriction and clotting of platelets

Conversely, PGI2, is produced to have the opposite effect on the walls of blood vessels where clots should not be forming PGE2 causes uterine contractions.

Prostaglandins

Activation of the inflammatory response, production of pain, and fever

When tissues are damaged, white blood cells flood to the site to try to minimize tissue destruction

Prostaglandins are produced as a result. Blood clots form when a blood vessel is damaged

A type of prostaglandin called thromboxane stimulates constriction and clotting of platelets

Conversely, PGI2, is produced to have the opposite effect on the walls of blood vessels where clots should not be forming PGE2 causes uterine contractions.

Need of the Drug That can cure pain and spasm in colic and

dysmenorrhea cases

DysmenMefenamic Acid & Dicyclomine Hydrochloride Tablets.

Dispels Pain & Spasm FastDispels Pain & Spasm Fast

MRP PTR PTS

24.30 18.51 16.66

MRP PTR PTS

30.75 23.43 21.09

Pharmacology

Mefenamic acid: analgesic, anti-inflammatory and antipyretic properties inhibits the enzymes of prostaglandin synthetase and also

antagonizes the actions of prostaglandin at the receptor sites

dual mode of action of Mefenamic acid offers significant advantages over other NSAIDs which merely inhibit prostaglandin synthesis

These effects may also be responsible for its effectiveness in the treatment of primary dysmenorrhoea

Dicyclomine

Dicyclomine is an anticholinergic. It is a competitive antagonist at muscuranic cholinergic neurons.

Reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle

Direct relaxing effect on smooth muscle Prevent spasm in the muscles of the gastrointestinal tract in

the irritable bowel syndrome Relaxes the muscle and prevents spasms from occurring. Slightly reduce the production of stomach acid.

Pharmacology

Blocks action of Ach Inhibits parasympathetic actions Relaxes smooth muscles of GIT, Biliary tract,

Urinary Tract, Uterus Synergy of Mefenamic acid and

Dicyclomine - Mefenamic acid erases pain and Dicyclomine

decreases spasm.

MOA

It also act as an antagonist at prostaglandin receptor sites. It has analgesic and antipyretic properties with minor anti-inflammatory activity

Mefenamic acid inhibits the enzymes coyclooxygenase (COX-1) (COX-2) and reduce the formation of prostaglandin.

Thus helps in relives the pain

Mefenamic Acid

PHARMACOLOGYMEFENAMIC ACID DICYCLOMINE

It is analgesic, anti inflammatory and anti pyretic property.

It is anti cholinergic in property

It inhibits the enzymes and antagonizes the action of prostaglandin

It decreases the effect of acetylcholine by blocking the receptors on smooth muscles

Dual mechanism of action offer advantages over NSAID

Direct relaxing effect on smooth muscles prevents spasm of IBS

This effect may responsible for treatment of DYSMENORRHOEA

It relaxes the muscles and prevent spasm from occurring thus decreases the production of stomach acid.

Synergy of both Mefenamic acid and Dicyclomine help in erase the PAIN and decreases the SPASM