DUKE UNIVERSITY MEDICAL CENTER CURRICULUM VITAE Date...

DUKE UNIVERSITY MEDICAL CENTER

CURRICULUM VITAE

Date Prepared: February 2018

Name: Roland Albert Matsouaka, PhD

Primary academic appointment: Department of Biostatistics and

Bioinformatics

Secondary appointment: Duke Clinical Research Institute

Present academic rank and title: Assistant Professor of Biostatistics and

Bioinformatics

Date and rank of first Duke Faculty

appointment:

September 2014; Assistant Professor of

Biostatistics and Bioinformatics

Place of Birth: Jacob, Republic of Congo

Citizen of: United States of America

EDUCATION

Institution Date Degree

High School Lycée Emery Patrice Lumumba

Brazzaville, Republic of Congo

1990 HS Diploma

College Université Marien Ngouabi

Brazzaville, Republic of Congo

1993 B.S. in Mathematics

Graduate or Professional School

Université de Ouagadougou

Ouagadougou, Burkina Faso

1995 M.S. in Mathematics

Université de Ouagadougou

Ouagadougou, Burkina Faso

1996 DEA (Postgrad) in Pure Mathematics

Université Nationale du Bénin

Cotonou, Republic of Benin

1999 DEA (Postgrad) in Applied Mathematics

Harvard School of Public Health

Boston, Massachusetts

2007 S.M. in Biostatistics

Harvard School of Public Health 2012 PhD in Biostatistics

Curriculum Vitae Roland Albert Matsouaka, PhD

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2012-2014

Postdoctoral Training in Causal Inference.

PROFESSIONAL TRAINING AND ACADEMIC CAREER

Institution Position/Title Date



Postdoctoral Fellow 2012-2014

Northeastern University


Visiting Scholar 2012-2014

RESEARCH AND PROFESSIONAL EXPERIENCE

1. Graduate Researcher Graduate School of Arts and Sciences and School

of Public Health, Harvard University 2007-2012

Developed a treatment assignments rule and quantified incremental value for new covariate(s) for personalized medicine using treatment index scores.

Proposed a weighted Wilcoxon test based on worst rank scoring imputation for informative missing data.

Developed power and sample size formulas for the ordinary Wilcoxon test under both tied and untied worst rank score imputations of informative missing data.

Conducted data analyses in the study of treatment effect on dendritic arborization complexity on animal models, with data collected through Sholl’s plot analysis method

Conducted data analyses in the study of treatment effect on dendritic arborization complexity on animal models, with data collected through Sholl’s plot analysis method

Conducted data analysis for the study of urinary biomarkers of acute kidney injury.

Worked through different projects, with researchers from

Renal Division, Dept. of Medicine, Brigham and Women’s Hospital, Boston, MA

Institute for Neurodegenerative Disease, Mass. General Hospital, Boston, MA

Molecular Pathology Unit, Mass. General Hospital, Boston, MA

Massachusetts Eye and Ear Infirmary, Boston, MA

2. Consultant Molecular Pathology Unit

Massachusetts General Hospital


Summer

2006 & 2007

Conducted data analysis to compare and select important predictors for patients undergoing non-traumatic cardiac arrest coma

Conducted data analysis to study YKL-40 protein expression to better distinguish diagnostically challenging brain tumors


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3. Visiting Researcher Unité FYMA, Université Catholique de Louvain

Louvain-la-Neuve, Belgium

2001–2002

Conducted research on wavelets and image processing with applications to medical imagery and detection of symmetry in patterns

PUBLICATIONS

Peer-reviewed articles and abstracts A. Statistical Methodology

1. Atem, F. D., Matsouaka, R. A., Zimmern V. E., 2019. Cox Regression Model with Randomly Censored Covariates. Biometrical Journal (just accepted), pp.1-15.

2. Dong, G., Hoaglin, D.C., Qiu, J., Matsouaka, R.A., Chang, Y.W., Wang, J. and Vandemeulebroecke, M., 2019. The win ratio: On interpretation and handling of ties. Statistics in Biopharmaceutical Research, (just-accepted), pp.1-14.

3. Matsouaka, R.A., Singhal, A.B. and Betensky, R.A., 2018. Optimal Weighted Wilcoxon–Mann–Whitney Test for Prioritized Outcomes. In New Frontiers of Biostatistics and Bioinformatics (pp. 3-40). Springer, Cham.

4. Matsouaka, R.A., Singhal, A.B. and Betensky, R.A., 2018. An optimal Wilcoxon–Mann–Whitney test of mortality and a continuous outcome. Statistical methods in medical research, 27(8), pp.2384-2400.

5. Atem, F. D. and Matsouaka, R. A. Linear Regression Model with a Randomly Censored Predictor: Estimation Procedures. Biostat and Biometrics Open Acc. J. 2017;1(2): 1-12.

6. Matsouaka, R.A. and Tchetgen Tchetgen, E.J., 2017. Instrumental variable estimation of causal odds ratios using structural nested mean models. Biostatistics, p.kxw059.

7. Glymour, M.M., Nguyen, Q.C., Matsouaka, R., Tchetgen Tchetgen, E.J., Schmidt, N.M. and Osypuk, T.L., 2016. Does mother know best? Treatment adherence as a function of anticipated treatment benefit. Epidemiology, 27(2), pp.265-275.

8. Matsouaka, R.A., Li, J. and Cai, T., 2014. Evaluating marker‐guided treatment selection strategies. Biometrics, 70(3), pp.489-499.

9. Matsouaka, R.A. and Betensky, R.A., 2015. Power and sample size calculations for the

Wilcoxon–Mann–Whitney test in the presence of death‐censored observations. Statistics in medicine, 34(3), pp.406-431.

10. Matsouaka, R.A. Tchetgen Tchetgen, E.J. Maximum Likelihood Estimation of Structural Nested Logistic Models with an Instrumental Variable, In Proceedings of the 29th Conference on Uncertainty in Artificial Intelligence (UAI-13). Seattle, Washington. 2013.

