drug metabolism-hydrolysis

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Transcript of drug metabolism-hydrolysis

  1. 1. Hydrolysis BY S.SRIVIDHYA III BIOCHEMISTRY
  2. 2. Introduction Enzymatic conversion of one chemical compound to another is called drug metabolism Aim :Make drug water soluble Mostly in liver (importance)
  3. 3. Phases of drug metabolism Phase I: Non-synthetic reactions such as cleavage e.g. oxidation, reduction, hydrolysis Formation or modification of a function group. More hydrophilic molecules are produces
  4. 4. Phase II Synthetic reactions such as conjugation with an endogenous substance e.g. sulfate, glycine, glucuronic acid More lipophobic molecules are produced
  5. 5. Hydrolysis Introduce water molecule For phase II Esters,amides,hydrazides and carbamates are hydrolysed Opposite to oxidation and reduction Takes a water molecule to cleave the drug Enzymes also found in kidney,intestine,plasma,etc Drugs : cholinesters,procaine,procainamide.
  6. 6. Atropine = tropine + tropic acid Cocaine = benzoic acid + ecgonine methyl ester. Procaine = p-amino acid (PABA) + diethyl amino ethanol. Acetylcholine = acetic acid + choline.
  7. 7. Reaction R-COO-R' + H2O R-COOH + R'-OH R-CO-NH-R' + H2O R-COOH + R'-NH2 Examples: cocaine to benzoylecognine ecognine methyl ester
  8. 8. Hydrolysis of procaine
  9. 9. References https://youtu.be/ztsBn8gsfHw https://www.news-medical.net/amp/health/Drug-Metabolism.aspx https://www.slideshare.net/suniu/drug-metabolism-16091624 https://www.unaab.edu.ng/attachments/484_PRINCIPLES%20OF%20DRU G%20METABOLISM%201Dr%20Saba.pdf