Drugs affecting Cardiovascular system
-
Upload
salman-habeeb -
Category
Healthcare
-
view
34 -
download
0
Transcript of Drugs affecting Cardiovascular system
![Page 1: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/1.jpg)
DRUGS AFFECTING CARDIOVASCULAR SYSTEM
![Page 2: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/2.jpg)
CARDIOTONICS
![Page 3: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/3.jpg)
?• Cardiotonic agents are drugs used to
increase the contractility and output in a hypodynamic heart without propotionate increase in 02 consumption
• Commonly used in the treatment of heart failure (HF)
![Page 4: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/4.jpg)
• Cardiotonic (inotropic) drugs affect the intracellular calcium levels in the heart muscle, leading to increased contractility.
• This increase in contraction strength leads to increased cardiac output, which causes increased renal blood flow and increased urine production
![Page 5: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/5.jpg)
TYPES
1. Cardiac glycosides2. Phosphodiesterase inhibitors
![Page 6: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/6.jpg)
CARDIAC GLYCOSIDES• Digoxin (Lanoxin) commonly used drug
• The cardiac glycosides were originally derived from Digitalis purpurea (Common Foxglove)
![Page 7: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/7.jpg)
Foxglove plantDigitalis lanata
![Page 8: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/8.jpg)
Mechanism of action
• Digoxin increases intracellular calcium and allows more calcium to enter myocardial cells during depolarization. That results
1. Increased force of myocardial contraction (a positive inotropic effect)
2. • Increased cardiac output and renal perfusion
![Page 9: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/9.jpg)
3. Slowed heart rate, owing to slowing of the rate of cellular repolarization (a negative chronotropic effect)4.Decreased conduction velocity through the atrioventricular(AV) node
![Page 10: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/10.jpg)
INDICATIONS
• Heart failure (HF)• Atrial flutter• Atrial fibrillation• Paroxysmal atrial tachycardia
![Page 11: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/11.jpg)
Dosage
• Digoxin is available for oral and parenteral administration.
• Oral- 0.75–1.25 mg PO• IV-0.125–0.25 mg IV
• Onset of action - 30–120 minutes when taken orally, 5–30 minutes when given intravenously
![Page 12: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/12.jpg)
Contraindications
• hypersensitivity to digitalis preparations• ventricular tachycardia or fibrillation• heart block or sick sinus syndrome• idiopathic hypertrophic subaortic stenosis
(IHSS)• acute MI• Renal failure
![Page 13: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/13.jpg)
Adverse Effects• headache, weakness, drowsiness and
vision changes• Digitalis toxicity ( serious side effect)
![Page 14: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/14.jpg)
Digitalis toxicity
• A serious syndrome that can occur when digoxin levels are too high
• Normal level- 0.5 -2.0 ng/ml signs and symptoms – anorexia, nausea,
vomiting, malaise, depression, irregular heart rhythms including heart block, atrial arrhythmias, and ventricular tachycardia
![Page 15: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/15.jpg)
• Antidote- Digoxin immune Fab (DigiFab)
![Page 16: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/16.jpg)
Nurses responsibilities
• Assess for contraindications or cautions• Perform a physical assessment• Assess cardiac status closely, including
pulse and blood pressure• Monitor apical pulse for 1 full minute
before administering the drug
![Page 17: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/17.jpg)
• Hold the dose if the pulse is less than 60 beats/min in an adult or less than 90 beats/min in an infant; retake the pulse in 1 hour. If the pulse remains low, document it, withhold the drug, and notify the prescriber
• Monitor the pulse for any change in quality or rhythm
![Page 18: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/18.jpg)
• Administer intravenous doses very slowly over at least 5 minutes to avoid cardiac arrhythmias and adverse effects.
