6- 5 lifiifiwilltififiilli

¥l5§'l¥lZlia§T%>5l5'§'l$(D miiiilfi‘Wilt® QM;

_ I — G) :11 t~1'§§7§a)§sl:ifi ®

{am/m;raa1rz>4:*n'; @ gi, kg 5, ii?%fifiK%T%%fi ¢>=>a1-aafioma

tfillkifllliiilififiafiawnm €fificmT&%fi

<3§@<Dfi¥flfi,fi§fifi® *1 */7°11/i téitfii

5*@§ @§mn@w¢a:-x@am-anfiaa

W%"Ei§ Y <Dfiifi%$M€tfiii68= <3§m

”$“3"m _' oEmn,mzfi@®%m@Wfi%%m%fififi)NO omamg

No H5“* Y% ogfiazomn®fi$E$-Eififi<3awwnn.@@%mazfim@%E%EE

X ‘/5'?"/Z

ifiiiii.-’,<“iP\|l'1I'1;"l2i’i’i§?li'l,’l‘fi§‘li'.i<‘: L'Ci@J51‘?.l'$_'i3%E L722?) E *6. l§l’%‘l“'1€E’$:i§J5FlTZ.> ?§t7f>\“C‘F'»=E.l%E.'I'~i

75‘17>\“D7J*o7:i%’ET, ifs, ¥li7’;lZ|E$?]§€Z=flfclflflilii&'lifiE£l3$5?7§§'lZ~%i£i%éTi.¢ Eli. E5Zb?)'Cl§§E

fiK%¢a%%%%M¢&.zcc.%@rEfifim%ami&%EWLrLi5&.%@&@El '§'l‘fi§0)i¢7§>'G <‘:“/Mic lZ9F§l"°§Z%"i¥%5'§ill£ L933? LT %>. l§¥E‘li0)'|%]\/\7f"9€§fi‘~i*:|‘%’5:?¥'%Z.> Z 9; lif‘

%&~\l§§E’f$lll3§3'Z>5l§'l€E0)§¥lfllili, ifilflliri-1i¥lllfifi'liE'i°$l|lElliiEo 'C%7i1‘1ZTZ>'lZ~§7J“35 V), *0)

CLSI (Clinical and Laboratory Standards Institute I llfilfii NCCLS) “C‘l:l:, §“Fillli7:7‘li2lll3§TE> 71“

4 F54 ‘/7§fii%U_<l,'Cb*5 (i€6—7).

2P*§§?é(D?HW‘iHll$§f~‘Ei5'E0)lJi‘I3>O%0)$2'§':l%'“§, Tit7l9*fil‘§?I*T‘§li. lfifii ' £1? ' ‘lH|lE‘l£' H5?! ' §i5l‘»’li%l§ic E

’$:lfi¥kTZ>¥5fi§’Fl'$ilC%’5€<. TEIWQEL7:§i5FJr0)li?§lHUillE’i’H3]!/"C§13lllfiTZ>. C7l’LF>li.

l‘9€§$' H5? ' $1??? <‘;°0)%i‘l5’Z'~'i'Ell L, §§H?FPa'ill‘iEllriil€*if~§é VJ iZL7;i%’E1‘0)lfiE?'£§£5.'l‘i ii

7‘.:lil#fi*§(§)l’€ (repeatability)]. l5]*7|‘fi§;‘-%~'-JC“_l:?i‘i'.%l“l10)~%|3i>“§i7l¢Z.>El7€|'=F'FaEl5|‘§(5§)f=‘%

(within-laboratory precision), 5':-Z1‘Z>l‘fi§§F’n‘ill;,*5l)‘Z>§FE-Elfiifilfi(%)E (reproducibility) E263-00610

$6??? #|‘il§€’£‘?1¥. T HI. ;Fi'lEiiE0)1§9FE’|€£§1lil‘fil'\(\

i€6-7 CLSI (Z81%:iElE$£0Jl§fi1&*lCBE?'€>4?rli*L0)§¥fflfiiz"i7Ii4 F54?EfiEfl$¥$Nfi1€E0)$§§E0)§¥lfi$z*E EP5-A2—Evaluation of Precision Performance of Clinical

