Sanjiv Kaul, MD Distinguished Professor of Cardiology Professor of Medicine and Radiology Chief, Division of Cardiovascular Medicine kauls@ohsu.edu

Clinical Focus: Dr. Kaul’s major clinical interests are coronary artery and valvular heart

disease.

Research Interest: Dr. Kaul is a pioneer in cardiovascular imaging, having spearheaded

most of the developments in myocardial contrast echocardiography and making major contributions to the field of nuclear cardiology. He studies coronary physiology and

pathophysiology, both in animal models and in humans. He has published over 250 papers in

the most prestigious cardiovascular journals. He has been funded continuously by the National Institutes of Health since 1986 and has received numerous grants from the

American Heart Association. He was the recipient of the AFMR Outstanding Investigator Award in 1995 given to a person under the age of 45 for their body of work.

Sample Publications: Kaul S, Spotnitz WD, Glasheen WP, Touchstone DA. Mechanism of ischemic mitral regurgitation:

an experimental evaluation. Circulation 84:2167-2180, 1991. Sabia PJ, Powers ER, Ragosta M, Sarembock IJ, Burwell LR, Kaul S. An association between

collateral blood flow and myocardial viability in patients with recent myocardial infarction. N Engl J Med 372:1825-1831, 1992.

Jayaweera AR, Edwards N, Glasheen WP, Villanueva FS, Abbott RD, Kaul S. In-vivo myocardial

kinetics of air-filled albumin microbubbles during myocardial contrast echocardiography: comparison with radiolabeled red blood cells. Circ Res 74:1157-1165, 1994.

Jayaweera AR, Wei K, Coggins M, Bin JP, Goodman C, Kaul S. Role of capillaries in determining coronary blood flow reserve: New insights using myocardial contrast echocardiography. Am J Physiol 277:H2363-H2372, 1999.

Rim S-J, Leong-Poi H, Lindner JR, Wei K, Fisher NG, Kaul S. The Decrease in Coronary Blood Flow Reserve During Hyperlipidemia Is Secondary to an Increase in Blood Viscosity. Circulation

104:2704-2709, 2001.

Division of Cardiovascular Medicine Faculty

Jonathan R. Lindner, MD

Professor of Medicine (OHSU)

Associate Chief for Education

Director, Cardiovascular Fellowship Program (OHSU, VAMC)

lindnerj@ohsu.edu

Clinical Focus: Dr. Lindner specializes in noninvasive cardiac imaging and has a clinical interest

in ischemic and valvular heart disease.

Research Interests: Dr. Lindner leads an NIH-sponsored laboratory group that studies

molecular imaging of inflammation, ischemia, and angiogenesis. This technique relies on the

development and testing of targeted ultrasound contrast agents that adhere to molecules expressed during pathogenesis. There are also research efforts to develop new methods for

site-targeted drug and gene delivery with ultrasound and microbubble carriers; and to study microvascular physiology at the capillary level using both ultrasound and intravital microscopy.

Dr. Lindner’s clinical research interests include microvascular no-reflow in acute MI, diabetic

microvascular disease, and novel methods for evaluating peripheral vascular disease.

Sample Publications: Leong Poi H, Christiansen J, Heppner P, Lewis C, Klibanov AL, Kaul S, Lindner JR. Assessment of

endogenous and therapeutic arteriogenesis by contrast ultrasound molecular imaging of integrin

expression. Circulation 111:3248-3254, 2005. Lindner JR. Microbubbles in medical imaging: current applications and future directions. Nat Rev

Drug Discov 3:527-532, 2004. Kaufmann B, Sanders JM, Davis C, Xie A, Aldred P, Sarembock IJ, Lindner JR. Molecular imaging of

inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-I. Circulation 2007;116:276-284.

Behm CZ, Kaufmann BA, Lankford M, Sanders JM, Kaul S, Lindner JR. Molecular imaging of VCAM-

1 and inflammatory cell recruitment during arteriogenesis and vasculogenesis. Circulation 2008;117:2902-2911.

Rami Alharethi, MD

Assistant Professor of Medicine (OHSU)

alhareth@ohsu.edu

Clinical Focus: Treatment of advanced heart failure and cardiac transplantation

Research Interest: Allograft vasculopathy and the use of beta blocker in advanced heart failure

Sample Publications: Movesesian MA, Alharethi R. “Inhibitors of cyclic nucleotide phosphodiesterase PDE3 a adjunct therapy for

dilated cardiomyopathy” Expert Opin Investig Drugs 11(11)1529-1536, 2002

Bullinga, JR, Alharethi R, Schram MS, Bristow MR, Gilbert EM. “Changes in Heart Rate Variability correlated to Hemodynamic Improvement with Chronic Carvedilol Therapy in Heart Failure” J Card Fail 11(9):693-9, 2005.

Alharethi R, Bader F, Kfoury AG, Hammond, EH, Karwande SV, Gilbert EM, Doty DB, Hagan ME, Thomas H, Renlund DG. “Tricuspid Valve Replacement after Cardiac Transplantation” J Heart Lung Transplant 25(1):48-52, 2006.

May HT, Alharethi R, Anderson JL, Muhlestein JB, Reyna SP, Bair TL, Horne BD, Kfoury AG, Carlquist

JF, Renlund DG “Homocysteine Levels Are Associated with Increased Risk of Congestive Heart

Failure in Patients with and without Coronary Artery Disease”. Cardiology. 2006 Aug 28;107(3):178-184. Alharethi R, Hershberger RE. “Beta-blocker use in decompensated heart failure” Curr Heart Fail Rep. 2006

Jun;3(2):75-80.