• Avoid administering the oral drug with food or antacids to avoid delays in absorption
• Obtain digoxin level as ordered; monitor the patient for therapeutic digoxin level (0.5–2 ng/mL)
![Page 19: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/19.jpg)
• Maintain emergency equipment on standby if digoxin toxicity develops
• Provide thorough patient teaching, including the name of the drug, dosage prescribed, technique for monitoring pulse and acceptable pulse parameters, dietary measures if appropriate, measures to avoid adverse effects, warning signs of possible toxicity and need to notify health care provider
![Page 20: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/20.jpg)
PHOSPHODIESTERASE INHIBITORS
• milrinone (Primacor)• This drugs block the enzyme
phosphodiesterase.This blocking effect leads to an increase in myocardial cell cyclic adenosine monophosphate (cAMP), which increases calcium levels in the cell
![Page 21: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/21.jpg)
INDICATIONS
• short-term treatment of HF that has not responded to digoxin or diuretics alone or that has had a poor response to digoxin, diuretics, and vasodilators
![Page 22: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/22.jpg)
DOSAGE
• Intravenous• (PRIMACOR IV 10Mg/ml inj) dose- 50 microgram/kg iv bolus followed
by 0.4-1.0 microgram/kg/min infusion
![Page 23: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/23.jpg)
Contraindications• hypersensitivity to phosphodiesterase
inhibitors• severe aortic or pulmonic valvular disease• acute MI
![Page 24: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/24.jpg)
Adverse Effects• ventricular arrhythmias (which can
progress to fatal ventricular fibrillation), hypotension, and chest pain
• GI effects include nausea, vomiting, anorexia, and abdominal pain
• Thrombocytopenia occurs frequently with milrinone
![Page 25: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/25.jpg)
• Precipitates form when these drugs are given in solution with furosemide
![Page 26: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/26.jpg)
Nurses responsibilities
• Assess for contraindications or cautions: any known allergies to these drugs or to avoid hypersensitivity reactions;
• acute aortic or pulmonic valvular disease, • acute myocardial infarction • ventricular arrhythmias
![Page 27: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/27.jpg)
• Pregnancy and lactation• Assess cardiac status closely, including
pulse and blood pressure• Protect the drug from light to prevent drug
degradation• Monitor input and output and record daily
weight
![Page 28: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/28.jpg)
• Monitor platelet counts before and regularly during therapy to ensure that the dose is appropriate, inspect the skin for bruising or petechiae to detect early signs
of thrombocytopenia• Provide life-support equipment on standby
![Page 29: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/29.jpg)
• Provide thorough patient teaching, including the name of the drug, dosage prescribed, measures to avoid adverse effects, warning signs of problems, and the need for periodic monitoring and evaluation
![Page 30: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/30.jpg)
ANTIANGINALS
![Page 31: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/31.jpg)
ANGINA• It is a pain syndrome due to induction of
an adverse oxygen supply/demand situation in a portion of myocardium
![Page 32: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/32.jpg)
• Antianginal drugs are used to help restore the appropriate supply-and-demand ratio in oxygen delivery to the myocardium.
![Page 33: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/33.jpg)
How they act
• These drugs can work to improve blood delivery to the heart muscle
• (1) by dilating blood vessels (i.e.,increasing the supply of oxygen)
(2) by decreasing the work of the heart (i.e.decreasing the demand for oxygen).
![Page 34: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/34.jpg)
Classification
• Nitrates a. short acting nitrates Eg: Glyceryl trinitrate (Nitroglycerine) b.Long acting nitrates Eg; Isosorbide dinitrate (sorbitrate)• betA-BLOCKERS Eg; Atenelol, Propanalol
![Page 35: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/35.jpg)
• Calcium channel blockers a. phenyl alkamine Eg: verapamil b. benzothiazepine Eg: Diltiazem c. Dihydropyridines Eg: Nifidipine, Amlodipine
![Page 36: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/36.jpg)
• Potassium channel openers Eg: Nicorandil• OTHers Eg: Ivabradine
![Page 37: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/37.jpg)
Nitrates• Nitrates are drugs that act directly on
smooth muscle to cause relaxation and to depress muscle tone
• isosorbide dinitrate (Isordil)• isosorbide mononitrate• nitroglycerin
![Page 38: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/38.jpg)
Mechanism of action• The nitrates relax and dilate veins,
arteries, and capillaries, allowing increased blood fl ow through the vessels and lowering systemic blood pressure because of a drop in resistance.