Chemistry Devices I Approved Guideline - Second Edition (2004)5flllE5£0JlE$5'li0J§iFfili$£ EP6-A—Evaluation of the Linearity of Quantitative Measurement

Procedures I A Statistical Approach I Approved Guideline (2003)!lfi%#%E(7J§5§lCE5'§‘?a§il?§§£ EP7-A—lnterference Testing in Clinical Chemistry I Approved

Guideline (2002)§%?£#5l’&l3iL\f:ifl|l1€$£li's‘30)1J‘T:JI'J 0J§¥fi1fi5£ EP9-A2 Method Comparison and Bias Estimation Using Patient

Samples I Approved Guideline - Second Edition (2002)E§l‘i§iz"i0)iifiE0)§fiB’\J§5Ffilfi EP10-A2—Preliminary Evaluation of Quantitative Clinical

Laboratory Methods I Approved Guideline - Second Edition (2002)Eil§§52’§0J'lfi*Lfi€0)1—*7‘§¥filli$lllE EP12-A—User Protocol for Evaluation of Qualitative Test

Performance I Approved Guideline (2002)7 l" U “J 7Z9JJ¥0J§¥ffifii£ EP14-A2—Evaluation of Matrix Effects I Approved Guideline -

Second Edition (2004)l%§E.\'tIE6E?_\'0)1--'U’1€EfiE‘l§§iE ~ EP15-A—User Demonstration of Performance for Precision and

Accuracy I Approved Guideline (2001)l‘§Hil3R5tEi|!E5?(7)§¥iilli§5lll§ EP17-A—Protocols for Determination of Limits of Detection and

Limits of Quantitation I Approved Guideline (2004)

Eufiweneumzsmm.fifi%@@E&iefififiwwfiufifififiofifica9.W%li%/J‘, i§%li%7€0)Z'§§iJ€'fi<T. C0)5‘l5, @%l3l3l“!i§'C‘%|55-§‘?lZFwE.l%E&Z£Z>i5UillE0)i;E‘¢>9€

U,§@fifi%@@E,£lW§Wfi%§&LTfifi%fi®1%(fi€HW)€$fi&LtHW

%§§(Mmmmm(®fiimmmMm)kE@%§§(MmwamMflmm@Mm)T%é.

llifififififitfifififi)Wefififi[UBZMm:w%fi&&UmE%%o%%é(E§&d%E)u%wlo%%@

ifiurnwmfifiaaobnaiu.n—@§§cae-%fi-am%aaom%%w&—iKL,fi%%t@®—ELtfifl%fi9fiLW%Lt&éwmfifiowefiecib.fi%E@#%%wawm%&%u£w&fi%éc%e

n@®&DfiLWE@%~@x%";%£T5k,fifi%§M%fl%mE@®%$@%(fl»@%fi%fi(CWw"c%éne.czc.fi9fiLw%®@fiu,%fifi®%w%%fi%fiiTétbx;2M@UL#%iLw(B$%$%$fi§&W%1%%W$m§u£H&%§&§®%%2* - flZ%§?l"lilli‘i£¥‘ET$l‘—E5l§Tl'i7i. 1999 1 V) ).mfieeu,amou%%e#~etrwaaaa,ameaeuw%¢a.nfit.eee

&wiEsfi9fiLmE%#u,fi¥@%fi§Eo&%&E.MfiHu;@f%&&9&§%mT5.Ltfiof,%%H®1@®fiUfiLME%%#%BW%%E%ib&lU.&KfiTB%-HW%%§%@fiufii¢a%%u%@tu6#,¥w%c%iLt%%§#%ena

