Dna Replication Notes
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Transcript of Dna Replication Notes
DNA Replication
DNA and ChromosomesoDNA is tightly packedoA human cell contains more than 1 meter of DNA
oHow does it fit in the nucleus and form a chromosome?oHistones are proteins that DNA twists around
oDNA and protein pack together to form a substance called chromatin
DNA ReplicationoMaking a copy of the genetic instructions of the cell
oBase pairing provides all the information needed to replicate DNAoEach strand is said to be “complementary”
Chromosome –Tightly packed DNA and proteins
DNA Polymerase – building and proofreading enzyme
DNA Polymerase – buildingand proofreading enzyme
Replication ForkY-shaped region where original strand unwinds
Free nucleotides
Leading Strand
Lagging Strand
Helicase – untwists and separates the strandOriginal DNAActs as a template
Original DNAActs as a template
Strand DifferencesLeading Strand◦ Builds DNA toward the replication fork
Lagging Strand◦ Fills in with Okazaki fragments away from the replication fork
◦ Ligase with help glue together
DNA Mutation