Dianna M. E . Bardo , MD

Assistant Professor of Radiology and Medicine (OHSU)

Director of Cardiac Radiology

bardod@ohsu.edu

Clinical Focus: Dr. Bardo is a Diagnostic Radiologist with subspecialty certification in Neuroradiology and

Pediatric Radiology. She founded the Cardiovascular MR and CT program at The University of Chicago before joining the faculty at OHSU. Her clinical interests lie in pediatric and adult congenital heart

disease and in pediatric and adult neurological manifestations of cardiovascular disease.

Research Interest: Dr. Bardo is involved in numerous clinical research projects which investigate the

physics of cardiovascular imaging, especially motion of the coronary arteries and atherosclerotic calcification, and effective radiation dose and the 3-dimensional MR and MDCT imaging in congenital

heart disease. She is also investigating the correlation of coronary artery disease with cerebrovascular stroke risk.

Sample Publications: Bardo DME and Restrepo CS.Cardiac Imaging Casebase. 2009 (in press). Thieme Publishers. New York.

This is a case-based review of cardiac MR and CT images in book format containing 100 cases presented as an unknown, with differential diagnosis, essential facts of the diagnosis, detailed imaging findings,

pearls, pitfalls, and suggested reading materials. Bardo DME, Kachenoura N, Newby B, Lang RM, Mor-Avi V. Multidetector computed tomography evaluation of left ventricular volumes: sources of error and guidelines for their minimization. J Cardiovasc CT. 2008;

2(4):222-230. Bardo DME, Brown P. Cardiac Multidetector Computed Tomography: Basic Physics of Image Acquisition and Clinical Applications. Clin Cardiol Rev. 2008; 4(3): 231-243. King M, Giger ML, Suzuki K, Bardo DME, Greenberg, B, Lan L, Pan X. Computer-aided assessment of

motion-contaminated calcified plaques in cardiac multidetector CT. Med Physics. 2007; 34(12):4876-4889.

Craig Broberg, MD

Assistant Professor of Medicine (OHSU)

brobergc@ohsu.edu

Clinical Focus: Dr. Broberg’s clinical focus is in adult congenital heart disease as well as magnetic

resonance imaging and other non-invasive imaging.

Research Interests: His research interests are in the etiology of heart failure in congenital heart

disease, and the optimal management of cyanotic heart disease, specifically patients with

Eisenmenger Syndrome.

Sample Publications: Broberg CS, Ujita M, Prasad SK, Li W, Bouzas B, Bax B, Rubens M, Gibbs JSR, Burman J, Gatzoulis MA. “Pulmonary Arterial Thrombosis in Eisenmenger Syndrome is Associated with Biventricular

Dysfunction and Decreased Pulmonary Blood Flow Velocity.” J Am Coll Cardiol. 2007 Aug 14;50(7):634-42

Broberg CS, Uebing A, Cuomo L, Thein SL, Papadopoulos MG, Gatzoulis MA. “Adult Patients with

Eisenmenger Syndrome Report Flying Safely on Commercial Airlines.” Heart. 2007, Dec;93(12):1599-603.

Broberg CS, Bax BE, Okonko DO, Rampling MW, Bayne S, Harries C, Davidson SJ, Uebing A, Khan

AA, Thein S, Gibbs JS, Burman J, Gatzoulis MA.. “Blood Viscosity and its Relation to Iron Deficiency, Symptoms, and Exercise Capacity in Adults with Cyanotic Congenital Heart Disease.”

JACC July 18, 2006. 48(2):356-65 Broberg CS, Ujita M, Babu-Narayan S, Rubens M, Prasad SK, Gibbs JS, Gatzoulis MA. “Massive

Pulmonary Artery Thrombosis with Haemoptysis in Adults with Eisenmenger Syndrome: A Clinical Dilemma.” Heart 90(11):e63, 2004.

Joaquin Cigarroa, MD Associate Professor of Medicine (OHSU) Associate Chief of Clinical Affairs Director, Cardiac Catheterization Laboratory

cigarroa@ohsu.edu

Clinical Focus: Coronary Artery Disease, Valvular Heart Disease

Research Interests: Acute Coronary Syndrome, Coronary Vasomotor Tone

Sample Publications: Cigarroa JE, Hillis LD. Percutaneous coronary interventions: Guidelines,

short and long term results and comparison with coronary artery bypass grafting. Cardiology Clinics 2006 May: 24(2):255-63 Nguyen K, Cigarroa JE, Lange RA, Hillis LD, Keeley EC. Presence and extent of angiographic

coronary narrowing in patients with left bundle branch block. Am J Cardiology 2004;93, 1426-1427.

Crispin H. Davies, MD

Associate Professor of Medicine (VAMC)

Director, Cardiac Catheterization Laboratory, Portland VA Medical Center crispin.davies@va.gov

Clinical Focus: Dr. Davies specializes in interventional cardiology with specific interests in acute

coronary syndromes, cardiogenic shock, chronic occlusions, and rotational atherectomy.

Research Interests: Dr. Davies’ research interest is in intravascular imaging and assessment

of intermediate lesion severity.

Sample Publications: Davies CH, Ormerod OJM. Diagnosis and Management of Failed Coronary Thrombolysis. Lancet 351:11941-1196, 1998.

Lodi R. Rajagopalan B. Blamire AM. Cooper JM. Davies CH. Bradley JL. Styles Schapira AH. Cardiac energetics are abnormal in Friedreich ataxia patients in the absence of cardiac

dysfunction and hypertrophy: an in-vivo 31P magnetic resonance spectroscopy study.