• Nitrates decreases the preload and afterload
![Page 39: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/39.jpg)
INDICATIONS
• LONG ACTING NITRATES Taken before chest pain begins in situations in
which exertion or stress can be anticipated for prevention of angina in adults; taken daily for management of chronic angina
SHORT ACTING NITRATES• Treatment of acute angina attack; prevention of
anginal attacks
![Page 40: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/40.jpg)
AVAILABLE FORMS• Nitroglycerin is available as• sublingual tablet, • Translingual spray, • Intravenous solution• Transdermal patch, • Topical ointmentor paste, • Transmucosal agent
![Page 41: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/41.jpg)
DOSAGE
• Isosorbide nitrate- 2.5–5 mg SL 5-mg chewable tablet; 5–20 mg PO;
• Nitroglycerin- 5 mcg/min via IV infusion pump every 3–5 min; • 0.4-mg metered dose sublingual, up to three
doses in 15 min for acute attack
![Page 42: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/42.jpg)
Contraindications• Hypersensitivity• Severe anemia• Head trauma or cerebral hemorrhage• pregnancy or lactation
![Page 43: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/43.jpg)
Adverse effect
• Central nervous system (CNS) headache, dizziness, and weakness• Gastrointestinal (GI) nausea, vomiting, and incontinence.Cardiovascular Hypotension• Integumentary flushing, pallor, increased perspiration.
![Page 44: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/44.jpg)
Nurses responsibilities
• Assess for contraindications• Assess cardiopulmonary status closely,
including pulse rate, blood pressure, heart rate, and rhythm (30min)
• Always check the expiration date on the bottle and protect the medication from heat and light
• Instruct the patient that a sublingual dose may be repeated in 5 minutes if relief is
![Page 45: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/45.jpg)
is not felt, for a total of three doses; if pain persists, the patient should go to an emergency room•Rotate the sites of topical form•Taper the dose gradually (over 4 to 6 weeks) after long-term therapy
![Page 46: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/46.jpg)
BETA BLOCKERS• Beta-adrenergic blockers are used to
block the stimulatory effects of the sympathetic nervous system.
• Eg- Atenelol Propanalol Metoprolol
![Page 47: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/47.jpg)
Mechanism of action
• The beta-blockers competitively block beta-adrenergic receptors in the heart and decreasing the influence of the SNS on these tissues. The result is a decrease in the excitability of the heart, a decrease in cardiac output, a decrease in cardiac oxygen consumption, and a lowering
of blood pressure.
![Page 48: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/48.jpg)
INDICATIONS
• Long-term management of angina pectoris.
• To prevent reinfarction in stable patients 1 to 4 weeks after an MI
![Page 49: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/49.jpg)
CONTRAINDICATIONS
• Bradycardia, heart block, and cardiogenic shock
• Pregnancy and lactation• Cautious administration to Asthma,
chronic obstructive pulmonary disease, or thyrotoxicosis
![Page 50: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/50.jpg)
DOASGE
• ORAL- 50-100 mg • INTRAVENOUS - 5mg -15mg
![Page 51: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/51.jpg)
NURSES RESPONSIBILITY
• Assess for contraindications or cautions• Do not stop these drugs abruptly after
chronic therapy, but taper gradually over 2 weeks
• Monitor blood pressure, pulse, rhythm, and cardiac output regularly
• Continuously monitor any patient receiving an intravenous form of these drugs
![Page 52: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/52.jpg)
CALCIUM CHANNEL BLOCKERS
• amlodipine (Norvasc),• diltiazem (Cardizem)• nicardipine (Cardene)• nifedipine• verapamil (Calan, Isoptin).
