Dr. Samuel M. Meier-Menches, MRSC C U R R I C U L U M V I ...
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Personal Details contact LinkedIn: Samuel M. Meier www.researchgate.net/profile/Samuel_Meier/ web [email protected] Scientific Career Dr. Samuel M. Meier-Menches, MRSC CURRICULUM VITAE 0000-0002-8930-4574 ORCID Post-doctoral research associate at Cardiff University with Prof. A. Casini Field: Bioinorganic Medicinal Chemistry Applications: Synthesis, Mass spectrometry, FRET Post-doctoral research at the University of Vienna with Prof. C. Gerner Field: Analytical Medicinal Chemistry/Chemical Proteomics Applications: Synthesis, Mass spectrometry, LC-MS, Top-down, Bottom-up Ph.D. degree in chemistry from the University of Vienna with Prof. B. Keppler Short scientific mission at the Ruhr University Bochum with Prof. N. Metzler-Nolte Topic: Metal-Peptide Conjugates Ph.D. studies at the University of Vienna with Prof. B. Keppler Field: Bioinorganic Medicinal Chemistry Master’s degree in chemistry at the ETH Zurich Master’s thesis at the University of Zurich with Prof. R. Alberto Bachelor’s degree in chemistry at the EPF Lausanne SOCRATES student exchange at the University of Edinburgh Semester project with Prof. P.J. Sadler 2013 – 2016 2013 2011 2009 – 2013 2009 2007 2016 – 2017 Keywords Antitumour Agents · Bioanalytical Techniques · Cancer · Drug Discovery · Drug Effects · Mass Spectrometry · Proteomics · Synthesis h index 16 N° of citations 821 2018-Mar-15 @ scopus.com Post-doctoral research at the University of Vienna with Prof. C. Gerner Field: Analytical Medicinal Chemistry Applications: Synthesis, Mass spectrometry, LC-MS 2017 – present 1│8 Alpbach Summer School on Entrepreneurship I.E.C.T. – Hermann Hauser and organized by the University of Cambridge CfEL Training 2015
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ScientificCareer
Dr.SamuelM.Meier-Menches,MRSCCURRICULUMVITAE
0000-0002-8930-4574ORCID
Post-doctoralresearchassociateatCardiffUniversitywithProf.A.CasiniField: BioinorganicMedicinalChemistryApplications: Synthesis,Massspectrometry,FRETPost-doctoralresearchattheUniversityofViennawithProf.C.GernerField: AnalyticalMedicinalChemistry/ChemicalProteomicsApplications: Synthesis,Massspectrometry,LC-MS,Top-down,Bottom-upPh.D.degreeinchemistryfromtheUniversityofViennawithProf.B.KepplerShortscientificmissionattheRuhrUniversityBochumwithProf.N.Metzler-NolteTopic: Metal-PeptideConjugatesPh.D.studiesattheUniversityofViennawithProf.B.KepplerField: BioinorganicMedicinalChemistryMaster’sdegreeinchemistryattheETHZurichMaster’sthesisattheUniversityofZurichwithProf.R.AlbertoBachelor’sdegreeinchemistryattheEPFLausanneSOCRATESstudentexchangeattheUniversityofEdinburghSemesterprojectwithProf.P.J.Sadler
2013–2016
20132011
2009–2013
2009
2007
2016–2017
Keywords AntitumourAgents·BioanalyticalTechniques·Cancer·DrugDiscovery·DrugEffects·MassSpectrometry·Proteomics·Synthesis
hindex16N°ofcitations821
Post-doctoralresearchattheUniversityofViennawithProf.C.GernerField: AnalyticalMedicinalChemistryApplications: Synthesis,Massspectrometry,LC-MS
2017–present
