Drosophila shows a prominent homeostatic response to sleep deprivation
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Transcript of Drosophila shows a prominent homeostatic response to sleep deprivation
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CS (6HRS) NOV 25, 2001--JAN 11, 2002 n=87
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Shaw PJ, Cirelli C, Greenspan RJ, Tononi G. Science, 2000
Hendricks et al., Sleep 2003
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Fly sleep is modulated by stimulants and hypnotics
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Fly sleep is accompanied by EEG changes
Nitz DA, van Swinderen B, Tononi G, Greenspan RJ. Current Biology 12:1934-1940, 2002
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Cirelli and Tononi, Mol Brain Res, 1998; Cirelli, Gutierrez, Tononi, Neuron 2004
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Fly sleep is characterized by changes in gene expression similar to those observed in mammals
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Summary: Sleep in flies shares key featureswith sleep in mammals
Like mammalian sleep, sleep-like states in Drosophila are:
• consolidated into long period of quiescence• characterized by increased arousal thresholds• homeostatically regulated• modulated by stimulants and hypnotics• associated with changes in brain electrical activity • associated with changes in gene expression