![Page 53: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/53.jpg)
MECHANISM OF ACTION
• Calcium channel blockers inhibit the movement of calcium ions across the membranes of myocardial and arterial muscle cells, altering the action potential and blocking muscle cell contraction.
• This will results loss of smooth muscle tone, vasodilation, and decreased peripheral resistance occur
![Page 54: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/54.jpg)
• Decreases the preload and afterload which results in decreases cardiac workload and oxygen consumption.
![Page 55: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/55.jpg)
INDICATIONSTreatment of •Prinzmetal angina •Chronic angina•Effort associated angina•Hypertension.•Verapamil is also used to treat cardiac tachyarrhythmias because it slows conduction more than the other calcium channel blockers do
![Page 56: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/56.jpg)
Contraindications• Hypersensitivity• Pregnancy and lactationCaution should be used with • heart block or sick sinus syndrome• Renal or hepatic dysfunction• Heart Failure ,
![Page 57: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/57.jpg)
Adverse Effects• CNS -dizziness, light-headedness,
headache, and fatigue. • GI- nausea and hepatic injury related to
direct toxic effects on hepatic cells. Cardiovascular -hypotension, bradycardia, peripheral edema, and heart block.
• Skin- flushing and rash
![Page 58: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/58.jpg)
NURSES RESPONSIBILITIES
• Assess for contraindications• Inspect skin for color and integrity• Monitor blood pressure very carefully• Provide thorough patient teaching
![Page 59: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/59.jpg)
Potassium channel openers
• Potassium channel openers activates the ATP sensitive potassium channels thereby hyperpolarising the vascular smooth muscles.
• This results in reduction in vascular tone • That will lead to a decrease in preload and
afterload• EG- Nicorandil
![Page 60: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/60.jpg)
Dosage
• Oral- 5-20mg
![Page 61: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/61.jpg)
INDICATIONS
• Prevention and long term treatment of chronic stable angina pectoris
• Reduction in the risk of acute coronary syndromes in patients with chronic stable angina
![Page 62: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/62.jpg)
contraindications
• Hypersensitivity • Cardiogenic shock• hypotension
![Page 63: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/63.jpg)
Side effects
• Flushing• Palpitation• Weakness• Headache• Dizziness• vomiting
![Page 64: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/64.jpg)
Nurses responsibility
• Assess the hypersensitivity and contraindications
• Regular monitoring of vital signs • Health education• asses the oral cavity for oral ulcers
![Page 65: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/65.jpg)
OTHERS- IVABRADINE
• Ivabradine is a newer type of drug
• Mechnism of action- it acts by reducing the heart rate by specific inhibition of the funny
channel (cyclic nucleotide-gated)• It specifically inhibits the cardiac
pacemaker and therby reducing heart rate
![Page 66: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/66.jpg)
indications
• Chronic stable angina patients with normal sinus rhythm
• Chronic heart failure
![Page 67: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/67.jpg)
Dosage
• Oral- 2.5-5mg
![Page 68: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/68.jpg)
Contraindications
• Resting heart rate less than 70• Cardiogenic shock• Acute M I• Sick sinus syndrome• Severe hepatic injury• Pregnency and lactation
![Page 69: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/69.jpg)
Side effects
• Blurred vision• Bradycardia• Syncope• Headache• Constipation• Muscle cramps
![Page 70: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/70.jpg)
Nurses responsibility
• Check for hypersensitivity and contraindications
• Assess the pulse rate and blood pressure• Check the liver function test regularly• Check for visual disturbances• Health education
![Page 71: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/71.jpg)
ANTIHYPERTENSIVES
![Page 72: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/72.jpg)
?
HYPERTENSION
![Page 73: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/73.jpg)
•REGULATORS OF BLOOD PRESSURE ?
