Confidential Overview for

LifeSpan International, Inc.

“DNA and Anti-Aging Managementthrough Nature and Science”

The information contained herein is furnished on a confidential basis to a limited number of sophisticated individuals for the purpose of providing certain information about LifeSpan International.

Innovator in the field of advanced proprietary DNA sciences and marketers of natural anti-aging solutions derived from patented extracts and processes

AC-11® is a patented product designed to manage the effects of aging and cell damage by supporting the body's natural ability to repair and maintain its DNA. AC-11® is an extract from the bark of a specific Uncaria, a plant indigenous to the Amazon rainforest.

Optigenex Inc. has developed a patented and proprietary process for isolating the plant's active compound, which is then converted into a water-soluble material that can remain in suspension or can be consumed in tablet or powder form as well as topically for cosmeceuticals, sun care, nutritional beverages and pet products.

AC-11® has been shown to block the body's NF-kB pathway, the primary pathway for autoimmune diseases such as inflammatory bowel disease, arthritis, certain types of insulin dependency, lupus and other conditions – it’s a catalyst that sets DNA Repair in motion.

• Patented extract from the bark of a specific Uncaria vine

• Patented extraction method that isolates the potent Carboxy Alkyl Esters which comprise the active ingredients in the bark

• No high molecular weight alkaloids associated with adverse reactions

• Sustainable Growth Project which is controlled by the Brazilian Environmental Institute (IBAMA)

• Work projects are conducted under the Floravida Institutes guidance

• Patented natural DNA repair product

• Anti-inflammatory

• Boosts immune system function

• Highly water-soluble standardized product

• Protected, proprietary process eliminates 7 crude extracts known to cause side effects

• Validated in pre-clinical and clinical studies and published peer-reviewed articles

• Outstanding safety profile

• Measurable clinical endpoints

• Stability data > 5 years

• LD50 > 8000 mg/kg– Our current recommended oral dosage is 350mg per day– Topical study doses range from 0.5% to 5.0% in solution

• No known toxicity

• Stability in activity & color as an ingredient in cosmetics

• Passes cosmetic micro-efficacy studies under USP challenge test method

• DSHEA registered

• Prop 65 Compliant

• Production relationship with Centroflora Group, Brazil's premier natural ingredient producer

• State-of-the-art plant housing Optigenex-owned specialized AC-11® manufacturing equipment

• Patented Extraction Process U.S. Patent No. 6,039,949

• Certified ISO 9002

AC-11® was developed and rigorously tested to ensure quality and effectiveness• Comparison of a broad spectrum anti-aging nutritional supplement with and without the

addition of a DNA repair enhancing AC-11® extract• DNA repair enhancement of aqueous extracts of specific Uncaria in a human volunteer

study• Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae)• Uncaria tomentosa inhibits TNFα production and scavenges free radicals: role in

cytoprotection • Anti-inflammatory actions of specific Uncaria: the role of NF-κB • DNA repair enhancement of aqueous extracts of specific Uncaria in a human volunteer

study• Enhanced DNA repair, immune function and reduced toxicity of AC-11®, a novel aqueous

extract from specific Uncaria

Clinical studies abstracts available @www.AC-11.com

Rainforest plants are responsible for 25%of the drugs used by Western medicine. 70% of the plants identified as having anti-cancer characteristics by the US National Cancer Institute are found only in the tropical rainforest. Well over 100 corporations and U.S. government agencies are studying rainforest plants for their medicinal capacities. However, the process of bringing a rainforest drug, or any pharmaceutical product, to market is long and costly.

• AC-11® Bulk• Cosmeceuticals• Hair Care (In Development)• Supplements• Powders (near future)

• Sun Care launch scheduled for Spring of 2008 – Sun Care market valued at $1 billion– Will highlight AC-11® reversing effect on sun-

damaged skin and a natural sunscreen.

• $35 billion market, luxury brands growing 20+% annually– Anti-aging and cleansers

show strongest growth – Simplicity of regimen,

branding, and ingredients influence consumer use

– Product efficacy and careful luxury distribution placement is key

Anti-Aging Science

• Supplements• Sun Care- Anti-Aging• Cosmeceutical Skin Car

• Cosmeceuticals are the fastest growing sector of the cosmetic industry. Their use has dramatically risen In recent years.