B. Health Application

1. McHugh K, DeVore AD, Wu J, Matsouaka RA, Fonarow GC, Heidenreich PA, Yancy CW, Green JB, Altman N, Hernandez AF. Heart Failure With Preserved Ejection Fraction and Diabetes: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019 Feb 12;73(5):602-611. doi: 10.1016/j.jacc.2018.11.033. Review. PMID: 30732715

2. Piccini JP, Xu H, Cox M, Matsouaka RA, Fonarow GC, Butler J, Curtis AB, Desai N, Fang

M, McCabe PJ, Page RL, Turakhia M, Russo AM, Knight BP, Sidhu M, Hurwitz JL, Ellenbogen KA, Lewis WR; Get With The Guidelines-AFIB Clinical Working Group and


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Hospitals. Adherence to Guideline-Directed Stroke Prevention Therapy for Atrial Fibrillation is Achievable: First Results from Get With The Guidelines-Atrial Fibrillation (GWTG-AFIB). Circulation. 2019 Jan 31. doi: 10.1161/CIRCULATIONAHA.118.035909. [Epub ahead of print] PMID: 30700141

3. Song S, Liang L, Fonarow GC, Smith EE, Bhatt DL, Matsouaka RA, Xian Y, Schwamm LH,

Saver JL. Comparison of Clinical Care and In-Hospital Outcomes of Asian American and White Patients With Acute Ischemic Stroke. JAMA Neurol. 2019 Jan 22. doi: 10.1001/jamaneurol.2018.4410. [Epub ahead of print] PMID: 30667466

4. Echouffo-Tcheugui JB, Zhao S, Brock G, Matsouaka RA, Kline D, Joseph JJ. Visit-to-Visit Glycemic Variability and Risks of Cardiovascular Events and All-Cause Mortality: The ALLHAT Study. Diabetes Care. 2019 Jan 18. pii: dc181430. doi: 10.2337/dc18-1430. [Epub ahead of print] PMID: 30659073

5. Chu SY, Cox M, Fonarow GC, Smith EE, Schwamm L, Bhatt DL, Matsouaka RA, Xian Y,

Sheth KN. Temperature and Precipitation Associate With Ischemic Stroke Outcomes in the United States. J Am Heart Assoc. 2018 Nov 20;7(22):e010020. doi: 10.1161/JAHA.118.010020. PMID: 30571497

6. Likosky DS, Harrington SD, Cabrera L, DeLucia A 3rd, Chenoweth CE, Krein SL, Thibault D,

Zhang M, Matsouaka RA, Strobel RJ, Prager RL. Collaborative Quality Improvement Reduces Postoperative Pneumonia After Isolated Coronary Artery Bypass Grafting Surgery. Circ Cardiovasc Qual Outcomes. 2018 Nov;11(11):e004756. doi: 10.1161/CIRCOUTCOMES.118.004756. PMID: 30571334

7. Echouffo-Tcheugui JB, Sheng S, DeVore AD, Matsouaka RA, Hernandez AF, Yancy CW,

Heidenreich PA, Bhatt DL, Fonarow GC. Glycated Hemoglobin and Outcomes of Heart Failure (from Get With the Guidelines-Heart Failure). Am J Cardiol. 2019 Feb 15;123(4):618-626. doi: 10.1016/j.amjcard.2018.11.023. Epub 2018 Dec 3. PMID: 30553509

8. Inohara T, Manandhar P, Kosinski AS, Matsouaka RA, Kohsaka S, Mentz RJ, Thourani VH,

Carroll JD, Kirtane AJ, Bavaria JE, Cohen DJ, Kiefer TL, Gaca JG, Kapadia SR, Peterson ED, Vemulapalli S. Association of Renin-Angiotensin Inhibitor Treatment With Mortality and Heart Failure Readmission in Patients With Transcatheter Aortic Valve Replacement. JAMA. 2018 Dec 4;320(21):2231-2241. doi: 10.1001/jama.2018.18077. PMID: 30512100

9. Zachrison KS, Onnela JP, Hernandez A, Reeves MJ, Camargo CA Jr, Cox M, Matsouaka

RA, Metlay JP, Goldstein JN, Schwamm LH. Ischemic Stroke Transfer Patterns in the Northeast United States. J Stroke Cerebrovasc Dis. 2019 Feb;28(2):295-304. doi: 10.1016/j.jstrokecerebrovasdis.2018.09.048. Epub 2018 Oct 30. PMID: 30389376

10. Wangqin R, Laskowitz DT, Wang Y, Li Z, Wang Y, Liu L, Liang L, Matsouaka RA, Saver JL,

Fonarow GC, Bhatt DL, Smith EE, Schwamm LH, Prvu Bettger J, Hernandez AF, Peterson ED, Xian Y. International Comparison of Patient Characteristics and Quality of Care for Ischemic Stroke: Analysis of the China National Stroke Registry and the American Heart Association Get With The Guidelines--Stroke Program. J Am Heart Assoc. 2018 Oct 16;7(20):e010623. doi: 10.1161/JAHA.118.010623. PMID: 30371291

11. Myint PK, Sheng S, Xian Y, Matsouaka RA, Reeves MJ, Saver JL, Bhatt DL, Fonarow GC,

Schwamm LH, Smith EE. Shock Index Predicts Patient-Related Clinical Outcomes in


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Stroke. J Am Heart Assoc. 2018 Sep 18;7(18):e007581. doi: 10.1161/JAHA.117.007581. PMID: 30371191

12. Arnold SV, Cohen DJ, Dai D, Jones PG, Li F, Thomas L, Baron SJ, Frankel NZ, Strong S,

Matsouaka RA, Edwards FH, Brennan JM. Predicting Quality of Life at 1 Year After Transcatheter Aortic Valve Replacement in a Real-World Population. Circ Cardiovasc Qual Outcomes. 2018 Oct;11(10):e004693. doi: 10.1161/CIRCOUTCOMES.118.004693. PMID: 30354575