![Page 74: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/74.jpg)
• Antihypertensives are the drugs that used to treat hypertension
![Page 75: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/75.jpg)
CLASSIFICATIONS• DIURETICS LOOP DIURETICS Eg- furosemide THIAZIDE DIURETICS Eg- Hydrochlorothiazide POTASSIUM SPARING DIURETICS Eg- Spirinolactone
![Page 76: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/76.jpg)
ADRENERGIC inhibitors•CENTRALLY ACTING α- ADRENERGIC ANTAGONISTS Eg- Clonidine•PERIPHERALLY ACTING α- ADRENERGIC ANTAGONISTS Eg- Reserpine• α- ADRENERGIC BLOCKERS Eg-Prazocin
![Page 77: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/77.jpg)
• β- ADRENERGIC BLOCKERS Eg- Atenelol
• Calcium Channel Blockers Eg- Amlodipine Nifidipine
![Page 78: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/78.jpg)
ANGIOTENSIN INHIBITORS• ANGIOTENSIN-CONVERTING ENZYME (ACE) INHIBITORS Eg- Captopril, Enalapril
• Angiotensin II–Receptor Blockers Eg- Losartan Telmisartan
• Vasodilators Eg- Nitroglycerin
![Page 79: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/79.jpg)
• DIRECT VASODILATORS Eg- Nitroglycerin Sodium nitroprusside
![Page 80: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/80.jpg)
DIURETICS
Drugs that increase the production of urine
![Page 81: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/81.jpg)
LOOP DIURETICS
They inhibit the sodium and chloride reabsorption in the thick segment of the ascending limb of the loop of Henle as well as in the proximal convoluted tubule and the distal diluting site
Eg- furosemide( Lasix)
![Page 82: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/82.jpg)
Dosage
• 40 mg PO t.i.d
![Page 83: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/83.jpg)
Thiazide diuretics
Inhibit sodium and chloride reabsorption in the distal convoluted tubule
•These drugs are the first-line drugs used to manage essential hypertension when drug therapy is needed
![Page 84: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/84.jpg)
• Eg- Hydrochlorothiazide
• Dosage- 25–100 mg/d
![Page 85: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/85.jpg)
Potassium Sparing Diuretics
• The potassium-sparing diuretics are not as powerful as the loop diuretics, but they retain potassium instead of wasting it
• Eg- spironolactone (Aldactone) amiloride (Midamor)
![Page 86: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/86.jpg)
Mechanism of action
• Spironolactone acts as an aldosterone antagonist, blocking the actions of aldosterone in the distal tubule.
• It decreases the elimination of potassium
![Page 87: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/87.jpg)
Dosage
• 50–100 mg/d PO
![Page 88: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/88.jpg)
CONTRAINDICATIONS
• Hypersensitivity• Fluid and electrolyte imbalances• Severe renal failure cautious administration with Systemic lupus erythematous( SLE) Gout Pregnancy and lactation
![Page 89: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/89.jpg)
SIDE EFFECTS
• Common side effects GI upset fluid and electrolyte imbalances hypotension electrolyte disturbances
![Page 90: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/90.jpg)
• Side effects ( thiazide and loop diuretics) 1.hypokalemia weakness, muscle cramps, and arrhythmia 2. hypercalcemia 3. decreased excretion of uric acid
![Page 91: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/91.jpg)
• Side effects ( potassium sparing diuretics) 1. Hyperkalemia lethargy, confusion, ataxia, muscle cramps, and cardiac arrhythmias.
![Page 92: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/92.jpg)
![Page 93: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/93.jpg)
![Page 94: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/94.jpg)
![Page 95: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/95.jpg)
![Page 96: Drugs affecting Cardiovascular system](https://reader035.fdocuments.net/reader035/viewer/2022062523/58d0de391a28ab47238b6bfb/html5/thumbnails/96.jpg)