November 5, 2015

Actions & Recommendations of PublicUniversities and Colleges of Veterinary MedicineAAVMC | APLU Task Force on Antibiotic Resistance in Production Agriculture

A Call to Action✤ 2014 PCAST report,

Combating Antibiotic-resistant Bacteria

✤ 2015 National Action Plan

✤ 2015 WHO Global Action Plan

✤ 2015 California legislation

Agriculture’s Role

✤ Must be full partners with human medical community

✤ Gives “One Health” perspective

✤ Ensures animal health and enhanced production

Who are we?

Association of American Veterinary Medical Colleges✤ 49 accredited veterinary medical colleges

✤ United States, Canada, Europe and Australia

✤ 23 affiliate members

Association of Public & Land-grant Universities✤ 237 public research universities, land-grants

and affiliated organizations

✤ United States, Canada and Mexico

✤ $41 billion in university-based research annually

Task Force Membership✤ Agriculture and veterinary colleges

✤ Production animal community - NPPC, NCC & NCBA

✤ Pharmaceutical Industry - AHI

✤ Observers from federal agencies - FDA & USDA

RecommendationsEducation | Outreach | Research

Education

✤ Building a common body of knowledge through curriculum

✤ Reaching practitioners through Continuing Education

✤ Utilizing existing avenues such as the National Veterinary Accreditation Program

Outreach

✤ Producers and farmers

✤ Cooperative Extension

Service

✤ Next Generation - FFA, 4H

& STEM Groups

Outreach

✤ Public education

✤ Partnerships between human and animal health

✤ Objective third-party verification

Research Principles

✤ Need for trans- and inter-disciplinary teams

✤ Incorporating private sector as collaborators

✤ Embracing the concept of “One Health”

✤ Performing both basic and applied research

Basic Research

✤ Increasing our understanding of antibiotic-resistant bacteria

✤ How is resistance transferred

✤ Impacts of co-selective pressures on emergence & dissemination

✤ Interaction between host immunocompetence and resistance

✤ Generation & analysis of metagenomic data

Basic Research

✤ Finding alternatives to current antibiotics

✤ New products

✤ Potential alternatives

✤ Developing the pipeline

Applied Research✤ Developing methods &

tools

✤ To carry out metagenomic analyses

✤ To model antibiotic use and resistance risk assessment

✤ To improve diagnostic capabilities

Applied Research✤ Assessing resistance in production agriculture

✤ Incentives and motivations for antibiotic use across sectors

✤ Compare, contrast and assess best practices

✤ Evaluate the success of stewardship programs for both farm & companion animal populations

Applied Research✤ Assessing resistance in production agriculture

✤ Assess the impacts of FDA Guidances 209 & 213

✤ Economic

✤ Animal welfare & health

✤ Reduction of antibiotic resistance

✤ Develop models and longitudinal studies to measure changes in antibiotic resistance patterns & predict true risk to human health

Next StepsImplementing the recommendations

Engaging stakeholders

✤ Federal agencies

✤ Producer | Veterinary | Public health | Consumer groups

✤ Congressional offices

✤ Intergovernmental organizations

Educational Workshops and Leadership Forums

✤ Pool of experts at AAVMC/APLU member institutions

✤ Collaborative initiatives

✤ Advocate for role of agriculture in implementing US National Action Plan

Congressional outreach

✤ Organize Congressional Briefings

✤ Work with veterinary caucus & others already engaged

✤ Educate additional members & staff on the role of agriculture

University-based Pilot Projects

✤ Research, education and stewardship

✤ Target universities primed for One Health approach

✤ Work toward larger state-level initiatives

University Research Organization

✤ Multi-stakeholder initiative

✤ Coordinate and support collaborative research and educational programs

✤ Incorporating private sector as collaborators

✤ One Health approach

Need to know more?

✤ Information | Partnerships

✤ Contact:

✤ Chase A. Crawford, DVM, MS, Director, Antimicrobial Resistance Initiative

✤ ccrawford@aavmc.org