Drug Repositioning · Traditional Drug Development 10-15 years, $1 billion, 90% of drug candidates...
Transcript of Drug Repositioning · Traditional Drug Development 10-15 years, $1 billion, 90% of drug candidates...
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Drug Repositioning: New Uses for Old Drugs LTI Research Speaking Requirement
Suyoun Kim Advisor: Madhavi Ganapathiraju
[email protected] http://www.suyoun.kim
6/30/2014
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● Introduction of drug repositioning ● Network-based approach, ProphNet ● Side effect information of drugs ● QnA
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● Introduction of drug repositioning ● Network-based approach, ProphNet ● Side effect information of drugs ● QnA
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GPCR Pathway
Drug and GPCR
● Cell surface signalling proteins
● Control signaling pathways
➢ Drug is designed to
bind and activate GPCR to behave to cure disease
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Introduction
● Traditional Drug Development ○ 10-15 years, $1 billion, 90% of drug candidates fail
➢ Drug Repositioning? ○ Find new uses for existing, approved drugs
Requip Parkinson
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Introduction
● Traditional Drug Development ○ 10-15 years, $1 billion, 90% of drug candidates fail
➢ Drug Repositioning? ○ Find new uses for existing, approved drugs
Requip Parkinson
Restless Legs
Syndrome
New Interaction
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Introduction
● Traditional Drug Development ○ 10-15 years, $1 billion, 90% of drug candidates fail
➢ Drug Repositioning? ○ Find new uses for existing, approved drugs
➢ Not require new clinical trial ➢ Reduce Time, Money, and Risk of failure
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Background
● Availability of diverse biological data o Currently known drug-disease interaction o Chemical or molecular features of drug compound o Underlying processes of disease
● “Guilt-by-association” principle o Sharing interaction ⇔ same function, same biological
process
● Challenge o Understand interconnection between diverse features and
identify qualified one
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Related Works
● Ligand-based approach o Ligand: molecule binds to protein o Chemical structure of drug compounds o Protein sequences
● Pharmacological approach o Infer whether two drugs share target disease o Observable effects of drugs
● Network based approach o Construct network and predict drug-target interaction o Based on known drug-target interactions
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Network-based method
QQ T
T
Drug
Protein
Disease
Drug
Protein
Disease
Interaction
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Approach
● Side effects of drugs ● Network-based algorithm:
o ProphNet (Martinez, et al. 2012) o Combine diverse biological data
➢ Goal: Applying Side-effect information into network-based model to discover new drug-disease interaction more accurately
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Network-based method
By propagating node value through the path
from query/drug to target/disease,
obtain the prioritized target/disease list suggesting degree of interaction with query/drug
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Network-based method Example A.
1
2
3 6
5
4
Highly Correlated
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Network-based method
6
5
4 1
2
3
NOT Correlated
Example B.
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● Introduction of drug repositioning ● Network-based approach, ProphNet ● Side effect information of drugs ● QnA
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Side Effect of Drugs
QQ T
T
Drug
Protein
Disease
Drug
Protein
Disease
Interaction
● Baseline
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Side Effect of Drugs
QQ T
T
Drug
Protein
Disease
Side Effect
Drug
Protein
Disease
Interaction
● Baseline + SE
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Side Effect of Drugs
● SIDER2 ○ Marketed medicines and
their side effects, frequency of side effects
○ Extracted from public medical documents, by text mining
# of Side Effect 4,192
# of Drugs 996
http://sideeffects.embl.de
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Side Effect of Drugs
● Network → Drug-Drug adjacency matrix ● Node → Drug ● Edge value → Side Effect (SE) Similarity
between two drugs
★ All SE are NOT equally informative 1. Rareness score → how SE appears rarely?
Ex) “dizziness” << “yellow skin” 1. Correlation score
Ex) “chest discomfort”, “chest pressure”, ... << “eye pain”
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Dataset
● Disease-Disease (OMIM) o 5,080 x 5,080
● Protein Domain-Protein Domain (DOMINE) o 5,490 x 5,490
● Drug-Drug (DrugBank) o 1,109 x 1,109
● Protein-protein Interaction (HPRD) o 8,919 x 8,919
● Protein Domain-Drug (Pfam UniProt) ● Drug-Domain (DrugBank) ● Protein-Protein Domain (OMIM)
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Evaluation
● 1,337 test cases (explicit drug-disease pairs)
● Leave-one-out (LOO) test: o Remove one known A-B interaction, using A as query,
and measure where B is ranked
● Areas under the ROC curves (AUC), o TP/Positives vs. FP/Negatives at various thresholds o TP = Rank of case disease is below the threshold, o FP = Rank of case disease is NOT below the threshold
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Results
● SE improves AUC to predict new interaction ● Predicted disease was ranked 177 out of 5,080 on
average
Baseline Baseline + SE
AUC 0.956 0.965
Mean Ranking (5,080) 222.53 177.66
STDEV 566 514
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Discussion
★ Incorporating Side Effect information of drugs can help to predict new drug-disease interaction more accurately.
★ Adverse reaction of marketed drugs, can help to uncover the new uses for known drugs.
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Thank You!
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QnA
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★ Pairwise Correlation ★ Individual
Correlation score ○ Hierarchical Clustering
Appendix
★ Rareness score
★ SE similarity score
A B C
20 20 50
30
50
Ca=35 Cb=35 Cc=50