[2]H%fi§E-HWfi%§&§Wfi%§B%~HW%%Eu,@®—ELtfifluowf,§B—iLtfi®fi9fiLw%%EBfi@

fiefi titifififl ~— lll. iB'lEi£0)(§§E'l$§¥lfi

i6-8 §I2%E(Dy —GT5Eii (U/I) 0J1 El2|§.| 20 E|F5UJ5E'lE@iElEB12 3 4 5 6 7 8 91011121314151617181920llfilfi 47 51 53 46 47 49 48 54 49 51 48 49 50 49 50 53 54 50 49 482l§l§ 47 48 53 47 48 50 50 52 49 53 47 51 47 50 53 54 55 50 49 50

2 2 X,-,2= 1o0,o22.o, 2 2 X,-,~ = 1,998.0, 2 7', . *= 199,99o.o, E = 49.95

rttZ4i was %EHfi®1B2@20B§®flEEw7Dwb ;

1 v7

60

;s..._t,,_,2.WWMM,MwW.M.“/.9W,.W,..MMWWi~i_...w._M,MM..,,.,.~. ~.,.v,,.tM,~W.e..,~,,iM_,,,.tWW.,.M,*,_2,,-M.MM.M.M 2 2. §~W\\'N V A1rv»~~£~rlIl~l:~r\v\r~%4<Q¢¢\‘<r~0I4P\AF¢l@»\€/Vk~44'lé‘Ol'll'IF"l4P'

5

i

i 55 . ' . .::1 fill

E 50 1iii

OIO

I OI

OIID

I

O

O

OI

II

OI

OIO O

OOO

Zt s%i045

40 I I I l K

0 5 10 15 20 itaut El

5.. W M #~\'O/v~yfl/Vr"lnI'v<‘VV'vV\wv&v'4h€\~4/‘/~J\4~n *4¢4A~4*4*4~4~"44r .2 M )4 , ,. ..._\. 2., ,._ 'v\l;~4V'"<"(~"%*¢\~V* . Lt, .. . 1, Y\4~ W,.W2

L.%new%@#efi%§%%%Te.¥—2uB%ofi§%EtW%u,@o~%Lt7—)1/JI[l‘Z§i: <‘:°®%¥§¥1l7.l§’$:’li1'El n 2|-Y k El F5, .%~%l‘filZl-M‘: lfillfilliflllfib, iB|lEllE%i€6—8 0)Ji 5 l:i t 4155. 6-6 lC7T<T‘lB.ll’i€llE0)7°U v l\ [YUP 6, El l7~]@%§JJ<‘:li‘i1'|JlC El FH'i0)§§}J7J*§.??~<Y5 611

Z9 r‘: 3 ii, El F5 ' El l7~]0)W’¢7’Z§}JiJ§fi?l‘li'C“% Z>—7BEE|§®6}§i$Hfii£ (W p.108) ’$:5fiFFl'9"Z>.

(E15, Yfifiic El PHElE§JJ0)7il?7Lt?’<‘7:?»??_b?>7§¢v\k é ii, é‘7"‘— 5' ’i*~¥fi L“Ci=‘§'*l51l1Z.>§‘1fl7I: SD ’$:%0)ifl'l%‘(2E0)i%’£’%-‘E<‘:1'f’LlfJiv\.

$6-8 ®i%{?\ §}§5lfi‘1fi®i%§'§li?k®JZ '3 lift (J, El Wfifiillfihfififi El F'a'1%§JJ7f>‘€’.§’~<)?> I5ha.

2&9) =ZZ(x,-,~—:7)2 = 221.9, eisls1E=fT= 39Eiraweii = n 20?, - W =194.9, eizlsifi :/A =19, $fi§3‘%itr VA =10.26Eiméiii = 22(2) - x,)* = 27.0, EH3)? 1fE = 20, T\fi§5*%5t= VE =1.35

F0 = VA/I/E = 7.6 2/fi920(0.01>= 2.94(#251,, E,-liiflllzillfix,-,-0>El/W)¥1°@ll'E, §i1t4*.¥1alra>

J;§B%%§'EJC V), EFi=='1iF§(%"‘)l“>‘{&: ElP‘li%(¥‘)F§0)l‘i'r‘%i€fi%tZ‘2§iii,%fi'C“2F>Z> SDA, SDE IBJZ U‘ct/A. ct/E eawa.

