Dr Sutrisno-Aub in Perimenopause

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    EVALUASI DAN MANAJEMEN

    PERDARAHAN UTERUS ABNORMAL (AUB)PADA PERIODE PERIMENOPAUSE

    S U T R I S N ODivision of Human Reproductive Endocrinology and Fertility

    Department of Obstetrics and GynecologiBrawijaya University Faculty of Medicine / Saiful Anwar Hospital

    Malang

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    Perdarahan uterus abnormal adalah keluhan yang palingsering yang membawa wanita ke dokter umum / Obs Gyn

    (Livingstone M, Fraser IS, 2002; Zinger M, 2008, Sweet MG, 2011)

    PERDARAHAN UTERUS ABNORMAL (AUB) :Hampir semua wanita pernah mengalaminya ...

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    Istilah yang digunakan untuk menggambarkan

    Heavy Menstrual Bleeding

    Menorrhagia

    Hypermenorrhea

    Menometrorrhagia

    Dysfunctional Uterine Bleeding

    Functional Uterine Hemorrhage

    Excessively Heavy Menstrual Loss

    Ovulatory Menorrhagia

    Anovulatory MenorrhagiaFunctional Menorrhagia

    Essential menorrhagia

    Idiopathic Menorrhagia

    Primary menorrhagia

    Uncomplicated Menorrhagia

    Symptomatic MenorrhagiaPersistent menorrhagia

    Unexplained menorrhagia

    Genuine Menorrhagia

    Idiopathic Uterine Hemorrhage

    Anomalou Uterine Hemorrhage

    EpimenorrheaEpimenorrhagia

    Polymenorrhea

    Polymenorrhagia

    Metropathia Hemorrhagica

    CONTOH !!!

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    PolypA denomyosis

    L eiomyoma

    Malignancy / Hyperplasia

    Coagulopathy

    Ovulatory disfunction

    Non yet classified

    Endometrium

    Iatrogenic

    KOMPONEN STRUKTUR KOMPONEN NON STRUKTUR

    Visualisasi dgn imaging / PA

    Similar !FIGO cervical cancer staging 1920

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    PERDARAHAN UTERUSABNORMAL

    FaktorKehamilan

    dll

    Kepastiankeluar dari

    serviks

    KomplikasiPerdarahan

    AKUT KRONIS

    LANGKAH-LANGKAH PENDEKATAN

    RASIONAL

    INVESTIGASI SISTEMATIS PALM - COEIN

    TATA LAKSANA

    STEP 1

    STEP 2

    STEP 3

    STEP 4

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    INVESTIGASI SISTEMATIS

    P A L M C O E I N

    Anamnesa

    sistematis Pemeriksaanfisik

    Pemeriksaan

    Lab/penunjang

    FaktorOvulasi

    "

    Hematologi" Endokrin

    " Coagulopathy

    hereditary

    Penyakit2Obat

    Pola hidup

    Evaluasi Uterus

    Secara TEPAT

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    PERIMENOPAUSE ?

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    Menopause:Tidak haidRetrospektif : 1 tahun sejak tdk haid sama sekali.

    Perimenopause:Transisi sekitar menopause. Sebelum menopausesampai 1 tahun setelah menopause.

    Postmenopause:

    Periode setelah satu tahun menopause

    Definisi : Pre-menopausePeri-menopauseMenopase

    Post-menopause

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    AGE

    PERIMENOPAUSEREPRODUCTIVEPERIMENARCHE

    Anovulatoar

    Disorder of blood

    coagulation

    Pregn. Disorders

    Medicinal

    Reprod. Tractpathologies

    Anovulatoar

    Struktural

    Malignancy

    Risk factor of

    malignancy

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    ALUR TATA LAKSANA AUB - HIFERI

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    BOBOTNYA

    DI PROSESDIAGNOSTIK

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    ! " # $ % & '

    -A 5:#(# B "6/%/=3 !"#$%&'( *+,%-#, .(,,/-#0 1!*.2

    Diagnostic

    Exploration of endocervical canalSuspected endometrial polyps

    Suspected submucous leiomyomas

    Evaluation of endometrial lining

    Focal pathologically suspect lesions (endometrial ca)

    Misplaced foreign bodiesUterine anomalies

    Intrauterine adhesions

    Evaluation of uterotubal junctions

    Evaluasi uterus : endometrium miometrium

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    Leioioma uteri, Malignancy / Hyperplasia

    Polip endometrium, Adenomiosis

    PERDARAHAN UTERUS ABNORMAL

    KOMPONEN STRUKTUR

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    Evaluasi struktur uterus dan rongga uterus

    345

    634

    784

    494

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    HSG

    TVS

    SISOHS

    MRI

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    HSG : x - ray

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    TVS

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    ! " # $ % & '

    -A 5:#(# B "6/%/=3 !"#$%&'( *+,%-#, .(,,/-#0 1!*.2

    Diagnostic

    Exploration of endocervical canalSuspected endometrial polyps

    Suspected submucous leiomyomas

    Evaluation of endometrial lining

    Focal pathologically suspect lesions (endometrial ca)