Cardiovascular Research 52(1):111-9, 2001. Conklin HM, Huang X, Davies CH, Sahn DJ, Shively BK. Biphasic Left Ventricular Outflow and Its

Mechanism in Hypertrophic Obstructive Cardiomyopathy. Journal of the American Society of Echocardiography 17(4):375-83, 2004.

Henry DeMots, MD

Professor of Medicine (OHSU)

Medical Director, University Medical Group

demotsh@ohsu.edu

Clinical Focus: Dr. DeMots’ special interests are in heart failure and coronary artery disease. He is

widely recognized for his teaching contributions in the field of inpatient cardiology. He received his medical degree in 1966 from Northwestern University in Chicago, and completed his residency and fellowship at

OHSU. Dr. DeMots has been board certified in Internal Medicine and Cardiology since 1966.

George D. Giraud, MD, PhD

Associate Professor of Medicine (VAMC)

giraudg@ohsu.edu, george.giraud@va.gov

Clinical Focus: Dr. Giraud’s clinical interest is in cardiovascular imaging.

Research Interest: Dr. Giraud is working closely with Kent Thornburg in studies on fetal cardiac

growth, regulation and development. A specific area of focus is the effect of maternal-fetal

environment on contractile physiology and the biochemical indicators involved.

Susan Grauer, MD

Assistant Professor of Medicine (VAMC)

grauers@ohsu.edu, susan.grauer@va.gov

Clinical Focus: Dr. Grauer is a clinician educator who practices general cardiology with a focus

on echocardiography and with special interest in valvular heart disease and pericardial disease.

Saurabh Gupta, MD

Assistant Professor of Medicine (OHSU)

guptasa@ohsu.edu

Clinical Focus: Dr Gupta’s major clinical interests are in structural heart disease interventions especially

in valvular heart disease. He is board certified in Interventional Cardiology and Cardiovascular diseases.

Research Interest: Dr Gupta’s research interests involve assessing individualized titration strategies of

antiplatelet therapy in patients at risk for atherothrombotic events. He also studies the impact of

percutaneous interventions (mitral valvuloplasty) on the intensity of heart sounds assessed by acoustic phono-cardiography.

Sample Publications: Gupta S et al. Coronary revascularization (surgical or percutaneous) in patients with chronic total

occlusions confers a significant survival advantage when compared to medical therapy. 2009 submitted JACC Interventions.

Gupta S et al. Successful treatment of right heart thromboemboli with intra-venous recombinant tissue-type plasminogen activator after laparoscopic appendectomy: a case report.

2009 submitted CCI.

Gupta S et al. Primary Cardiac Pheochromocytoma, Images Section, Journal of American College of Cardiology (In press JACC091608-3161)

Mark T. Hattenhauer, MD

Assistant Professor of Medicine (OHSU)

hattenha@ohsu.edu

Clinical Focus: Dr. Hattenhauer has been practicing cardiology since 1974. His interests include general and preventive cardiology and interventional cardiology. Dr. Hattenhauer performed the first balloon angioplasty in the state of Oregon in June 1981.

A. Ranjith Jayaweera, Ph.D.

Research Professor of Medicine (OHSU)

jayaweer@ohsu.edu

Research Interests: Dr. Jayaweera is a biophysicist/medical physicist with a multidisciplinary

approach to solving problems. His strength is in developing mathematical models to

explain, characterize and understand the basic mechanisms involved in experimental observations. Some of his research interests are microvascular perfusion and function using

contrast sonography, and cardiovascular mechanics.

Sample Publications: Jayaweera AR, Wei K, Coggins M, Bin JP, Goodman C, Kaul S. Role of capillaries in determining CBF

reserve: new insights using myocardial contrast echocardiography. Am J Physiol 277(46):H2363-

H2372, 1997.

Wei K, Jayaweera AR, Firoozan S, Linka A, Skyba DM, Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation 97:473-483, 1998.

Dent JM, Jayaweera AR, Glasheen WP, Nolan SP, Spotnitz WD, Villanueva FS, Kaul S. A mathematical

model for the quantitation of mitral regurgitation: Experimental validation in the canine model using

contrast echocardiography. Circulation 86:553-562, 1992.

Antony Y. Kim, MD Associate Professor of Medicine (OHSU) Director, Heart Failure and Transplant kimto@ohsu.edu

Clinical Focus: Dr. Antony Kim specializes in clinical heart failure and heart transplantation. The

program at OHSU is a historic and thriving clinical enterprise and has performed over 500 transplants

since it began. Research Interests: Dr. Kim’s NIH-funded lab is presently exploring the broader theme of dynamic

protein structure using two specific motifs: namely, (1) surface proteins on the endocardium and (2) a

surface receptor on platelets. We are currently investigating the pathogenesis of cardiomyopathy and

endocardial dysfunction-- the origin and development of endocardial-myocardial pathobiology. My research interests also include vascular biology in heart failure, and more specifically in endothelial

function involving various pathologic states. My research program extends to the broader field of hemostasis and thrombosis related to cardiovascular disease.