BF-§1i%%%=& 150,,= = 2.1, ct/A = 100 >< 50,,/E = 4.2 (%)amleae 150E =(//Z =1.2, ct/E =100 >< SDE/F? = 2.3 (%)

111% Ji V), Z@)"’é‘¥E§f’\.il‘Jrllil'il/‘ii%l§<"‘<@)’l‘i1Z|-<’i’Z’§)Z> EH11 lfilifillibfn‘; €<0)iF§%l§, '§"ii:2‘9’6.

,§%l’fi1Zl§‘l§|li@0)5l‘§%‘l‘:;§’<i_’%”'.':.r€l]5l5TZ>§|7€*§l§_7§§UW)J1 5 lCi§'rf51l’LZ.>.$Vqil%)%Z1SD5= = 2.4. ct/5 =100 >< $03/it = 4.8 (%)

C.0)l?fl0)i%%, Ell7\]§%'"“=%i:§@‘l/C BFa“J§1='1%;7§‘7<%i <, ‘iRlJ%‘Ziii0)i|‘§’1Y€‘l§'_'Z%l’I1TlJ:é'=-ti'/'ii~i llli, Ell“-5263-00610

¥EH

$65 fififiilfl T lll. $5llEi£0)l§§E'l$§5Plflfi

§¥é%ll§@"*9“Z>il¢%“€7b*‘E%“C%%> : 2 6=‘1o91~z>. 2 1;, H1t~r;%it19roi%l%11§§_ei(Pii*6i1i£ro>tacat>1111“. lfiill-<l7\1i1El3‘J%’é§iJ0)il5§3‘0)7<%§ 2 20:9 L. $91‘; 9/J\2<l1‘11l;t‘@£2H(J§§)1l:§d<§1=’§%&=‘1%i4E§§liiFEE L'Cv>Z9 2 $llltfli<l"Z> (W p.73). f; ff L. FP‘l$li'§li7;i'?°1i11‘Z%§9iZ; 2“iEili4<V9%Eii7fi1c 3w&%uowru%fLs:o%ifi#fi%c2&w

GB,H%'HW@fi%EM,}RrR%EE#6$%$K%E?%5(WpWl2 1;, %1>i‘%tfi§r~Fl1v~ l51’LZ>‘iE|l’iE‘i£li, 111212219242 2262622 é 1921242 : 2 11%

<. \»<“>%1>®i%l§ (l1iE- PP -?P1i%l’%:v>3t§fit%JE) lli1‘L'C0)t'§?%%"l%%flW>“Ca‘a <.

[3]%EKfi?&fi%E7n7v4w(mm2PW5§1%'ot§2'€-5 0)§§Fiilfili, 11%)’:-‘ii f;1i£ici%Eo’-'e’=1E%i¥t19=214“slJ5l>i Liflli L. El 11116224» El 11:1

%%E%SD¢CVc§fiT&:2#%w.L#L,%<®w%&®wEfi%m%E@L5u%1~1<2<:.¢2>; 2%fii11I511'Ca‘s l), iHIl2’€i£®§%‘=?__'.%%¥ifili, 1i%§l:;1‘6l)Z>l%lifi1§4JZi¢ 60>; (J Zbifllli%§fi£%K0wffi5:2N%iLw.:flK%LfMA®fififu,WHO®7§%4A / 7 ‘Y “E4 %$1lf. ' i%§"§¥§§§/i"(“i/%l"5E'=7l1.'C\/\Z> response error relationship (RER) '1’

precision profile (PP) ’%2l$iv>f;%l1iil1ii£f1“zF)Z>. 7|-VH1, ‘iF.|l$§'t?.lfi0)é5‘ifilZYl97:o'Ci%’£§‘F§'§ii§§1Z