    Misplaced foreign bodiesUterine anomalies

    Intrauterine adhesions

    Evaluation of uterotubal junctions

    Evaluasi uterus : endometrium miometrium

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    ?@C D

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    TVS COLOR DOPLER

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    TVS COLOR DOPLER 3D

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    WINDOW

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    S I S

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    CEC FC#%3*) E*G593/* C/*/,&9:)$/=$#0,&H

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    N/%.9:)3* OPL P$)) OQL P)*9/* 2PL ): #%L RSST1

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    Parsons AK, 2001

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    TUJUAN PEMERIKSAAN

    )#*&+$,- .//0

    Melihat kelainan di :

    Canalis servicalis

    Otot polos uterus (myometrium)Endometrium

    Cavum uteri

    Tuba Fallopi

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    TVS

    CEC

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    CEC D

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    CEC U 9)+$):/$& )*./():$35(

    ! :;-+? !*.@

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    M30)$0%#93# )*./():$35(

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    CEC D >/%30

    C#=3V#% CEC W 0/%&09 .)*=#* "Q *= 6039

    FR U X ((HC#=3V#% ?@C "Q /G TR ((1

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    SIS

    COLOR DOPLER

    POLIP

    Y \\ &)#$ /%.

    ]3:, Y^P

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    ;&/(# 958(5I/#9#

    38 years old woman with AUB

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    MYOMA UTERI SUBMUCOUS

    TVS

    SIS

    3 D

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    SINEKIACAV.UTERI

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    ! " # $ % & '

    -A 5:#(# B "6/%/=3 !"#$%&'( *+,%-#, .(,,/-#0 1!*.2

    Diagnostic

    Exploration of endocervical canal

    Suspected endometrial polyps

    Suspected submucous leiomyomas

    Evaluation of endometrial lining

    Focal pathologically suspect lesions (endometrial ca)

    Misplaced foreign bodies

    Uterine anomalies

    Intrauterine adhesions

    Evaluation of uterotubal junctions

    Evaluasi uterus : endometrium miometrium

    VISUAL!!TERAPI!.. ++++++++++

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    Dokter!!!!.

    Visual langsungSasaran target tepat

    Mengurangi Error

    Target biopsi jelas

    Jaringan biopsi representatif

    Manfaat TERAPI

    ?

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    Melihat endocervix

    Melihat uterine cavity

    Melihat endometriumMelihat tubal osteium

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    MYOMA UTERI SUBMUCOUS

    TVS

    SIS

    OHS

    W -

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    Uterus dan serviks reguler, ostia bebas

    AUB - O

    Polip korpus kecil di cornua tuba kiri, kavum

    reguler, ostia tuba bebas bilateral

    Myoma submukosa Uterus septus (septum kecil dengan panjang 5

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    Adhesi intrauterin grade 1 (ruptur akibat sheathhisteroskop

    Hiperplasia endometrium

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    Myoma submukosaMyoma submukosa dengan pembuluhDarah yang besar besar.

    Uterus subseptus hiperplasia

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    Polip corpus fibrosa besar di dinding posterior Polip corpus

    Ny M, 36 th

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    WHICH ONE

    THE BEST

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    C)*936J:#9 .#* 90)93J93:#9 CEC

    ;).3+#$) C)$43+) Y.43#9/$& C/((3:)L T___

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    TVS - OHS

    Shalev J et al, 2000

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    Salim R et al, 2004

    AB 494 < 634

    P b di TVS SIS d OHS d k AUB

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    Perbandingan TVS, SIS dan OHS pada kasus AUBpada usia reproduksi

    Kelekci S, 2005

    Fertility Sterility, 2005

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    Sardo et al, 2008

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    Akurasi Diagnosis untuk Evaluasi Kelainan di Uterus

    Grup Dx Benar (%) Dx Salah (%)

    HSG 60 40SIS 54 46

    OHS 72 28

    Brown SE et al, 2000

    Evaluasi Uterine Cavity dengan MRI TVS HSE (SIS) dan Hysteroscopy

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    Evaluasi Uterine Cavity dengan MRI, TVS, HSE (SIS), dan Hysteroscopy

    Dueholm M et al, 2001

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    Safety: TVS, SIS dan OHS aman, komplikasi jarang,cocok untuk AUB pada perimenopase.

    Effectiveness: SIS lebih efektif dari TVS untuk mendeteksi

    beberapa kelainan intrakaviter.

    SIS dan OHS mempunyai kemampuan yang samadalam hal sensitifitas, spesifisitas, PPV dan NPV

    Cost-Effectiveness : SIS lebih murah daripada OHS.

    Namun kemampuan OHS lebih dalam hal

    kemampuan sebagai terapi.Rekomendasi: TVS dan SIS bisa menjadi prosedur yang baik

    dalam mengevaluasi perdarahan perimenopause

    T KE HOME M SS GE

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    SELALUSEHAT

    SAMPAIUSIA

    MENOPAUSE

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    THANK YOU