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AlpbachSummerSchoolonEntrepreneurshipI.E.C.T.–HermannHauserandorganizedbytheUniversityofCambridgeCfEL
Training2015
SamuelM.Meier,*ChristopherGerner,BernhardK.Keppler,MariaAgostinaCinelluandAngelaCasini*MassSpectrometryUncoversMolecularReactivitiesofCoordinationandOrgnaometallicGold(III)DrugCandidatesinCompetitiveExperimentsthatCorrelatetotheirBiologicalEffectInorganicChemistry,2016,55,4248–4259. *correspondingauthorsDominiqueKreutz,AndreaBileck,KerstinPlessl,DeniseWolrab,BernhardK.Keppler,SamuelM.MeierandChristopherGernerResponseProfilingUsingShotgunProteomicsEnablesGlobalMetallodrugMechanismsofActiontobeEstablishedChemistry–AEuropeanJournal,2017,23,1881–1890.SamuelM.Meier,MuhammadHanif,ZenitaAdhireksan,VerenaPichler,MariaNovak,ElisabethJirkovsky,MichaelA.Jakupec,VladimirB.Arion,CurtA.Davey,BernhardK.KepplerandChristianG.HartingerNovelMetal(II)Arene2-Pyridinecarbothioamides:ARationaletoOrallyActiveOrganometallicAnticancerAgentsChemicalScience,2013,4,1837–1846.ChristianArtner,HannahU.Holtkamp,ChristianG.Hartinger,SamuelM.Meier-Menches*andBernhardK.Keppler*DNAorProtein?CapillaryZoneElectrophoresis–MassSpectrometryRapidlyElucidatesMetallodrugBindingSelectivityChemicalCommunications,2017,53,8002–8005. *correspondingauthors
SamuelM.Meier,*DominiqueKreutz,LilliWinter,MatthiasH.M.Klose,KlaudiaCseh,TamaraWeiss,AndreaBileck,BeatrixAlte,JohannaC.Mader,SamirJana,AnneshaChatterjee,ArindamBhattacharyya,MichaelaHejl,MichaelA.Jakupec,PetraHeffeter,WalterBerger,ChristianG.Hartinger,BernhardK.Keppler,GerhardWicheandChristopherGerner*AnOrganorutheniumAnticancerAgentShowsUnexpectedTargetSelectivityForPlectinAngewandteChemieInt.Ed.,2017,56,8267–8271. *correspondingauthorsfeaturedin:-blog.pnas.org/2017/06/journal-club-metal-shows-rare-specificity-in-early-tests-of-cancer-fighting-capabilities/-mobil.derstandard.at/2000059195222/Krebsmedikament-Wirkmechanismus-entdeckt
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SelectedArticles
SelectedArticles
Dr.SamuelM.Meier-Menches,MRSC
SamuelM.Meieretal.InorganicChemistry,2016
MuhammadHanifetal.ChemPlusChem,2017
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SamuelM.Meieretal.Angew.Chem.Int.Ed.,2017
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StevenW.Magennis,AbrahaHabtemariam,OlgaNovakova,JohnB.Henry,SamuelMeier,SimonParsons,IainD.H.Oswald,ViktorBrabecandPeterJ.SadlerDualTriggeringofDNABindingandFluorescenceviaPhotoactivationofaDinuclearRuthenium(II)AreneComplexInorganicChemistry,2007,46,5059–5068.MuhammadHanif,HelenaHenke,SamuelM.Meier,SanelaMartic,MahmoudLabib,WolfgangKandioller,MichaelA.Jakupec,VladimirB.Arion,Heinz-BernhardKraatz,BernhardK.KepplerandChristianG.HartingerIstheReactivityofM(II)-AreneComplexesof3-Hydroxy-2(1H)-pyridonestoBiomoleculestheAnticancerActivityDeterminingParameter?InorganicChemistry,2010,49,7953–7963.MuhammadHanif,SamuelM.Meier,WolfgangKandioller,AnnaBytzek,MichaelaHejl,ChristianG.Hartinger,AlexeyA.Nazarov,VladimirB.Arion,MichaelA.Jakupec,PaulJ.DysonandBernhardK.KepplerFromHydrolyticallyLabiletoHydrolyticallyStableRu(II)-AreneAnticancerComplexeswithCarbohydrate-Derivedco-LigandsJournalofInorganicBiochemistry,2011,105,224–231.SamuelM.Meier,MuhammadHanif,WolfgangKandioller,BernhardK.KepplerandChristianG.HartingerBiomoleculeBindingvs.AnticancerActivity:ReactionsofRu(arene)[(thio)pyr-(id)one]CompoundswithAminoAcidsandProteinsJournalofInorganicBiochemistry,2012,108,91–95.SamuelM.Meier,YuryO.Tsybin,PaulJ.Dyson,BernhardK.KepplerandChristianG.HartingerFragmentationMethodsontheBalance:UnambiguousTop-DownMassSpectrometricCharacterizationofOxaliplatin-UbiquitinBindingSitesAnalyticalandBioanalyticalChemistry,2012,402,2655–2662. 10thAnniversaryIssueGerlindeGrabmann,SamuelM.Meier,YuliaY.Scaffidi-Domianello,MarkusGalanski,BernhardK.KepplerandChristianG.HartingerCZEandCZE-ESI-MSStudiesontheStabilityofAnticancercis-andtrans-[bis(2-propanoneoxime)dihalidoplatinum(II)]ComplexesJournalofChromatographyA,2012,1267,156–161. MariaV.Babak,SamuelM.Meier,AlexanderRoller,MichaelA.Jakupec,BernhardK.KepplerandChristianG.HartingerAm(m)inesmaketheDifference:OrganometallicRutheniumAm(m)ineComplexesandTheirChemistryinAnticancerDrugDevelopmentChemistry–AEuropeanJournal,2013,19,4308–4318.SamuelM.Meier,MuhammadHanif,ZenitaAdhireksan,VerenaPichler,MariaNovak,ElisabethJirkovsky,MichaelA.Jakupec,VladimirB.Arion,CurtA.Davey,BernhardK.KepplerandChristianG.HartingerNovelMetal(II)Arene2-Pyridinecarbothioamides:ARationaletoOrallyActiveOrganometallicAnticancerAgentsChemicalScience,2013,4,1837–1846.WolfgangKandioller,EvelynBalsano,SamuelM.Meier,UteJungwirth,SimoneGöschl,AlexanderRoller,MichaelA.Jakupec,WalterBerger,BernhardK.KepplerandChristianG.HartingerOrganometallicAnticancerComplexesofLapachol:MetalCentre-DependentFormationofReactiveOxygenSpeciesandCorrelationwithCytotoxicityChemicalCommunications,2013,49,3348–3350.
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AnatolieGavriluta,MariaNovak,JeanBernardTommasino,SamuelM.Meier,MichaelA.Jakupec,DominiqueLuneauandVladimirB.ArionOsmium-NitrosylComplexeswithGlycine,PicolinicAcid,L-ProlineandD-Proline:Synthesis,StructuresandAntiproliferativeActivityZeitschriftfüranorganischeundallgemeineChemie,2013,639,1590–1597.GabrielE.Büchel,AnatolieGavriluta,MariaNovak,SamuelM.Meier,MichaelA.Jakupec,OleseaCuzan,ConstantinTurta,Jean-BernardTommasino,ErwannJeanneau,GhenadieNovitchi,DominiqueLuneauandVladimirB.ArionStrikingDifferenceinAntiproliferativeActivityofRuthenium-andOsmium-NitrosylComplexeswithAzoleHeterocyclesInorganicChemistry,2013,52,6273–6285.SamuelM.Meier,MariaNovak,WolfgangKandioller,MichaelA.Jakupec,VladimirB.Arion,NilsMetzler-Nolte,BernhardK.KepplerandChristianG.HartingerIdentificationoftheStructuralDeterminantsforAnticancerActivityofaRutheniumArenePeptideConjugateChemistry–AEuropeanJournal,2013,19,9297–9307.VerenaPichler,SimoneGoeschl,SamuelM.Meier,AlexanderRoller,MichaelA.Jakupec,MarkusGalanskiandBernhardK.KepplerBulkyN(,N)-(Di)alkylethane-1,2-diamineplatinum(II)CompoundsasPrecursorsforGeneratingUnsymmetricallySubstitutedPlatinum(IV)ComplexesInorganicChemistry,2013,52,8151–8162.MichaelF.Primik,SimoneGöschl,SamuelM.Meier,NadineEberherr,MichaelA.Jakupec,ÉvaA.Enyedy,GhenadieNovitchiandVladimirB.ArionDicopper(II)andDizinc(II)ComplexeswithNonsymmetricDinucelatingLigandsBasedonIndolo-[3,2-c]quinolines:Synthesis,Structre,CytotoxicityandIntracellularDistributionInorganicChemistry,2013,52,10137–10146.MuhammadHanif,SamuelM.Meier,AlexeyA.Nazarov,JulieRisse,AntonLegin,AngelaCasini,MichaelA.Jakupec,PaulJ.Dyson,BernhardK.KepplerandChristianG.HartingerInfluenceoftheπ-CoordinatedAreneontheBiologicalFunctionofRuthenium(II)CarbohydrateOrganometallicComplexesFrontiersinChemistry,2013,DOI:10.3389/fchem.2013.00027.BrittaFischer,PetraHeffeter,KushtrimKryeziu,LarsGille,SamuelM.Meier,WalterBerger,ChristianR.KowolandBernhardK.KepplerPoly(LacticAcid)NanoparticlesoftheLeadAnticancerRutheniumCompoundKP1019anditsSurfactant-MediatedActivationDaltonTransactions,2014,43,1096–1104.AnnaRathgeb,AndreasBoehm,MariaNovak,AnatolieGavriluta,OrsolvaDömötör,Jean-BernardTommasino,EvaEnyedy,SerguiShova,SamuelM.Meier,MichaelA.Jakupec,DominiqueLuneauandVladimirArionRuthenium-NitrosylComplexeswithGlycine,L-Alanine,L-Valine,L-Proline,D-Proline,L-Serine,L-ThreonineandL-Tyrosine:Synthesis,X-rayDiffractionStructures,SpectroscopicandElectrochemicalPropertiesandAntiproliferativeActivityInorganicChemistry,2014,53,2718–2729.SamuelM.Meier,MariaBabak,BernhardK.KepplerandChristianG.HartingerEfficientlyDetectingMetalldrug-ProteinAdducts:IonTrapvs.Time-of-FlightMassAnalyzerChemMedChem,2014,9,1351–1355.
PUBLICATIONLIST
ResearchArticles
Dr.SamuelM.Meier-Menches,MRSC
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SamuelM.Meier,MariaS.Novak,WolfgangKandioller,MichaelA.Jakupec,AlexanderRoller,BernhardK.KepplerandChristianG.HartingerAqueousChemistryandAntiproliferativeActivityofaPyrone-basedPhosphoramidateRu(Arene)AnticancerAgentDaltonTransactions,2014,43,9851–9855.AlexeyA.Nazarov,SamuelM.Meier,OlivierZava,YuliaN.Nosova,ElenaR.Milaeva,ChristianG.HartingerandPaulJ.DysonProteinRuthenationandDNAAlkylation:Chlorambucil-functionalizedRAPTAComplexesandTheirAnticancerActivityDaltonTransactions,2015,44,3614–3623. MariaV.Babak,DamianPlazuk,SamuelM.Meier,HomayonJohnArabshahi,JohannesReynisson,BlazejRychlik,AndrzejBlauz,KatarzynaSzulc,MuhammadHanif,SebastianStrobl,AlexanderRoller,BernhardK.KepplerandChristianG.HartingerHalf-SandwichRuthenium(II)BiotinConjugatesasBiologicalVectorstoCancerCellsChemistry–AEuropeanJournal,2015,21,5110–5117.MariaV.Babak,SamuelM.Meier,KilianHuber,JohannesReynisson,AntonA.Legin,MichaelA.Jakupec,AlexanderRoller,AlexeyStukalov,ManuelaGridling,KeirynL.Bennett,JacquesColinge,WalterBerger,PaulJ.Dyson,GiulioSuperti-Furga,BernhardK.KepplerandChristianG.HartingerTargetProfilingofanAntimetastaticRAPTAAgentbyChemicalProteomics:RelevancetotheModeofActionChemicalScience,2015,6,2449–2456.Paul-SteffenKuhn,LauraCremer,AnatolieGavriluta,KatarinaK.Jovanović,LanaFilipović,AlfredA.Hummer,GabrielE.Büchel,BiljanaP.Dojčinović,SamuelM.Meier,AnnetteRompel,SinišaRadulović,JeanBernardTommasino,DominiqueLuneauandVladimirB.ArionHeteropentanuclearOxalato-Bridgednd-4f(n=4,5)MetalComplexeswithNOLigand:Synthesis,Crystalstructures,AqueousStabilityandAntiproliferativeActivityChemistry–AEuropeanJournal,2015