10162. §5‘1‘JT‘l£lZJ:Z>|EEl%0)§fi<5&1lE (#19 > l~iFj’t°l$ifi'él’§‘Zt; 2*) 2~iRIl%ir.é (1%):-*2) <DFfi%'C“iHllEL'Cu\é,'.‘-i'C‘€J5l5l 72751122: 07; z>. L75‘ L, $1211? 9 2 4 Wfiiboatinatica 9,

79~1:1F=“l (H115) £91116‘: 1l’L'Cv\>Zcv\,E‘—il:‘i£%‘J‘E>'1Z~%7f>“zlbZ>.RER 11, RIA ll:§5v>“C5l%%l1’l‘filYl-<7§“Zi‘iflllEé 112,, 1 2 2111141 L, ifllfiiwiiazoéfialiaoie

%§=5:PFiilli1“%>. %tfi(4<®:§iHll%(iIei®%,%¥»iiEy,~1 2y,20>2.% R}/1' (= l 9,1 — y,-2 I >, i7;lil‘%$fifi Spy, (= Ry,'/1.128) 2112141111, 9,-1 2 y,-9 0914116 5, 721691111: 2 O 17°11 9 r L, 522121122:§%®%fifi%§T.—%K1#%@K&5KOflTRW§%fi?6fiW%%L,C®%%K9)/"Cl/‘ < ’37§‘0)‘E'7“‘)l/7)“T%l11'§'1E‘1’l-“Cl/W07)“, §9ii.J9~1l_§y r‘: %0)§l=‘1§’_-'§§§‘%ilay2 0)F'H'1ll, fllfiit 0' Y

= ao + a1y’?Z7§Ki§ay = a0 + aly + azyz ’Z:?'§$Lil&1§9'%> C k75§’;»¢'2b\. 7;7’fL. ayli1El0)'7’~—

96262 1 9, ifiIEi11>0>9‘~*— 5' 27°-1» L'C?’EE9‘éli 5 11*‘; y=.it, PP 11 RER 2 91%611z>%%29i"i§y,-v>§P=%v>t%i€fi%>2)tlwc, 11121252911211:

11>iHl%iiEXo§%%>2PFtfli<r6fii£c&>&. 12196. 1%)?“ l:1sl1z>iEIl%§¥‘=%-.62 6-X &9"1l’Ll;f,l“£§1'f9§V)ll=E%7.J§ slope = dy/a'X'C‘§)Z> C. k €'ifiv\, ax = ay/(dy/a'X) k3i?<Y5f57l”LZ>.

tfiL,mAPmA®%fi2Lti$ifi%fi##fi%c%9.fi%fi#E%@%%2m/<<lr&@1>=‘t§%E2 i,¢Z.>. %:c, PP o>i%/-:?=t>:iiflIl%i1'a 2,-1 2 x,-2 0% RX, 11> 616626124262512,), if;1;t2*2§iJi9T<§ic ct/X, (= 100 >< SDX,-/E,-, %) 2101611, $211162, >2i%$il11:2/)r7"1:1 9t L, 11121162a%2a>r961%22P9“a6411:¢ti11141P21t1r>/4, : 2 t>fi1o11.z>.

6-711,111116 CEA 0) EIA i£l::<st»f, Eiatfiizl-<r<%:iiHl'iLf; 2 3 0) RER 2 PP <~zl6/6.2*; ff L. RER K’ PP “(~16 F9 115 SDY, SDX, CI/X 6: 2*i;t§Eé%%E§2§r0>3?i§7E14Jt:7< %~ "5 22?? *6

@629,%%uu%ofi%2a6%e#a6:2226221526300610

fififi l‘1‘?§§i‘!i T lll. iE'lEi2=t0)i§§E‘|i{E11iilli

6-7CEAO) EIA lC.3“$l7‘Z> RER <‘: PP

li mm IE. ° (SD), (W)