Sample Publications: Kim AY, Walinsky PL, Kolodgie FD, Bian C, Sperry JL, Deming CB, Peck EA, Shake JG, Ang GB, Esmon

CT, Virmani R, Stuart RS, Rade JJ. Early Loss of Thrombomodulin Expression Impairs Vein Graft Thromboresistance- Implications for Vein Graft Failure. Circulation Research 90: 205 – 212 2002

Sperry JL, Deming CB, Bian C, Walinsky PL, Kass DA, Kolodgie FD, Virmani R, Kim AY, Rade JJ. Wall Tension Is A Potent Negative Regulator of In Vivo Thrombomodulin Expression. Circulation Research 92: 41 – 47 2003.

Deming CB, Kim AY, Regard JB, Bian C, Rade JJ. cDNA Cloning of Rabbit Thrombomodulin and Characterization of Gene Expression in Cardiovascular Tissue. DNA Sequence 14(6):399-405 2003.

Jack Kron, MD Professor of Medicine (OHSU) Director, Electrophysiology Laboratory kronj@ohsu.edu

Clinical Focus: Dr. Kron specializes in electrophysiology and clinical arrhythmia management. Research Interests: He is currently engaged in clinical trials involving arrhythmia

management, atrial fibrillation, implantable defibrillators and radiofrequency catheter

ablation.

Sample Publications: Kron J, Yao Q, Olarte A, Halperin B, Raitt M, Renfroe E, et.al. Lead complications with nonthoracotomy

defibrillation lead systems in the AVID study. Circulation 96:supp 1-77, 1997.

Flaker GC, Belew K, Vidailet HJ, Beckman KJ, Kron J, Safford R, Mickel M. Differences between asymptomatic and symptomatic patients with atrial fibrillation in the Atrial Fibrillation Follow-Up

Investigation of Rhythm Management (AFFIRM) Study. PACE 26(II):966, 2003.

Steinberg JS, Sadaniantz A, Kron J, et al. Analysis of Cause-Specific Mortality in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Study. Circulation 109:1973, 2004.

Greg Larsen, MD

Associate Professor of Medicine (VAMC)

Chief, Cardiology Section, Portland VA Medical Center

greg.larsen@va.gov; larseng@ohsu.edu

Clinical Focus: Dr. Larsen is an interventional cardiologist with interests in the cath lab evaluation of patients presenting with acute coronary syndromes, CHF, valvular heart

disease and chronic angina.

Research Interests: Dr. Larsen’s interests include outcomes studies of patients with acute

and chronic coronary artery disease as well as cost-effectiveness analysis. He currently directs an 8-center VA trial evaluating the outcomes and quality of life of patients

presenting with acute coronary syndromes.

Sample Publications : Larsen GC, Hallstrom AP, McAnulty JH, Pinski S, Olarte A, Sullivan S, Brodsky M, Powell J, Marchant C,

Jennings C, Akiyama T. Cost-effectiveness of the implantable cardioverter-defibrillator versus

antiarrhythmic drugs in survivors of serious ventricular tachyarrhythmias: results of the

Antiarrhythmics Versus Implantable Defibrillators (AVID) economic analysis substudy. Circulation 105:2049-57, 2002.

Wilt TJ, Rubins HB, MacDonald R, Rutks I, Nelson D, Pineros S, Larsen, GC, Ho M, McCall AM, Sales A. Effectiveness of statins in adults with coronary heart disease: a systematic review and meta-analysis

from randomized controlled trials. Archives of Internal Medicine 2004 164(13):1427-36, 2004. McFalls EO, Ward HB, Moritz TE, Littooy F, Santilli S, Rapp J, Larsen GC, Reda DJ. Clinical predictors

of outcome among patients undergoing vascular surgery: The non-randomized registry from the

Coronary Artery Revascularization Prophylaxis (CARP) trial. Journal of Vascular Surgery 2007; 46: 694-700.

D. Elizabeth Le, M.D.

Assistant Professor of Medicine (VAMC)

lee@ohsu.edu

Clinical Focus: Echocardiography, heart failure, and cardiovascular health and disease in

Women.

Research Interests: Using the technique of myocardial contrast echocardiography to study

coronary physiology and microcirculation in the normal heart and the pathophysiology of

chronic ischemic cardiomyopathy

Sample Publications:

Le DE, Pelberg RA, Leong-Poi H, Bin JP, Linden J, Kaul S. A1-receptor blockade: a novel approach for assessing myocardial viability in chronic ischemic cardiomyopathy. J Am Soc of Echocardiogr 16:764-

769, 2003.

Le DE, Jayaweera AR, Wei K, Coggins MP, Lindner JR, Kaul S. Changes in myocardial blood volume over a wide range of coronary driving pressures: role of capillaries beyond the autoregulatory range.

Heart 90:1199-1205, 2004. Le DE, Powers ER, Bin JP, Leong-Poi H, Goodman NC, Kaul S. Transmyocardial revascularization

ameliorates ischemia by reversing paradoxical catecholamine-induced vasoconstriction. J Nuclear Cardiol 2007;14: 207-214.

David S. Lee, MD

Assistant Professor of Medicine (OHSU)

leeda@ohsu.edu

Clinical Focus: vascular disease including coronary, carotid, cerebral, and peripheral

Research Interests: carotid and cerebral atherosclerotic disease, acute stroke

Sample Publications: Casserly IF, Abou-Chebl A, Fathi RB, Lee DS, Saw J, Exaire JE, Kapadia SR. Bajzer CT,

Yadav JS. Slow-flow Phenomenon During Carotid Artery Intervention with Embolic Protection Devices: Predictors and Clinical Outcome. JAm Coil Cardiol. 2005;46(8):1466-

72 Epub 2005. Yen MH, Lee DS, Kapadia 5, Sachar R, Schneider J, Satava ME, Bajzer CT, Bhatt DL,

Yadav IS. Symptomatic Patients Have Similar Outcomes Compared to Asymptomatic Patients After Carotid Artery Stenting with Emboli Protection. Am J Cardiol. 2005;95(2):297-300.

