DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA...

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DNA: Structure I • Chromosomes • Chromatin • Histones

Transcript of DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA...

Page 1: DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA replication machinery Figure 28.25 ... DNA: Structure Author: Western Oregon University

DNA: Structure I

• Chromosomes• Chromatin• Histones

Page 2: DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA replication machinery Figure 28.25 ... DNA: Structure Author: Western Oregon University

Chromosomes

Page 3: DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA replication machinery Figure 28.25 ... DNA: Structure Author: Western Oregon University

Eukaryotic Chromosomes

• DNA and HistoneProteins

• packaging of DNA • nucleosomes

Page 4: DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA replication machinery Figure 28.25 ... DNA: Structure Author: Western Oregon University

Chromatin Structure

Page 5: DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA replication machinery Figure 28.25 ... DNA: Structure Author: Western Oregon University

Histones

• Composed of proteins • rich in lysine and

arginine• conserved

Page 6: DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA replication machinery Figure 28.25 ... DNA: Structure Author: Western Oregon University

Structure of Nucleosomes

• H2a, H2b, H3, H4 octamer

• H1 linker

Page 7: DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA replication machinery Figure 28.25 ... DNA: Structure Author: Western Oregon University

Histone H1

Page 8: DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA replication machinery Figure 28.25 ... DNA: Structure Author: Western Oregon University

Replication of histones

Requires histone chaperone proteins

Page 9: DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA replication machinery Figure 28.25 ... DNA: Structure Author: Western Oregon University

DNA structure II

• DNA• Composition of DNA • Evidence for genetic material • Structure • Implications of the structure

Page 10: DNA: Structure I - WOU Homepageguralnl/311DNAIhist.pdf · Pearson Benjamin Cummings. ... DNA replication machinery Figure 28.25 ... DNA: Structure Author: Western Oregon University

DNA & Nucleotides


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S Phase: DNA Synthesis. Every cell has Specific DNA Nucleus contains DNA Nucleus contains DNA –Each cell in one body has identical DNA DNA DNA –Set number.

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CHAPTER 25 DNA Metabolism DNA replication DNA repair DNA recombination Key topics:

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Mendelian Genetics - WOU Homepageguralnl/311Mendelian Genetics.pdf · Mendelian Genetics • Mendel & the Quantitative approach • Monohybrid Cross--Law of Segregation • Dihybrid

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