• The use of natural and especially botanical products is increasingly preferred by consumers

• The largest area of the Cosmeceutical market is skin care (60%) with special emphasis on the category of sun care and anti-aging.

Explosive Growth

30

35

40

45

50

55

60

2005 2006 2007

Year

USD

Billions

Figure 1. Source: Medical Insight Global Aesthetic Market Study, 2004.

*All information on this page taken from data according to “Household and Personal Care TODAY”

Prof. Products(7% )

Hair Care(15% )

OtherProducts(18% )Skin Care(60% )

Figure 2. Cosmeceutical product demand. The figure was reproduced from: http://www.in-cosmetics.com/files/incos05_Phytopharm.pdf

0100200300400500600700800900

1950 2000 2025

Anti-Aging Product Growth • U.S. Europe, Japan and Australia represent the largest markets

• From 2002-2006, annual growth rates averaged 20% per year

• Expected to continue to grow at approximately 24.3 % per year through 2007

DRIVING FACTORS

• Growing interest in anti-aging products (e.g. Propecia, Botox, etc.) by aging population

• Younger generation is keenly aware of aging signs and are interested in preventing aging process

• AC-11® DNA Repair Proprietary world wide potential market.

*Source: Medical Insight Global Aesthetic Market Study, 2004.

World population over 60 (million)Figure 3. Anti-aging product growth. The figure was reproduced from: http://www.in-cosmetics.com/files/incos05_Phytopharm.pdf

• The world Cosmeceutical market is growing faster than any other cosmetic sectors. The world Cosmeceutical market today is about US$35 billion in sales.

• The largest markets for cosmeceuticals worldwide is the U.S. and Europe.• LifeSpan distribution in all categories is targeted for the U.S. and International

distribution.• LifeSpan has worldwide connections to partner with the top distributors in the

world for each country as well as duty-free.

• The LifeSpan Anti-Aging Science with AC-11® contains some of the most effective anti-aging and potent anti-oxidant ingredients, which have been shown to reduce fine lines by 30%, and wrinkles by 60%, a new generation of cosmeceuticals.

• LifeSpan is the only Network Marketing Company in the world with AC-11® working at the source of aging itself.

Before | After

• AC-11• Pentavitin• Pepha-tight• MDI Complex• Matrixyl 3000• Sepilift DPHP

• Scientifically proven to reverse the effects of sun damage.Before & After Ultra Violet Imaging

• $2.4 billion Oral Supplement market• Targeted consumers

– 50+ consumers from upper incomes who attended college – Healthy lifestyle (healthy diet, non-smoker, normal weight, physically

active)– Many health professionals

Source: 2004 Nutrition Business Journal (NBJ)

• A $25 billion market

• Aging boomers focus on health, quality of life and wellness

• Increased emphasis on disease prevention

• Complimentary and alternative treatments on the rise

• Growth in specialty supplements

“. . . the accumulation of random damage to the building blocks of life - especially to DNA, certain proteins, carbohydrates and lipids (fats) – that begins early in life and eventually exceeds the body’s self repair capabilities”

Leonard Hayflick, PhD., UCSFS. Jay Olshanky, PhD., UICBruce Carnes, PhD., UIC

Scientific American, June 2002; 286(6):92-95

Mutations

Replication errors

Persistent DNA damage

Genomic instability

DNA DAMAGE

REPLICATION

AGING

CANCER

National Institute of Health

Oxidative Stress

Damage to DNA (nucleus & mitochondria)

Poor DNA Repair

Aging and Aging Conditions

YOUR ENVIRONMENT

(Poor diet, stress, pollution, smoking, exercise, sun exposure generate free radicals)

OXIDATIVE STRESS

GOOD GENE REPAIR

equals Antiaging

GENE DAMAGE

equals Aging

ALTERED GENE EXPRESSION

Hobbled Proteins

(Glycation)

Wrong soup mix

(Mitochonria function)

Misfiring genetic switches

(Methylation and acetylation)

Immune glitches

(Inflammation)

Faulty cell communication

(Hormone imbalance)

DNA DAMAGEDNA DAMAGE

Mutagenic Diseases

e.g. CancerMutagenic Diseases

e.g. Cancer

Chronic Disease

e.g. InflammationChronic Disease

e.g. Inflammation

Two possible health consequences

The major cause of human disease has been identified as DNA damage by reactive oxygen species. This has been reviewed as a contributing factor for the origin and progression of a number of conditions including aging, autoimmunity, HIV infection and cancer.

