Clinical Research SummitDr Graham LoveChief ExecutiveHealth Research Board

Radisson Blu, Athlone, 14 Oct 2015

Healthy people through excellent research and applied knowledge

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Conclusions……..Research active Trusts had lower risk-adjusted mortality for acute admissions, which persisted after adjustment for staffing and other structural factors.

Sample R&D Intensities

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• Healthcare is a KNOWLEDGE industry!• Expectations & costs are rising out of sync with resources. This is not sustainable.• We need a much smarter use of our resources, people, processes & technology to

meet healthcare needs/expectations.• Our healthcare system needs a much greater self-learning capacity: an ability to

research & develop people/processes/technology both in Ireland and to absorb them from abroad.

• That capacity is not strong in our healthcare system at present.€13,000,000,000€150,000,0001.1%

£109,000,000,000£2,400,000,0002.20%

$53,000,000,000$2,800,000,0005.28%

Total spendR&D spendR&D as % of total

However, recently we have made important progress

A ~€100million jigsaw that is now clicking together…..

The Groups & the CRFs/infrastructure are aligning...

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Dublin North East

Dublin Midlands

Ireland East

South/South West

Saolta

(Mid-West)

(Children’s)

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1 U

nder

pinn

ing

2 A

etio

logy

3 P

reve

ntio

n

4 D

etec

tion

and

Dia

gnos

is

5 T

reat

men

t Dev

elop

men

t

6 T

reat

men

t Eva

luat

ion

7 D

isea

se M

anag

emen

t

8 H

ealth

Ser

vice

s

-15%

-10%

-5%

0%

5%

10%

15%

Per

cent

age

Profile of HRB spend 2010-2014 (~€200m)

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0% 5% 10% 15% 20% 25%

0.04%

0.14%

0.90%0.93%

1.21%

1.68%

1.96%

2.21%2.32%

2.48%

3.28%

3.83%4.28%

4.45%

5.11%

5.77%

7.41%9.72%

19.41%

22.86%

Percentage of spending attributed to all health categories: 2010-2014 (~€200m)

Percentage

Heal

th C

ateg

ory

So what next? A previewl2016-2020: ~€235 million plan (~50% already committed)

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Enabler BBuild a strong enabling enviornmentBuild a strong enabling environment for health research in Ireland.

Enabler ASupport exceptional researchers and leadersSupport the exceptional researchers, talent and leadership we need toundertake high-quality research and generate evidence.

Focus 1Address major

health challenges

Support innovative,

investigator- led and internationally

competitive research to address

major health challenges in

society.

Focus 2Support

healthcare interventions

Support the

design, conduct and evaluation of

healthcare intervention

studies in order to improve health outcomes and health service

delivery.

Focus 3Address the

research needs of the Irish

health system

Support partnership-driven

research, information and

evidence that meet the needs of the Irish health and

social care system.

Underpinning Support Organisational performance

Achieve & sustain organisational excellence, foster transparency and accountability, and demonstrate impact.

DRAFT – not final!!

What specific actions can we take to improve our system now?Hospital (Group) CEOs• Speed up Hospital

approvals for studies/trials

• ‘Encourage’ research in member hospitals to go via CRF

• Mainstream research into your upcoming Group Strategies

Pharma• Drive feasibility

studies for multi-site trials into the infrastructure, via HRB CRCI

• (based on credibility of above) secure full multi-site studies to Ireland

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