DNA Double stranded Complimentary Composed of Nucleotides.
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Transcript of DNA Double stranded Complimentary Composed of Nucleotides.
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Protein Synthesis
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DNADouble strandedComplimentaryComposed of
Nucleotides
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DNA replicationDNA Helicase – breaks
hydrogen bonds holding complimentary strands together
Forms replication fork Leading strandLagging strand
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DNA ReplicationDNA is read 5’ to 3’
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Leading Stand
Helicase -> RNA pimase -> DNA polymerase
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Lagging Stands
Helicase -> RNA primase -> DNA polymerase -> okazaki fragments -> DNA polymerase cleans up RNA primase strand -> DNA ligase
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MovieReplication
http://highered.mcgraw-hill.com/sites/0072943696/student_view0/chapter3/animation__dna_replication__quiz_1_.html
http://www.hhmi.org/biointeractive/dna-replication-advanced-detail
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Protein Synthesis 2 parts
Transcription To copy segment of
DNATranslation
To translate the language of nitrogenous bases into amino acids
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RNA vs. DNADifference between mRNA and DNA
Single stranded vs. Double stranded The sugar has an extra oxygen, ribose vs.
deoxyribose Uses uricil “U” instead of thymine
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TranscriptionProduction of mRNA
RNA primase binds to DNA at a promoter region
RNA polymerase adds bases copying the gene
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MovieTranscription
http://www.dnalc.org/resources/3d/13-transcription-advanced.html
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PackagedmRNA is processed to leave the nucleus
Extras are cut out Splicosomes
Introns Exons
Poly-A tail 5’ cap
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TranslationmRNA has left the nucleus.Binds with ribosomemRNA -> tRNA -> amino acids -> folded
proteins
What’s the Problem?mRNA
UGGCUUGCAUGCCGGAGUCCACGUAAUCA
Into Amino acids
AUCG
Amino Acids
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TranslationtRNA consists of a
Anticodon – 3 bases that match codonAmino acid
Codon – 3 base sequence on mRNA
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TranslationmRNA -> tRNA -> amino acids -> proteins
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TranslationmRNA
UGGCUUGCAUGCCGGAGUCCACGUAAUCA
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MovieTranslation
http://www.hhmi.org/biointeractive/translation-basic-detail