13. Luo N, Xu H, Jneid H, Fonarow GC, Lopes RD, Piccini JP, Curtis AB, Russo AM, Lewis WR,

Matsouaka RA, Granger CB, Mentz RJ, Al-Khatib SM. Use of Oral Anticoagulation in Eligible Patients Discharged With Heart Failure and Atrial Fibrillation. Circ Heart Fail. 2018 Oct;11(10):e005356. doi: 10.1161/CIRCHEARTFAILURE.118.005356. PMID: 30354398

14. Kochar A, Li Z, Harrison JK, Hughes GC, Thourani VH, Mack MJ, Matsouaka RA, Cohen

DJ, Peterson ED, Jones WS, Vemulapalli S. Stroke and Cardiovascular Outcomes in Patients With Carotid Disease Undergoing Transcatheter Aortic Valve Replacement. Circ Cardiovasc Interv. 2018 Jun;11(6):e006322. doi: 10.1161/CIRCINTERVENTIONS.117.006322. PMID: 29895600

15. Ziaeian B, Heidenreich PA, Xu H, DeVore AD, Matsouaka RA, Hernandez AF, Bhatt DL,

Yancy CW, Fonarow GC. Medicare Expenditures by Race/Ethnicity After Hospitalization for Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2018 May;6(5):388-397. doi: 10.1016/j.jchf.2017.12.007. Epub 2018 Apr 11. PMID: 29655830

16. Joseph L, Bashir M, Xiang Q, Yerokun BA, Matsouaka RA, Vemulapalli S, Kapadia S,

Cigarroa JE, Zahr F. Prevalence and Outcomes of Mitral Stenosis in Patients Undergoing Transcatheter Aortic Valve Replacement: Findings From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapies Registry. J Am Heart Assoc. 2018 Apr 6;7(8). pii: e008088. doi: 10.1161/JAHA.117.008088. PMID: 29622149

17. Alaeddine M, Badhwar V, Grau-Sepulveda MV, Wei LM, Cook CC, Halkos ME, Thourani VH, Jacobs JP, Matsouaka R, Meza J, Brennan M, Gleason TG, Chu D. Aortic clamping strategy and postoperative stroke. J Thorac Cardiovasc Surg. 2018 Oct;156(4):1451-1457.e4. doi: 10.1016/j.jtcvs.2018.03.160. Epub 2018 Apr 13.

18. Wadhera RK, Joynt Maddox KE, Fonarow GC, Zhao X, Heidenreich PA, DeVore AD, Matsouaka RA, Hernandez AF, Yancy CW, Bhatt DL. Association of the Affordable Care Act's Medicaid Expansion With Care Quality and Outcomes for Low-Income Patients Hospitalized With Heart Failure. Circ Cardiovasc Qual Outcomes. 2018 Jul;11(7):e004729. doi: 10.1161/CIRCOUTCOMES.118.004729

19. Bhatt AS, Liang L, DeVore AD, Fonarow GC, Solomon SD, Vardeny O, Yancy CW, Mentz

RJ, Khariton Y, Chan PS, Matsouaka R, Lytle BL, Piña IL, Hernandez AF. Vaccination Trends in Patients With Heart Failure: Insights From Get With The Guidelines-Heart Failure. JACC Heart Fail. 2018 Oct;6(10):844-855. doi: 10.1016/j.jchf.2018.04.012.

20. Chang LL, Xu H, DeVore AD, Matsouaka RA, Yancy CW, Fonarow GC, Allen LA, Hernandez AF. Timing of Postdischarge Follow-Up and Medication Adherence Among Patients With Heart Failure. J Am Heart Assoc. 2018 Apr 1;7(7). pii: JAHA.117.007998. doi: 10.1161/JAHA.117.007998. PM:29606640

https://www.ncbi.nlm.nih.gov/pubmed/29754790








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21. Warraich HJ, Xu H, DeVore AD, Matsouaka R, Heidenreich PA, Bhatt DL, Hernandez AF, Yancy CW, Fonarow GC, Allen LA. Trends in Hospice Discharge and Relative Outcomes Among Medicare Patients in the Get With The Guidelines-Heart Failure Registry JAMA Cardiol. 2018 Aug 29. doi: 10.1001/jamacardio.2018.2678

22. Greene NH, Jooste EH, Thibault DP, Wallace AS, Wang A, Vener DF, Matsouaka RA, Jacobs ML, Jacobs JP, Hill KD, Ames WA. A Study of Practice Behavior for Endotracheal Intubation Site for Children With Congenital Heart Disease Undergoing Surgery: Impact of Endotracheal Intubation Site on Perioperative Outcomes-An Analysis of the Society of Thoracic Surgeons Congenital Cardiac Anesthesia Society Database. Anesth Analg. 2018 Sep 5. doi: 10.1213/ANE.0000000000003594

23. Selvaraj S, Fonarow GC, Sheng S, Matsouaka RA, DeVore AD, Heidenreich PA, Hernandez AF, Yancy CW, Bhatt DL. Association of Electronic Health Record Use With Quality of Care and Outcomes in Heart Failure: An Analysis of Get With The Guidelines-Heart Failure. J Am Heart Assoc. 2018 Mar 30;7(7). pii: JAHA.117.008158. doi: 10.1161/JAHA.117.008158. PM:29602768

24. Pandey A, Patel KV, Liang L, DeVore AD, Matsouaka R, Bhatt DL, Yancy CW, Hernandez AF, Heidenreich PA, de Lemos JA, Fonarow GC. Association of Hospital Performance Based on 30-Day Risk-Standardized Mortality Rate With Long-term Survival After Heart Failure Hospitalization: An Analysis of the Get With The Guidelines-Heart Failure Registry. JAMA Cardiol. 2018 Jun 1;3(6):489-497. doi: 10.1001/jamacardio.2018.0579. PM:29532056

