Dustin Borg, ME Patrick Henley, BME Ali Husain, BME Nick Stroeher, BME Advisor: Dr. Paul King
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Dustin Borg, MEDustin Borg, ME
Patrick Henley, BMEPatrick Henley, BME
Ali Husain, BMEAli Husain, BME
Nick Stroeher, BMENick Stroeher, BME
Advisor: Dr. Paul KingAdvisor: Dr. Paul King

Our Dutch Team Our Dutch Team MembersMembers
Willem-Jan van Harskamp, Willem-Jan van Harskamp, Applied PhysicsApplied Physics
Vivian Roode, BMEVivian Roode, BME
Gijs Snieders, BMEGijs Snieders, BME
M. van Vlimmeren, BMEM. van Vlimmeren, BME
Advisor: Dr. Eva Advisor: Dr. Eva AdamowiczAdamowicz

RelevanceRelevance Dental applications:Dental applications:
– Clean cavitiesClean cavities– Less painfulLess painful– Treat irregular surfacesTreat irregular surfaces

Skin treatmentSkin treatment– healing of various lesions and ulcers of healing of various lesions and ulcers of
skin, intestines and larynx skin, intestines and larynx

Current Level of Current Level of Development of Plasma Development of Plasma Needle TechnologyNeedle Technology Evaluation of the electrical Evaluation of the electrical
characteristics of the plasma characteristics of the plasma needleneedle
Sensing the gap width by Sensing the gap width by monitoring the discharge power monitoring the discharge power consumptionconsumption
Control of the gap width with Control of the gap width with robotic actuationrobotic actuation

What We Will What We Will ContributeContributeEindhoven Eindhoven
Students:Students: Correct gap width Correct gap width
by implementing by implementing electro-electro-mechanical mechanical actuators and actuators and control algorithmscontrol algorithms
Vanderbilt Students:Vanderbilt Students: Design a plasma Design a plasma
needle catheter needle catheter that will be better that will be better suited for medical suited for medical use than the use than the existing prototypeexisting prototype
Possibly testing on Possibly testing on cell culturescell cultures

Our Progress So FarOur Progress So Far
ResearchResearch Literature from EindhovenLiterature from Eindhoven
CoordinationCoordination Overseas communication issuesOverseas communication issues NetMeetingNetMeeting

What is Plasma?What is Plasma?Plasma is a state of matter with enough free charged particles so that its dynamics are heavily influenced by electromagnetic forces.
gaseous fluid-like mixture of ions, free electrons,radicals and excited atoms and molecules
The Plasma Needle uses Low-Temperature Plasma (LTP)
small fraction of neutral particles in gas are ionized
electrons are high energy; ions are ambient temp.
retains neutral charge
http://solar.physics.montana.edu/martens/plasma/

Composition of the Composition of the NeedleNeedle
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The AC source produces Radio Frequent (RF) discharges on the order of 1-100 MHz
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This design uses Capacitively Coupled Plasma to create E field from voltage difference
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In the middle is a metal wire with a sharp point electrode for the E field
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The coaxial metal tube is grounded Helium gas is moved into space between
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Wire is insulated so that plasma is generated only at tip; it appears like a ball 1 mm in diameter
____The Development of a Smart-Scanning Probe for the Plasma Needle, Ewout van der Laan

The Plasma NeedleThe Plasma Needle
The Development of a Smart-Scanning Probe for the Plasma Needle, Ewout van der Laan

Current Known EffectsCurrent Known EffectsMain effect is the dissolution of tissue Main effect is the dissolution of tissue
Most likely Plasma Needle damages Most likely Plasma Needle damages CAMCAM proteins and proteins and causes breakup of tissue without accidentally killing cellscauses breakup of tissue without accidentally killing cells
Destruction of CAM Destruction of CAM proliferation of proliferation of free radicalsfree radicals (O, OH) (O, OH)
The Development of a Smart-Scanning Probe for the Plasma Needle, Ewout van der Laan

Gas Plasma CatheterGas Plasma CatheterBasic DefinitionBasic Definition
– Plastic tube confining thin wire containing Plastic tube confining thin wire containing plasma electrode for insertion into the body plasma electrode for insertion into the body (bloodstream, lungs, etc.). (bloodstream, lungs, etc.).
General Design GoalsGeneral Design Goals BiocompatibleBiocompatible ThinThin FlexibleFlexible Capable of separating gas from tissue and fluidsCapable of separating gas from tissue and fluids
– Porous MembranePorous Membrane1.1. Maintain plasma operation under “closed”conditionsMaintain plasma operation under “closed”conditions2.2. Permit sufficient active plasma particles to escape Permit sufficient active plasma particles to escape
through membranethrough membrane

Immediate GoalsImmediate Goals(through end of semester)(through end of semester)
1.1. Construction of plasma needle prototypeConstruction of plasma needle prototype Acquire current schematics Acquire current schematics Arrange for financingArrange for financing Identify and select manufacturing contactIdentify and select manufacturing contact
2.2. Focused research efforts Focused research efforts CatheterCatheter
MaterialsMaterials SpecificationsSpecifications Selectively Porous MembranesSelectively Porous Membranes
3.3. Solidify CoordinationSolidify Coordination Maintain contact with our counterpartsMaintain contact with our counterparts Expand and improve lines of communicationExpand and improve lines of communication

TimelineTimeline
DecemberDecember
JanuaryJanuary
FebruaryFebruary
MarchMarch
AprilApril
Catheter Research
Construction of Functioning Plasma Needle Setup
Material Selection and Design of CatheterCatheter ConstructionPhysical Testing of Plasma Needle Catheter CombinationTherapeutic Testing on Tissue Cultures