0.10 — (n=30) 10

i 0.08 - — 4§ O‘ CV,‘ Q_Q6 - R=0.00413+0.0477y.~

'2 .. 6*) 5 'U:0.04 — ' — 2

1t

0' 0002-°,-. °° ' 30*

. Q

O O0 $39.‘ .'. | 1 O 1 1 l O

' 0 05 to (00) 20 40 60Y1 CEA (ng/ml)

i,“,,,,,2.,,,.W,,.W,,..,,,.,,,.,,MWu,,,...,.2~.,.,.,l..,.... I ~ W 4 ~~

3- El’§0)§¥fflfiM%%%®E§%%%T5Kd,Lfi®%$W%fiW&tE%fi®%%%E%%%W,ifi%

$#8EL<EfiE%éfltfi§%%$%EKlUfiEKfiE%%%T%l&#i%T%é.%éMi%%%wfMEfi%%%%K%étbKU,WMEEE#%%fi%K%E%T,3%

$®%F%E®%%%%Hf.®%$%€t%¢&?flifi%K%T%E$#@fiK£fiL.Wfifi%KdWifi%®%%E#@8h5,&E®%fififiEéh&Hhfi&%&w.L#L,m‘lfiic t“0)$lZl<I%?\.“5l‘%Lli—ii*£lIi*E’E1‘§fi5265‘7'-f='C“$) V). ‘iHll’zE§Fl%<‘: <‘: ¥> (1%? < 0)? l\ ‘J 9 7 X)i3Z55‘7b‘"éi§i&%Ec&&L<e9.%n6#m%@oE§m¢&#6m%%2%i2;2#%a.%CT.W%E®EE%%%TéKm,%$%E®Wi.Efififi%,%M@Wfi%,%Efi.%

%(T%)%E®%%fi%.%$t&5NEEt®kfifi%&E%<wfififififiéhé.

[1]%$%E®M£%$%EuM%&o&E@%mum<W%en,%fiow%&u%o@2&%T2.%nufi

Lmemefiwau,%e¥%#&a16e%@ue>zPafiucfieeeraafieaaLtfiar.mim%$%Eufa6%%owE&@%fi%Eu@afi6¢a:5&%m@%e629.E§2%%¢etwo%¢%H2Lrfi%¢6%uu&fi2%T6

&m%#~&¢2:2#%%ént%fi%$%H2%wrm%&@EE%¥m¢2um.mo25229205.1226.%m@fi22aami&c%&%$%E2&40@fi9fiLm%L,%nem%@#e¥w@2¥%@o9&%%fiZ%%iwe(wpmn.%Lf,%entEfiB%o&#u%fifi#€inn@,%o%§uxH&EEufiEénrw62%%¢a.2fiL.MiEKmH%%fi#%5t@,fi9fiLMEmB%%if%fi¢&:2fi%iLw

efioiaa3m$u2o%$%E#%6na%em,%%@2mi@@%%2@%fifiu;@<%fiL.mM%fi%%.~%%fi§%.:tE%fi@%n%n#%mcaa.

263 00610

$65 fifififll —* lll. iEllEi£0)i§§E‘|'£§¥ffifi

[2J7§v7mefia@e2me1ame&o%a@eam14em.mefi%un@%u22a%@2m

E¢2tp7§>2(§m>2mw2.fi¥79>22&w29>2uk%én,znaefiiKfib&w&%fi@K#tlU#$Dé.t2Z@,tU7UkUFME&T7Ukn—»$%£@@I@W$@fi%7V%U*W@%§€§Wétb,WW77V7%£6%§#%ofi

:2,2922690.new22e:4wamaa620.mefi@2ne§e¢%e2L<.%2wmfifl%fi&2umwena.29>2fiflm,v199222Lf@fi%#%%fi%2fiwLfw&:26E§&fiEc,%§fimu%w&%%u%u%®fi#%*én6