25. McCarthy FH, Vemulapalli S, Li Z, Thourani V, Matsouaka RA, Desai ND, Kirtane A, Anwaruddin S, Williams ML, Giri J, Vallabhajosyula P, Li RH, Herrmann HC, Bavaria JE, Szeto WY. Association of Tricuspid Regurgitation With Transcatheter Aortic Valve Replacement Outcomes: A Report From The Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. Ann Thorac Surg. 2018 Apr;105(4):1121-1128. PM:29502934

26. Li S, Fonarow GC, Mukamal K, Xu H, Matsouaka RA, DeVore AD, Bhatt DL. Sex and Racial Disparities in Cardiac Rehabilitation Referral at Hospital Discharge and Gaps in Long-Term Mortality. J Am Heart Assoc. 2018 Apr 6;7(8). pii: JAHA.117.008088. doi: 10.1161/JAHA.117.008088. PM:29626153

27. Kochar A, Li Z, Harrison JK, Hughes GC, Thourani VH, Mack MJ, Matsouaka RA, Cohen DJ, Peterson ED, Jones WS, Vemulapalli S. Stroke and Cardiovascular Outcomes in Patients With Carotid Disease Undergoing Transcatheter Aortic Valve Replacement. Circ Cardiovasc Interv. 2018 Jun;11(6):e006322. PM:29895600

28. Brescia AA, Rankin JS, Cyr DD, Jacobs JP, Prager RL, Zhang M, Matsouaka RA, Harrington SD, Dokholyan RS, Bolling SF, Fishstrom A, Pasquali SK, Shahian DM, Likosky DS. Determinants of Variation in Pneumonia Rates After Coronary Artery Bypass Grafting. Ann Thorac Surg. 2018 Feb;105(2):513-520. PM:29174785

29. Inohara T, Xian Y, Liang L, Matsouaka RA, Saver JL, Smith EE, Schwamm LH, Reeves MJ, Hernandez AF, Bhatt DL, Peterson ED, Fonarow GC. Association of Intracerebral Hemorrhage Among Patients Taking Non-Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality. JAMA. 2018 Feb 6;319(5):463-473. PM:29372247

30. Malaisrie SC, McCarthy PM, Kruse J, Matsouaka R, Andrei AC, Grau-Sepulveda MV, Friedman DJ, Cox JL, Brennan JM. Burden of preoperative atrial fibrillation in patients undergoing coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2018 Jun;155(6):2358-2367.e1. PM:29523404

31. Echouffo-Tcheugui, J.B., Xu, H., Matsouaka, R.A., Xian, Y., Schwamm, L.H., Smith, E.E., Bhatt, D.L., Hernandez, A.F., Heidenreich, P.A. and Fonarow, G.C., 2018. Diabetes and long-








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term outcomes of ischaemic stroke: findings from Get With The Guidelines-Stroke. Eur Heart J. 2018 Jul 1;39(25):2376-2386. doi: 10.1093/eurheartj/ehy036.

32. Gupta, A., Allen, L.A., Bhatt, D.L., Cox, M., DeVore, A.D., Heidenreich, P.A., Hernandez, A.F., Peterson, E.D., Matsouaka, R.A., Yancy, C.W. and Fonarow, G.C., 2017. Association of the Hospital Readmissions Reduction Program Implementation With Readmission and Mortality Outcomes in Heart Failure. JAMA cardiology.

33. Abramowitz, Y., Vemulapalli, S., Chakravarty, T., Li, Z., Kapadia, S., Holmes, D., Matsouaka, R.A., Wang, A., Cheng, W., Forrester, J.S. and Smalling, R., 2017. Clinical Impact of Diabetes Mellitus on Outcomes After Transcatheter Aortic Valve Replacement: Insights From the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. Circulation: Cardiovascular Interventions, 10(11), p.e005417.

34. Shah, K.S., Xu, H., Matsouaka, R.A., Bhatt, D.L., Heidenreich, P.A., Hernandez, A.F., Devore, A.D., Yancy, C.W. and Fonarow, G.C., 2017. Heart failure with preserved, borderline, and reduced ejection fraction: 5-year outcomes. Journal of the American College of Cardiology, 70(20), pp.2476-2486.

35. Reeves MJ, Fonarow GC, Xu H, Matsouaka RA, Xian Y, Saver J, Schwamm L, Smith EE. Is Risk-Standardized In-Hospital Stroke Mortality an Adequate Proxy for Risk-Standardized 30-Day Stroke Mortality Data? Findings From Get With The Guidelines-Stroke. Circ Cardiovasc Qual Outcomes. 2017 Oct;10(10). pii: e003748. doi: 10.1161/CIRCOUTCOMES.117.003748. PM:29021333

36. Smith EE, Saver JL, Cox M, Liang L, Matsouaka R, Xian Y, Bhatt DL, Fonarow GC, Schwamm LH. Increase in Endovascular Therapy in Get With The Guidelines-Stroke After the Publication of Pivotal Trials. Circulation. 2017 Dec 12;136(24):2303-2310. doi: 10.1161/CIRCULATIONAHA.117.031097. Epub 2017 Oct 5. PM:28982689

37. Hansen, J.W., Foy, A., Yadav, P., Gilchrist, I.C., Kozak, M., Stebbins, A., Matsouaka, R., Vemulapalli, S., Wang, A., Wang, D.D. and Eng, M.H., 2017. Death and dialysis after transcatheter aortic valve replacement: an analysis of the STS/ACC TVT Registry. JACC: Cardiovascular Interventions, 10(20), pp.2064-2075.

38. Kon, Z.N., Bittle, G.J., Pasrija, C., Vemulapalli, S., Grau-Sepulveda, M.V., Matsouaka, R.A., Taylor, B., Gammie, J.S. and Griffith, B.P., 2017. Incidence and Outcomes of Surgical Pulmonary Embolectomy in the United States: An Analysis of the Society of Thoracic Surgery Database. Journal of the American College of Surgeons, 225(4), p.e11.