Lee DS, Bhatt DL, Moliterno Di, Peacock WF, Ellis SG, Topol EJ. The Combination of Enoxaparin, Glycoprotein lIb/Illa Inhibitors and an Early Invasive Approach Among Acute Coronary Syndrome

Patients. J lnvasive Cardiology. 2004;l6(2):46-51.

Karen MacMurdy, MD

Assistant Professor of Medicine (VAMC)

macmurdy@ohsu.edu, Karen.macmurdy@va.gov

Clinical Focus: Management of heart rhythm disorders and device therapy

Research Interest: Clinical trials involving the prevention and treatment of ventricular

arrhythmias

Cheryl L. Maslen, PhD

Professor of Cardiovascular Medicine and Molecular & Medical Genetics

Associate Director of OHSU Heart Research Center

Director, NW Center for Thoracic Aortic Aneurysm Research

Director, Program in Molecular and Cellular Bioscience

maslenc@ohsu.edu

Research Interest: Dr. Maslen’s research group is focused on the genetic basis of cardiovascular

defects, including congenital heart defects and thoracic aortic aneurysms. Dr. Maslen is a leader in

gene discovery for cardiovascular defects, including identifying the gene for Marfan syndrome, a

major cause of thoracic aortic aneurysms, and the discovery of the first known genetic risk factor for atrioventricular septal defects. She is a principal investigator for two NIH-sponsored national level

projects; The National Down Syndrome Heart Project, and the National Registry for Genetically Triggered Thoracic Aortic Aneurysms and Related Conditions (GenTAC).

Sample Publications:

Robinson, S.W., Morris, C.D., Goldmuntz, E., Reller, M.D., Jones, M.A., Steiner, R.D, Maslen, C.L. (2003) Missense mutations in CRELD1 are associated with cardiac atrioventricular septal defects.

Am. J. Hum. Genet. 72: 1047-1052.

Maslen, C.L. (2004) The Molecular Genetics of Atrioventricular Septal Defects. Current Opinion in

Cardiology. 19(3): 205-210. Maslen, C.L., Babcock, D., Redig, J.K., Kapeli, K., Akkari, Y.M., Olson, S.B. (2006) CRELD2: Gene

mapping, alternate splicing, and comparative genomic identification of the promoter region. Gene 382C: 111-120.

Maslen, C.L., Babcock, D., Robinson, S.W., Bean L.J.H., Willour, V., Sherman, S. CRELD1 Mutations

Contribute to the Occurrence of Cardiac Atrioventricular Septal Defects in Down Syndrome. Am. J. Med. Genet. 140: 2501-2505.

Maureen Mays, MD, MS Assistant Professor of Medicine

Director of Preventive Cardiology maysm@ohsu.edu

Clinical Focus: Primary and secondary prevention in children and adults. She practices

guideline-based risk factor reduction and treatment of lipid disorders, hypertension, diabetes, metabolic syndrome, obesity and emerging risk factors.

Research Interests: Noninvasive imaging, the impact of Metabolic Syndrome on

macrovascular disease, treatment of cardiovascular risk factors in women, and the impact of

rheumatologic conditions on risk of cardiovascular disease.

Sample Publications: Mays ME, Fraizer MC, Aeschlimann SE, Korcarz CE, McBride PE, Douglas PS, Stein JH. Is subclinical atherosclerosis more prevalent in patients with metabolic syndrome? Circulation 2003; 108:IV-743.

Tzou WS, Korcarz CE, Mays ME, Aeschlimann SE, Stein JH. Skin cholesterol content identifies increased carotid intima-media thickness in asymptomatic adults. American Heart Journal 2005 Dec, 150: 1135-9.

John H. McAnulty, MD

Professor of Medicine, Emeritus (OHSU)

jmcanult@lhs.org

Clinical Focus: Dr. McAnulty specializes in clinical cardiology and arrhythmia, including

electrophysiology procedures, device implantation and management of atrial and ventricular

arrhythmias.

Research Interests: His research interests involve antiarrhythmic effects of n-3 fatty acids,

arrhythmias, pacemakers and defibrillators. Dr. McAnulty is currently engaged in clinical trials involving the study of treatments for ventricular and atrial arrhythmias.

Edward S. Murphy, MD

Professor of Medicine (VAMC)

Former Director, Cardiovascular Fellowship Program (OHSU, VAMC)

edward.murphy@va.gov

Clinical Focus: Dr. Murphy is an interventional cardiologist with an interest in clinical trials in Cardiology. He has received many awards for teaching while serving as the Director of

Cardiovascular Training.

Research Interest: Dr. Murphy’s current research focus is on clinical trials in atherosclerosis.

George A. Pantely, MD

Professor of Medicine (OSHU)

pantelyg@ohsu.edu

Clinical Focus: Dr. Pantely specializes in congenital heart disease in the adult, pregnancy in women

with heart disease, and echocardiology.

Research Interests: Dr. Pantely’s research interests include long-term survival in adults with

congenital heart disease, and mechanisms of systemic right ventricular failure.

Sample Publications: Babu-Narayan SV, Goktekin O, Moon JCC, Broberg CS, Pantely GA, Pennell DJ, Gatzoulis MA, Kilner

PJ. Late gadolinium enhancement cardiovascular magnetic resonance of the systemic right ventricle in adults with

previous atrial redirection surgery for transposition of the great arteries. Circ 2005;111:2091-

2098. Adult Congenital Heart Disease: A Practical Guide. Gatzoulis MA, Swann L,Therrien J, Pantely GA,

Editors. Blackwell Publishing, 2005. Pantely GA, Gatzoulis MA. Simple septal defects. In Kisslo J and Nihoyannopoulos P (eds), Clinical

Echocardiography, Elsevier Publishing (pending publication).

Merritt Raitt, MD

Associate Professor of Medicine (VAMC)

merritt.raitt@va.gov

Clinical Focus: Dr. Raitt is a clinical and research electrophysiologist.

Research Interest: Dr. Raitt is currently leading a double blind randomized multi-center trial of

spironolactone in patients with implantable defibrillators. Other research interests include the electrophysiology of atrial fibrillation where Dr. Raitt has done work on electrical remodeling, P

wave signal averaging, and frequency analysis of surface and intracardiac atrial fibrillation signals.

Sample Publications: Raitt MH, Kusumoto W, Giraud G, McAnulty J. Reversal of Electrical Remodeling After Cardioversion

of Persistent Atrial Fibrillation. J Cardiovasc Electrophys 2004 15:507-512. Raitt MH, Connor WE, Morris C, Kron J, Halperin B, Chugh SS, McClelland J, Cook J, MacMurdy K,

Swenson R, Connor SL, Gerhard G, Kraemer DF, Oseran D, Marchant C, Calhoun D, Shnider R, McAnulty J. Fish oil supplementation and risk of ventricular tachycardia and ventricular

fibrillation in patients with implantable defibrillators: a randomized controlled trial. JAMA. 2005

293:2884-91. Raitt MH, Volgman AS, Zoble RG, Charbonneau L, Padder FA, O'Hara GE, Kerr D; AFFIRM

Investigators. Prediction of the recurrence of atrial fibrillation after cardioversion in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study. Am Heart J. 2006

151:390-6.

Tran T, Raitt MH. Predicting imminent episodes of ventricular tachycardia using heart rate. PACE. 2007; 30:874-884.

Raitt MH, Implantable cardioverter-defibrillator shocks: a double-edged sword? J Am Coll Cardiol. 2008; 51:1366-8.

Diana Rinkevich, MD

Adj. Associate Professor of Medicine (OHSU)

Director of the Heart Disease in Women Program

rinkevic@ohsu.edu

Clinical Focus: Heart disease in women, microvascular dysfunction as a cause of chest pain in women with no angiographic evidence of coronary artery disease, and the use of noninvasive diagnostic tools for the diagnosis and treatment of heart disease. Research Interest: Evaluation of pathophysiologic changes in the microcirculation in women with syndrome X. She was recently awarded with seed funding from the Center for Women’s Health and Gender-Based Medicine for her study “Elucidating the Role of Microvascular Dysfunction in Heart Disease in Women”. Sample Publications: Rinkevich D, Kaul S, Wang XQ, Tong KL, Belcik T, Kalvaitis S, Lepper W, Dent J, Wei K: Regional left ventricular perfusion and function in patients presenting to the emergency department with chest pain and no ST-segment elevation. Eur Heart J. Epub 2005 May 25. Kavaitis S, Kaul S, Tong KL, Rinkevich D, Belcik T, Wei K: Effect of Time Delay on the Diagnostic Use of Contrast Echocardiography in Patients Presenting to the Emergency Department with Chest Pain and no S-T Segment Elevation. J Am Soc. Echocardiogr. 2006 Dec;19(12): 1488-93. Tong KL, Kaul S, Wang XQ, Rinkevich D, Kalvaitis S, Belcik T, Lepper W, Foster WA, Wei K: Myocardial contrast echocardiography versus thrombolysis in myocardial infarction score in patients presenting to the emergency department with chest pain and a nondiagnostic electrocardiogram. J Am Coll Cardiol. 2005 Sep 6;46(5):920-7.

Michael D. Shapiro, DO

Assistant Professor of Medicine (OHSU)

Director of Cardiac MRI and CT

Medical Director, Cardiac Rehabilitation

shapirmi@ohsu.edu

Clinical Focus: Dr. Shapiro’s clinical focus deals with noninvasive cardiac imaging with

cardiovascular CT and MRI. Dr. Shapiro has been awarded the 2009 American College of Cardiology W. Proctor Harvey, MD Young Teacher Award.

Research Interests: His research interests include noninvasive coronary angiography and

myocardial perfusion imaging with cardiac CT and myocardial edema and infarct imaging with

cardiac MRI.

Sample Publications: Shapiro MD, Butler J, Rieber, J, Sheth TN, Cury RC, Ferencik, M, Nichols JH, Goehler A, Abbara S, Pena AJ, Brady TJ, Hoffmann U. Analytic Approaches to Establish the Diagnostic Accuracy of

Coronary Computed Tomography Angiography as a Tool for Clinical Decision-making. Am J Cardiol 2007;99:122-1127.

Shapiro MD, Nieman K, Nomura C, Nasir K, Hoffman U, Abbara S, Gold HK, Jang IK, Brady TJ, Cury RC. Utility of Cardiovascular Magnetic Resonance to Predict Left Ventricular Recovery

after Primary Percutaneous Coronary Intervention for Patients presenting with Acute ST-

Segment Elevation Myocardial Infarction. Am J Cardiol 2007;100:211-216. Shapiro MD, Neilan, TG, Jassal DS, Samy B, Hoffmann U, Sarwar A, Butler J, Brady TJ, Cury RC.