,21,13703–13713.SamuelM.Meier,BesnikMuqaku,RonaldUllmann,AndreaBileck,DominiqueKreutz,JohannaC.Mader,SiegfriedKnasmüllerandChristopherGernerProteomicandMetabolomicAnalysesRevealContrastingAnti-InflammatoryEffectsofanExtractofMucorRacemosusSecondaryMetabolitesComparedtoDexamethasonePLoSONE,2015,10,e0140367.doi:10.1371/journal.pone.0140367.Paul-SteffenKuhn,SamuelM.Meier,KatarinaK.Jovanović,IsoldeSandler,LeonFreitag,GhenadieNovitchi,LeticiaGonzález,SinišaRadulovićandVladimirB.ArionRuthenium-CarbonylComplexeswithAzoleHeterocycles:Synthesis,X-rayDiffractionStructures,DFTCalculations,SolutionBehaviorandAntiproliferativeActivityEuropeanJournalofInorganicChemistry,2016,1566–1576.LucianoOehninger,SarahSpreckelmeyer,PavloHolenya,SamuelM.Meier,SuzanCan,HamedAlborzinia,BernhardK.Keppler,StefanWolflandIngoOttRhodium(I)NHCBioorganometallicsasCytotoxicAgentswithDistinctEffectsonCellularSignalingJournalofMedicinalChemistry,2016,58,9591–9600.KatharinaAuer,AnnaBachmayr-Heyda,NyamdelgerSukhbaatar,StefanieAust,KlausG.Schmetterer,SamuelM.Meier,ChristopherGerner,ChristophGrimm,ReinhardHorvatandDietmarPilsTheRoleoftheImmuneSysteminthePeritonealTumorSpreadofHighGradeSerousOvarianCancerOncotarget,2016,7,61336–61354.
PUBLICATIONLIST
ResearchArticles
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SamuelM.Meier*,ChristopherGerner,BernhardK.Keppler,MariaAgostinaCinellu,AngelaCasini*MassSpectrometryUncoversMolecularReactivitiesofCoordinationandOrgnaometallicGold(III)DrugCandidatesinCompetitiveExperimentsthatCorrelatetotheirBiologicalEffectInorganicChemistry,2016,55,4248–4259. *correspondingauthorsBesnikMuqaku,Ammar,Tahir,PhilipKlepeisz,AndreaBileck,RupertL.Mayer,SamuelM.Meier,MarleneGerner,KlausSchmettererandChristopherGernerCoffeeConsumptionModulatesInflammatoryProcessesinanIndividualFashionMolecularNutritionandFoodResearch,2016,60,2529–2541.AnnaBachmayr-Heyda,StefanieAust,KatharinaAuer,SamuelM.Meier,KlausSchmetterer,SabineDekan,ChristopherGernerandDietmarPilsIntegrativeSystemicandLocalMetabolomicswithImpactonSurvivalinHighGradeSerousOvarianCancerClinicalCancerResearch,2016,23,2081–2092.DominiqueKreutz,AndreaBileck,KerstinPlessl,DeniseWolrab,BernhardK.Keppler,SamuelM.MeierandChristopherGernerResponseProfilingUsingShotgunProteomicsEnablesEstablishingGlobalMetallodrugMechanismsofActionChemistry–AEuropeanJournal,2017,23,1881–1890.BesnikMuqaku,MartinEisinger,SamuelM.Meier,AmmarTahir,AstridSlany,TobiasPukrop,SebastianHaferkamp,AlbrechtReichleandChristopherGernerMulti-omicsAnalysisofSerumSamplesDemonstratesReprogrammingofOrganFunctionsviaSystemicCalciumMobilizationandPlateletActivationinMetastaticMelanomaMolecular&CellularProteomics,2017,16,86–99.NadineS.Sommerfeld,EkaterinaSchreiber-Brynzak,MatthiasH.M.Klose,AndreaBileck,SamuelM.Meier,ChristopherGerner,MichaelA.Jakupec,MarkusGalanski,BernhardK.KepplerLowGenerationPAMAMDendrimersasDrugCarriersforPt(IV)ComplexesEuropeanJournalofInorganicChemistry,2017,1713–1720. VIParticleAmmarTahir,AndreaBileck,BesnikMuqaku,LauraNiederstätter,DominiqueKreutz,RupertL.Mayer,DeniseWolrab,SamuelM.Meier,AstridSlanyandChristopherGernerCombinedProteomeandEicosanoidProfilingRevealsNovelImplicationsofHumanFibroblastsinChronicInflammation