39. Brennan JM, Thomas L, Cohen DJ, Shahian D, Wang A, Mack MJ, Holmes DR, Edwards FH, Frankel NZ, Baron SJ, Carroll J, Thourani V, Tuzcu EM, Arnold SV, Cohn R, Maser T, Schawe B, Strong S, Stickfort A, Patrick-Lake E, Graham FL, Dai D, Li F, Matsouaka RA, O'Brien S, Li F, Pencina MJ, Peterson ED., 2017. Transcatheter Versus Surgical Aortic Valve Replacement: Propensity-Matched Comparison. Journal of the American College of Cardiology, 70(4), pp.439-450.

40. Vemulapalli, S., Holmes, D.R., Dai, D., Matsouaka, R., Mack, M.J., Grover, F.L., Makkar, R.R., Thourani, V.H. and Douglas, P.S., 2018. Valve Hemodynamic Deterioration and Cardiovascular Outcomes in TAVR: A Report from the STS/ACC TVT Registry™. Am Heart J.;195:1-13.

41. Mavromatis K, Thourani VH, Stebbins A, Vemulapalli S, Devireddy C, Guyton RA, Matsouaka R, Ghasemzadeh N, Block PC, Leshnower BG, Stewart JP, Rumsfeld JS, Lerakis S, Babaliaros V. Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis and Mitral Regurgitation. Ann Thorac Surg. 2017 Dec;104(6):1977-1985. doi: 10.1016/j.athoracsur.2017.05.065. Epub 2017 Sep 29. PM:28965619


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42. Arnold, S.V., Spertus, J.A., Vemulapalli, S., Li, Z., Matsouaka, R.A., Baron, S.J., Vora, A.N., Mack, M.J., Reynolds, M.R., Rumsfeld, J.S. and Cohen, D.J., 2017. Quality-of-life outcomes after transcatheter aortic valve replacement in an unselected population: a report from the STS/ACC Transcatheter Valve Therapy Registry. JAMA Cardiology, 2(4), pp.409-416.

43. Hyman MC, Vemulapalli S, Szeto WY, Stebbins A, Patel PA, Matsouaka RA, Herrmann HC, Anwaruddin S, Kobayashi T, Desai ND, Vallabhajosyula P, McCarthy FH, Li R, Bavaria JE, Giri J. Conscious Sedation Versus General Anesthesia for Transcatheter Aortic Valve Replacement: Insights from the National Cardiovascular Data Registry Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry. Circulation. 2017 Nov 28;136(22):2132-2140. PM:28864443

44. Anderson, B.R., Wallace, A.S., Hill, K.D., Gulack, B.C., Matsouaka, R., Jacobs, J.P., Bacha, E.A., Glied, S.A. and Jacobs, M.L., 2017. Association of Surgeon Age and Experience With Congenital Heart Surgery Outcomes. Circulation: Cardiovascular Quality and Outcomes, 10(7), p.e003533.

45. Carroll, J.D., Vemulapalli, S., Dai, D., Matsouaka, R., Blackstone, E., Edwards, F., Masoudi, F.A., Mack, M., Peterson, E.D., Holmes, D. and Rumsfeld, J.S., 2017. Procedural Experience for Transcatheter Aortic Valve Replacement and Relation to Outcomes: The STS/ACC TVT Registry. Journal of the American College of Cardiology, 70(1), pp.29-41.

46. Khan, N.I., Siddiqui, F.M., Goldstein, J.N., Cox, M., Xian, Y., Matsouaka, R.A., Heidenreich, P.A., Peterson, E.D., Bhatt, D.L., Fonarow, G.C. and Schwamm, L.H., 2017. Association Between Previous Use of Antiplatelet Therapy and Intracerebral Hemorrhage Outcomes. Stroke, pp.STROKEAHA-117.

47. Sherwood, M.W., Xiang, K., Matsouaka, R., Vemulapalli, S., Vora, A., Peterson, E. and Rao, S., 2017. Patterns of red blood cell transfusion and associated outcomes in patients undergoing TAVR: Insights for the STS/ACC TVT Registry. JACC, 11(69), p.1297.

48. O'Byrne ML, Kim S, Hornik CP, Yerokun BA, Matsouaka RA, Jacobs JP, Jacobs ML, Jonas RA. Effect of Obesity and Underweight Status on Perioperative Outcomes of Congenital Heart Operations in Children, Adolescents, and Young Adults: An Analysis of Data From the Society of Thoracic Surgeons Database. Circulation. 2017 Aug 22;136(8):704-718. doi: 10.1161/CIRCULATIONAHA.116.026778. Epub 2017 Jun 16. PM:28626087.

49. Tankazyan, H., Tyagi, G., Stebbins, A., Matsouaka, R., Wang, A., Vemulapalli, S., Jutzy, K., Abudayyeh, I., Szeto, W., Cohen, D. and Thourani, V., 2017. Impact of the presence of coronary artery disease and timing of revascularization on outcomes of patients undergoing transcatheter aortic valve replacement: insights STS/ACC TVT Registry. JACC, 11(69), p.1227.

50. Jalnapurkar, S., Zhao, X., Heidenreich, P., Bhatt, D., Smith, E., DeVore, A., Hernandez, A., Matsouaka, R., Yancy, C. and Fonarow, G., 2017. A hospital level analysis of 30-day readmission for heart failure patients and long-term survival among highest and lowest performing hospitals, findings from the Get With The Guidelines-Heart Failure. JACC, 11(69), p.2565.

51. Vora, A., Dai, D.D., Matsouaka, R., Harrison, J.K., Hughes, G.C., Sherwood, M., Piccini, J., Cohen, D., Holmes, D., Bhardwaj, B. and Thourani, V., 2017. New-onset atrial fibrillation following transcatheter aortic valve replacement: incidence, anticoagulant strategy, and outcomes. JACC, 11(69), p.961.