Detection of Left Atrial Appendage Thrombus by Multi-Detector Computed Tomography comparative study with Transesophageal Echocardiography. J Comput Assist Tomogr.

2007;31:905-909.

Jiri Sklenar, PhD

Research Associate Professor

sklenarj@ohsu.edu

Research Interests: Dr. Sklenar specializes in development of algorithms and custom

software for image processing and quantification of medical images, with particular emphasis

on contrast echocardiography and targeted imaging. Other interests include medical informatics, data modeling, and internet technologies

Sample Publications: Coggins MP, Sklenar J, Le E, Wei K, Lindner J, Kaul S: Noninvasive Prediction of Ultimate Infarct

Size at the Time of Acute Coronary Occlusion Based on the Extent and Magnitude of Collateral-Derived Myocardial Blood Flow. Circulation 104:2471-2477, 2001.

Ellegala DB, Leong-Poi H, Carpenter JE, Klibanov AL, Kaul S, Shaffrey ME, Sklenar J, Lindner JR:

Imaging tumor angiogenesis with contrast ultrasound and microbubbles targeted to alpha(v)beta3. Circulation 108:336-41, 2003.

Leong-Poi H, Coggins MP, Sklenar J, Jayaweera AR, Wang XQ, Kaul S. Role of collateral blood flow in the apparent disparity between the extent of abnormal wall thickening and perfusion defect

size during acute myocardial infarction and demand ischemia. Journal of the American College of Cardiology 45(4):565-72, 2005.

Karl Stajduhar, MD

Assistant Professor of Medicine (OHSU)

Program Director, Electrophysiology Fellowship

Director, Cardiology Clinic

stajduha@ohsu.edu

Clinical Focus: Dr. Stajduhar specializes in clinical cardiology and arrhythmias, including electrophysiology and radiofrequency catheter ablation procedures, device implantation and management of atrial and ventricular arrhythmias.

Research Interests: His current research efforts include clinical trials involving arrhythmia

management, atrial fibrillation, implantable defibrillators and radiofrequency catheter ablation.

Sample Publications: Shry EA, Dacus J, Van De Graaff E, Hjelkrem M, Stajduhar KC, Steinhubl SR. Usefulness of the

response to sublingual nitroglycerin as a predictor of ischemic chest pain in the emergency

department. Am J of Cardiol 90(11):1264-6, 2002.

Galbreath AD, Krasuski RA, Smith B, Stajduhar KC, Kwan MD, Ellis R, Freeman GL. Long-term Healthcare and Cost Outcomes of Disease Management in a Large, Randomized, Community

Based Population with Heart Failure. Circulation 110:3518-3526, 2004. Eckart RE, Scoville SL, Campbell CL, Shry EA, Stajduhar KC, Potter RN, Pearse LA, Virmani R.

Sudden death in young adults: A 25-year review of autopsies in military recruits. Annals of Internal Medicine 141:829-834, 2004.

Er ic Stecker , MD

Assistant Professor of Medicine (OHSU)

Director, Inpatient Cardiology

steckere@ohsu.edu

Clinical Focus: Electrophysiologist – advanced ablations and ICD’s

Research Interest: Risk stratification of sudden cardiac arrest

Sample Publications: Stecker EC, Vickers C, Waltz J, Miu C, John BT, Mariani R, McAnulty JH, Gunson K, Jui J, Chugh SS.

“Population-based analysis of sudden cardiac death with and without left ventricular systolic dysfunction: Two-year findings from the Oregon Sudden Unexpected Death Study.” 2006. JACC

47:1161-66. Stecker EC, Sono M, Gunson K, Jui J, Chugh SS . “Allelic variants of SCN5A do not affect risk of sudden

cardiac arrest in patients with coronary artery disease.” 2006. Heart Rhythm 3:697-700.

Stecker EC, Zargarian M, Dogra V, John BT, Kron J, McAnulty JH, Chugh SS. “Native QRS duration predicts the occurrence of arrhythmic events in ICD recipients.” 2006. Europace 8:859-62

Chugh SS, Reinier K, Stecker ES. “Learning from a real world analysis of ICD recipients: co-morbidities matter.” 2007. JACC 49:2416-18.

Kent Thornburg, PhD

M. Lowell Edwards Chair

Professor of Medicine (OHSU)

Professor of Physiology/Pharmacology & Biomedical Engineering

Associate Chief for Research

Director, Heart Research Center

thornbur@ohsu.edu

Research Interest: Dr. Thornburg’s research has focused on the placental and fetal mechanisms

that underlie programming. He is currently pursuing studies on the role of the role of Ang II in regulating placental transport proteins, placental-fetal fluid balance in regulating heart

development, and differential gene expression in placental under- and over-growth.

Sample Publications: Davis L, Thornburg KL, Giraud GD. The effects of anaemia as a programming agent in the fetal

heart. J Physiol 565.1:35-41, 2005.

Thornburg KL, Bagby SP, Giraud GD. Maternal adaptations to pregnancy. In: Knobil and Neill: Physiology of Reproduction. (In press) 2005.

Louey S, Thornburg KL. The prenatal environment and later cardiovascular disease. Early Hum Dev 81(9):745-51, 2005.

Thornburg KL, Louey S. Fetal roots of cardiac disease. Heart 91(7):867-8, 2005.