STEP 1. DNA damage detected. Enzymes uncoil and unzip DNA. (NFk-B inhibition works here also by stopping free radicals that damage DNA)

STEP 2. Uncoiled structure gives access to repair enzymes.

STEP 3. Damaged or misplaced nucleotides are cut out by DNA repair enzymes. (Active genes are repaired first, then less active genes)

STEP 4. New segments are moved into place and the seams are sealed by other enzymes.

#4

#2#3

#1

DNA repair of damageDNA repair of damage

No diseaseNo diseaseMutagenic and toxic disease

Mutagenic and toxic disease

Incomplete Complete

Gene Deficiency

Biochemical Inhibition

AC-11 Present

Natural DNA Repair

AC-11 Absent

Natural DNA Repair

• Articles by Dr. Noah Scheinfeld, Optigenex Chief Medical Consultant

Botanical extract protects against UV

Study results intriguing, researchers look to further applications Jul 1, 2006

Journal of Drugs in Dermatology

AC-11 and Dimercine Two DNA Enhancers

February 2006 • Volume 5 • Issue 2

Skin and Aging

DNA Repair Adjuvants

February 2006

Patents Include:• U.S. patent no. 6,039,949

“Method of Preparation and Composition of a Water Soluble Extract of the Plant Species Uncaria”. This patent is directed to a method for preparing the extract and for its administration generally.

• U.S. patent no. 6,238,675 B1“Method of Preparation and Composition of a Water Soluble Extract of the Plant Species Uncaria for Enhancing Immune, Anti-inflammatory and Anti-tumor Processes of Warm Blooded Animals”. This patent is directed to composition of the extract described in the ‘949 patent and its pharmaceutical use for the enhancement of the immune, anti-inflammatory, anti-tumor processes.

• U.S. patent no. 6,361,805 B2 “Method of Preparation and Composition of a Water Soluble Extract of the Plant Species Uncaria for Enhancing Immune, Anti-inflammatory and Anti-tumor and DNA Repair Processes of Warm Blooded Animals”. This patent extends coverage to DNA repair.

• U.S. patent no. 6,974,784 B2“Method of Preparation and Composition of a Water Soluble Extract of the Bioactive Component of the Plant Species Uncaria for Enhancing Immune, Anti-inflammatory and Anti-tumor and DNA Repair Processes of Warm Blooded Animals”. The patent is directed to administer the isolated purified active ingredient of the composition claimed in the ‘675 patent, quinic acid alkyl ester.

Pending Applications: • 20060068035

“Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals.

• 20050176825“Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals

• 20030170320“Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals.

Foreign Patents: • PCT Application WO 2003/074062

“Isolation, Purification and Structural Identification of a Bioactive Component of a Water Soluble Extract of a Botanical Species for Enhancing Immune, Anti-inflammatory, Anti-Tumor and DNA Repair Processes of Warm Blooded Animals”. This application covers the water soluble extract.

• Nick Mangeris (C.E.O., Sales & Marketing Director)• Darrel Davis, B.A. (Executive V.P.)• George Berry (C.O.O. & Bio-Chemist)• Kim Hubartt (Manager, IT & Customer Support)• Bruce Wood (Vice President, Sales & Marketing)• Dr. Neil Solomon, M.D., Ph.D. (Medical Advisor & Science Director)• Anthony Worth, B.S., C.N., IAACN (Technical Director & Scientific Advisor)• Serdar Abaci (Webmaster)

LifeSpan International“Anti-Aging Management

through Science™”17 Timberland Pass Bedford, IN 47421812-279-5433(LIFE)

www.lifespaninternational.com