52. Joseph, L., Bashir, M., Xiang, Q., Yerokun, B., Matsouaka, R., Vemulapalli, S., Kapadia, S. and Zahr, F., 2017. Prevalence and outcomes of mitral stenosis in patients undergoing transcatheter aortic valve replacement: finding from the Society of Thoracic


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Surgeons/American College of Cardiology (STS/ACC) Transcatheter valve therapies (TVT) Registry. Journal of the American College of Cardiology, 11(69), p.1221.

53. Gilstrap, L.G., Fonarow, G.C., Desai, A.S., Liang, L., Matsouaka, R., DeVore, A.D., Smith, E.E., Heidenreich, P., Hernandez, A.F., Yancy, C.W. and Bhatt, D.L., 2017. Initiation,

Continuation, or Withdrawal of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers and Outcomes in Patients Hospitalized With Heart Failure With Reduced Ejection Fraction. Journal of the American Heart Association, 6(2), p.e004675.

54. Menon, B.K., Cox, M., Saver, J.L., Goyal, M., Xian, Y., Peterson, E.D., Matsouaka, R., Hernandez, A.F., Jahan, R., Yavagal, D. and Gupta, R., 2017. Door-to-puncture and First Pass Times for Endovascular Thrombectomy: Predictors and Changes Over Time in GWTG-stroke.

55. Khan NI, Siddiqui FM, Goldstein JN, Cox M, Xian Y, Matsouaka RA, Heidenreich PA, Peterson ED, Bhatt DL, Fonarow GC, Schwamm LH, Smith EE. Association Between Previous Use of Antiplatelet Therapy and Intracerebral Hemorrhage Outcomes. Stroke. 2017 Jul;48(7):1810-1817. PM:28596454

56. Arnold, S.V., Spertus, J.A., Vemulapalli, S., Li, Z., Matsouaka, R.A., Baron, S.J., Vora, A.N., Mack, M.J., Reynolds, M.R., Rumsfeld, J.S. and Cohen, D.J., 2017. Quality-of-life outcomes after transcatheter aortic valve replacement in an unselected population: a report from the STS/ACC Transcatheter Valve Therapy Registry. JAMA cardiology, 2(4), pp.409-416.

57. Kamal, N., Sheng, S., Xian, Y., Matsouaka, R., Hill, M.D., Bhatt, D.L., Saver, J.L., Reeves, M.J., Fonarow, G.C., Schwamm, L.H. and Smith, E.E., 2017. Delays in door-to-needle times and their impact on treatment time and outcomes in get with the guidelines-stroke. Stroke, 48(4), pp.946-954.

58. Ziaeian B, Heidenreich PA, Xu H, DeVore AD, Matsouaka RA, Hernandez AF, Bhatt DL, Yancy CW, Fonarow GC. Medicare Expenditures by Race/Ethnicity After Hospitalization for Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2018 May;6(5):388-397. doi: 10.1016/j.jchf.2017.12.007. Epub 2018 Apr 11. PM:29655830

59. Ziaeian B, Heidenreich PA, Xu H, DeVore AD, Matsouaka RA, Hernandez AF, Bhatt DL, Yancy CW, Fonarow GC. Race/Ethnic Differences in Outcomes Among Hospitalized Medicare Patients With Heart Failure and Preserved Ejection Fraction. JACC Heart Fail. 2017 Jul;5(7):483-493. doi: 10.1016/j.jchf.2017.02.012. Epub 2017 May 10. PM:28501527

60. Hira, R.S., Bhatt, D.L., Fonarow, G.C., Heidenreich, P.A., Ju, C., Virani, S.S., Bozkurt, B., Petersen, L.A., Hernandez, A.F., Schwamm, L.H. and Eapen, Z.J., Michelle A. Albert, M. A., Liang, L., Matsouaka, R. A., Peterson, E. D. , Jneid, H., 2016. Temporal Trends in Care and Outcomes of Patients Receiving Fibrinolytic Therapy Compared to Primary Percutaneous Coronary Intervention: Insights From the Get With The Guidelines Coronary Artery Disease

(GWTG‐CAD) Registry. Journal of the American Heart Association, 5(10), p.e004113.

61. Medford‐Davis, L.N., Fonarow, G.C., Bhatt, D.L., Xu, H., Smith, E.E., Suter, R., Peterson, E.D., Xian, Y., Matsouaka, R.A. and Schwamm, L.H., 2016. Impact of Insurance Status on Outcomes and Use of Rehabilitation Services in Acute Ischemic Stroke: Findings From Get With The Guidelines‐Stroke. J. Am. Heart Assoc., 5(11), p.e004282.

62. Baron, S.J., Cohen, D.J., Suchindran, S., Pencina, M., Dai, D., Matsouaka, R. and Brennan, J.M., 2016. Development of a Risk Prediction Model for 1-Year Mortality After Surgical vs. Transcatheter Aortic Valve Replacement in Patients With Severe Aortic Stenosis

63. Pandey, A., Golwala, H., Xu, H., DeVore, A.D., Matsouaka, R., Pencina, M., Kumbhani, D.J., Hernandez, A.F., Bhatt, D.L., Heidenreich, P.A. and Yancy, C.W., 2016. Association of 30-day readmission metric for heart failure under the hospital readmissions reduction program with quality of care and outcomes. JACC: Heart Failure, 4(12), pp.935-946.


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64. Alfredsson, J., Stebbins, A., Brennan, J.M., Matsouaka, R., Afilalo, J., Peterson, E.D., Vemulapalli, S., Rumsfeld, J.S., Shahian, D., Mack, M.J. and Alexander, K.P., 2016. Gait speed predicts 30-day mortality following transcatheter aortic valve replacement: results from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry™. Circulation, pp.CIRCULATIONAHA-115.

65. W. Don, A. Johnson, A. Stebbins, S. Vemulapalli, R. Matsouaka, C. Burke, S. Le, E. Verrier, M. Reisman, L. Dean, G. Aldea, Impact of pulmonary hypertension on outcomes of patients undergoing transcatheter aortic valve replacement: Report from the TVT registry. Submitted to American College of Cardiology.

