Doc, I don't want to be a guinea pig!
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Transcript of Doc, I don't want to be a guinea pig!
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7/28/2019 Doc, I don't want to be a guinea pig!
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Its not really clear hw guiea ig
came i he icure. Bu he rerai
Dc, I d wa be a guiea ig!
uually made, meime i je, whea juir dcr i abu carry u amir rcedure uch a eig u a
dri. or whe a aie i ld ha heregular r adard heray lger
eem wrk r him ad he huld
cider vel heraie.Guiea ig are acually
rarely ued r medicalreearch, ad ever rearig mir rce-
dure. Mice culd be
quie mifed by hirerai hugh.they are he em requely
ued r reearch. Burarely are heir cri-bui ackwledged by:
Dc, I d wa be a mue!Humur aide, d aie be-ei rm ariciai i cliical rial,
ad hw are hey reced i hey d?
What clinical trials entail
Medical reearch aimal r humaubjec are ricly creeed ad m-
red by he Iiuial Aimal Caread Ue Cmmiee i he cae ai-mal, r by a Iiuial Review BardIRB) i he cae huma.
aie r ideed aye, ca
meime hld he irm i-
i ha a eciic reame i
he be eve whe deii-
ive daa i available.such a ii ca ur u
be righ, r wrg. Hldig ucha belie i he abece deiiive
daa ca reve he aie rmgeig beer reame, ad
eve be harmul, i hewr-cae ceari.
Whe i i ciei-
ically uclear which w r mre -
ible reamei be r he
aie, a i-i equi-
ie exi.thi ca lybe r e lv e d
by cducig acieiically rigru
udy. Fr me medicalcdii, hi wuld i ac
be he ly way be air heaie i quei.
Fr examle, i a radmied c-rlled r a hae III rial, e w
reame r he ame cliical cdi-i i radmly aiged he aie
by a cmuer rgramme.Eiher heray r reame arm i
likely have i w aciaed rik
ad eial beei.Wihu a rerly cduced cliical
rial, here will be iuicie cieiic
daa r dcr kw which rea-
me beei a aie beer. Durighe cure he udy, i daa emerge
ha e heray i beer r aie,
Whe adard heraie are lger alicable r ueul r he aie,ew heraie may avail. Bu eve i care a iue, uch ew heraie are
uually available uide he ighly
crlled ad legilaed evirme
a cliical rial.Becaue cliical rial are very clely
mired by regulary auhriie,
aie i cliical rial are al mreclely lked afer ha aie wihimilar cdii cliical rial.
I curie wih a develed medicalad cieiic culure, aie me-
ime ravel lg diace avail hem-elve he ew heraie ered bycliical rial, kwig ha uch rea-me may be heir ly he r recv-
ery. Very e, hey are reerred by
heir alruiic regular hyicia, whmay have bee he ir irm heir
aie ha a rial beig cduced a a
aricular iiui may beei hem.s i me circumace, i may be a bad idea be a guiea ig. Hmm...
I mea a mue.
OpiniOn 17JULAUG 2013 sInGApoRE HEALtH
prer pierce Chw i aseir Cula sigareGeeral Hial Dear-me Geeral surgery, adCure Direcr a he Duke-nUs Graduae Medical schl,sigare. He ha ublihedexeively hea-biliarycacer ad garieial
rmal umur, ad carried u bh re-cliical
ad cliical reearch brachyheray i heac-ellular carcima ad acreaic cacer. prerChw ha received w naial Medical ReearchCucil Reearch Fellwhi.
pHoto:ALECIAnEo
Doc, I dont want tobe a guinea pig!For patients who no longer respond to standard treatment,participating in a clinical trial ofers the possibility o a cure
he rial will be ed ad he beer
heray will be recmmeded. I a du-
ble-blid udy where eiher he dcr
r aie kw which w drug a
aie i allcaed , a ideede
Daa ad saey Mirig Cmmiee
decide i he udy huld be ed.the member he cmmiee have
direc cac wih he aie i herial bu have ull acce daa.
Cliical rial are gvered by ric
iclui ad exclui crieria ad ly
a very eciic gru aie i eligi-
ble r ay give cliical rial. A IRB, r
iace, will cider he cdii
he aie eligible r he rial wheciderig arval a cliical rial.
Uig cacer a a examle, i here
i adard heray available r heage ha eciic dieae, hi her-
ay mu be ued ir. oly whe he
adard heray i lger eecive,
r i he adard heray i ui-able r he aie, ca he aie beerlled i a cliical rial. sme hae
I rial erl bh aie a well ahealhy idividual wh are cme-aed r heir ar iciai.
phae I udie ca have diereaim, uch a iveigae wha de a ew drug are arriae r aie,
ad may al be diere rm laerhae cliical rial which iveigaehw eecive he ew drug are. phae
I rial are very imra, a wihu
hem, ew heraie will be ir-duced.
Benefits to patients
Cliical rial are ceraily imra rciey. Bu ca idividual aie bee-
i rm cliical rial?
Bh rgaiai eure hareearch ubjec are arriaely adwell ake care . Addiially, a IRB
guided by he ricile equiiewhe ciderig arval all cliical
rial huma ubjec, exce r well
r -ill aie i hae I udie.A ii cliical equi-
ie ccur whehere i geuie
uceraiy wihihe exer medicalcmmuiy eceari ly he
ar he idividual ivei-gar abu he reerred rea-me, accrdig a aer byBejami Freedma ublihed ihe new Eglad Jural Medi-cie i 1987. Wha hi mea i ha a
ha i i ime, he cieiic wrldde have ay deiie daa ha aye w r mre ible reame
i available i he m eicaciu
r he aie. A idividual dcr, he
CliniCal trials are
governed by striCt
nClusion and
exClusion Criteria and
only a very speCifiC
group of patients is
eligible for any given
CliniCal trial.
By Professor Pierce chow