Disentangling hippocampal and amygdala contribution to ... · s s Disentangling hippocampal and...
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Copyright © 2019 the authors
Research Articles: Behavioral/Cognitive
Disentangling hippocampal and amygdalacontribution to human anxiety-like behaviour
https://doi.org/10.1523/JNEUROSCI.0412-19.2019
Cite as: J. Neurosci 2019; 10.1523/JNEUROSCI.0412-19.2019
Received: 21 February 2019Revised: 25 August 2019Accepted: 29 August 2019
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Disentangling hippocampal and amygdala
contribution to human anxiety-like
behaviour
Running head: Hippocampus and amygdala in human anxiety-like behaviour
Dominik R Bach1, 2 *Martina Hoffmann3, Carsten Finke3,4, Rene Hurlemann5,6, Christoph J.
Ploner3
Figures: 5
Tables: 3
Introduction:
Discussion:
Abstract
Significance statement
Introduction
Methods
Participants.
Table 1.
Patient
Age Sex Lesion Etiology Clinical note
Figure 1:
Design & procedure: approach/avoidance conflict task.
figure 1
see figure 3
Design & procedure: safe predator exposure task 2 (HC study).
Design & procedure: memory test.
figure 3
Data analysis.
Decision to approach:
Approach and return latency:
Comparison between patients:
Accounting for memory impairment and other confounds:
Safe predator exposure task:
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�pexGauss t
ex e ex ex terfc ex t
T2
mle.m
Results
Figure 2.
Healthy control participants' behaviour is similar to previous reports
Table 2:
Action (proportion approach) Approach latency Return latency
F df epsilon p F df p F df p
Recollection of threat memory
Figure 3.
HC but not amygdala lesions impact on approach decision
Table 3:
< .001*
0.033*
0.011*
Figure 4.
Selective HC and amygdala but not MTL lesions may impact on approach latency
Amygdala/MTL but not selective HC lesions impact on return latency
MTL lesions impact on response generation but not on subjective task structure
Figure 5.
w w
Discussion
Acknowledgements
References