66. Keeling, B., Thourani, V., Aliawadi, G., Kim, S., Cyr, D., Badhwar, V., Jacobs, J., Brennan, J.M., Meza, J., Matsouaka, R. and Halkos, M.E., 2017. Conversion From Off-Pump Coronary Artery Bypass Grafting to On-Pump Coronary Artery Bypass Grafting. Ann Thorac Surg. 2017 Oct;104(4):1267-1274. PM:28610886

67. S. Likosky, J. S. Rankin, D. D. Cyr, J. P. Jacobs, R. L. Prager, M. Zhang, R. A. Matsouaka, S. D. Harrington, Determinants of Hospital Variation in Pneumonia Rates after Coronary Artery Bypass Grafting: an Analysis from the Society of Thoracic Surgeons Adult Cardiac Surgery Database. Submitted to American Association of Thoracic Surgery.

68. J. Qu, R. Matsouaka, B. T. Hyman, and C. L. Grosskreutz. Calcineurin inhibition causes retinal ganglion cell degeneration. Molecular Vision 2012; 18: 2828-2838.

69. E. Hudry, H. Wu, M. Arbel-Ornath, T. Hashimoto, R. A. Matsouaka, D. Joyner, Z. Fan, T. L. Spires-Jones, R. Betensky, B. J. Backsai, and B. T. Hyman, Inhibition of the NFAT pathway alleviates Amyloid Beta neurotoxicity in a mouse model of Alzheimer disease. The Journal of Neuroscience 2012; 32(9):3176-3192.

70. T. L. Spires-Jones, K. Kay, R. A. Matsouaka, A. Rozkalne, R. Betensky, B. T. Hyman, Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain, Neurosci. Lett. 2011; 487(3): 260-263.

71. V. S. Vaidya, S. Waikar, M. A. Ferguson, F. B. Collings, K. Sunderland, C. Gioules, G. Bradwin, R. A. Matsouaka, R. Betensky, G. C. Curhan, and J. V. Bonventre, Urinary Biomarkers for Sensitive and Specific Detection of Acute Kidney Injury in Human, Clin. Transl. Sci. 2008; 1(3): 200-208.

SCHOLARLY SOCIETIES

American Statistical Association

Chaired sessions

International Biometric Society

Chaired sessions

Institute of Mathematical Statistics

Institute of Mathematical Statistics

National Institute of Statistical Sciences

Southern Regional Council on Statistics

REVIEWER

Statistics in Medicine; American Heart Journal; Biometrical Journal; VA Scientific Merit Review.

TALKS AND PRESENTATIONS


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1. Analysis of a composite endpoint, with interim analysis of mortality. Joint Statistical Meetings 2009,

2. Wilcoxon test in presence of missing observations due to death: power and sample size calculations. Future Faculty Workshop. Rice University, Houston TX; 2012.

3. Maximum Likelihood Estimation of Logistic Structural Logistic Models with an Instrumental variable. Poster presentation at the Atlantic Causal Inference Conference. Harvard University, 2013.

4. Maximum Likelihood Estimation of Logistic Structural Nested Models with an instrumental variable. 29th Conference on Uncertainty in Artificial Intelligence; University of Washington, 2013.

5. Likelihood-Based Estimation of Logistic Structural Nested Models in Randomized Clinical Trials with Non-compliance. 2013 NC-ASA Symposium: Celebrating the International Year of Statistics; North Carolina State University, 2013

6. Analysis of non-mortality outcome in clinical trials of a potentially lethal disease. ENAR 2015

7. Data analysis via instrumental variables for binary outcomes, SIGMA, Duke University, 2015

8. How to identify markers through risk models? JSM 2015

CONFERENCES AND WORKSHOPS

Event Place Date

2013 NC-ASA Symposium: Celebrating the International Year of Statistics

North Carolina State University, Raleigh, NC

2013

Future Faculty Workshop Rice University, Houston, TX 2012

Harvard Merck Workshop Harvard School of Public Health, Boston, MA

2010-2013

Building Future Faculty Program North Carolina State University, Raleigh, NC

2010

Symposium in Honor of Steve Lagakos

Harvard Medical School, Boston, MA 2010

Harvard Schering-Plough Workshop

Harvard School of Public Health, Boston, MA

2009

RESEARCH SUPPORT 3UL1-TR01117-04S1 (PI: Ebony Boulware) 05/01/2016-04/30/2018 NCATS/Duke CTSA (UL1): Statistical Methods for Complex Data in CVD research The goal of this award is to develop statistical methods that combines multiple endpoints into single composite endpoints based on a pre-specified hierarchy of the component outcomes using the global rank endpoint framework. Role: Principal Investigator of the related Diversity training grant.

1R01HL118336-01 (PI: Butch Tsiatis; Duke PI: O’Brien, Sean) 06/01/2013-05/31/2017

NHLBI/North Carolina State University (NCSU)

Statistical Methods for Complex Data in Cardiovascular Disease (Subcontract)


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The goal of this research is to provide health sciences researchers with novel, principled statistical

methods for addressing several complex challenges arising in cardiovascular disease with time-

to-an-event endpoints in large observational databases and clinical trials. The grant is

collaboration between NCSU and Duke and was awarded under the NIH multiple PI mechanism.

Role: Co-Investigator

DCRI 661 Society of Thoracic Surgeons (STS) (PI: Peterson, Eric) 01/01/2013-12/31/2015

STS Data Warehouse and Analysis Center

The goal of this project is to manage a national data warehouse for the STS adult cardiac surgery

database, the STS congenital cardiac surgery database, and the STS General Thoracic Surgery

database. The data warehouse harvests and analyzes data from more than 1000 US and

Canadian hospitals. Duke develops models for risk adjustment and risk prediction, performs

research analyses, and develops statistical methodology for feedback reporting to participating

surgeons and institutions.