AnalyticalChemistry,2017,89,1945–1954.ChristinaM.Hochkogler,BarbaraLieder,PetraRust,DavidBerry,SamuelM.Meier,MarcPignitter,AlessandraRiva,AlinaLeitinger,AnneBruk,SimoneWagner,ChristopherGerner,MichaelWagner,SabineWidder,JakobP.Ley,GerhardE.KrammerandVeronikaSomozaEffectsofa12-WeekInterventionwithNonivamide,aTRPV1Agonist,onPeripheralSerotoninandBodyCompositionMolecularNutritionandFoodResearch,2017,DOI:10.1002/mnfr.201600731.StefanieAust,SophieFelix,KatharinaAuer,AnnaBachmayr-Heyda,LukasKenner,SabineDekan,SamuelM.Meier,ChristopherGerner,ChristophGrimmandDietmarPilsAbsenceofPD-L1onTumorCellsisAssociatedwithReducedMHCIExpressionandPD-L1ExpressionIncreasesinRecurrentSerousOvarianCancerScientificReports,2017,7,42929.AndreaBileck,RupertL.Mayer,DominiqueKreutz,TamaraWeiss,SabineTaschner-Mandl,SamuelM.Meier,AstridSlanyandChristopherGernerEvaluationofInflammation-RelatedSignalingEventsCoveringPhosphorylationandNuclearTranslocationofProteinsBasedonMassSpectrometryDataJournalofProteomics,2017,152,161–171.
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Dr.SamuelM.Meier-Menches,MRSC
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[38] MuhammadHanif,SamuelM.Meier,ZenitaAdhireksan,HelenaHenke,SanelaMartic,SanamMovassaghi,MahmoudLabib,WolfgangKandioller,StephenM.F.Jamieson,MichaelaHejl,MichaelA.Jakupec,Heinz-BernhardKraatz,CurtA.Davey,BernhardK.KepplerandChristianG.HartingerTheFunctionalizationofRuII(η6-p-cymene)(3-hydroxy-2-pyridone)Complexeswith(Thio)Morpholine:SynthesisandBioanalyticalStudiesChemPlusChem,2017,82,841–847.MatthewP.Sullivan,MichaelGroessl,SamuelM.Meier,RichardL.Kingston,DavidC.GoldstoneandChristianG.HartingerTheMetalationofHenEggWhiteLysozymeImpactsProteinStabilityasShownbyIonMobilityMassSpectrometry,DifferentialScanningCalorimetryandX-RayCrystallographyChemicalCommunications,2017,53,4246–4249.SamuelM.Meier,*DominiqueKreutz,LilliWinter,MatthiasH.M.Klose,KlaudiaCseh,TamaraWeiss,AndreaBileck,BeatrixAlte,JohannaC.Mader,SamirJana,AnneshaChatterjee,ArindamBhattacharyya,MichaelaHejl,MichaelA.Jakupec,PetraHeffeter,WalterBerger,ChristianG.Hartinger,BernhardK.Keppler,GerhardWicheandChristopherGerner*AnOrganorutheniumAnticancerAgentShowsUnexpectedTargetSelectivityForPlectinAngewandteChemieInt.Ed.,2017,56,8267–8271. *correspondingauthorsMatthiasH.M.Klose,MichaelaHejl,PetraHeffeter,MichaelA.Jakupec,SamuelM.Meier-Menches*,WalterBergerandBernhardK.Keppler*Post-DigestionStabilizationofOsmiumEnablesQuantitationbyICP-MSinCellCultureandTissueAnalyst,2017,142,2327–2332. *correspondingauthorsChristianArtner,HannahU.Holtkamp,ChristianG.Hartinger,SamuelM.Meier-Menches*andBernhardK.Keppler*DNAorProtein?CapillaryZoneElectrophoresis–MassSpectrometryRapidlyElucidatesMetallodrugBindingSelectivityChemicalCommunications,2017,53,8002–8005. *correspondingauthorsChristianArtner,HannahU.Holtkamp,ChristianG.Hartinger*andSamuelM.Meier-Menches*CharacterizingActivationMechanismsandBindingPreferencesofRutheniumMetallo-ProdrugsbyaCompetitiveBindingAssayJournalofInorganicBiochemistry,2017,177,322–327. *