[3]wE%@®¥m1.Efifi

‘ZE|l’2E1FBI7J“ifl|Ji%'fi@§a\ifilZ2‘5l/"C, *"§l‘1€E’*lZF‘6'1%E7.1“YZ¢<l7E71lV5’l€l"¢%1%/2 “Cl/\Z> 71> E’) 7§"EliE§?3~TZ.1

fi%T$5.%%§®fiW%ifi%&E?&%%KfifiLtfifi%NfiL,E%@t%%E%E

fiTéfi%fi—fiKfibh5.fifiKloTfifi®viUv7Zfi&#%RLME@K%%%5

i%l5&W%E@,%WKioTfifi@%%%U%fi§&E®%%M,%@fi¢&fiEfi¢%

F§l5%‘l§4JlZ‘(F'1/E1‘L'C1'F§%L7:?§‘iV15l‘il’i’)9l5lv\'C1l('£§1TZ>. ifs, )5l5lv\Z>’lfi1Zl§lZlEl7€Zr? l~ ‘) ‘Y 7 Z§)J§'E

@¥%%E&EKlé%%®fi%%%%T6§%T§,fififi®WWKOwTEfififi%%%fi

Téii’) 7.73111 1/‘.

Hfifificu,Efi%fi%E®fl%#%<.%®fiEm1&fi®%$%E%awm7§>2fifluielfiituzfifififififiicae.:@:2u.wi&®E%fi#%fién<w&:&%%%&?5#,#Efifi®§E&&é§E®%i%fi@W$fi$%fi®%%&Efifikfil

V) 5 Z1 Vb 0)'C‘3bZ>7§‘i5, |E|’$’l‘fiE‘(£lZ2‘<3v\'C blflUi$'li%'i’?fl¥l$‘3'Z>7fEfii)%P93Z0)l‘§‘1%i€*lZl’§’i’)5l5l\/‘.

’lfi§‘§f9§€’li’§§.L’1L?Z¢f.>§l‘¢lfi14§‘%iE|l'i|"L‘§‘Z> Z 2: 70*‘, El lE'1§JZ§§il’<i:‘iW’)‘€="d'Z> fsbbll 1) 7§§il'C“§>%>.

Efifififififiwf,%%§fiWT#Efi%&fiH%fi%%%TZkfiéw.Chd,%E$

E@%§fi%&€fi$%WfifiE&R§K&MZ&®fi%T%U,%®§@%Wii@&%WT

/'5. ifllli_l:l§E'T_’E;?.f:i%é‘, iE”§’liiE|l5'£i'E%lZ]\Z>JZ ’)§iV§3l‘%V’5’$$R‘iH|li'EL. i1‘?$R1’§§§(’5.’%li‘f$fi

%fik?6

2.fi$WfiCi§@fi

—7i, ‘iH|lEfi@0)Tl5Eli, iHVlE7fl”5%0)%/J\i€*l‘fiHZl“C“% Z19‘??? (detectability) “$35116.

l’§lIlI1'l3E5?~ (limit of detection) 0)%i'E‘(iVili, 7*? ‘/ 7 535i‘-‘l0)i-iii V) ii l./‘lB|J5'i1lE@5}31?’i’ *6 5: ll,

%W%fiET77V7fifl&EWL5éfifififi®@%,%%%&§6U(&w%®%%5§®&T5fiUk,$6b®%&WkTé§W®%$%5%UTkT&&E)%boTib6fiEK

J1 o “H9530 61l1Z>. i fc, Eilifii? (limit of quantitation) ii, E1)/‘1§§E)§'K“fi§@lt l/‘:15?

$®@@fiE7U7?4WWWfi%%@§#M%UTt&&%E%$iT6fiE&E#%6

YZCJB, El'%1l‘fi§l::Bv>*C, 7l‘fii5lZ1l3E§i'~L1_F@‘lfllli1iEli, ii?’ l~L1TJ l:$li%T%.263-00610

$65 fifififii Ill. §B'lfi$5.‘?\U)l§§E'lLi..§5F(i1'fi