DCRI 5743 (PI: Peterson, Eric) 03/01/2012-12/31/2015

American College of Cardiology/Society of Thoracic Surgeons

Transcatherer Valve Therapy (TVT) Registry Analytic Center

This is a registry of patients with valvular heart disease to monitor device performance, long-term

outcomes, and performance of comparative effectiveness research.


PCORI (PI: Matthew Brennan) 01/01/2014‐12/31/2016

Optimizing Health Outcomes in Patients with Symptomatic Aortic Valve Disease

The goal of this research is to compare contemporary health outcomes with surgical versus

transcatheter aortic valve replacement and to create a decision support tool for use by patients

and clinicians.


1R01HS022525 (PI: Donald Likosky, PhD (University of Michigan Medical School)) 09/2013-

09/2017

Optimizing Prevention of Health-Acquired Infections After Cardiac Surgery

The goal of this project is to identify patient risk factors and clinical practices associated with

healthcare-acquired infections (HAIs) after cardiac surgery, to develop and implement

standardized practices for preventing HAIs after cardiac surgery and to evaluate the effectiveness

of standardized practices in preventing HAIs after cardiac surgery.

ROLE: DCRI Principal Investigator

HONORS, AWARDS, SPECIAL RECOGNITIONS, AND FELLOWSHIPS

Awards Institution Date

Harvard Neurostatistics Training Grant Harvard School of Public Health, Boston, MA

2008–2012


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Harvard Cancer Training Grant Harvard School of Public Health, Boston, MA 2006–2008

Horace W. Goldsmith Fellowship Harvard School of Public Health, Boston, MA 2005–2006

Bourse de la Coopération Belge Université Nationale du Bénin, Cotonou, République du Benin

1998–2002

Bourse d’études de l’Etat Congolais

Université Marien Ngouabi, Brazzaville, République du Congo

1990-1996

TEACHING EXPERIENCE AND MENTORSHIP Lecturer

Course title: BIOSTAT 702 (Applied Statistical Methods I)

Program Institution Date

Department of Biostatistics and Bioinformatics

Duke University August 2015–Present

Teach a class of 28 students on introductory biostatistics topics; 2-hour lectures, twice a week

Develop course curriculum, assignments and exams

Co-head Teaching Fellow

Developed, organized, and led training programs for graduate TAs

Program Institution Date

Departmental Teaching Fellowship

Derek Bok Center, Harvard University

Cambridge, Massachusetts

2008–2012

Department of Biostatistics



2008–2012

Teaching Assistant (TA) (laboratory, office hours, and grading responsibilities) Harvard University Department of Biostatistics, Boston MA 2008–2010

Course Instructor

BIO 250: Probability Theory and Applications II (Fall 2009, 2010 and 2011) Advanced elective course for Biostatistics PhD students.

Bob Gray

BIO 200: Principles of Biostatistics (Fall 2007 and 2008)

Introductory biostatistics course, mostly for biomedical MPH students. (Served as Head TA: managed a class of about 150 students, supervised 7 others TAs, held weekly TA meetings, revised and updated lab materials, etc.)

David Wypij

BIO 202: Principles of Biostatistics I (Summer 2008)

Introductory biostatistics course (Part I) for biomedical MPH students

Marcia Testa

BIO 203: Principles of Biostatistics II (Summer 2008)

Introductory biostatistics course (Part II) for biomedical MPH students Jiang Hongyu

http://www.hsph.harvard.edu/faculty/david-wypij/

http://www.hsph.harvard.edu/faculty/marcia-testa/


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Harvard University Extension School, Cambridge MA 2008–2010

Course Instructor

STAT E-50: Introduction to Statistics (Fall 2009–Spring 2010) Joan Weinstein

STAT E-102: Fundamentals of Biostatistics (Spring & Summer 2010) Bernard Rosner

Biostatistics Tutor

Institution Topics Date

Office of Student Affairs,

Harvard University

Regressions; Clustered, Survival, and

Longitudinal Analysis; Analysis of Rates and

Proportions

2005-2012

High School Mathematics Teacher

Institution Place Date

Lycée Notre Dame Porto-Novo, Republic of Benin 1998–2001

Lycée Technique Ouagadougou, Burkina-Faso 1995–1998

Groupe Scolaire du Plateau Ouagadougou, Burkina-Faso 1995–1996

Moniteur des Travaux Dirigés (laboratory and grading responsibilities)

Institution Place Date

Université de Ouagadougou Ouagadougou, Burkina-Faso 1996–1998

Analyse I and Analyse II (Instructors: Akry Koulibaly and Albert Ouedraogo)

Equivalent to Calculus I and Calculus II: classes for students majoring in Economics ORGANIZATIONS AND PARTICIPATION

Organization Status Date

American Statistical Association Member 2007-Present

International Biometric Society, Eastern North American Region

Member 2011-Present

American Association for the Advancement of Science Member 2016-Present

AREAS OF RESEARCH INTERESTS My research interests are motivated by challenges that arise in clinical, biomedical, and public health settings with the goal of developing, applying, and integrating these methods and other innovative statistical approaches to assist in decision making and advance health care research. My current methodological interests are in the areas of:

models selection and validation;

risk adjustment and health care evaluation;

biomarker evaluation;

personalized medicine in disease diagnosis, prognosis, and treatment;

http://www.extension.harvard.edu/about/faculty/joan-r-weinstein.jsp%3Bjsessionid%3DHBDJOLCELLAN

http://www.hsph.harvard.edu/faculty/david-wypij/


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prediction methods;

causal inference methods;

semiparametric and nonparametric methods. My research activities focus on developments of statistical methods required for appropriate responses to analytical challenges of complex cardiovascular research outcomes. LANGUAGES French (fluent) PERSONAL INFORMATION

Preferred Name: Roland

Office Address: Duke Clinical Research Institute 200 Morris Street Office 7826 Durham, NC 27701

Mailing Address: Duke Box 3850 Durham, NC 27710

Office Phone Number 919 668 7838

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