correspondingauthorsÖzdenKaraca,ValeriaScalcon,SamuelM.Meier-Menches,RiccardoBonsignore,JurriaanM.J.L.Brouwer,FedericaTonolo,AlessandraFolda,MariaPiaRigobello,FritzE.KühnandAngelaCasiniCharacterizationofHydrophilicGold(I)N-HeterocyclicCarbene(NHC)ComplexesasPotentTrxRInhibitorsUsingBiochemicalandMassSpectrometricApproachesInorganicChemistry,2017,56,14237–14250.MargotN.Wenzel,SamuelM.Meier-Menches,ThomasL.Williams,EberardRämisch,GiampaoloBaroneandAngelaCasiniSelectiveTargetingofPARP-1ZincFingerRecognitionDomainswithAu(III)OrganometallicsChemicalCommunications,2018,54,611–614.MatthiasH.M.Klose,SarahTheiner,ChristophKornauth,SamuelM.Meier-Menches,*PetraHeffeter,WalterBerger,GundaKoellenspergerandBernhardK.Keppler*BioimagingofIsostericOsmiumandRutheniumAnticancerAgentsbyLA–ICP-MSMetallomics,2018,DOI:10.1039/C8MT00012C. *correspondingauthors
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[47] MariaV.Babak,MartinPfaffeneder-Kmen,SamuelM.Meier-Menches,MariaS.Novak,SarahTheiner,CynthiaLicona,ChristopheOrvain,AlexandreGriess,MichaelaHejl,MuhammadHanif,MichaelA.Jakupec,BernhardK.Keppler,ChristianGaiddonandChristianG.HartingerRolloverCyclometalatedBipyridinePlatinumComplexesasPotentAnticancerAgents:ImpactoftheAncillaryLigandsontheModeofActionInorganicChemistry,2018,57,2851–2864.RupertL.Mayer,AstridSlany,MarleneC.Gerner,AndreaBileck,SamuelM.Meier-Menches,SamuelM.Gerner,JohannaC.Mader,KlausG.Schmetterer,TobiasPukrop,AlbrechtReichle,JosefD.SchwarzmeierandChristopherGernerAging-RelatedProteomeAlterationsinBCellsMayPredisposeforChronicLymphocyticLeukemiaMolecularandCellularProteomics,2018,17,290–303.
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ResearchArticles
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[1] WolfgangKandioller,AndreaKurzwernhart,MuhammadHanif,SamuelM.Meier,HelenaHenke,BernhardK.KepplerandChristianG.HartingerPyroneDerivativesandMetals:FromNaturalProductstoMetal-BasedDrugsJournalofOrganometallicChemistry,2011,696,999–1010.ChristianG.Hartinger,MichaelGroessl,SamuelM.Meier,AngelaCasiniandPaulJ.DysonApplicationofMassSpectrometricTechniquestoDelineatetheModes-of-ActionofAnticancerMetallodrugsChemicalSocietyReviews,2013,42,6186–6199.ÖzdenKaraca,SamuelM.Meier-Menches,AngelaCasiniandFritzE.KühnOntheBindingModesofMetalNHCComplexeswithDNASecondaryStructures:ImplicationsforTherapyandImagingChemicalCommunications,2017,53,8249–8260.SamuelM.Meier-Menches,*ChristianG.Hartinger,ChristopherGerner,WalterBergerandBernhardK.KepplerStructure-ActivityRelationshipsforRutheniumandOsmiumAnticancerAgents–TowardsClinicalDevelopmentChemicalSocietyReviews,2018,47,909–928.
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BookChapters
MatthewP.Sullivan,HannahU.Holtkamp,SamuelM.MeierandChristianG.HartingerChapter10:TheAnalysisofTherapeuticMetalComplexesandTheirBiomolecularInteractionsinInorganicandOrganometallicTransitionMetalComplexeswithBiologicalMoleculesandLivingCells,Editor:KennethLo,2017,1stEdition,Elsevier,AcademicPress,406pages,ISBN:9780128038147.
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ReviewsandPerspectives
Dr.SamuelM.Meier-Menches,MRSC