Kevin Wei, MD

Associate Professor of Medicine (OHSU)

weik@ohsu.edu

Clinical Focus: Dr. Wei sub-specializes in noninvasive cardiac imaging and has a clinical interest

in myocardial contrast echocardiography. Research Interests: Dr.Wei has focused his research on the evaluation of pathophysiologic

changes in the microcirculation in the setting of coronary artery disease, and has applied these

phenomena to the noninvasive detection and quantification of stenoses with myocardial contrast echocardiography.

Recently, his translational research has extended observations made in the animal laboratory to The patient, and ongoing studies are evaluating the clinical utility of contrast echocardiography

in the Emergency Department, as well as the role of the microvasculature in other cardiac diseases.

Sample Publications: Wei K, Tong KL, Wang, XQ, Belcik T, Rafter P, Ragosta M, Kaul S. Detection of Coronary Stenosis at

Rest With Myocardial Contrast Echocardiography. Circulation 112:1154-1160, 2005. Rinkevich D, Kaul S, Lepper W, Wang XQ, Tong KL, Belcik T, Kalvaitis S, Lepper W, Dent JM, Wei K.

Regional Left ventricular Perfusion and Function in Patients Presenting to the Emergency

Department with Chest Pain and no ST Segment Elevation. Eur Heart J 26:1606-1611, 2005. Tong KL, Kaul S, Wang XQ, Rinkevich D, Kalvaitis S, Belcik T, Lepper W, Foster WA, Wei K.

Myocardial Contrast Echocardiography versus Thrombolysis in Myocardial Infarction Score in Patients Presenting to the Emergency Department with Chest Pain and a Non-Diagnostic

Electrocardiogram. J Am Coll Cardiol 46:920-927, 2005.

Joseph B. Weiss, MD, PhD

Assistant Professor of Molecular Medicine & Cardiology (OHSU) weissjo@ohsu.edu

Clinical Focus: Dr. Weiss practices general cardiology with a specific focus on adult congenital

heart disease.

Research Interests: The Weiss lab studies heart and smooth muscle development in

Drosophila and mice. This accomplished research group takes advantage of the evolutionary

conservation of developmental mechanisms and the power of developmental genetics in Drosophila to advance our understanding of mammalian organogenesis. One striking example of

conserved developmental mechanisms is the homeodomain protein Tinman. Homozygous

Drosophilia tinman mutant embryos have neither heart nor smooth muscle. Heterozygous human mutants in the Tinman homologue Nkx2.5 evince a broad spectrum of congenital heart lesions.

Starting with this evolutionarily conserved transcriptional regulator of heart and smooth muscle development, we have established a method to identify genes that are direct targets of Tinman

regulation.

Zhengfeng Zhou, MD, PhD

Assistant Professor of Medicine (OHSU)

Assistant Professor of Physiology and Pharmacology

zhouzh@ohsu.edu

Research Interests: The research in Dr. Zhou’s lab is to study molecular mechanisms of

genetic diseases involving cardiac arrhythmias. They have concentrated their studies on two

congenital diseases, long QT syndrome (LQTS) and arrhythmogenic right ventricular dysplasia (ARVD). LQTS is a disease associated with prolonged cardiac action potential duration and

prolonged QT intervals on ECG, which can lead to ventricular arrhythmia and sudden death. One of

the major forms of LQTS (LQT2) is caused by mutations in the human ether-a-go-go-related gene (hERG) that encodes a voltage-gated potassium channel in the heart. To date, more than 300 hERG

mutations have been identified in patients with LQTS. Current studies are investigating the mechanisms of defective protein trafficking of LQT2 mutant channels, and determining how LQT2

mutations lead to defects in splicing and stability of mutant mRNA. ARVD is an inherited disorder

characterized by prominent arrhythmias and the replacement of muscle in the heart by fatty tissue. Eight disease-causing genes have been identified in autosomal dominant and recessive forms of

ARVD. Most of these genes encode desmosomal proteins including plakoglobin, desmoplakin, plakophilin-2, desmoglein-2, and desmocollin-2. A prominent feature of ARVD mutations is that

more than 60% of these mutations are nonsense or frameshift mutations that introduce premature termination codons. The goal of this project is to determine the role of the nonsense-mediated

mRNA decay (NMD) pathway in the pathogenesis of ARVD mutations. Understanding how these

genetic defects lead to the disease at molecular levels will provide important information directed toward the development of therapeutic strategies for patients with LQTS and ARVD.

Sample Publications Anderson CL, Delisle BP, Anson BD, Kilby JA, Will ML, Tester DJ, Gong Q, Zhou Z, Ackerman MJ

and January CT. Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking- deficient) mechanism. Circulation 113:365-373, 2006.

Gong Q, Jones MA and Zhou Z. Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome. J. Biol. Chem 280:4069-4074, 2006.

Gong Q, Zhang L, Vincent GM, Horne BD and Zhou Z. Nonsense mutations in hERG cause a

decrease in mutant mRNA transcripts by nonsense-mediated mRNA decay in human long QT syndrome. Circulation 116:17-24, 2007.

Bhuiyan ZA, Momenah TS, Gong Q, Amin AS, Ghamdi SA, Carvalho JS, Homfray T, Mannens MMAM, Zhou Z, Wilde AAM. Recurrent intrauterine fetal loss due to near absence of HERG: Clinical and

functional characterization of a homozygous nonsense HERG mutation. Heart Rhythm 5:553-561, 2008.

Gong Q, Zhang L, Moss AJ, Vincent GM, Ackerman MJ, Robinson JC, Jones MA, Tester DJ and Zhou

Z. A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome. J. Mol. Cell. Cardiol. 44:502-509, 2008.